Irene M Jones

Summary

Affiliation: Lawrence Livermore National Laboratory
Country: USA

Publications

  1. ncbi request reprint Three somatic genetic biomarkers and covariates in radiation-exposed Russian cleanup workers of the chernobyl nuclear reactor 6-13 years after exposure
    Irene M Jones
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, California 94550, USA
    Radiat Res 158:424-42. 2002
  2. ncbi request reprint Studies of thioguanine-resistant lymphocytes induced by in vivo irradiation of mice
    Irene M Jones
    Chemistry, Materials, Earth and Life Sciences, Lawrence Livermore National Laboratory, Livermore, California, USA
    Environ Mol Mutagen 49:343-50. 2008
  3. ncbi request reprint Exploration of methods to identify polymorphisms associated with variation in DNA repair capacity phenotypes
    Irene M Jones
    Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Mutat Res 616:213-20. 2007
  4. ncbi request reprint Total gene deletions and mutant frequency of the HPRT gene as indicators of radiation exposure in Chernobyl liquidators
    I M Jones
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, CA 94550, USA
    Mutat Res 431:233-46. 1999
  5. ncbi request reprint Evaluation of three somatic genetic biomarkers as indicators of low dose radiation effects in clean-up workers of the Chernobyl nuclear reactor accident
    I M Jones
    Biology and Biotechnology Research Program, L 441 Lawrence Livermore National Laboratory, Livermore, California, USA
    Radiat Prot Dosimetry 97:61-7. 2001
  6. ncbi request reprint Induction and decline of HPRT mutants and deletions following a low dose radiation exposure at Chernobyl
    Cynthia B Thomas
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, L 441, P O Box 808, Livermore, CA 94550, USA
    Mutat Res 499:177-87. 2002
  7. ncbi request reprint Four human FANCG polymorphic variants show normal biological function in hamster CHO cells
    John M Hinz
    Biosciences Directorate, Lawrence Livermore National Laboratory, PO Box 808, Livermore, CA 94551 0808, USA
    Mutat Res 602:34-42. 2006
  8. doi request reprint Inter-individual variation in DNA double-strand break repair in human fibroblasts before and after exposure to low doses of ionizing radiation
    Paul F Wilson
    Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94551 0808, USA
    Mutat Res 683:91-7. 2010
  9. ncbi request reprint Challenges and complexities in estimating both the functional impact and the disease risk associated with the extensive genetic variation in human DNA repair genes
    Harvey W Mohrenweiser
    Biology and Biotechnology Research Program, L 448, Lawrence Livermore National Laboratory, 7000 East Avenue, CA 94551 0808, USA
    Mutat Res 526:93-125. 2003
  10. pmc Disparate contributions of the Fanconi anemia pathway and homologous recombination in preventing spontaneous mutagenesis
    John M Hinz
    Chemistry, Materials, and Life Sciences Directorate, L441, Lawrence Livermore National Laboratory, P O Box 808, Livermore, CA 94551 0808, USA
    Nucleic Acids Res 35:3733-40. 2007

Detail Information

Publications24

  1. ncbi request reprint Three somatic genetic biomarkers and covariates in radiation-exposed Russian cleanup workers of the chernobyl nuclear reactor 6-13 years after exposure
    Irene M Jones
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, California 94550, USA
    Radiat Res 158:424-42. 2002
    ..Based on this estimated dose, the risk of exposure-related cancer is expected to be low...
  2. ncbi request reprint Studies of thioguanine-resistant lymphocytes induced by in vivo irradiation of mice
    Irene M Jones
    Chemistry, Materials, Earth and Life Sciences, Lawrence Livermore National Laboratory, Livermore, California, USA
    Environ Mol Mutagen 49:343-50. 2008
    ..The marked variation of mutant frequency, as a function of time after irradiation and of dose rate, emphasize the need to evaluate these variables carefully and consistently in future studies...
  3. ncbi request reprint Exploration of methods to identify polymorphisms associated with variation in DNA repair capacity phenotypes
    Irene M Jones
    Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Mutat Res 616:213-20. 2007
    ..The results should encourage research into utilization of multivariate analytical methods for epidemiological studies of the association of genetic variation in complex genotypes with risk of common diseases...
  4. ncbi request reprint Total gene deletions and mutant frequency of the HPRT gene as indicators of radiation exposure in Chernobyl liquidators
    I M Jones
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, CA 94550, USA
    Mutat Res 431:233-46. 1999
    ....
  5. ncbi request reprint Evaluation of three somatic genetic biomarkers as indicators of low dose radiation effects in clean-up workers of the Chernobyl nuclear reactor accident
    I M Jones
    Biology and Biotechnology Research Program, L 441 Lawrence Livermore National Laboratory, Livermore, California, USA
    Radiat Prot Dosimetry 97:61-7. 2001
    ..The G PA assay did not detect an exposure effect. The results indicate that measuring frequency of translocations by FISH is preferred for low dose radiation, retrospective biochemistry...
  6. ncbi request reprint Induction and decline of HPRT mutants and deletions following a low dose radiation exposure at Chernobyl
    Cynthia B Thomas
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, L 441, P O Box 808, Livermore, CA 94550, USA
    Mutat Res 499:177-87. 2002
    ..05). The results illustrate the sensitivity of HPRT somatic mutation as a biomarker for populations with low dose radiation exposure, and the dependence of this sensitivity on time elapsed since radiation exposure...
  7. ncbi request reprint Four human FANCG polymorphic variants show normal biological function in hamster CHO cells
    John M Hinz
    Biosciences Directorate, Lawrence Livermore National Laboratory, PO Box 808, Livermore, CA 94551 0808, USA
    Mutat Res 602:34-42. 2006
    ..Using this novel system for determining FANCG functionality, we detect no decrement in function of the human FANCG polymorphic variants examined...
  8. doi request reprint Inter-individual variation in DNA double-strand break repair in human fibroblasts before and after exposure to low doses of ionizing radiation
    Paul F Wilson
    Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94551 0808, USA
    Mutat Res 683:91-7. 2010
    ....
  9. ncbi request reprint Challenges and complexities in estimating both the functional impact and the disease risk associated with the extensive genetic variation in human DNA repair genes
    Harvey W Mohrenweiser
    Biology and Biotechnology Research Program, L 448, Lawrence Livermore National Laboratory, 7000 East Avenue, CA 94551 0808, USA
    Mutat Res 526:93-125. 2003
    ..In closing, we raise some of the non-technical challenges to the utilization of the full richness of the genetic variation to reduce disease occurrence and ultimately improve health care...
  10. pmc Disparate contributions of the Fanconi anemia pathway and homologous recombination in preventing spontaneous mutagenesis
    John M Hinz
    Chemistry, Materials, and Life Sciences Directorate, L441, Lawrence Livermore National Laboratory, P O Box 808, Livermore, CA 94551 0808, USA
    Nucleic Acids Res 35:3733-40. 2007
    ....
  11. ncbi request reprint Many amino acid substitution variants identified in DNA repair genes during human population screenings are predicted to impact protein function
    Tong Xi
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Genomics 83:970-9. 2004
    ..These variants are expected to be the molecular genetic and biochemical basis for the associations of reduced DNA repair capacity phenotypes with elevated cancer risk...
  12. ncbi request reprint Identification of 127 amino acid substitution variants in screening 37 DNA repair genes in humans
    Harvey W Mohrenweiser
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, California 94550, USA
    Cancer Epidemiol Biomarkers Prev 11:1054-64. 2002
    ....
  13. ncbi request reprint Deletion and insertion in vivo somatic mutations in the hypoxanthine phosphoribosyltransferase (hprt) gene of human T-lymphocytes
    K J Burkhart-Schultz
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, California 94551, USA
    Environ Mol Mutagen 30:371-84. 1997
    ..The diverse mutation spectrum indicates that multiple mechanisms operated at many different sequences and provides a resource for examination of deletion mutation...
  14. ncbi request reprint Variation in DNA repair is a factor in cancer susceptibility: a paradigm for the promises and perils of individual and population risk estimation?
    H W Mohrenweiser
    Biology and Biotechnology Research Program, L 452, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Mutat Res 400:15-24. 1998
    ....
  15. ncbi request reprint New insights into the Fanconi anemia pathway from an isogenic FancG hamster CHO mutant
    Robert S Tebbs
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, P O Box 808, Livermore, CA 94551 0808, USA
    DNA Repair (Amst) 4:11-22. 2005
    ..We propose that the primary function of FA proteins is to maintain chromosomal continuity by stabilizing replication forks that encounter nicks, gaps, or replication-blocking lesions...
  16. ncbi request reprint Candidate protein biodosimeters of human exposure to ionizing radiation
    Francesco Marchetti
    Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, USA
    Int J Radiat Biol 82:605-39. 2006
    ..To conduct a literature review of candidate protein biomarkers for individual radiation biodosimetry of exposure to ionizing radiation...
  17. ncbi request reprint The genetic basis for variation in radiation sensitivity in the general population
    I M Jones
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, California, USA
    Radiat Res 163:700-1. 2005
  18. ncbi request reprint Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans
    M R Shen
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, California 94550, USA
    Cancer Res 58:604-8. 1998
    ....
  19. ncbi request reprint XRCC1 and glutathione-S-transferase gene polymorphisms and susceptibility to radiotherapy-related malignancies in survivors of Hodgkin disease
    Ann C Mertens
    Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    Cancer 101:1463-72. 2004
    ..Survivors of Hodgkin disease (HD), in particular, have been shown to be at high risk of subsequent malignancy, the occurrence of which has been associated strongly with exposure to radiotherapy...
  20. ncbi request reprint Bilirubin UDP-glucuronosyltransferase 1A1 (UGT1A1) gene promoter polymorphisms and HPRT, glycophorin A, and micronuclei mutant frequencies in human blood
    Delores J Grant
    Environmental Genomics Section, Laboratory of Computational Biology and Risk Assessment, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mutat Res 560:1-10. 2004
    ..More detailed studies examining UGT1A1 promoter variation, oxidant/antioxidant balance and genetic damage will be needed...
  21. ncbi request reprint A comparison of somatic mutational spectra in healthy study populations from Russia, Sweden and USA
    Peri Noori
    Department of Biosciences, The Karolinska Institute, Novum, SE 14157 Huddinge, Sweden
    Carcinogenesis 26:1138-51. 2005
    ..07) when Bonferroni correction for multiple comparisons was made (P < 0.008 required for significance). Age and smoking did not account for these differences. Other factors causing mutational differences need to be explored...
  22. ncbi request reprint DNA damage among thyroid cancer and multiple cancer cases, controls, and long-lived individuals
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, EPS 7092, MSC 7238, Bethesda, MD 20892 7238, USA
    Mutat Res 586:173-88. 2005
    ..Measuring this DNA damage phenotype may contribute to the identification of susceptible sub-groups. Our observations require replication in a prospective study with a large number of pre-diagnostic samples...
  23. ncbi request reprint Second cancers after radiotherapy: any evidence for radiation-induced genomic instability?
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, Maryland, USA
    Radiat Res 163:702-3. 2005
  24. pmc No evidence for differences in DNA damage assessed before and after a cancer diagnosis
    Parveen Bhatti
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 17:990-4. 2008
    ..More work is needed to characterize the effect of cancer diagnosis on other phenotypic assays...