V M Weaver

Summary

Affiliation: Lawrence Berkeley National Laboratory
Country: USA

Publications

  1. pmc Functional culture models to study mechanisms governing apoptosis in normal and malignant mammary epithelial cells
    V M Weaver
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley 94720, USA
    J Mammary Gland Biol Neoplasia 4:193-201. 1999
  2. pmc The organizing principle: microenvironmental influences in the normal and malignant breast
    Mina J Bissell
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Differentiation 70:537-46. 2002
  3. ncbi request reprint Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures
    Christy Hebner
    Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, CA, USA
    Annu Rev Pathol 3:313-39. 2008
  4. pmc A human breast cell model of preinvasive to invasive transition
    Aylin Rizki
    Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Cancer Res 68:1378-87. 2008
  5. pmc beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium
    Valerie M Weaver
    Department of Pathology and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cancer Cell 2:205-16. 2002
  6. ncbi request reprint The tissue microenvironment as an epigenetic tumor modifier
    Meredith Unger
    Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 223:315-47. 2003
  7. pmc Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors
    Nastaran Zahir
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 163:1397-407. 2003
  8. ncbi request reprint Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin
    Chengfeng Yang
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    J Biol Chem 280:24363-70. 2005
  9. ncbi request reprint Analysis of protein expression during oxidative stress in breast epithelial cells using a stable isotope labeled proteome internal standard
    Yuan Yan
    Center for Cancer Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    J Proteome Res 4:2007-14. 2005

Collaborators

Detail Information

Publications9

  1. pmc Functional culture models to study mechanisms governing apoptosis in normal and malignant mammary epithelial cells
    V M Weaver
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley 94720, USA
    J Mammary Gland Biol Neoplasia 4:193-201. 1999
    ..These models could now be used to investigate how the basement membrane represses apoptosis in normal cells, and how breast cancers become death-resistant...
  2. pmc The organizing principle: microenvironmental influences in the normal and malignant breast
    Mina J Bissell
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Differentiation 70:537-46. 2002
    ..How this context determines functional integrity, and how its loss can lead to malignancy, appears to have much to do with tissue structure and polarity...
  3. ncbi request reprint Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures
    Christy Hebner
    Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, CA, USA
    Annu Rev Pathol 3:313-39. 2008
    ..We review how 3D models are being used to investigate fundamental cellular and biophysical mechanisms associated with breast cancer progression that have not been readily amenable to traditional genetic or biochemical analysis...
  4. pmc A human breast cell model of preinvasive to invasive transition
    Aylin Rizki
    Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Cancer Res 68:1378-87. 2008
    ..This model provides a new tool for dissection of mechanisms by which preinvasive breast cells could acquire invasiveness in a metaplastic context...
  5. pmc beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium
    Valerie M Weaver
    Department of Pathology and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cancer Cell 2:205-16. 2002
    ..These results indicate that integrin-induced polarity may drive tumor cell resistance to apoptosis-inducing agents via effects on NFkappaB...
  6. ncbi request reprint The tissue microenvironment as an epigenetic tumor modifier
    Meredith Unger
    Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 223:315-47. 2003
  7. pmc Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors
    Nastaran Zahir
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 163:1397-407. 2003
    ..Therefore, epithelial tumors could survive in the absence of exogenous basement membrane through autocrine LM-5-alpha6beta4 integrin-RAC-NFkappaB signaling...
  8. ncbi request reprint Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin
    Chengfeng Yang
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    J Biol Chem 280:24363-70. 2005
    ....
  9. ncbi request reprint Analysis of protein expression during oxidative stress in breast epithelial cells using a stable isotope labeled proteome internal standard
    Yuan Yan
    Center for Cancer Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    J Proteome Res 4:2007-14. 2005
    ..These results suggest that the malignant T4-2 cells have acquired more resistance to H(2)O(2)-induced apoptosis than the nonmalignant S-1 cells...