Hong Wei Wang

Summary

Affiliation: Lawrence Berkeley National Laboratory
Country: USA

Publications

  1. pmc Architecture of the yeast Rrp44 exosome complex suggests routes of RNA recruitment for 3' end processing
    Hong Wei Wang
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 104:16844-9. 2007
  2. ncbi request reprint Assembly of GMPCPP-bound tubulin into helical ribbons and tubes and effect of colchicine
    Hong Wei Wang
    Life Science Division, Lawrence Berkeley National Lab, Berkeley, California, USA
    Cell Cycle 4:1157-60. 2005
  3. ncbi request reprint Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex
    Stefan Westermann
    Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Cell 17:277-90. 2005
  4. ncbi request reprint The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends
    Stefan Westermann
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California 94720 3202, USA
    Nature 440:565-9. 2006
  5. ncbi request reprint Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms
    Hong Wei Wang
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, California 94720, USA
    Nat Struct Mol Biol 14:721-6. 2007
  6. pmc The Dam1 ring binds to the E-hook of tubulin and diffuses along the microtubule
    Vincent H Ramey
    Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Biol Cell 22:457-66. 2011
  7. pmc Architecture and flexibility of the yeast Ndc80 kinetochore complex
    Hong Wei Wang
    Life Science Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    J Mol Biol 383:894-903. 2008
  8. pmc Nucleotide-dependent bending flexibility of tubulin regulates microtubule assembly
    Hong Wei Wang
    Howard Hughes Medical Institute, University of California Berkeley, Berkeley, California 94720 3200, USA
    Nature 435:911-5. 2005
  9. pmc Substrate-specific structural rearrangements of human Dicer
    David W Taylor
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Struct Mol Biol 20:662-70. 2013
  10. ncbi request reprint Tubulin rings: which way do they curve?
    Eva Nogales
    Howard Hughes Medical Institute, Molecular and Cell Biology Department and Life Science Division, Lawrence Berkeley National Laboratory, 355 Life Sciences Addition, University of California, 94720 3200, USA
    Curr Opin Struct Biol 13:256-61. 2003

Collaborators

Detail Information

Publications22

  1. pmc Architecture of the yeast Rrp44 exosome complex suggests routes of RNA recruitment for 3' end processing
    Hong Wei Wang
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 104:16844-9. 2007
    ..The Rrp44-exosome (RE) architecture suggests an active site sequestration mechanism for strict control of 3' exoribonuclease activity in the RE complex...
  2. ncbi request reprint Assembly of GMPCPP-bound tubulin into helical ribbons and tubes and effect of colchicine
    Hong Wei Wang
    Life Science Division, Lawrence Berkeley National Lab, Berkeley, California, USA
    Cell Cycle 4:1157-60. 2005
    ..Finally, we add our thoughts on the possible biological meaning of tubulin polymerization versatility...
  3. ncbi request reprint Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex
    Stefan Westermann
    Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Cell 17:277-90. 2005
    ..These observations suggest a mechanism by which the kinetochore can recognize and stay attached to the plus ends of microtubules...
  4. ncbi request reprint The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends
    Stefan Westermann
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California 94720 3202, USA
    Nature 440:565-9. 2006
    ..The Dam1 ring complex is a molecular device that can translate the force generated by microtubule depolymerization into movement along the lattice to facilitate chromosome segregation...
  5. ncbi request reprint Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms
    Hong Wei Wang
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, California 94720, USA
    Nat Struct Mol Biol 14:721-6. 2007
    ..One of Ipl1's roles might be to fine-tune the coupling of the microtubule interaction with the conformational change required for oligomerization, with phosphorylation resulting in ring breakdown...
  6. pmc The Dam1 ring binds to the E-hook of tubulin and diffuses along the microtubule
    Vincent H Ramey
    Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Biol Cell 22:457-66. 2011
    ..The present studies constitute a significant step forward by linking structural and biochemical observations toward a comprehensive understanding of the Dam1 complex...
  7. pmc Architecture and flexibility of the yeast Ndc80 kinetochore complex
    Hong Wei Wang
    Life Science Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    J Mol Biol 383:894-903. 2008
    ..We hypothesize that the kink in Ndc80 is essential for correct kinetochore geometry and could be part of a tension-sensing mechanism at the kinetochore...
  8. pmc Nucleotide-dependent bending flexibility of tubulin regulates microtubule assembly
    Hong Wei Wang
    Howard Hughes Medical Institute, University of California Berkeley, Berkeley, California 94720 3200, USA
    Nature 435:911-5. 2005
    ..Closure into a microtubule does not require GTP hydrolysis...
  9. pmc Substrate-specific structural rearrangements of human Dicer
    David W Taylor
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Struct Mol Biol 20:662-70. 2013
    ..These findings implicate RNA structure and cofactors in determining substrate recognition and processing efficiency by human Dicer...
  10. ncbi request reprint Tubulin rings: which way do they curve?
    Eva Nogales
    Howard Hughes Medical Institute, Molecular and Cell Biology Department and Life Science Division, Lawrence Berkeley National Laboratory, 355 Life Sciences Addition, University of California, 94720 3200, USA
    Curr Opin Struct Biol 13:256-61. 2003
    ..How these kinks relate to what happens when the stored energy of GTP hydrolysis is released, freeing GDP*tubulin into an unconstrained state, remains an open question...
  11. doi request reprint Cryo-EM studies of microtubule structural intermediates and kinetochore-microtubule interactions
    Eva Nogales
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3220, USA
    Methods Cell Biol 95:129-56. 2010
    ..We describe the experimental in vitro protocols to produce biologically relevant self-assembled structures of Dam 1 around microtubules and their structural characterization by cryo-EM...
  12. pmc Ab initio reconstruction of helical samples with heterogeneity, disorder and coexisting symmetries
    Vincent H Ramey
    Biophysics Graduate Program, UC Berkeley, Berkeley, CA, USA
    J Struct Biol 167:97-105. 2009
    ....
  13. ncbi request reprint Structural mechanisms underlying nucleotide-dependent self-assembly of tubulin and its relatives
    Eva Nogales
    Howard Hughes Medical Institute, Molecular and Cell Biology Department, University of California Berkeley and Lawrence Berkeley National Laboratory, 355 LSA, University of California Berkeley, Berkeley, CA 94720 3200, USA
    Curr Opin Struct Biol 16:221-9. 2006
    ..In particular, a two-state mechanism has been proposed for the recycling of alphabeta-tubulin during the microtubule disassembly-assembly cycle; this mechanism may be unique to eukaryotic dimeric tubulin and the microtubule structure...
  14. ncbi request reprint Structural intermediates in microtubule assembly and disassembly: how and why?
    Eva Nogales
    Howard Hughes Medical Institute, Molecular and Cell Biology Department, UC Berkeley and Lawrence Berkeley National Lab, 355 LSA UC Berkeley, Berkeley, CA 94720 3200, USA
    Curr Opin Cell Biol 18:179-84. 2006
    ..The discovery of these intermediates a decade ago has been followed recently by quantitative descriptions of their structure and their relationship to nucleotide state...
  15. pmc Structural insights into RNA processing by the human RISC-loading complex
    Hong Wei Wang
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Nat Struct Mol Biol 16:1148-53. 2009
    ..A model generated by docking the available atomic structures of Dicer and Argonaute homologs into the RLC reconstruction suggests a mechanism for siRNA transfer from Dicer to AGO2...
  16. ncbi request reprint An iterative Fourier-Bessel algorithm for reconstruction of helical structures with severe Bessel overlap
    Hong Wei Wang
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA
    J Struct Biol 149:65-78. 2005
    ..The algorithm has also been applied with very satisfactory results to the reconstruction of 13-protofilament microtubules, which is another helical structure that suffer Bessel overlap, suggesting its generality...
  17. pmc Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing
    Weixing Zhao
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA, Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA, Institute of Biochemical Sciences, National Taiwan University, No 1, Sec 4, Roosevelt Road, Taipei 10617, Taiwan, Cell Cycle and Cancer Biology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA, Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA and Ministry of Education Key Laboratory of Protein Science, Tsinghua Peking Joint Center for Life Sciences, Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China
    Nucleic Acids Res 42:906-17. 2014
    ..A model of the Hop2-Mnd1-DMC1-ssDNA ensemble is proposed to explain how it mediates homologous DNA pairing in meiotic recombination. ..
  18. ncbi request reprint Two-dimensional crystallization of a small heat shock protein HSP16.3 on lipid layer
    Yong Chen
    Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane, Tsinghua University, Beijing 100084, PR China
    Biochem Biophys Res Commun 310:360-6. 2003
    ..These results provide a basis for further investigation on the unique dimeric structure of HSP16.3 and its functions in vivo...
  19. pmc Ring-like pore structures of SecA: implication for bacterial protein-conducting channels
    Hong Wei Wang
    Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembranes, Tsinghua University, Beijing 100084, China
    Proc Natl Acad Sci U S A 100:4221-6. 2003
    ..They do not form in solution or in the presence of uncharged phosphatidylcholine. These ring-like phospholipid-induced pore-structures may form the core of bacterial protein-conducting channels through bacterial membranes...
  20. ncbi request reprint [Enhancement by an in vivo-activated promoter of immunogenicity of recombinant attenuated Salmonella typhimurium expressing hepatitis C virus core antigen]
    Ping Zhao
    Department of Microbiology, Second Military Medical University, Shanghai 200433, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:266-70. 2003
    ....
  21. ncbi request reprint [Effect of N-terminal deletion on biological activity of vascular endothelial cell growth inhibitor]
    Min Zhang
    Department of Microbiology, Second Military Medical University, Shanghai 200433, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:133-7. 2003
    ..These results suggest that the first 43 amino acids from N-terminus of VEGI have no significant effect on biological activity, but the amino acids 44-51 at N-terminus are required for full biological activity...
  22. ncbi request reprint Polymorphism of structural forms of C-reactive protein
    Hong Wei Wang
    Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembranes, Tsinghua University, Beijing 100084, P R China
    Int J Mol Med 9:665-71. 2002
    ..The different structural forms may convert to each other under certain conditions, which gives some hints as to the structural basis of multiple functions of CRP...