E Nogales

Summary

Affiliation: Lawrence Berkeley National Laboratory
Country: USA

Publications

  1. ncbi request reprint Structural intermediates in microtubule assembly and disassembly: how and why?
    Eva Nogales
    Howard Hughes Medical Institute, Molecular and Cell Biology Department, UC Berkeley and Lawrence Berkeley National Lab, 355 LSA UC Berkeley, Berkeley, CA 94720 3200, USA
    Curr Opin Cell Biol 18:179-84. 2006
  2. ncbi request reprint Structural mechanisms underlying nucleotide-dependent self-assembly of tubulin and its relatives
    Eva Nogales
    Howard Hughes Medical Institute, Molecular and Cell Biology Department, University of California Berkeley and Lawrence Berkeley National Laboratory, 355 LSA, University of California Berkeley, Berkeley, CA 94720 3200, USA
    Curr Opin Struct Biol 16:221-9. 2006
  3. ncbi request reprint Structural insight into microtubule function
    E Nogales
    Department of Molecular and Cell Biology, University of California, Berkeley, and Lawrence Berkeley National Laboratory, Berkeley California 94720, USA
    Annu Rev Biophys Biomol Struct 30:397-420. 2001
  4. ncbi request reprint A structural view of microtubule dynamics
    E Nogales
    Department of Molecular and Cell Biology, UC Berkeley, California 94720 3200, USA
    Cell Mol Life Sci 56:133-42. 1999
  5. ncbi request reprint Recent structural insights into transcription preinitiation complexes
    E Nogales
    Howard Hughes Medical Institute, Molecular and Cell Biology Department, University of California at Berkeley, 94720 3200, USA
    J Cell Sci 113:4391-7. 2000
  6. ncbi request reprint Structural insights into microtubule function
    E Nogales
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA
    Annu Rev Biochem 69:277-302. 2000
  7. ncbi request reprint High-resolution model of the microtubule
    E Nogales
    Lawrence Berkeley National Laboratory, Molecular and Cell Biology Department, University of California at Berkeley, California 94720, USA
    Cell 96:79-88. 1999
  8. ncbi request reprint Tubulin and FtsZ form a distinct family of GTPases
    E Nogales
    Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nat Struct Biol 5:451-8. 1998
  9. pmc Structure-function insights into the yeast Dam1 kinetochore complex
    Eva Nogales
    Department of Molecular and Cell Biology, UC Berkeley Howard Hughes Medical Institute, UC Berkeley, Berkeley, CA 94720 3220, USA
    J Cell Sci 122:3831-6. 2009
  10. ncbi request reprint Crystallographic structure of tubulin: implications for dynamics and drug binding
    K H Downing
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Cell Struct Funct 24:269-75. 1999

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Structural intermediates in microtubule assembly and disassembly: how and why?
    Eva Nogales
    Howard Hughes Medical Institute, Molecular and Cell Biology Department, UC Berkeley and Lawrence Berkeley National Lab, 355 LSA UC Berkeley, Berkeley, CA 94720 3200, USA
    Curr Opin Cell Biol 18:179-84. 2006
    ..The discovery of these intermediates a decade ago has been followed recently by quantitative descriptions of their structure and their relationship to nucleotide state...
  2. ncbi request reprint Structural mechanisms underlying nucleotide-dependent self-assembly of tubulin and its relatives
    Eva Nogales
    Howard Hughes Medical Institute, Molecular and Cell Biology Department, University of California Berkeley and Lawrence Berkeley National Laboratory, 355 LSA, University of California Berkeley, Berkeley, CA 94720 3200, USA
    Curr Opin Struct Biol 16:221-9. 2006
    ..In particular, a two-state mechanism has been proposed for the recycling of alphabeta-tubulin during the microtubule disassembly-assembly cycle; this mechanism may be unique to eukaryotic dimeric tubulin and the microtubule structure...
  3. ncbi request reprint Structural insight into microtubule function
    E Nogales
    Department of Molecular and Cell Biology, University of California, Berkeley, and Lawrence Berkeley National Laboratory, Berkeley California 94720, USA
    Annu Rev Biophys Biomol Struct 30:397-420. 2001
    ..The combination of structural, genetic, biochemical, and biophysical data should soon give us a fuller understanding of the exquisite details in the regulation of the microtubule cytoskeleton...
  4. ncbi request reprint A structural view of microtubule dynamics
    E Nogales
    Department of Molecular and Cell Biology, UC Berkeley, California 94720 3200, USA
    Cell Mol Life Sci 56:133-42. 1999
    ..and the origin of microtubule destabilization, as well as the mode of action of antimitotic agents such as taxol...
  5. ncbi request reprint Recent structural insights into transcription preinitiation complexes
    E Nogales
    Howard Hughes Medical Institute, Molecular and Cell Biology Department, University of California at Berkeley, 94720 3200, USA
    J Cell Sci 113:4391-7. 2000
    ..A combination of methodologies may prove essential for a complete structural description of the initial steps in the expression of eukaryotic genes...
  6. ncbi request reprint Structural insights into microtubule function
    E Nogales
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA
    Annu Rev Biochem 69:277-302. 2000
    ..The combination of structural, genetic, biochemical, and biophysical data should soon give us a fuller understanding of the exquisite details in the regulation of the microtubule cytoskeleton...
  7. ncbi request reprint High-resolution model of the microtubule
    E Nogales
    Lawrence Berkeley National Laboratory, Molecular and Cell Biology Department, University of California at Berkeley, California 94720, USA
    Cell 96:79-88. 1999
    ..Extensive longitudinal interfaces between monomers have polar and hydrophobic components. At the lateral contacts, a nucleotide-sensitive helix interacts with a loop that contributes to the binding site of taxol in beta-tubulin...
  8. ncbi request reprint Tubulin and FtsZ form a distinct family of GTPases
    E Nogales
    Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nat Struct Biol 5:451-8. 1998
    ..Thus, tubulin and FtsZ form a distinct family of GTP-hydrolyzing proteins...
  9. pmc Structure-function insights into the yeast Dam1 kinetochore complex
    Eva Nogales
    Department of Molecular and Cell Biology, UC Berkeley Howard Hughes Medical Institute, UC Berkeley, Berkeley, CA 94720 3220, USA
    J Cell Sci 122:3831-6. 2009
    ..Additionally, the generality of the Dam1 mechanism has been questioned owing to the fact that there are no obvious Dam1 homologs beyond fungi. In this Commentary, we discuss recent structure-function studies of this intriguing complex...
  10. ncbi request reprint Crystallographic structure of tubulin: implications for dynamics and drug binding
    K H Downing
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Cell Struct Funct 24:269-75. 1999
    ..Understanding these interactions can provide fundamental information on the regulation of the microtubule system...
  11. ncbi request reprint New insights into microtubule structure and function from the atomic model of tubulin
    K H Downing
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Eur Biophys J 27:431-6. 1998
    ..The present tubulin model gives the first structural framework for understanding microtubule polymerization and its regulation by nucleotides and anti-mitotic drugs at the molecular level...
  12. ncbi request reprint Structural models for the self-assembly and microtubule interactions of gamma-, delta- and epsilon-tubulin
    Y F Inclán
    Howard Hughes Medical Institute, Molecular and Cell Biology Department, University of California at Berkeley, CA 94720 3200, USA
    J Cell Sci 114:413-22. 2001
    ..Conservation of key residues in gamma-tubulin suggests that it is capable of longitudinal self-assembly. The implications for the protofilament and template models of nucleation are considered...
  13. ncbi request reprint Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex
    Stefan Westermann
    Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Cell 17:277-90. 2005
    ..These observations suggest a mechanism by which the kinetochore can recognize and stay attached to the plus ends of microtubules...
  14. ncbi request reprint Structure of the alpha beta tubulin dimer by electron crystallography
    E Nogales
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nature 391:199-203. 1998
    ....
  15. pmc Architecture and flexibility of the yeast Ndc80 kinetochore complex
    Hong Wei Wang
    Life Science Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    J Mol Biol 383:894-903. 2008
    ..We hypothesize that the kink in Ndc80 is essential for correct kinetochore geometry and could be part of a tension-sensing mechanism at the kinetochore...
  16. pmc The Ndc80 kinetochore complex forms oligomeric arrays along microtubules
    Gregory M Alushin
    Biophysics Graduate Group, University of California, Berkeley, California 94720, USA
    Nature 467:805-10. 2010
    ..The complex's mode of interaction with the microtubule and its oligomerization suggest a mechanism by which Aurora B could regulate the stability of load-bearing kinetochore-microtubule attachments...
  17. pmc Ab initio reconstruction of helical samples with heterogeneity, disorder and coexisting symmetries
    Vincent H Ramey
    Biophysics Graduate Program, UC Berkeley, Berkeley, CA, USA
    J Struct Biol 167:97-105. 2009
    ....
  18. ncbi request reprint Tubulin rings: which way do they curve?
    Eva Nogales
    Howard Hughes Medical Institute, Molecular and Cell Biology Department and Life Science Division, Lawrence Berkeley National Laboratory, 355 Life Sciences Addition, University of California, 94720 3200, USA
    Curr Opin Struct Biol 13:256-61. 2003
    ..How these kinks relate to what happens when the stored energy of GTP hydrolysis is released, freeing GDP*tubulin into an unconstrained state, remains an open question...
  19. ncbi request reprint Molecular architecture and conformational flexibility of human RNA polymerase II
    Seth A Kostek
    Molecular and Cell Biology Department, University of California, Berkeley, Berkeley, California 94720, USA
    Structure 14:1691-700. 2006
    ..This hRNAPII study will serve as a structural platform to build up higher-order transcription and TCR complexes and to gain information that may be unique to the human RNAPII system...
  20. pmc Nucleotide-dependent bending flexibility of tubulin regulates microtubule assembly
    Hong Wei Wang
    Howard Hughes Medical Institute, University of California Berkeley, Berkeley, California 94720 3200, USA
    Nature 435:911-5. 2005
    ..Closure into a microtubule does not require GTP hydrolysis...
  21. ncbi request reprint Structural roles for human translation factor eIF3 in initiation of protein synthesis
    Bunpote Siridechadilok
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Science 310:1513-5. 2005
    ..Detailed modeling of eIF3 and eIF4F onto the 40S ribosomal subunit reveals that eIF3 uses eIF4F or the HCV IRES in structurally similar ways to position the mRNA strand near the exit site of 40S, promoting initiation complex assembly...
  22. pmc A mutation in gamma-tubulin alters microtubule dynamics and organization and is synthetically lethal with the kinesin-like protein pkl1p
    J L Paluh
    Department of Molecular Biology, University of California, Berkeley, California 94720 3200, USA
    Mol Biol Cell 11:1225-39. 2000
    ..We propose that Pkl1p rescues an impaired function of gamma-tubulin that involves non-tubulin protein-protein interactions, presumably with a second motor, MAP, or MTOC component...
  23. ncbi request reprint Tubulin and microtubule structure
    K H Downing
    Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Curr Opin Cell Biol 10:16-22. 1998
    ....
  24. ncbi request reprint Lipid-layer crystallization and preliminary three-dimensional structural analysis of AcrA, the periplasmic component of a bacterial multidrug efflux pump
    A J Avila-Sakar
    Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop Donner, Berkeley, CA 94720, USA
    J Struct Biol 136:81-8. 2001
    ..On one side the density has a tubular shape, with a thickness of about 25 A, while on the other side the densities of the upper and lower parts of the pseudo-helical path are fused into a shield...
  25. ncbi request reprint Tubulin structure: insights into microtubule properties and functions
    K H Downing
    Donner Laboratory Life Science Division Lawrence Berkeley National Laboratory Molecular and Cell Biology University of California Berkely CA 94720 USA
    Curr Opin Struct Biol 8:785-91. 1998
    ..Some of the ongoing work on tubulin can be interpreted in terms of its structure, which can serve to guide future studies...
  26. pmc Cross-correlation of common lines: a novel approach for single-particle reconstruction of a structure containing a flexible domain
    Richard J Hall
    Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Struct Biol 159:474-82. 2007
    ..Our approach overcame these limitations, giving us structural insight that was previously not possible...
  27. ncbi request reprint The orthogonal tilt reconstruction method: an approach to generating single-class volumes with no missing cone for ab initio reconstruction of asymmetric particles
    Andres E Leschziner
    Lawrence Berkeley National Laboratory, University of California, Berkeley, USA
    J Struct Biol 153:284-99. 2006
    ..We also propose a way of increasing the level of homogeneity in individual 2D classes (and volumes) in a heterogeneous data set and identifying the most homogeneous volumes...
  28. pmc Architecture of the yeast Rrp44 exosome complex suggests routes of RNA recruitment for 3' end processing
    Hong Wei Wang
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 104:16844-9. 2007
    ..The Rrp44-exosome (RE) architecture suggests an active site sequestration mechanism for strict control of 3' exoribonuclease activity in the RE complex...
  29. ncbi request reprint The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends
    Stefan Westermann
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California 94720 3202, USA
    Nature 440:565-9. 2006
    ..The Dam1 ring complex is a molecular device that can translate the force generated by microtubule depolymerization into movement along the lattice to facilitate chromosome segregation...
  30. ncbi request reprint Assembly of GMPCPP-bound tubulin into helical ribbons and tubes and effect of colchicine
    Hong Wei Wang
    Life Science Division, Lawrence Berkeley National Lab, Berkeley, California, USA
    Cell Cycle 4:1157-60. 2005
    ..Finally, we add our thoughts on the possible biological meaning of tubulin polymerization versatility...
  31. ncbi request reprint Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms
    Hong Wei Wang
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, California 94720, USA
    Nat Struct Mol Biol 14:721-6. 2007
    ..One of Ipl1's roles might be to fine-tune the coupling of the microtubule interaction with the conformational change required for oligomerization, with phosphorylation resulting in ring breakdown...
  32. ncbi request reprint Microtubule dynamics
    Rebecca Heald
    Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    J Cell Sci 115:3-4. 2002
  33. ncbi request reprint XKCM1 acts on a single protofilament and requires the C terminus of tubulin
    Hanspeter Niederstrasser
    Molecular and Cell Biology Department, University of California at Berkeley, Berkeley, CA 94720 3200, USA
    J Mol Biol 316:817-28. 2002
    ....
  34. ncbi request reprint Structure, function, and activator-induced conformations of the CRSP coactivator
    Dylan J Taatjes
    Howard Hughes Medical Institute and, Lawrence Berkeley National Laboratory, Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    Science 295:1058-62. 2002
    ..These results suggest that CRSP may potentiate transcription via specific activator-induced conformational changes...
  35. ncbi request reprint Visualizing flexibility at molecular resolution: analysis of heterogeneity in single-particle electron microscopy reconstructions
    Andres E Leschziner
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Biophys Biomol Struct 36:43-62. 2007
    ..We also discuss some of their recent applications to problems of biological interest...
  36. ncbi request reprint Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex
    Megan G Clarey
    Division of Biochemistry and Molecular Biology, Molecular and Cell Biology Department, 1 Barker Hall, University of California, Berkeley, California 94720, USA
    Nat Struct Mol Biol 13:684-90. 2006
    ..By analogy to the DNA-wrapping activity of DnaA, we posit that ORC together with Cdc6 prepares origin DNA for helicase loading through mechanisms related to the established pathway of prokaryotes...
  37. pmc Structural changes in TAF4b-TFIID correlate with promoter selectivity
    Wei Li Liu
    Howard Hughes Medical Institute, Li Ka Shing Center for Biomedical and Health Sciences, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Cell 29:81-91. 2008
    ....
  38. doi request reprint Cryo-EM studies of microtubule structural intermediates and kinetochore-microtubule interactions
    Eva Nogales
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3220, USA
    Methods Cell Biol 95:129-56. 2010
    ..We describe the experimental in vitro protocols to produce biologically relevant self-assembled structures of Dam 1 around microtubules and their structural characterization by cryo-EM...
  39. pmc Saccharomyces cerevisiae septins: supramolecular organization of heterooligomers and the mechanism of filament assembly
    Aurelie Bertin
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 105:8274-9. 2008
    ..Shs1 may be able to replace Cdc11 at the end of the rod. Our findings provide insights into the molecular mechanisms underlying the function and regulation of cellular septin structures...
  40. pmc Automated multi-model reconstruction from single-particle electron microscopy data
    Maxim Shatsky
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    J Struct Biol 170:98-108. 2010
    ..We propose the use of our approach as an efficient way to reconstruct distinct multiple models from heterogeneous data...
  41. pmc Phosphatidylinositol-4,5-bisphosphate promotes budding yeast septin filament assembly and organization
    Aurelie Bertin
    Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    J Mol Biol 404:711-31. 2010
    ....
  42. ncbi request reprint Structural studies of the human PBAF chromatin-remodeling complex
    Andres E Leschziner
    Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Structure 13:267-75. 2005
    ..The 2D analysis of PBAF:nucleosome complexes indicates that the nucleosome binds in the central cavity...
  43. pmc Structural insights into RNA processing by the human RISC-loading complex
    Hong Wei Wang
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Nat Struct Mol Biol 16:1148-53. 2009
    ..A model generated by docking the available atomic structures of Dicer and Argonaute homologs into the RLC reconstruction suggests a mechanism for siRNA transfer from Dicer to AGO2...
  44. pmc Structures of three distinct activator-TFIID complexes
    Wei Li Liu
    Howard Hughes Medical Institute, Molecular and Cell Biology Department, University of California at Berkeley, Berkeley, California 94720, USA
    Genes Dev 23:1510-21. 2009
    ..These results suggest that activator contact may induce unique structural features of TFIID, thus providing nanoscale information on activator-dependent TFIID assembly and transcription initiation...
  45. ncbi request reprint Cryo-electron microscopy studies of human TFIID: conformational breathing in the integration of gene regulatory cues
    Patricia Grob
    Molecular and Cell Biology Department, University of California, Berkeley, Berkeley, California 94720, USA
    Structure 14:511-20. 2006
    ..We propose that these density rearrangements in the structure are a likely reflection of the plasticity of the interactions between TFIID and its many partner proteins...
  46. pmc Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method
    Andres E Leschziner
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 104:4913-8. 2007
    ..We present a model of the RSC-nucleosome complex that rationalizes the single molecule results obtained by using optical tweezers and also discuss the mechanistic implications of our structures...
  47. ncbi request reprint Octomeric pyruvate-ferredoxin oxidoreductase from Desulfovibrio vulgaris
    Florian Garczarek
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    J Struct Biol 159:9-18. 2007
    ..This study demonstrates that the strategy of intermediate resolution EM reconstruction coupled to homology modeling and docking can be powerful enough to infer the functionality of single amino acid residues...
  48. ncbi request reprint Microtubule structure at 8 A resolution
    Huilin Li
    Life Sciences Division, Lawrence Berkeley National Laboratory, CA 94720, USA
    Structure 10:1317-28. 2002
    ....
  49. pmc The structural basis for regulated assembly and function of the transcriptional activator NtrC
    Sacha De Carlo
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA
    Genes Dev 20:1485-95. 2006
    ..Accompanying the hydrolysis cycle that is required for transcriptional activation, we observed major order-disorder changes in the GAFTGA loops involved in sigma(54) binding, as well as in the DNA-binding domains...
  50. ncbi request reprint An iterative Fourier-Bessel algorithm for reconstruction of helical structures with severe Bessel overlap
    Hong Wei Wang
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA
    J Struct Biol 149:65-78. 2005
    ..The algorithm has also been applied with very satisfactory results to the reconstruction of 13-protofilament microtubules, which is another helical structure that suffer Bessel overlap, suggesting its generality...
  51. ncbi request reprint Backtracking determines the force sensitivity of RNAP II in a factor-dependent manner
    Eric A Galburt
    Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nature 446:820-3. 2007
    ..4 pN. Taken together, these results describe a regulatory mechanism of transcription elongation in eukaryotes by which transcription factors modify the mechanical performance of RNAP II, allowing it to operate against higher loads...
  52. pmc Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation
    Anders M Naar
    Department of Cell Biology, Harvard Medical School, Massachusetts General Hospital Cancer Center, Charlestown 02129, USA
    Genes Dev 16:1339-44. 2002
    ..Together, our findings suggest that the human CRSP coactivator functions, at least in part, by mediating activator-dependent recruitment of RNA Pol II via the CTD...
  53. ncbi request reprint Tumor cells resistant to a microtubule-depolymerizing hemiasterlin analogue, HTI-286, have mutations in alpha- or beta-tubulin and increased microtubule stability
    Marianne S Poruchynsky
    Cancer Therapeutics Branch, The NCI Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Biochemistry 43:13944-54. 2004
    ..Unlike reports of mutations resulting in reduced drug affinity, the experimental data and location of mutations are consistent with resistance to HTI-286 mediated by microtubule-stabilizing mutations in beta- or alpha-tubulin...
  54. ncbi request reprint Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome
    Altaf H Sarker
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mail Stop 74R157, Berkeley, California 94720, USA
    Mol Cell 20:187-98. 2005
    ..Together, these results implicate coordinated recognition of stalled transcription by XPG and CSB in TCR initiation and suggest that TFIIH-dependent remodeling of stalled RNAPII without release may be sufficient to allow repair...
  55. ncbi request reprint A revised nomenclature for the human and rodent alpha-tubulin gene family
    Varsha K Khodiyar
    HUGO Gene Nomenclature Committee, Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Genomics 90:285-9. 2007
    ..This revised nomenclature provides a unified language for the discussion of these genes in mammalian species; it has been approved by the gene nomenclature committees of the three species and is supported by researchers in the field...

Research Grants8

  1. Structural studies of the eukaryotic transcription
    Eva Nogales; Fiscal Year: 2005
    ..To this end we will study the complexes formed by TFIID with the general activator Sp 1. ..
  2. Structural Studies of the Eukaryotic Transcription Initiation Machinery
    Eva Nogales; Fiscal Year: 2010
    ....