H W Mohrenweiser

Summary

Affiliation: Lawrence Livermore National Laboratory
Country: USA

Publications

  1. ncbi request reprint Challenges and complexities in estimating both the functional impact and the disease risk associated with the extensive genetic variation in human DNA repair genes
    Harvey W Mohrenweiser
    Biology and Biotechnology Research Program, L 448, Lawrence Livermore National Laboratory, 7000 East Avenue, CA 94551 0808, USA
    Mutat Res 526:93-125. 2003
  2. ncbi request reprint Identification of 127 amino acid substitution variants in screening 37 DNA repair genes in humans
    Harvey W Mohrenweiser
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, California 94550, USA
    Cancer Epidemiol Biomarkers Prev 11:1054-64. 2002
  3. ncbi request reprint Variation in DNA repair is a factor in cancer susceptibility: a paradigm for the promises and perils of individual and population risk estimation?
    H W Mohrenweiser
    Biology and Biotechnology Research Program, L 452, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Mutat Res 400:15-24. 1998
  4. ncbi request reprint Complex beta-satellite repeat structures and the expansion of the zinc finger gene cluster in 19p12
    E E Eichler
    Human Genome Center, BBRP, L 452, Lawrence Livermore National Laboratory, Livermore, California 94550, USA
    Genome Res 8:791-808. 1998
  5. ncbi request reprint Cloning and characterization of HARP/SMARCAL1: a prokaryotic HepA-related SNF2 helicase protein from human and mouse
    M A Coleman
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, California 94551, USA
    Genomics 65:274-82. 2000
  6. ncbi request reprint Arginine to tryptophan substitution in the active site of a human lactate dehydrogenase variant--LDHB GUA1: postulated effects on subunit structure and catalysis
    G C Shonnard
    Biology and Biotechonology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Biochim Biophys Acta 1315:9-14. 1996
  7. ncbi request reprint Regions of sex-specific hypo- and hyper-recombination identified through integration of 180 genetic markers into the metric physical map of human chromosome 19
    H W Mohrenweiser
    Human Genome Center, Lawrence Livermore National Laboratory, California 94550, USA
    Genomics 47:153-62. 1998
  8. ncbi request reprint The genetic basis for variation in radiation sensitivity in the general population
    I M Jones
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, California, USA
    Radiat Res 163:700-1. 2005
  9. ncbi request reprint JAK3 maps to human chromosome 19p12 within a cluster of proto-oncogenes and transcription factors
    S M Hoffman
    Human Genome Center, Lawrence Livermore National Laboratory, Livermore, California 94550, USA
    Genomics 43:109-11. 1997
  10. ncbi request reprint Interchromosomal duplications of the adrenoleukodystrophy locus: a phenomenon of pericentromeric plasticity
    E E Eichler
    Human Genome Center, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Hum Mol Genet 6:991-1002. 1997

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Challenges and complexities in estimating both the functional impact and the disease risk associated with the extensive genetic variation in human DNA repair genes
    Harvey W Mohrenweiser
    Biology and Biotechnology Research Program, L 448, Lawrence Livermore National Laboratory, 7000 East Avenue, CA 94551 0808, USA
    Mutat Res 526:93-125. 2003
    ..In closing, we raise some of the non-technical challenges to the utilization of the full richness of the genetic variation to reduce disease occurrence and ultimately improve health care...
  2. ncbi request reprint Identification of 127 amino acid substitution variants in screening 37 DNA repair genes in humans
    Harvey W Mohrenweiser
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, California 94550, USA
    Cancer Epidemiol Biomarkers Prev 11:1054-64. 2002
    ....
  3. ncbi request reprint Variation in DNA repair is a factor in cancer susceptibility: a paradigm for the promises and perils of individual and population risk estimation?
    H W Mohrenweiser
    Biology and Biotechnology Research Program, L 452, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Mutat Res 400:15-24. 1998
    ....
  4. ncbi request reprint Complex beta-satellite repeat structures and the expansion of the zinc finger gene cluster in 19p12
    E E Eichler
    Human Genome Center, BBRP, L 452, Lawrence Livermore National Laboratory, Livermore, California 94550, USA
    Genome Res 8:791-808. 1998
    ..The sequence data described in this paper have been submitted to GenBank under accession nos. AC003973 and AC004004.]..
  5. ncbi request reprint Cloning and characterization of HARP/SMARCAL1: a prokaryotic HepA-related SNF2 helicase protein from human and mouse
    M A Coleman
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, California 94551, USA
    Genomics 65:274-82. 2000
    ..HARP/SMARCAL1 transcripts are ubiquitously expressed in human and mouse tissues, with testis presenting the highest levels of mRNA expression in humans...
  6. ncbi request reprint Arginine to tryptophan substitution in the active site of a human lactate dehydrogenase variant--LDHB GUA1: postulated effects on subunit structure and catalysis
    G C Shonnard
    Biology and Biotechonology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Biochim Biophys Acta 1315:9-14. 1996
    ..The ability to maintain normal, tissue-specific kinetic properties could explain the absence of clinical manifestations in the homozygous LDHB GUA1 individuals...
  7. ncbi request reprint Regions of sex-specific hypo- and hyper-recombination identified through integration of 180 genetic markers into the metric physical map of human chromosome 19
    H W Mohrenweiser
    Human Genome Center, Lawrence Livermore National Laboratory, California 94550, USA
    Genomics 47:153-62. 1998
    ....
  8. ncbi request reprint The genetic basis for variation in radiation sensitivity in the general population
    I M Jones
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, California, USA
    Radiat Res 163:700-1. 2005
  9. ncbi request reprint JAK3 maps to human chromosome 19p12 within a cluster of proto-oncogenes and transcription factors
    S M Hoffman
    Human Genome Center, Lawrence Livermore National Laboratory, Livermore, California 94550, USA
    Genomics 43:109-11. 1997
  10. ncbi request reprint Interchromosomal duplications of the adrenoleukodystrophy locus: a phenomenon of pericentromeric plasticity
    E E Eichler
    Human Genome Center, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Hum Mol Genet 6:991-1002. 1997
    ....
  11. pmc Molecular analysis of a series of alleles in humans with reduced activity at the triosephosphate isomerase locus
    M Watanabe
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, CA 94550, USA
    Am J Hum Genet 58:308-16. 1996
    ..Thus, molecular alterations at the TPI locus were detected in 10 unrelated individuals in whom segregation of a phenotype of reduced TPI activity previously had been identified...
  12. ncbi request reprint Refined mapping of the three DNA repair genes, ERCC1, ERCC2, and XRCC1, on human chromosome 19
    H W Mohrenweiser
    Biomedical Sciences Division, Lawrence Livermore National Laboratory, Livermore, CA 94550
    Cytogenet Cell Genet 52:11-4. 1989
    ..2----q13.3 by in situ hybridization using fluorescently-labeled cosmid probes. ERCC1 and ERCC2 have been found to be separated by less than 250 kb by large fragment restriction enzyme site mapping...
  13. ncbi request reprint Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19
    S M Hoffman
    Human Genome Center, Lawrence Livermore National Laboratory, CA 94551, USA
    J Mol Evol 41:894-900. 1995
    ..The identification of all genes and pseudogenes in this cluster also makes it possible to determine the origins of some previously known variant P450 transcripts...
  14. ncbi request reprint Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer
    Tasha R Smith
    Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Lett 190:183-90. 2003
    ..74; 95% CI=1.13-67.53). Although larger studies are needed to validate the study results, our data suggest that amino acid substitution variants of XRCC1 and XRCC3 genes may contribute to breast cancer susceptibility...
  15. ncbi request reprint Exploration of methods to identify polymorphisms associated with variation in DNA repair capacity phenotypes
    Irene M Jones
    Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Mutat Res 616:213-20. 2007
    ..The results should encourage research into utilization of multivariate analytical methods for epidemiological studies of the association of genetic variation in complex genotypes with risk of common diseases...
  16. ncbi request reprint DNA-repair genetic polymorphisms and breast cancer risk
    Tasha R Smith
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Epidemiol Biomarkers Prev 12:1200-4. 2003
    ..We provide evidence that variants of XRCC1, XRCC3, and ERCC4/XPF genes, particularly in combination, contribute to breast cancer susceptibility...
  17. ncbi request reprint Many amino acid substitution variants identified in DNA repair genes during human population screenings are predicted to impact protein function
    Tong Xi
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Genomics 83:970-9. 2004
    ..These variants are expected to be the molecular genetic and biochemical basis for the associations of reduced DNA repair capacity phenotypes with elevated cancer risk...
  18. ncbi request reprint Genetic variation and exposure related risk estimation: will toxicology enter a new era? DNA repair and cancer as a paradigm
    Harvey W Mohrenweiser
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, California, USA
    Toxicol Pathol 32:136-45. 2004
    ..Similar issues exist in selecting the animal models most appropriate for predicting human risk from environmental exposures to toxic agents...
  19. ncbi request reprint Four human FANCG polymorphic variants show normal biological function in hamster CHO cells
    John M Hinz
    Biosciences Directorate, Lawrence Livermore National Laboratory, PO Box 808, Livermore, CA 94551 0808, USA
    Mutat Res 602:34-42. 2006
    ..Using this novel system for determining FANCG functionality, we detect no decrement in function of the human FANCG polymorphic variants examined...
  20. pmc Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1)
    Craig R Lee
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Chapel Hill, North Carolina, USA
    Pharmacogenet Genomics 17:145-60. 2007
    ..We sought to identify and characterize the functional relevance of genetic polymorphisms in PTGS1...
  21. ncbi request reprint Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6)
    Kelly Bleasby
    Laboratory of Pharmacology and Chemistry, The National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 314:923-31. 2005
    ....
  22. ncbi request reprint Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups
    Su Jun Lee
    Human Metabolism Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Pharmacogenetics 13:461-72. 2003
    ....
  23. ncbi request reprint Polymorphisms in human soluble epoxide hydrolase
    Beata D Przybyla-Zawislak
    Department of Pharmaceutical Sciences, University of Connecticut, 372 Fairfield Road, Unit 2092, Storrs, CT 06269 2092, USA
    Mol Pharmacol 64:482-90. 2003
    ..These results suggest that at least six hsEH variants exist in the human population and that at least four of these may influence hsEH-mediated metabolism of exogenous and endogenous epoxide substrates in vivo...
  24. pmc The discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression system
    Su Jun Lee
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Pharmacogenet Genomics 17:169-80. 2007
    ..We sequenced CYP26A1 in racially diverse individuals and assessed the metabolism of retinoic acid by newly identified coding alleles of CYP26A1 in a recombinant system...