Research Topics
Species | Irene M JonesSummaryAffiliation: Lawrence Livermore National Laboratory Country: USA Publications
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Detail Information
Publications
Three somatic genetic biomarkers and covariates in radiation-exposed Russian cleanup workers of the chernobyl nuclear reactor 6-13 years after exposureIrene M Jones
Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, California 94550, USA
Radiat Res 158:424-42. 2002..Based on this estimated dose, the risk of exposure-related cancer is expected to be low...
Studies of thioguanine-resistant lymphocytes induced by in vivo irradiation of miceIrene M Jones
Chemistry, Materials, Earth and Life Sciences, Lawrence Livermore National Laboratory, Livermore, California, USA
Environ Mol Mutagen 49:343-50. 2008..The marked variation of mutant frequency, as a function of time after irradiation and of dose rate, emphasize the need to evaluate these variables carefully and consistently in future studies...- Exploration of methods to identify polymorphisms associated with variation in DNA repair capacity phenotypesIrene M Jones
Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
Mutat Res 616:213-20. 2007..The results should encourage research into utilization of multivariate analytical methods for epidemiological studies of the association of genetic variation in complex genotypes with risk of common diseases... - Total gene deletions and mutant frequency of the HPRT gene as indicators of radiation exposure in Chernobyl liquidatorsI M Jones
Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, CA 94550, USA
Mutat Res 431:233-46. 1999.... - Evaluation of three somatic genetic biomarkers as indicators of low dose radiation effects in clean-up workers of the Chernobyl nuclear reactor accidentI M Jones
Biology and Biotechnology Research Program, L 441 Lawrence Livermore National Laboratory, Livermore, California, USA
Radiat Prot Dosimetry 97:61-7. 2001..The G PA assay did not detect an exposure effect. The results indicate that measuring frequency of translocations by FISH is preferred for low dose radiation, retrospective biochemistry... - Induction and decline of HPRT mutants and deletions following a low dose radiation exposure at ChernobylCynthia B Thomas
Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, L-441, P.O. Box 808, Livermore, CA 94550, USA
Mutat Res 499:177-87. 2002..05). The results illustrate the sensitivity of HPRT somatic mutation as a biomarker for populations with low dose radiation exposure, and the dependence of this sensitivity on time elapsed since radiation exposure... - Four human FANCG polymorphic variants show normal biological function in hamster CHO cellsJohn M Hinz
Biosciences Directorate, Lawrence Livermore National Laboratory, PO Box 808, Livermore, CA 94551 0808, USA
Mutat Res 602:34-42. 2006..Using this novel system for determining FANCG functionality, we detect no decrement in function of the human FANCG polymorphic variants examined... - Inter-individual variation in DNA double-strand break repair in human fibroblasts before and after exposure to low doses of ionizing radiationPaul F Wilson
Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94551 0808, USA
Mutat Res 683:91-7. 2010.... - Challenges and complexities in estimating both the functional impact and the disease risk associated with the extensive genetic variation in human DNA repair genesHarvey W Mohrenweiser
Biology and Biotechnology Research Program, L 448, Lawrence Livermore National Laboratory, 7000 East Avenue, CA 94551 0808, USA
Mutat Res 526:93-125. 2003..In closing, we raise some of the non-technical challenges to the utilization of the full richness of the genetic variation to reduce disease occurrence and ultimately improve health care... 
Disparate contributions of the Fanconi anemia pathway and homologous recombination in preventing spontaneous mutagenesisJohn M Hinz
Chemistry, Materials, and Life Sciences Directorate, L441, Lawrence Livermore National Laboratory, P O Box 808, Livermore, CA 94551 0808, USA
Nucleic Acids Res 35:3733-40. 2007....- Many amino acid substitution variants identified in DNA repair genes during human population screenings are predicted to impact protein functionTong Xi
Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
Genomics 83:970-9. 2004..These variants are expected to be the molecular genetic and biochemical basis for the associations of reduced DNA repair capacity phenotypes with elevated cancer risk... - Identification of 127 amino acid substitution variants in screening 37 DNA repair genes in humansHarvey W Mohrenweiser
Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, California 94550, USA
Cancer Epidemiol Biomarkers Prev 11:1054-64. 2002.... - Deletion and insertion in vivo somatic mutations in the hypoxanthine phosphoribosyltransferase (hprt) gene of human T-lymphocytesK J Burkhart-Schultz
Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, California 94551, USA
Environ Mol Mutagen 30:371-84. 1997..The diverse mutation spectrum indicates that multiple mechanisms operated at many different sequences and provides a resource for examination of deletion mutation... - Variation in DNA repair is a factor in cancer susceptibility: a paradigm for the promises and perils of individual and population risk estimation?H W Mohrenweiser
Biology and Biotechnology Research Program, L 452, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
Mutat Res 400:15-24. 1998.... - New insights into the Fanconi anemia pathway from an isogenic FancG hamster CHO mutantRobert S Tebbs
Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94551-0808, USA
DNA Repair (Amst) 4:11-22. 2005..We propose that the primary function of FA proteins is to maintain chromosomal continuity by stabilizing replication forks that encounter nicks, gaps, or replication-blocking lesions... - Candidate protein biodosimeters of human exposure to ionizing radiationFrancesco Marchetti
Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, USA
Int J Radiat Biol 82:605-39. 2006..Our findings have applications for early triage and follow-up medical assessments... - The genetic basis for variation in radiation sensitivity in the general populationI M Jones
Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, California, USA
Radiat Res 163:700-1. 2005 - Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humansM R Shen
Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, California 94550, USA
Cancer Res 58:604-8. 1998.... - XRCC1 and glutathione-S-transferase gene polymorphisms and susceptibility to radiotherapy-related malignancies in survivors of Hodgkin diseaseAnn C Mertens
Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
Cancer 101:1463-72. 2004..Survivors of Hodgkin disease (HD), in particular, have been shown to be at high risk of subsequent malignancy, the occurrence of which has been associated strongly with exposure to radiotherapy... - Bilirubin UDP-glucuronosyltransferase 1A1 (UGT1A1) gene promoter polymorphisms and HPRT, glycophorin A, and micronuclei mutant frequencies in human bloodDelores J Grant
Environmental Genomics Section, Laboratory of Computational Biology and Risk Assessment, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Mutat Res 560:1-10. 2004..More detailed studies examining UGT1A1 promoter variation, oxidant/antioxidant balance and genetic damage will be needed... - A comparison of somatic mutational spectra in healthy study populations from Russia, Sweden and USAPeri Noori
Department of Biosciences, The Karolinska Institute, Novum, SE-14157 Huddinge, Sweden
Carcinogenesis 26:1138-51. 2005..07) when Bonferroni correction for multiple comparisons was made (P < 0.008 required for significance). Age and smoking did not account for these differences. Other factors causing mutational differences need to be explored... - DNA damage among thyroid cancer and multiple cancer cases, controls, and long-lived individualsAlice J Sigurdson
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, EPS 7092, MSC 7238, Bethesda, MD 20892 7238, USA
Mutat Res 586:173-88. 2005..Measuring this DNA damage phenotype may contribute to the identification of susceptible sub-groups. Our observations require replication in a prospective study with a large number of pre-diagnostic samples... - Second cancers after radiotherapy: any evidence for radiation-induced genomic instability?Alice J Sigurdson
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, Maryland, USA
Radiat Res 163:702-3. 2005 - No evidence for differences in DNA damage assessed before and after a cancer diagnosisParveen Bhatti
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7238, USA
Cancer Epidemiol Biomarkers Prev 17:990-4. 2008..More work is needed to characterize the effect of cancer diagnosis on other phenotypic assays...