Robert O Ritchie

Summary

Affiliation: Lawrence Berkeley National Laboratory
Country: USA

Publications

  1. ncbi request reprint Fracture in human cortical bone: local fracture criteria and toughening mechanisms
    R K Nalla
    Materials Sciences Division, Lawrence Berkeley National Laboratory, and Department of Materials Science and Engineering, University of California, Berkeley, CA 94720 USA
    J Biomech 38:1517-25. 2005
  2. pmc Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice
    S S Ionova-Martin
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Osteoporos Int 22:2283-93. 2011
  3. doi request reprint How does human bone resist fracture?
    Robert O Ritchie
    Department of Materials Science and Engineering, University of California, Berkeley, CA, USA
    Ann N Y Acad Sci 1192:72-80. 2010
  4. pmc Measurement of the toughness of bone: a tutorial with special reference to small animal studies
    R O Ritchie
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Bone 43:798-812. 2008
  5. doi request reprint The conflicts between strength and toughness
    Robert O Ritchie
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nat Mater 10:817-22. 2011
  6. doi request reprint Mechanical adaptability of the Bouligand-type structure in natural dermal armour
    Elizabeth A Zimmermann
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nat Commun 4:2634. 2013
  7. pmc Differential maintenance of cortical and cancellous bone strength following discontinuation of bone-active agents
    Mohammad Shahnazari
    Department of Medicine, University of California Davis Medical Center, Sacramento, CA, USA
    J Bone Miner Res 26:569-81. 2011
  8. doi request reprint Structure and fracture resistance of alligator gar (Atractosteus spatula) armored fish scales
    Wen Yang
    Materials Science and Engineering Program, University of California, San Diego, La Jolla, CA 92093, USA
    Acta Biomater 9:5876-89. 2013
  9. doi request reprint Characterization of the effects of x-ray irradiation on the hierarchical structure and mechanical properties of human cortical bone
    Holly D Barth
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Biomaterials 32:8892-904. 2011
  10. pmc A novel biomimetic approach to the design of high-performance ceramic-metal composites
    Maximilien E Launey
    Materials Sciences Division, University of California, Berkeley, CA 94720, USA
    J R Soc Interface 7:741-53. 2010

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Fracture in human cortical bone: local fracture criteria and toughening mechanisms
    R K Nalla
    Materials Sciences Division, Lawrence Berkeley National Laboratory, and Department of Materials Science and Engineering, University of California, Berkeley, CA 94720 USA
    J Biomech 38:1517-25. 2005
    ..In particular, crack deflection and uncracked-ligament bridging are identified as the major mechanisms of toughening in cortical bone...
  2. pmc Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice
    S S Ionova-Martin
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Osteoporos Int 22:2283-93. 2011
    ....
  3. doi request reprint How does human bone resist fracture?
    Robert O Ritchie
    Department of Materials Science and Engineering, University of California, Berkeley, CA, USA
    Ann N Y Acad Sci 1192:72-80. 2010
    ....
  4. pmc Measurement of the toughness of bone: a tutorial with special reference to small animal studies
    R O Ritchie
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Bone 43:798-812. 2008
    ..Parallel experimental studies on wild-type rat and mouse femurs are used to evaluate the utility of these techniques and specifically to determine the coefficient of variation of the measured toughness values...
  5. doi request reprint The conflicts between strength and toughness
    Robert O Ritchie
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nat Mater 10:817-22. 2011
    ..We show how these new and natural materials can defeat the conflict of strength versus toughness and achieve unprecedented levels of damage tolerance within their respective material classes...
  6. doi request reprint Mechanical adaptability of the Bouligand-type structure in natural dermal armour
    Elizabeth A Zimmermann
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nat Commun 4:2634. 2013
    ....
  7. pmc Differential maintenance of cortical and cancellous bone strength following discontinuation of bone-active agents
    Mohammad Shahnazari
    Department of Medicine, University of California Davis Medical Center, Sacramento, CA, USA
    J Bone Miner Res 26:569-81. 2011
    ..Additional studies on the long-term effects on bone strength after discontinuation and with combination of osteoporosis medications are needed to improve our treatment of osteoporosis...
  8. doi request reprint Structure and fracture resistance of alligator gar (Atractosteus spatula) armored fish scales
    Wen Yang
    Materials Science and Engineering Program, University of California, San Diego, La Jolla, CA 92093, USA
    Acta Biomater 9:5876-89. 2013
    ..Additionally, we define the anisotropy of the toughness of the scales and relate this to the collagen fiber orientation...
  9. doi request reprint Characterization of the effects of x-ray irradiation on the hierarchical structure and mechanical properties of human cortical bone
    Holly D Barth
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Biomaterials 32:8892-904. 2011
    ....
  10. pmc A novel biomimetic approach to the design of high-performance ceramic-metal composites
    Maximilien E Launey
    Materials Sciences Division, University of California, Berkeley, CA 94720, USA
    J R Soc Interface 7:741-53. 2010
    ..These structures achieve an excellent fracture toughness of 40 MPa radicalm at a tensile strength of approximately 300 MPa. Salient toughening mechanisms are described together with further toughening strategies...
  11. ncbi request reprint The aminobisphosphonate risedronate preserves localized mineral and material properties of bone in the presence of glucocorticoids
    Guive Balooch
    Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Arthritis Rheum 56:3726-37. 2007
    ....
  12. pmc Osteopontin deficiency increases bone fragility but preserves bone mass
    Philipp J Thurner
    Department of Orthopaedic Surgery, University of California San Francisco, CA, USA
    Bone 46:1564-73. 2010
    ....
  13. pmc Age-related changes in the plasticity and toughness of human cortical bone at multiple length scales
    Elizabeth A Zimmermann
    Department of Materials Science and Engineering, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 108:14416-21. 2011
    ..The link between these processes is that the increased stiffness of the cross-linked collagen requires energy to be absorbed by "plastic" deformation at higher structural levels, which occurs by the process of microcracking...
  14. ncbi request reprint On the effect of X-ray irradiation on the deformation and fracture behavior of human cortical bone
    Holly D Barth
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Bone 46:1475-85. 2010
    ..Deep-ultraviolet Raman spectroscopy indicated that this behavior could be related to degradation in the collagen integrity...
  15. pmc The significance of crack-resistance curves to the mixed-mode fracture toughness of human cortical bone
    Elizabeth A Zimmermann
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Biomaterials 31:5297-305. 2010
    ..We show that the resulting mixed-mode (mode I+II) toughness depends strongly on the crack trajectory and is the result of the competition between the paths of maximum mechanical driving force and "weakest" microstructural resistance...
  16. ncbi request reprint How tough is brittle bone? Investigating osteogenesis imperfecta in mouse bone
    Alessandra Carriero
    Department of Bioengineering, Imperial College, London, United Kingdom Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA Department of Materials Science and Engineering, University of California Berkeley, Berkeley, CA, USA
    J Bone Miner Res 29:1392-401. 2014
    ....
  17. pmc Enhanced fatigue endurance of metallic glasses through a staircase-like fracture mechanism
    Bernd Gludovatz
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720
    Proc Natl Acad Sci U S A 110:18419-24. 2013
    ....
  18. pmc Higher doses of bisphosphonates further improve bone mass, architecture, and strength but not the tissue material properties in aged rats
    Mohammad Shahnazari
    Department of Internal Medicine, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Bone 46:1267-74. 2010
    ....
  19. ncbi request reprint On the increasing fragility of human teeth with age: a deep-UV resonance Raman study
    Joel W Ager
    Materials Science Division, Lawrence Berkeley National Laboratory, CA, USA
    J Bone Miner Res 21:1879-87. 2006
    ..The intensity of a spectroscopic feature from the peptide bonds in the collagen increases with tissue age, similar to a finding reported previously for human cortical bone...
  20. ncbi request reprint Protective role of Arapaima gigas fish scales: Structure and mechanical behavior
    Wen Yang
    Materials Science and Engineering Program, University of California, San Diego, La Jolla, CA 92093, USA
    Acta Biomater 10:3599-614. 2014
    ....
  21. doi request reprint Mixed-mode fracture of human cortical bone
    Elizabeth A Zimmermann
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Biomaterials 30:5877-84. 2009
    ..Specifically, in this orientation, the fracture toughness of bone is markedly decreased with increasing mode-mixity...
  22. doi request reprint Real-time quantitative imaging of failure events in materials under load at temperatures above 1,600 °C
    Hrishikesh A Bale
    Department of Materials Science and Engineering, University of California, Berkeley, California 94720, USA
    Nat Mater 12:40-6. 2013
    ..Our observations are key ingredients for the high-fidelity simulations used to compute failure risks under extreme operating conditions...
  23. doi request reprint Mixed-mode toughness of human cortical bone containing a longitudinal crack in far-field compression
    Diana Olvera
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Bone 50:331-6. 2012
    ..This is consistent, however, with the individual criteria of preferred mechanical vs. microstructural crack paths being commensurate in this orientation...
  24. doi request reprint The effect of aging on crack-growth resistance and toughening mechanisms in human dentin
    Kurt J Koester
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Biomaterials 29:1318-28. 2008
    ..With age, the role of these toughening mechanisms was diminished primarily to the lower fraction of unfilled, and hence microcracked, tubules...
  25. ncbi request reprint Fracture resistance of human cortical bone across multiple length-scales at physiological strain rates
    Elizabeth A Zimmermann
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Biomaterials 35:5472-81. 2014
    ..e., a "locking-up" of the viscous sliding and sacrificial bonding mechanisms, which are the origin of inelastic deformation (and toughness) in bone at small length-scales. ..
  26. doi request reprint An equivalent strain/Coffin-Manson approach to multiaxial fatigue and life prediction in superelastic Nitinol medical devices
    Amanda Runciman
    Department of Materials Science and Engineering, University of California, Berkeley, CA, USA
    Biomaterials 32:4987-93. 2011
    ....
  27. pmc TGF-beta regulates the mechanical properties and composition of bone matrix
    Guive Balooch
    Graduate Program in Oral and Craniofacial Sciences, Departments of Preventive and Restorative Dental Sciences and Cell and Tissue Biology, and Programs in Cell Biology and Development, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:18813-8. 2005
    ..Our results provide evidence that bone matrix properties are controlled by growth factor signaling...
  28. pmc Solution to the problem of the poor cyclic fatigue resistance of bulk metallic glasses
    Maximilien E Launey
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:4986-91. 2009
    ..These design strategies can be universally applied to any other metallic glass systems...
  29. pmc Canine cranial reconstruction using autologous bone marrow stromal cells
    Mahesh H Mankani
    Department of Surgery, University of California, San Francisco, San Francisco, CA 94143 0807, USA
    Am J Pathol 168:542-50. 2006
    ....
  30. ncbi request reprint Mechanistic aspects of fracture and R-curve behavior in human cortical bone
    R K Nalla
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Department of Materials Science and Engineering, University of California, Berkeley, CA 94720, USA
    Biomaterials 26:217-31. 2005
    ....
  31. ncbi request reprint Mechanistic aspects of in vitro fatigue-crack growth in dentin
    J J Kruzic
    Department of Materials Science and Engineering, Materials Sciences Division, Lawrence Berkeley National Laboratory, University of California, 381 Hearst Mining Building, Berkeley CA 94720, USA
    Biomaterials 26:1195-204. 2005
    ..These results are deemed to be of importance for an improved understanding of fatigue-related failures in teeth...
  32. ncbi request reprint Crack blunting, crack bridging and resistance-curve fracture mechanics in dentin: effect of hydration
    J J Kruzic
    Department of Materials Science and Engineering and Materials Sciences Division, Lawrence Berkeley National Laboratory, University of California, MC 1760, Berkeley, CA 94720, USA
    Biomaterials 24:5209-21. 2003
    ..The results of this work are deemed to be of importance from the perspective of modeling the fracture behavior of dentin and in predicting its failure in vivo...
  33. doi request reprint Unidirectional freezing of ceramic suspensions: in situ X-ray investigation of the effects of additives
    Benjamin Delattre
    Materials Sciences Division Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States
    ACS Appl Mater Interfaces 6:159-66. 2014
    ..We also examined the transition from a random particles-entrapment regime to a well-defined lamellar regime and proposed and discussed two mechanisms by which additives might affect the solidification process. ..
  34. doi request reprint Tetrapod nanocrystals as fluorescent stress probes of electrospun nanocomposites
    Shilpa N Raja
    Materials Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States
    Nano Lett 13:3915-22. 2013
    ..The tetrapod fluorescence stress-strain curve shape matches well with uniaxial stress-strain curves measured mechanically at all filler concentrations reported. ..
  35. doi request reprint Natural flexible dermal armor
    Wen Yang
    Materials Science and Engineering Program, University of California, San Diego, La Jolla, 92093, USA
    Adv Mater 25:31-48. 2013
    ..The understanding of such flexible dermal armor is important as it may provide a basis for new synthetic, yet bioinspired, armor materials...
  36. pmc Stress-corrosion crack growth of Si-Na-K-Mg-Ca-P-O bioactive glasses in simulated human physiological environment
    Don R Bloyer
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Biomaterials 28:4901-11. 2007
    ..At higher velocities, hydrodynamic effects reduce growth rates under conditions that would rarely pertain for small natural flaws in devices...
  37. ncbi request reprint In vitro fatigue-crack growth and fracture toughness behavior of thin-walled superelastic Nitinol tube for endovascular stents: A basis for defining the effect of crack-like defects
    Scott W Robertson
    Department of Materials Science and Engineering, University of California, Berkeley, CA 94720, USA
    Biomaterials 28:700-9. 2007
    ....
  38. ncbi request reprint On the in vitro fatigue behavior of human dentin: effect of mean stress
    R K Nalla
    Materials Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    J Dent Res 83:211-5. 2004
    ..The results provide the first fatigue data for human dentin under tension-compression loading and serve to map out safe and unsafe regimes for failure over a wide range of in vitro fatigue lives (< 10(3) to > 10(6) cycles)...
  39. doi request reprint Adhesion between biodegradable polymers and hydroxyapatite: Relevance to synthetic bone-like materials and tissue engineering scaffolds
    R E Neuendorf
    Department of Materials Science and Engineering, University of California, Berkeley, CA 94720, USA
    Acta Biomater 4:1288-96. 2008
    ..These results cast doubt on the use of biodegradable polymers/ceramic composites for load-bearing synthetic bone-like materials, as desired optimal mechanical properties are unlikely to be met in realistic physiological environments...
  40. ncbi request reprint Deep-ultraviolet Raman spectroscopy study of the effect of aging on human cortical bone
    J W Ager
    Lawrence Berkeley National Laboratory, Materials Sciences Division, Berkeley, California 94720
    J Biomed Opt 10:034012. 2005
    ....
  41. ncbi request reprint Mechanistic fracture criteria for the failure of human cortical bone
    R K Nalla
    Materials Sciences Division, Lawrence Berkeley National Laboratory, and Department of Materials Science and Engineering, University of California, Berkeley, California 94720, USA
    Nat Mater 2:164-8. 2003
    ..We provide estimates of the relative importance of these mechanisms, such as uncracked-ligament bridging...
  42. doi request reprint Reduced size-independent mechanical properties of cortical bone in high-fat diet-induced obesity
    S S Ionova-Martin
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Bone 46:217-25. 2010
    ..This study indicates that bone quantity and bone quality play important compensatory roles in determining fracture risk...
  43. pmc Role of alcohol in the fracture resistance of teeth
    R K Nalla
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Dent Res 85:1022-6. 2006
    ..This effect is considered to be associated with increased cross-linking of the collagen molecules from intermolecular hydrogen-bonding, where water is replaced with weaker hydrogen-bond-forming solvents such as alcohol...
  44. ncbi request reprint Fatigue-crack growth properties of thin-walled superelastic austenitic Nitinol tube for endovascular stents
    J M Stankiewicz
    Department of Materials Science and Engineering, University of California, Berkeley, California 94720, USA
    J Biomed Mater Res A 81:685-91. 2007
    ....
  45. ncbi request reprint Effect of orientation on the in vitro fracture toughness of dentin: the role of toughening mechanisms
    R K Nalla
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Department of Materials Science and Engineering, University of California, Berkeley, CA 94720, USA
    Biomaterials 24:3955-68. 2003
    ..Estimates for the contributions from each of these mechanisms are provided from theoretical models available in the literature...
  46. doi request reprint Mechanistic aspects of the fracture toughness of elk antler bone
    M E Launey
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Acta Biomater 6:1505-14. 2010
    ..We present an assessment of the toughening mechanisms acting in antler as compared to human cortical bone, and identify an enhanced role of inelastic deformation in antler which further contributes to its (intrinsic) toughness...
  47. ncbi request reprint A fracture-mechanics-based approach to fracture control in biomedical devices manufactured from superelastic Nitinol tube
    S W Robertson
    Department of Materials Science and Engineering, University of California, Berkeley, California 94720, USA
    J Biomed Mater Res B Appl Biomater 84:26-33. 2008
    ....
  48. ncbi request reprint On the fracture of human dentin: is it stress- or strain-controlled?
    R K Nalla
    Materials Sciences Division, Lawrence Berkeley National Laboratory, and Department of Materials Science and Engineering, University of California, Berkeley, California 94720, USA
    J Biomed Mater Res A 67:484-95. 2003
    ..The results presented are believed to be critical steps in the development of a micromechanical model for the fracture of human dentin that takes into consideration the influence of both the microstructure and the local failure mode...
  49. ncbi request reprint In vitro fatigue behavior of human dentin with implications for life prediction
    R K Nalla
    Materials Sciences Division, Lawrence Berkeley National Laboratory, and Department of Materials Science and Engineering, University of California, Berkeley, California 94720, USA
    J Biomed Mater Res A 66:10-20. 2003
    ..It is concluded that the presence of small (on the order of 250 microm) incipient flaws in human teeth will not radically affect their useful life...
  50. ncbi request reprint Aspects of in vitro fatigue in human cortical bone: time and cycle dependent crack growth
    R K Nalla
    Materials Sciences Division, Lawrence Berkeley National Laboratory, and Department of Materials Science and Engineering, University of California, Berkeley, CA 94720, USA
    Biomaterials 26:2183-95. 2005
    ..The results are discussed in light of the occurrence of fatigue-related stress fractures in cortical bone...
  51. ncbi request reprint Crystallographic texture for tube and plate of the superelastic/shape-memory alloy Nitinol used for endovascular stents
    S W Robertson
    Department of Materials Science and Engineering, University of California, Berkeley, California 94720, USA
    J Biomed Mater Res A 72:190-9. 2005
    ..In this article, we present a study on how geometry and heat treatment can affect the texture of Nitinol, with specific quantification of the texture of Nitinol tube used for the production of endovascular stents...
  52. doi request reprint The true toughness of human cortical bone measured with realistically short cracks
    K J Koester
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nat Mater 7:672-7. 2008
    ....
  53. ncbi request reprint Effects of polar solvents on the fracture resistance of dentin: role of water hydration
    R K Nalla
    Materials Sciences Division, Lawrence Berkeley National Laboratory, and Department of Materials Science and Engineering, University of California, Berkeley, CA 94720, USA
    Acta Biomater 1:31-43. 2005
    ..These results are analyzed both in terms of intrinsic and extrinsic toughening phenomena to further understand the micromechanisms of fracture in dentin and the specific role of water hydration...
  54. ncbi request reprint Tough, bio-inspired hybrid materials
    E Munch
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Science 322:1516-20. 2008
    ..These model materials can be used to identify the key microstructural features that should guide the synthesis of bio-inspired ceramic-based composites with unique strength and toughness...
  55. pmc Fatigue of dentin-composite interfaces with four-point bend
    Michal Staninec
    Department of Preventive and Restorative Dental Sciences, University of California, San Francisco, CA 94143, USA
    Dent Mater 24:799-803. 2008
    ..The objective was to determine the fracture and cyclic fatigue properties of composite-dentin beams bonded with a self-etching adhesive in four-point bend...
  56. ncbi request reprint In vitro fracture toughness of human dentin
    V Imbeni
    Materials Sciences Division, Lawrence Berkeley National Laboratory, and Department of Materials Science and Engineering, University of California, Berkeley, California 94720, USA
    J Biomed Mater Res A 66:1-9. 2003
    ..The effect of acuity of the precrack on the fracture toughness of human dentin is discussed in the context of these data...