Mark G Knize

Summary

Affiliation: Lawrence Livermore National Laboratory
Country: USA

Publications

  1. ncbi request reprint Factors affecting human heterocyclic amine intake and the metabolism of PhIP
    Mark G Knize
    Biology and Biotechnology Research Program, PO Box 808, Lawrence Livermore National Laboratory, Livermore, CA 94551 9900, USA
    Mutat Res 506:153-62. 2002
  2. ncbi request reprint Human exposure to heterocyclic amine food mutagens/carcinogens: relevance to breast cancer
    James S Felton
    Molecular and Structural Biology Division, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
    Environ Mol Mutagen 39:112-8. 2002
  3. ncbi request reprint Impact of environmental exposures on the mutagenicity/carcinogenicity of heterocyclic amines
    James S Felton
    Biology and Biotechnology Research Program, L 452, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA
    Toxicology 198:135-45. 2004
  4. ncbi request reprint PhIP carcinogenicity in breast cancer: computational and experimental evidence for competitive interactions with human estrogen receptor
    Brian J Bennion
    Biosciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, California 94551, USA
    Chem Res Toxicol 18:1528-36. 2005
  5. ncbi request reprint Mutagenic activity and heterocyclic amine carcinogens in commercial pet foods
    Mark G Knize
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Mutat Res 539:195-201. 2003
  6. ncbi request reprint Formation and human risk of carcinogenic heterocyclic amines formed from natural precursors in meat
    Mark G Knize
    Biosciences Directorate, University of California, Lawrence Livermore National Laboratory 7000 East Avenue, Livermore, CA 94550, USA
    Nutr Rev 63:158-65. 2005
  7. ncbi request reprint An in vitro model system to predict the bioaccessibility of heterocyclic amines from a cooked meat matrix
    Kristen S Kulp
    Biology and Biotechnology Research Program, PO Box 808, Lawrence Livermore National Laboratory, Livermore, CA 94551 9900, USA
    Food Chem Toxicol 41:1701-10. 2003
  8. ncbi request reprint Mutagenic potency of food-derived heterocyclic amines
    James S Felton
    Chemistry, Materials and Life Sciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94551, USA
    Mutat Res 616:90-4. 2007
  9. ncbi request reprint Chemical and biological differentiation of three human breast cancer cell types using time-of-flight secondary ion mass spectrometry
    Kristen S Kulp
    Biosciences Directorate and Chemistry and Material Sciences Directorate, P O Box 808, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
    Anal Chem 78:3651-8. 2006
  10. ncbi request reprint Distinguishing monosaccharide stereo- and structural isomers with TOF-SIMS and multivariate statistical analysis
    Elena S F Berman
    Biosciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, California 94550, USA
    Anal Chem 78:6497-503. 2006

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Factors affecting human heterocyclic amine intake and the metabolism of PhIP
    Mark G Knize
    Biology and Biotechnology Research Program, PO Box 808, Lawrence Livermore National Laboratory, Livermore, CA 94551 9900, USA
    Mutat Res 506:153-62. 2002
    ..This newly developed methodology will allow us to assess prevention strategies that reduce the possible risks associated with PhIP exposure...
  2. ncbi request reprint Human exposure to heterocyclic amine food mutagens/carcinogens: relevance to breast cancer
    James S Felton
    Molecular and Structural Biology Division, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
    Environ Mol Mutagen 39:112-8. 2002
    ..This work is suited to investigate individual exposure and risk, especially for breast cancer, from these potent dietary mutagens...
  3. ncbi request reprint Impact of environmental exposures on the mutagenicity/carcinogenicity of heterocyclic amines
    James S Felton
    Biology and Biotechnology Research Program, L 452, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA
    Toxicology 198:135-45. 2004
    ..Numerous environmental chemicals found in food or the atmosphere can impact the exposure, metabolism, and cell proliferation response of heterocyclic amines...
  4. ncbi request reprint PhIP carcinogenicity in breast cancer: computational and experimental evidence for competitive interactions with human estrogen receptor
    Brian J Bennion
    Biosciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, California 94551, USA
    Chem Res Toxicol 18:1528-36. 2005
    ..We propose that the mechanism for the tissue-specific carcinogenicity seen in the rat breast tumors and the presumptive human breast cancer associated with the consumption of well-done meat maybe mediated by this receptor activation...
  5. ncbi request reprint Mutagenic activity and heterocyclic amine carcinogens in commercial pet foods
    Mark G Knize
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Mutat Res 539:195-201. 2003
    ..From these findings it is hypothesized that there is a connection between dietary heterocyclic amines and cancer in animals consuming these foods...
  6. ncbi request reprint Formation and human risk of carcinogenic heterocyclic amines formed from natural precursors in meat
    Mark G Knize
    Biosciences Directorate, University of California, Lawrence Livermore National Laboratory 7000 East Avenue, Livermore, CA 94550, USA
    Nutr Rev 63:158-65. 2005
    ..Human cancer epidemiology studies related to the consumption of well-done meat products are listed and compared in this review...
  7. ncbi request reprint An in vitro model system to predict the bioaccessibility of heterocyclic amines from a cooked meat matrix
    Kristen S Kulp
    Biology and Biotechnology Research Program, PO Box 808, Lawrence Livermore National Laboratory, Livermore, CA 94551 9900, USA
    Food Chem Toxicol 41:1701-10. 2003
    ..These results may have important ramifications for human feeding studies, which assume that the total amount of each HA in the meat matrix is equally bioavailable...
  8. ncbi request reprint Mutagenic potency of food-derived heterocyclic amines
    James S Felton
    Chemistry, Materials and Life Sciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94551, USA
    Mutat Res 616:90-4. 2007
    ..The other factor of 20 is not clearly understood but is downstream from the oxidation step. The application of QSAR (chemical characteristics) to biological principles related to mutagenesis is explored in this report...
  9. ncbi request reprint Chemical and biological differentiation of three human breast cancer cell types using time-of-flight secondary ion mass spectrometry
    Kristen S Kulp
    Biosciences Directorate and Chemistry and Material Sciences Directorate, P O Box 808, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
    Anal Chem 78:3651-8. 2006
    ..Ultimately, we anticipate characterizing rare chemical changes that may provide clues to single cell progression within carcinogenic and metastatic pathways...
  10. ncbi request reprint Distinguishing monosaccharide stereo- and structural isomers with TOF-SIMS and multivariate statistical analysis
    Elena S F Berman
    Biosciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, California 94550, USA
    Anal Chem 78:6497-503. 2006
    ....
  11. ncbi request reprint Biodegradation of potential diesel oxygenate additives: dibutyl maleate (DBM), and tripropylene glycol methyl ether (TGME)
    Alfredo A Marchetti
    Environmental Science Division, Lawrence Livermore National Laboratory, 7000 East Avenue, L 396, Livermore, CA 94550, USA
    Chemosphere 52:861-8. 2003
    ..From an environmental standpoint, these results combined with the transport predictions indicate that DBM is a better choice than TGME as a diesel additive...
  12. ncbi request reprint A meat and potato war: implications for cancer etiology
    James S Felton
    Biosciences Directorate, Lawrence Livermore National Laboratory Livermore, CA 94551, USA
    Carcinogenesis 27:2367-70. 2006
    ..What conclusion about risks from these dietary carcinogens can we make from the available scientific data?..
  13. ncbi request reprint Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humans
    David G Walters
    BIBRA International Ltd, Woodmansterne Road, Carshalton, Surrey SM5 4DS, UK
    Carcinogenesis 25:1659-69. 2004
    ..This study demonstrates that cruciferous vegetable consumption can induce both the phase I and II metabolism of PhIP in humans...
  14. ncbi request reprint Dietary exposure to heterocyclic amines in a Chinese population
    Kin Yoke Wong
    Department of Community, Occupational and Family Medicine, Faculty of Medicine, National University of Singapore, Singapore
    Nutr Cancer 52:147-55. 2005
    ..Seven specific meat-cooking method combinations contributed 90.1% of this intake, namely, pan-fried fish, pork, and chicken, deep-fried chicken as well as fish, roasted/barbecued pork, and grilled minced beef...