P A Kenny

Summary

Affiliation: Lawrence Berkeley National Laboratory
Country: USA

Publications

  1. pmc Keystone symposium: the role of microenvironment in tumor induction and progression, Banff, Canada, 5-10 February 2005
    Jamie L Bascom
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Breast Cancer Res 7:113-8. 2005
  2. pmc Targeting the tumor microenvironment
    Paraic A Kenny
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Front Biosci 12:3468-74. 2007
  3. ncbi request reprint Tackling EGFR signaling with TACE antagonists: a rational target for metalloprotease inhibitors in cancer
    Paraic A Kenny
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS977 225A, University of California, Berkeley, CA 94720, USA
    Expert Opin Ther Targets 11:1287-98. 2007
  4. ncbi request reprint Three-dimensional extracellular matrix culture models of EGFR signalling and drug response
    P A Kenny
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977 225A, University of California, Berkeley, CA 94720, USA
    Biochem Soc Trans 35:665-8. 2007
  5. ncbi request reprint TACE: a new target in epidermal growth factor receptor dependent tumors
    Paraic A Kenny
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS977 225A, University of California, Berkeley, CA 94720, USA
    Differentiation 75:800-8. 2007
  6. pmc Targeting TACE-dependent EGFR ligand shedding in breast cancer
    Paraic A Kenny
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    J Clin Invest 117:337-45. 2007
  7. pmc Receptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cells
    Paraic A Kenny
    Section of Gene Function and Regulation, Institute of Cancer Research, London, SW3 6JB, UK
    BMC Cancer 5:3. 2005
  8. pmc 42nd Annual Meeting of the American Society for Cell Biology, San Francisco, California, USA, 14-18 December 2002
    Paraic A Kenny
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Breast Cancer Res 5:147-53. 2003
  9. pmc Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: the role of extracellular matrix and its degrading enzymes
    M J Bissell
    Cancer Biology Department, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, 94720, USA
    Cold Spring Harb Symp Quant Biol 70:343-56. 2005
  10. pmc Three-dimensional culture models of normal and malignant breast epithelial cells
    Genee Y Lee
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nat Methods 4:359-65. 2007

Collaborators

Detail Information

Publications17

  1. pmc Keystone symposium: the role of microenvironment in tumor induction and progression, Banff, Canada, 5-10 February 2005
    Jamie L Bascom
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Breast Cancer Res 7:113-8. 2005
    ..The 30 oral presentations and over 130 posters provided an excellent forum for discussing emerging data in this rapidly advancing field...
  2. pmc Targeting the tumor microenvironment
    Paraic A Kenny
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Front Biosci 12:3468-74. 2007
    ..In this article, we describe some of the "druggable" targets and processes within the tumor microenvironment and review the approaches being taken to disrupt these interactions...
  3. ncbi request reprint Tackling EGFR signaling with TACE antagonists: a rational target for metalloprotease inhibitors in cancer
    Paraic A Kenny
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS977 225A, University of California, Berkeley, CA 94720, USA
    Expert Opin Ther Targets 11:1287-98. 2007
    ..This review presents the background to these findings and a rationale for the continued development of TACE inhibitors for the treatment of epidermal growth factor receptor-dependent epithelial tumors...
  4. ncbi request reprint Three-dimensional extracellular matrix culture models of EGFR signalling and drug response
    P A Kenny
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977 225A, University of California, Berkeley, CA 94720, USA
    Biochem Soc Trans 35:665-8. 2007
    ....
  5. ncbi request reprint TACE: a new target in epidermal growth factor receptor dependent tumors
    Paraic A Kenny
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS977 225A, University of California, Berkeley, CA 94720, USA
    Differentiation 75:800-8. 2007
    ..This review focuses on a subset of these proteins, which are cleaved by tumor necrosis factor alpha-converting enzyme (TACE)/ADAM17, and on their role in cancer...
  6. pmc Targeting TACE-dependent EGFR ligand shedding in breast cancer
    Paraic A Kenny
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    J Clin Invest 117:337-45. 2007
    ....
  7. pmc Receptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cells
    Paraic A Kenny
    Section of Gene Function and Regulation, Institute of Cancer Research, London, SW3 6JB, UK
    BMC Cancer 5:3. 2005
    ..Such alterations in the cellular transcriptional profile are believed to underlie the pathogenesis of these cancers. We have sought to identify novel target genes of this pathway in mouse mammary epithelial cells...
  8. pmc 42nd Annual Meeting of the American Society for Cell Biology, San Francisco, California, USA, 14-18 December 2002
    Paraic A Kenny
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Breast Cancer Res 5:147-53. 2003
    ....
  9. pmc Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: the role of extracellular matrix and its degrading enzymes
    M J Bissell
    Cancer Biology Department, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, 94720, USA
    Cold Spring Harb Symp Quant Biol 70:343-56. 2005
    ..These findings illustrate how normal tissue structure controls the response to extracellular signals so as to preserve tissue specificity and growth status...
  10. pmc Three-dimensional culture models of normal and malignant breast epithelial cells
    Genee Y Lee
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nat Methods 4:359-65. 2007
    ..Alternatively, the 3D 'on-top' assay, in which cells are cultured on top of a thin lrECM gel overlaid with a dilute solution of lrECM, may be used as described in Box 2 (Fig. 1 and Fig. 2)...
  11. pmc The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression
    Paraic A Kenny
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Mol Oncol 1:84-96. 2007
    ..We further demonstrate that consistent differences in genes encoding signal transduction proteins emerge when even tumor cells are cultured in 3D microenvironments...
  12. pmc Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture
    Ju Han
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS Comput Biol 6:e1000684. 2010
    ..Specifically, PPARgamma has been associated with the invasive stellate morphological phenotype, which corresponds to triple-negative pathobiology. PPARgamma has been validated through two supporting biological assays...
  13. pmc Tumor reversion: correction of malignant behavior by microenvironmental cues
    Paraic A Kenny
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Int J Cancer 107:688-95. 2003
    ..This paradigm has been successfully used to treat acute promyelocytic leukemia, and it remains the task of biomedical researchers to identify additional targets for the reversion of other human malignancies...
  14. pmc Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer
    Marcia V Fournier
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cancer Res 66:7095-102. 2006
    ..This study represents a novel unsupervised approach to identifying breast cancer markers that may be of use clinically...
  15. pmc Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT?
    Derek C Radisky
    Department of Cancer Biology, Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA
    J Cell Biochem 101:830-9. 2007
    ..This connection provides a new perspective on the development of the fibrosis and tumor microenvironments...
  16. pmc Localization of plasma membrane and secretory calcium pumps in the mammary gland
    Helen M Faddy
    School of Pharmacy, The University of Queensland, Steele Building, Brisbane, QLD 4072, Australia
    Biochem Biophys Res Commun 369:977-81. 2008
    ..Our studies highlight the likely specific roles of PMCA2 and SPCA2 in lactation and indicate that calcium transport into milk is a complex interplay between apical and secretory pathways...