Hidetoshi Mori

Summary

Affiliation: Lawrence Berkeley National Laboratory
Country: USA

Publications

  1. pmc Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1
    Hidetoshi Mori
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Development 140:343-52. 2013
  2. pmc Laser scanning-based tissue autofluorescence/fluorescence imaging (LS-TAFI), a new technique for analysis of microanatomy in whole-mount tissues
    Hidetoshi Mori
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Am J Pathol 180:2249-56. 2012
  3. pmc The hemopexin domain of MMP3 is responsible for mammary epithelial invasion and morphogenesis through extracellular interaction with HSP90β
    Ana Luísa Correia
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Genes Dev 27:805-17. 2013
  4. pmc Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening
    Jordi Alcaraz
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977R225A, Berkeley, CA 94720, USA
    Integr Biol (Camb) 3:1153-66. 2011
  5. pmc Coherent angular motion in the establishment of multicellular architecture of glandular tissues
    Kandice Tanner
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 109:1973-8. 2012
  6. doi request reprint Constructing three-dimensional models to study mammary gland branching morphogenesis and functional differentiation
    Alvin T Lo
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Mammary Gland Biol Neoplasia 17:103-10. 2012
  7. pmc Self-organization of engineered epithelial tubules by differential cellular motility
    Hidetoshi Mori
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:14890-5. 2009
  8. pmc Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia
    Jordi Alcaraz
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    EMBO J 27:2829-38. 2008
  9. doi request reprint The perivascular niche regulates breast tumour dormancy
    Cyrus M Ghajar
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nat Cell Biol 15:807-17. 2013
  10. pmc Patterned collagen fibers orient branching mammary epithelium through distinct signaling modules
    Douglas G Brownfield
    Department of Bioengineering, University of California Berkeley, Berkeley, CA 94720, USA
    Curr Biol 23:703-9. 2013

Collaborators

Detail Information

Publications12

  1. pmc Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1
    Hidetoshi Mori
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Development 140:343-52. 2013
    ..These results shed light on hitherto undescribed non-proteolytic activities of Mmp14 that are necessary for the Itgb1-dependent biochemical and mechanical signals that regulate branching in the mammary epithelium...
  2. pmc Laser scanning-based tissue autofluorescence/fluorescence imaging (LS-TAFI), a new technique for analysis of microanatomy in whole-mount tissues
    Hidetoshi Mori
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Am J Pathol 180:2249-56. 2012
    ..This technique could be useful for rapid diagnosis of human clinical samples and possibly the effect of subtle variations such as low dose radiation...
  3. pmc The hemopexin domain of MMP3 is responsible for mammary epithelial invasion and morphogenesis through extracellular interaction with HSP90β
    Ana Luísa Correia
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Genes Dev 27:805-17. 2013
    ..Our data also may shed light on the failure of strategies to use MMP inhibitors in cancer treatment and other related disorders...
  4. pmc Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening
    Jordi Alcaraz
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977R225A, Berkeley, CA 94720, USA
    Integr Biol (Camb) 3:1153-66. 2011
    ....
  5. pmc Coherent angular motion in the establishment of multicellular architecture of glandular tissues
    Kandice Tanner
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 109:1973-8. 2012
    ..We propose that CAMo is an integral step in the formation of the tissue architecture and that its disruption is involved in malignant transformation...
  6. doi request reprint Constructing three-dimensional models to study mammary gland branching morphogenesis and functional differentiation
    Alvin T Lo
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Mammary Gland Biol Neoplasia 17:103-10. 2012
    ..These designer microenvironments are useful for both understanding branching morphogenesis and signaling integrations, but also for analysis of individual susceptibilities and drug testing...
  7. pmc Self-organization of engineered epithelial tubules by differential cellular motility
    Hidetoshi Mori
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:14890-5. 2009
    ..These results indicate that differential directional persistence can give rise to patterns within model developing tissues...
  8. pmc Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia
    Jordi Alcaraz
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    EMBO J 27:2829-38. 2008
    ..Our data indicate that tissue-specific gene expression is controlled by both the tissues' unique biochemical milieu and mechanical properties, processes involved in maintenance of tissue integrity and protection against tumorigenesis...
  9. doi request reprint The perivascular niche regulates breast tumour dormancy
    Cyrus M Ghajar
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nat Cell Biol 15:807-17. 2013
    ..Our work reveals that stable microvasculature constitutes a dormant niche, whereas sprouting neovasculature sparks micrometastatic outgrowth. ..
  10. pmc Patterned collagen fibers orient branching mammary epithelium through distinct signaling modules
    Douglas G Brownfield
    Department of Bioengineering, University of California Berkeley, Berkeley, CA 94720, USA
    Curr Biol 23:703-9. 2013
    ..Our data provide an explanation for how the stromal ECM encodes architectural cues for branch orientation as well as how the branching epithelium interprets and reinforces these cues through distinct signaling processes...
  11. pmc The metastasis-promoting protein S100A4 regulates mammary branching morphogenesis
    Kristin Andersen
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Dev Biol 352:181-90. 2011
    ..We suggest that S100A4-mediated effects during branching morphogenesis provide a plausible mechanism for how it may function in breast cancer progression...
  12. pmc The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium
    Jimmie E Fata
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Dev Biol 306:193-207. 2007
    ..Our findings indicate that expression of morphogenetic effectors, proliferation, and cell-type decisions during mammary organoid morphogenesis are intimately dependent on the duration of activation of MAPK(ERK1,2) activation...