Research Topics
| Mark G KnizeSummaryAffiliation: Lawrence Livermore National Laboratory Country: USA Publications
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Detail Information
Publications
Factors affecting human heterocyclic amine intake and the metabolism of PhIPMark G Knize
Biology and Biotechnology Research Program, PO Box 808, Lawrence Livermore National Laboratory, Livermore, CA 94551 9900, USA
Mutat Res 506:153-62. 2002..This newly developed methodology will allow us to assess prevention strategies that reduce the possible risks associated with PhIP exposure...- Human exposure to heterocyclic amine food mutagens/carcinogens: relevance to breast cancerJames S Felton
Molecular and Structural Biology Division, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
Environ Mol Mutagen 39:112-8. 2002..This work is suited to investigate individual exposure and risk, especially for breast cancer, from these potent dietary mutagens... - Impact of environmental exposures on the mutagenicity/carcinogenicity of heterocyclic aminesJames S Felton
Biology and Biotechnology Research Program, L 452, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA
Toxicology 198:135-45. 2004..Numerous environmental chemicals found in food or the atmosphere can impact the exposure, metabolism, and cell proliferation response of heterocyclic amines... - PhIP carcinogenicity in breast cancer: computational and experimental evidence for competitive interactions with human estrogen receptorBrian J Bennion
Biosciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, California 94551, USA
Chem Res Toxicol 18:1528-36. 2005..We propose that the mechanism for the tissue-specific carcinogenicity seen in the rat breast tumors and the presumptive human breast cancer associated with the consumption of well-done meat maybe mediated by this receptor activation... - Mutagenic activity and heterocyclic amine carcinogens in commercial pet foodsMark G Knize
Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
Mutat Res 539:195-201. 2003..From these findings it is hypothesized that there is a connection between dietary heterocyclic amines and cancer in animals consuming these foods... - Formation and human risk of carcinogenic heterocyclic amines formed from natural precursors in meatMark G Knize
Biosciences Directorate, University of California, Lawrence Livermore National Laboratory 7000 East Avenue, Livermore, CA 94550, USA
Nutr Rev 63:158-65. 2005..Human cancer epidemiology studies related to the consumption of well-done meat products are listed and compared in this review... - An in vitro model system to predict the bioaccessibility of heterocyclic amines from a cooked meat matrixKristen S Kulp
Biology and Biotechnology Research Program, PO Box 808, Lawrence Livermore National Laboratory, Livermore, CA 94551 9900, USA
Food Chem Toxicol 41:1701-10. 2003..These results may have important ramifications for human feeding studies, which assume that the total amount of each HA in the meat matrix is equally bioavailable... - Mutagenic potency of food-derived heterocyclic aminesJames S Felton
Chemistry, Materials and Life Sciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94551, USA
Mutat Res 616:90-4. 2007..The other factor of 20 is not clearly understood but is downstream from the oxidation step. The application of QSAR (chemical characteristics) to biological principles related to mutagenesis is explored in this report... - Chemical and biological differentiation of three human breast cancer cell types using time-of-flight secondary ion mass spectrometryKristen S Kulp
Biosciences Directorate and Chemistry and Material Sciences Directorate, P O Box 808, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
Anal Chem 78:3651-8. 2006..Ultimately, we anticipate characterizing rare chemical changes that may provide clues to single cell progression within carcinogenic and metastatic pathways... - Distinguishing monosaccharide stereo- and structural isomers with TOF-SIMS and multivariate statistical analysisElena S F Berman
Biosciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, California 94550, USA
Anal Chem 78:6497-503. 2006.... - Biodegradation of potential diesel oxygenate additives: dibutyl maleate (DBM), and tripropylene glycol methyl ether (TGME)Alfredo A Marchetti
Environmental Science Division, Lawrence Livermore National Laboratory, 7000 East Avenue, L 396, Livermore, CA 94550, USA
Chemosphere 52:861-8. 2003..From an environmental standpoint, these results combined with the transport predictions indicate that DBM is a better choice than TGME as a diesel additive... - A meat and potato war: implications for cancer etiologyJames S Felton
Biosciences Directorate, Lawrence Livermore National Laboratory Livermore, CA 94551, USA
Carcinogenesis 27:2367-70. 2006..What conclusion about risks from these dietary carcinogens can we make from the available scientific data?.. - Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humansDavid G Walters
BIBRA International Ltd, Woodmansterne Road, Carshalton, Surrey SM5 4DS, UK
Carcinogenesis 25:1659-69. 2004..This study demonstrates that cruciferous vegetable consumption can induce both the phase I and II metabolism of PhIP in humans... - Dietary exposure to heterocyclic amines in a Chinese populationKin-Yoke Wong
Department of Community, Occupational and Family Medicine, Faculty of Medicine, National University of Singapore, Singapore
Nutr Cancer 52:147-55. 2005..Seven specific meat-cooking method combinations contributed 90.1% of this intake, namely, pan-fried fish, pork, and chicken, deep-fried chicken as well as fish, roasted/barbecued pork, and grilled minced beef...