Derek C Radisky

Summary

Affiliation: Lawrence Berkeley National Laboratory
Country: USA

Publications

  1. pmc Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
    Derek C Radisky
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nature 436:123-7. 2005
  2. pmc Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia
    Jordi Alcaraz
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    EMBO J 27:2829-38. 2008
  3. ncbi request reprint Proliferation and polarity in breast cancer: untying the Gordian knot
    Hong Liu
    Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cell Cycle 4:646-9. 2005
  4. pmc Epimorphin is a novel regulator of the progesterone receptor isoform-a
    Jamie L Bascom
    Authors Affiliations Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California Mayo Clinic Cancer Center, Jacksonville, Florida College of Staten Island, City University of New York, Staten Island, New York and Department of Bioscience, Kwansei Gakuin University, Sanda, Japan
    Cancer Res 73:5719-29. 2013
  5. pmc Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2
    Hong Liu
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 103:4134-9. 2006
  6. pmc Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis
    Connie S Chen
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 284:6877-84. 2009
  7. pmc Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells
    Hong Liu
    Life Science Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA 94720, USA
    J Cell Biol 164:603-12. 2004
  8. pmc Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells
    Celeste M Nelson
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Cell Biochem 105:25-33. 2008
  9. pmc The organizing principle: microenvironmental influences in the normal and malignant breast
    Mina J Bissell
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Differentiation 70:537-46. 2002
  10. ncbi request reprint Cancer. Respect thy neighbor!
    Derek C Radisky
    Division of Life Sciences, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Science 303:775-7. 2004

Detail Information

Publications19

  1. pmc Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
    Derek C Radisky
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nature 436:123-7. 2005
    ..These findings identify a previously undescribed pathway in which a component of the breast tumour microenvironment alters cellular structure in culture and tissue structure in vivo, leading to malignant transformation...
  2. pmc Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia
    Jordi Alcaraz
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    EMBO J 27:2829-38. 2008
    ..Our data indicate that tissue-specific gene expression is controlled by both the tissues' unique biochemical milieu and mechanical properties, processes involved in maintenance of tissue integrity and protection against tumorigenesis...
  3. ncbi request reprint Proliferation and polarity in breast cancer: untying the Gordian knot
    Hong Liu
    Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cell Cycle 4:646-9. 2005
    ....
  4. pmc Epimorphin is a novel regulator of the progesterone receptor isoform-a
    Jamie L Bascom
    Authors Affiliations Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California Mayo Clinic Cancer Center, Jacksonville, Florida College of Staten Island, City University of New York, Staten Island, New York and Department of Bioscience, Kwansei Gakuin University, Sanda, Japan
    Cancer Res 73:5719-29. 2013
    ..These findings elucidate a hitherto unknown transcriptional regulator of Pgr-a, and shed light on how overexpression of Epim leads to malignancy...
  5. pmc Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2
    Hong Liu
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 103:4134-9. 2006
    ....
  6. pmc Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis
    Connie S Chen
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 284:6877-84. 2009
    ..These results provide a dramatic demonstration of the use of structural information about one molecule to define a functional motif of a second molecule that is related at the sequence level but highly divergent functionally...
  7. pmc Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells
    Hong Liu
    Life Science Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA 94720, USA
    J Cell Biol 164:603-12. 2004
    ..These findings reveal key events of the PI3K pathway that play distinct roles to maintain tissue polarity and that when disrupted are instrumental in the malignant phenotype...
  8. pmc Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells
    Celeste M Nelson
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Cell Biochem 105:25-33. 2008
    ..Our data reveal a previously unanticipated cell shape-dependent mechanism that controls this key phenotypic alteration and provide insight into the distinct mechanisms activated by different EMT-inducing agents...
  9. pmc The organizing principle: microenvironmental influences in the normal and malignant breast
    Mina J Bissell
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Differentiation 70:537-46. 2002
    ..How this context determines functional integrity, and how its loss can lead to malignancy, appears to have much to do with tissue structure and polarity...
  10. ncbi request reprint Cancer. Respect thy neighbor!
    Derek C Radisky
    Division of Life Sciences, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Science 303:775-7. 2004
  11. pmc Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT?
    Derek C Radisky
    Department of Cancer Biology, Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA
    J Cell Biochem 101:830-9. 2007
    ..This connection provides a new perspective on the development of the fibrosis and tumor microenvironments...
  12. doi request reprint Matrix metalloproteinase-induced fibrosis and malignancy in breast and lung
    Derek C Radisky
    Mayo Clinic Cancer Center, Griffin Cancer Research Building, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Proc Am Thorac Soc 5:316-22. 2008
    ....
  13. ncbi request reprint NF-kappaB links oestrogen receptor signalling and EMT
    Derek C Radisky
    Nat Cell Biol 9:361-3. 2007
  14. doi request reprint Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development
    Lidiya S Orlichenko
    Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA
    Clin Exp Metastasis 25:593-600. 2008
    ..Here, we provide an overview of recent findings of MMP action in tumors and the mechanisms by which MMPs induce both phenotypic and genotypic alterations that facilitate tumor progression...
  15. pmc Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression?
    Eva A Turley
    London Health Sciences Centre, University of Western Ontario, London, ON, Canada
    Nat Clin Pract Oncol 5:280-90. 2008
    ..We also highlight the role of RAS-controlled signaling mediators, ERK1, ERK2 and phosphatidylinositol 3-kinase, as microenvironmental responsive regulators of EMT...
  16. ncbi request reprint Stromal induction of breast cancer: inflammation and invasion
    Evette S Radisky
    Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA
    Rev Endocr Metab Disord 8:279-87. 2007
    ....
  17. pmc Matrix metalloproteinase-induced genomic instability
    Derek C Radisky
    Mayo Clinic Cancer Center, Jacksonville, FL 32225, USA
    Curr Opin Genet Dev 16:45-50. 2006
    ..Delineating the mechanisms involved in these processes and identifying how they are coordinated in vivo could aid identification of the crucial contribution of MMPs to tumorigenesis...
  18. ncbi request reprint Epithelial-mesenchymal transition
    Derek C Radisky
    Mayo Clinic Cancer Center, Griffin Cancer Research Building, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    J Cell Sci 118:4325-6. 2005
  19. ncbi request reprint Matrix metalloproteinase-induced epithelial-mesenchymal transition: tumor progression at Snail's pace
    Jennifer A Przybylo
    Mayo Clinic Cancer, 4500 San Pablo Avenue, Jacksonville, FL 32225, USA
    Int J Biochem Cell Biol 39:1082-8. 2007
    ..In this review, we examine how MMPs and Snail function in tumor progression and how identification of an MMP-Snail signaling axis provides insight into new anticancer therapeutic strategies...