Affiliation: Lawrence Livermore National Laboratory
Ovcharenko I, Loots G, Nobrega M, Hardison R, Miller W, Stubbs L. Evolution and functional classification of vertebrate gene deserts. Genome Res. 2005;15:137-45 pubmed
..Stable gene deserts resist chromosomal rearrangements and appear to harbor multiple distant regulatory elements physically linked to their neighboring genes, with the linearity of conservation invariant throughout vertebrate evolution. ..
Ovcharenko I, Stubbs L, Loots G. Interpreting mammalian evolution using Fugu genome comparisons. Genomics. 2004;84:890-5 pubmed
..This newly defined threshold identifies 90% of all human/Fugu noncoding ECRs without the assistance of human-Fugu genome alignments and provides a very efficient filter for identifying functional human/mouse ECRs. ..