Mark A Labarge
Affiliation: Lawrence Berkeley National Laboratory
- Of microenvironments and mammary stem cellsMark A Labarge
Lawrence Berkeley National Laboratory, Berkeley, CA, USA
Stem Cell Rev 3:137-46. 2007..These studies together create a robust portrait of mammary gland biology and identify the location of the stem cell niche, elucidate a developmental hierarchy, and suggest how the niche might be manipulated for therapeutic benefit...
- Is CD133 a marker of metastatic colon cancer stem cells?Mark A Labarge
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
J Clin Invest 118:2021-4. 2008..In light of these new findings, the popular notion that CD133 is a marker of colon CSCs may need to be revised...
- Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?Mina J Bissell
Department Cancer Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
Cancer Cell 7:17-23. 2005
- The difficulty of targeting cancer stem cell nichesMark A Labarge
Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Clin Cancer Res 16:3121-9. 2010....
- Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironmentsMark A Labarge
Lawrence Berkeley National Laboratory, Division of Life Sciences, Berkeley, CA 94720, USA
Integr Biol (Camb) 1:70-9. 2009..We report on the functional ability of those proteins of the mammary gland that maintain quiescence, maintain the progenitor state, and guide progenitor differentiation towards myoepithelial and luminal lineages...
- Accumulation of multipotent progenitors with a basal differentiation bias during aging of human mammary epitheliaJames C Garbe
Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Cancer Res 72:3687-701. 2012..Together, our findings provide a cellular basis to explain the observed vulnerability to breast cancer that increases with age...
- Evidence for a stem cell hierarchy in the adult human breastRene Villadsen
Department of Cellular and Molecular Medicine, Faculty of Health Sciences, and Zoophysiological Laboratory, University of Copenhagen, and Department of Pathology, State University Hospital, Copenhagen, Denmark
J Cell Biol 177:87-101. 2007..These findings identify an adult human breast ductal stem cell activity and its earliest descendants...
- IGF-I increases bone marrow contribution to adult skeletal muscle and enhances the fusion of myelomonocytic precursorsAlessandra Sacco
Department of Molecular Pharmacology, Baxter Laboratory in Genetic Pharmacology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Cell Biol 171:483-92. 2005..These results provide novel evidence that a single factor, IGF-I, is sufficient to enhance the fusion of bone marrow derivatives with adult skeletal muscle...
- Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursorsRegis Doyonnas
Baxter Laboratory in Genetic Pharmacology and Department of Molecular Pharmacology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 101:13507-12. 2004..Irrespective of the underlying mechanisms, these data suggest that the HSC derivatives that integrate into regenerating muscle fibers exist in the pool of hematopoietic cells known as myelomonocytic progenitors...
- Biological progression from adult bone marrow to mononucleate muscle stem cell to multinucleate muscle fiber in response to injuryMark A Labarge
Baxter Laboratory for Genetic Pharmacology, Department of Microbiology and Immunology, Department of Molecular Pharmacology, Stanford University School of Medicine, CCSR 4215, Stanford, CA 94305, USA
Cell 111:589-601. 2002..The stress-induced progression of BMDC to muscle satellite cell to muscle fiber results in a contribution to as many as 3.5% of muscle fibers and is due to developmental plasticity in response to environmental cues...