Research Topics
Genomes and Genes | Derek C RadiskySummaryAffiliation: Lawrence Berkeley National Laboratory Country: USA Publications
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Publications
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instabilityDerek C Radisky
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Nature 436:123-7. 2005..These findings identify a previously undescribed pathway in which a component of the breast tumour microenvironment alters cellular structure in culture and tissue structure in vivo, leading to malignant transformation...- Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epitheliaJordi Alcaraz
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
EMBO J 27:2829-38. 2008..Our data indicate that tissue-specific gene expression is controlled by both the tissues' unique biochemical milieu and mechanical properties, processes involved in maintenance of tissue integrity and protection against tumorigenesis... - Proliferation and polarity in breast cancer: untying the Gordian knotHong Liu
Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Cell Cycle 4:646-9. 2005.... - Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2Hong Liu
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 103:4134-9. 2006.... - Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesisConnie S Chen
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
J Biol Chem 284:6877-84. 2009..These results provide a dramatic demonstration of the use of structural information about one molecule to define a functional motif of a second molecule that is related at the sequence level but highly divergent functionally... - Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cellsHong Liu
Life Science Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA 94720, USA
J Cell Biol 164:603-12. 2004..These findings reveal key events of the PI3K pathway that play distinct roles to maintain tissue polarity and that when disrupted are instrumental in the malignant phenotype... - Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cellsCeleste M Nelson
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
J Cell Biochem 105:25-33. 2008..Our data reveal a previously unanticipated cell shape-dependent mechanism that controls this key phenotypic alteration and provide insight into the distinct mechanisms activated by different EMT-inducing agents... - The organizing principle: microenvironmental influences in the normal and malignant breastMina J Bissell
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Differentiation 70:537-46. 2002..How this context determines functional integrity, and how its loss can lead to malignancy, appears to have much to do with tissue structure and polarity... - Cancer. Respect thy neighbor!Derek C Radisky
Division of Life Sciences, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
Science 303:775-7. 2004 - Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT?Derek C Radisky
Department of Cancer Biology, Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA
J Cell Biochem 101:830-9. 2007..This connection provides a new perspective on the development of the fibrosis and tumor microenvironments... - Matrix metalloproteinase-induced fibrosis and malignancy in breast and lungDerek C Radisky
Mayo Clinic Cancer Center, Griffin Cancer Research Building, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Proc Am Thorac Soc 5:316-22. 2008.... - NF-kappaB links oestrogen receptor signalling and EMTDerek C Radisky
Nat Cell Biol 9:361-3. 2007 - Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor developmentLidiya S Orlichenko
Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA
Clin Exp Metastasis 25:593-600. 2008..Here, we provide an overview of recent findings of MMP action in tumors and the mechanisms by which MMPs induce both phenotypic and genotypic alterations that facilitate tumor progression... - Stromal induction of breast cancer: inflammation and invasionEvette S Radisky
Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA
Rev Endocr Metab Disord 8:279-87. 2007.... - Matrix metalloproteinase-induced epithelial-mesenchymal transition: tumor progression at Snail's paceJennifer A Przybylo
Mayo Clinic Cancer, 4500 San Pablo Avenue, Jacksonville, FL 32225, USA
Int J Biochem Cell Biol 39:1082-8. 2007..In this review, we examine how MMPs and Snail function in tumor progression and how identification of an MMP-Snail signaling axis provides insight into new anticancer therapeutic strategies... - Epithelial-mesenchymal transitionDerek C Radisky
Mayo Clinic Cancer Center, Griffin Cancer Research Building, 4500 San Pablo Road, Jacksonville, FL 32224, USA
J Cell Sci 118:4325-6. 2005 - Matrix metalloproteinase-induced genomic instabilityDerek C Radisky
Mayo Clinic Cancer Center, Jacksonville, FL 32225, USA
Curr Opin Genet Dev 16:45-50. 2006..Delineating the mechanisms involved in these processes and identifying how they are coordinated in vivo could aid identification of the crucial contribution of MMPs to tumorigenesis... - Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression?Eva A Turley
London Health Sciences Centre, University of Western Ontario, London, ON, Canada
Nat Clin Pract Oncol 5:280-90. 2008..We also highlight the role of RAS-controlled signaling mediators, ERK1, ERK2 and phosphatidylinositol 3-kinase, as microenvironmental responsive regulators of EMT...