Kristen S Kulp

Summary

Affiliation: Lawrence Livermore National Laboratory
Country: USA

Publications

  1. ncbi Identification of urine metabolites of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine following consumption of a single cooked chicken meal in humans
    K S Kulp
    Biology and Biotechnology Research Program, L 452, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Carcinogenesis 21:2065-72. 2000
  2. ncbi Essiac and Flor-Essence herbal tonics stimulate the in vitro growth of human breast cancer cells
    Kristen S Kulp
    Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Breast Cancer Res Treat 98:249-59. 2006
  3. ncbi Chemical and biological differentiation of three human breast cancer cell types using time-of-flight secondary ion mass spectrometry
    Kristen S Kulp
    Biosciences Directorate and Chemistry and Material Sciences Directorate, P O Box 808, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
    Anal Chem 78:3651-8. 2006
  4. ncbi PhIP metabolites in human urine after consumption of well-cooked chicken
    K S Kulp
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 7000 East Avenue, L 452, Livermore, CA 94551 9900, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 802:143-53. 2004
  5. ncbi An in vitro model system to predict the bioaccessibility of heterocyclic amines from a cooked meat matrix
    Kristen S Kulp
    Biology and Biotechnology Research Program, PO Box 808, Lawrence Livermore National Laboratory, Livermore, CA 94551 9900, USA
    Food Chem Toxicol 41:1701-10. 2003
  6. ncbi Factors affecting human heterocyclic amine intake and the metabolism of PhIP
    Mark G Knize
    Biology and Biotechnology Research Program, PO Box 808, Lawrence Livermore National Laboratory, Livermore, CA 94551 9900, USA
    Mutat Res 506:153-62. 2002
  7. ncbi PhIP carcinogenicity in breast cancer: computational and experimental evidence for competitive interactions with human estrogen receptor
    Brian J Bennion
    Biosciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, California 94551, USA
    Chem Res Toxicol 18:1528-36. 2005
  8. ncbi Impact of environmental exposures on the mutagenicity/carcinogenicity of heterocyclic amines
    James S Felton
    Biology and Biotechnology Research Program, L 452, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA
    Toxicology 198:135-45. 2004
  9. ncbi Human exposure to heterocyclic amine food mutagens/carcinogens: relevance to breast cancer
    James S Felton
    Molecular and Structural Biology Division, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
    Environ Mol Mutagen 39:112-8. 2002
  10. ncbi Distinguishing monosaccharide stereo- and structural isomers with TOF-SIMS and multivariate statistical analysis
    Elena S F Berman
    Biosciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, California 94550, USA
    Anal Chem 78:6497-503. 2006

Research Grants

  1. Studying the interaction of Flor-Essence Tonic and PHIP
    Kristen Kulp; Fiscal Year: 2004

Collaborators

Detail Information

Publications12

  1. ncbi Identification of urine metabolites of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine following consumption of a single cooked chicken meal in humans
    K S Kulp
    Biology and Biotechnology Research Program, L 452, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Carcinogenesis 21:2065-72. 2000
    ....
  2. ncbi Essiac and Flor-Essence herbal tonics stimulate the in vitro growth of human breast cancer cells
    Kristen S Kulp
    Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Breast Cancer Res Treat 98:249-59. 2006
    ..In this study, we evaluated Flor-Essence and Essiac for their effects on the growth of human tumor cells in culture...
  3. ncbi Chemical and biological differentiation of three human breast cancer cell types using time-of-flight secondary ion mass spectrometry
    Kristen S Kulp
    Biosciences Directorate and Chemistry and Material Sciences Directorate, P O Box 808, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
    Anal Chem 78:3651-8. 2006
    ..Ultimately, we anticipate characterizing rare chemical changes that may provide clues to single cell progression within carcinogenic and metastatic pathways...
  4. ncbi PhIP metabolites in human urine after consumption of well-cooked chicken
    K S Kulp
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 7000 East Avenue, L 452, Livermore, CA 94551 9900, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 802:143-53. 2004
    ..Our results suggest that quantifying PhIP metabolites should make future studies of individual susceptibility and dietary interventions possible...
  5. ncbi An in vitro model system to predict the bioaccessibility of heterocyclic amines from a cooked meat matrix
    Kristen S Kulp
    Biology and Biotechnology Research Program, PO Box 808, Lawrence Livermore National Laboratory, Livermore, CA 94551 9900, USA
    Food Chem Toxicol 41:1701-10. 2003
    ..These results may have important ramifications for human feeding studies, which assume that the total amount of each HA in the meat matrix is equally bioavailable...
  6. ncbi Factors affecting human heterocyclic amine intake and the metabolism of PhIP
    Mark G Knize
    Biology and Biotechnology Research Program, PO Box 808, Lawrence Livermore National Laboratory, Livermore, CA 94551 9900, USA
    Mutat Res 506:153-62. 2002
    ..This newly developed methodology will allow us to assess prevention strategies that reduce the possible risks associated with PhIP exposure...
  7. ncbi PhIP carcinogenicity in breast cancer: computational and experimental evidence for competitive interactions with human estrogen receptor
    Brian J Bennion
    Biosciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, California 94551, USA
    Chem Res Toxicol 18:1528-36. 2005
    ..We propose that the mechanism for the tissue-specific carcinogenicity seen in the rat breast tumors and the presumptive human breast cancer associated with the consumption of well-done meat maybe mediated by this receptor activation...
  8. ncbi Impact of environmental exposures on the mutagenicity/carcinogenicity of heterocyclic amines
    James S Felton
    Biology and Biotechnology Research Program, L 452, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA
    Toxicology 198:135-45. 2004
    ..Numerous environmental chemicals found in food or the atmosphere can impact the exposure, metabolism, and cell proliferation response of heterocyclic amines...
  9. ncbi Human exposure to heterocyclic amine food mutagens/carcinogens: relevance to breast cancer
    James S Felton
    Molecular and Structural Biology Division, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
    Environ Mol Mutagen 39:112-8. 2002
    ..This work is suited to investigate individual exposure and risk, especially for breast cancer, from these potent dietary mutagens...
  10. ncbi Distinguishing monosaccharide stereo- and structural isomers with TOF-SIMS and multivariate statistical analysis
    Elena S F Berman
    Biosciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, California 94550, USA
    Anal Chem 78:6497-503. 2006
    ....
  11. ncbi Preparation of single cells for imaging/profiling mass spectrometry
    Elena S F Berman
    Chemistry, Materials, Earth, and Life Sciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94550, USA
    J Am Soc Mass Spectrom 19:1230-6. 2008
    ..This preparation technique makes possible routine imaging/profiling MS analysis of individual cultured cells, allowing for understanding of molecular processes within individual cells...
  12. ncbi Flor-Essence herbal tonic does not inhibit mammary tumor development in Sprague Dawley rats
    L Michelle Bennett
    Center for Cancer Research, NCI, NIH, Bethesda, MD 20852, USA
    Breast Cancer Res Treat 88:87-93. 2004
    ..Flor-Essence tonic is a complex mixture of herbal extracts used by cancer patients because of anecdotal evidence that it can treat or prevent disease...

Research Grants1

  1. Studying the interaction of Flor-Essence Tonic and PHIP
    Kristen Kulp; Fiscal Year: 2004
    ..It is important to determine how currently used CAMs are interacting with dietary carcinogens to influence health. Science based information is needed so that people can make informed lifestyle choices. ..