Bo Hang

Summary

Affiliation: Lawrence Berkeley National Laboratory
Country: USA

Publications

  1. pmc Formation and repair of tobacco carcinogen-derived bulky DNA adducts
    Bo Hang
    Life Sciences Division, Department of Cancer and DNA Damage Responses, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Nucleic Acids 2010:709521. 2010
  2. pmc Thirdhand smoke causes DNA damage in human cells
    Bo Hang
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Mutagenesis 28:381-91. 2013
  3. ncbi request reprint Novel activity of Escherichia coli mismatch uracil-DNA glycosylase (Mug) excising 8-(hydroxymethyl)-3,N4-ethenocytosine, a potential product resulting from glycidaldehyde reaction
    Bo Hang
    Donner Laboratory, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Biochemistry 41:2158-65. 2002
  4. ncbi request reprint Substrate specificity of human thymine-DNA glycosylase on exocyclic cytosine adducts
    Bo Hang
    Department of Genome Stability, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Chem Biol Interact 165:230-8. 2007
  5. ncbi request reprint Repair of exocyclic DNA adducts: rings of complexity
    Bo Hang
    Department of Molecular Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Bioessays 26:1195-208. 2004
  6. ncbi request reprint Chloroethylnitrosourea-derived ethano cytosine and adenine adducts are substrates for Escherichia coli glycosylases excising analogous etheno adducts
    Anton B Guliaev
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    DNA Repair (Amst) 3:1311-21. 2004
  7. ncbi request reprint Miscoding properties of 1,N6-ethanoadenine, a DNA adduct derived from reaction with the antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea
    Bo Hang
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Mutat Res 531:191-203. 2003
  8. ncbi request reprint Alkylpurine-DNA-N-glycosylase excision of 7-(hydroxymethyl)-1,N6-ethenoadenine, a glycidaldehyde-derived DNA adduct
    Ping Wang
    Department of Molecular Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    DNA Repair (Amst) 5:23-31. 2006
  9. pmc Structural insights by molecular dynamics simulations into differential repair efficiency for ethano-A versus etheno-A adducts by the human alkylpurine-DNA N-glycosylase
    Anton B Guliaev
    Donner Laboratory, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Nucleic Acids Res 30:3778-87. 2002
  10. ncbi request reprint 8-(Hydroxymethyl)-3,N(4)-etheno-C, a potential carcinogenic glycidaldehyde product, miscodes in vitro using mammalian DNA polymerases
    B Singer
    Donner Laboratory, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Biochemistry 41:1778-85. 2002

Research Grants

  1. HUMAN ENZYME REPAIR OF EXOCYCLIC ADDUCTS
    Bo Hang; Fiscal Year: 2001
  2. Enzyme Repair of Exocyclic Adducts
    Bo Hang; Fiscal Year: 2003
  3. BIOCHEMICAL MECHANISM OF EXOCYCLIC ADDUCTS IN CANCER
    Bo Hang; Fiscal Year: 2004
  4. Enzyme Repair of Excoyclic Adducts
    Bo Hang; Fiscal Year: 2004
  5. Enzyme Repair of Excoyclic Adducts
    Bo Hang; Fiscal Year: 2005

Collaborators

Detail Information

Publications17

  1. pmc Formation and repair of tobacco carcinogen-derived bulky DNA adducts
    Bo Hang
    Life Sciences Division, Department of Cancer and DNA Damage Responses, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Nucleic Acids 2010:709521. 2010
    ..This paper highlights the recent progress made in the areas concerning formation and repair of bulky DNA adducts in the context of tobacco carcinogen-associated genotoxic and carcinogenic effects...
  2. pmc Thirdhand smoke causes DNA damage in human cells
    Bo Hang
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Mutagenesis 28:381-91. 2013
    ..The findings of this study demonstrate for the first time that exposure to THS is genotoxic in human cell lines...
  3. ncbi request reprint Novel activity of Escherichia coli mismatch uracil-DNA glycosylase (Mug) excising 8-(hydroxymethyl)-3,N4-ethenocytosine, a potential product resulting from glycidaldehyde reaction
    Bo Hang
    Donner Laboratory, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Biochemistry 41:2158-65. 2002
    ..We believe that these findings may have biological and structural implications in defining the role of 8-HM-epsilonC in glycosylase recognition/repair...
  4. ncbi request reprint Substrate specificity of human thymine-DNA glycosylase on exocyclic cytosine adducts
    Bo Hang
    Department of Genome Stability, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Chem Biol Interact 165:230-8. 2007
    ..These findings expand the TDG substrate range and aid in understanding the structural requirements for TDG substrate specificity...
  5. ncbi request reprint Repair of exocyclic DNA adducts: rings of complexity
    Bo Hang
    Department of Molecular Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Bioessays 26:1195-208. 2004
    ..It is also apparent that more information is needed for a better understanding of the biological and structural implications of exocyclic adducts and their repair...
  6. ncbi request reprint Chloroethylnitrosourea-derived ethano cytosine and adenine adducts are substrates for Escherichia coli glycosylases excising analogous etheno adducts
    Anton B Guliaev
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    DNA Repair (Amst) 3:1311-21. 2004
    ..However, also as shown by MD, the stacking interaction between the EC base and Phe 30 in the Mug active site is reduced as compared to the epsilonC base, which could account for the lower EC activity observed in this study...
  7. ncbi request reprint Miscoding properties of 1,N6-ethanoadenine, a DNA adduct derived from reaction with the antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea
    Bo Hang
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Mutat Res 531:191-203. 2003
    ..Although there was a measurable extent of error-free nucleotide incorporation, all these polymerases primarily misincorporated opposite EA, indicating that the adduct, similar to epsilonA, is a miscoding lesion...
  8. ncbi request reprint Alkylpurine-DNA-N-glycosylase excision of 7-(hydroxymethyl)-1,N6-ethenoadenine, a glycidaldehyde-derived DNA adduct
    Ping Wang
    Department of Molecular Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    DNA Repair (Amst) 5:23-31. 2006
    ..These novel substrate specificities could have both biological and structural implications...
  9. pmc Structural insights by molecular dynamics simulations into differential repair efficiency for ethano-A versus etheno-A adducts by the human alkylpurine-DNA N-glycosylase
    Anton B Guliaev
    Donner Laboratory, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Nucleic Acids Res 30:3778-87. 2002
    ..We propose that the observed destabilization of the EA adduct at the active site, such as reduced stacking interactions, could account for the biochemically observed weaker recognition of EA by APNG as compared to epsilonA...
  10. ncbi request reprint 8-(Hydroxymethyl)-3,N(4)-etheno-C, a potential carcinogenic glycidaldehyde product, miscodes in vitro using mammalian DNA polymerases
    B Singer
    Donner Laboratory, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Biochemistry 41:1778-85. 2002
    ....
  11. pmc Structural insights by molecular dynamics simulations into specificity of the major human AP endonuclease toward the benzene-derived DNA adduct, pBQ-C
    Anton B Guliaev
    Donner Laboratory, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Nucleic Acids Res 32:2844-52. 2004
    ..The position of the adduct at the enzyme active site, together with the hydrogen bond network, suggests a similar reaction mechanism for phosphodiester bond cleavage of oligonucleotide containing pBQ-C as reported for the AP site...
  12. ncbi request reprint Metal inhibition of human N-methylpurine-DNA glycosylase activity in base excision repair
    Ping Wang
    Department of Molecular Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Toxicol Lett 166:237-47. 2006
    ..These data suggest that inhibition of MPG activity may contribute to metal genotoxicity and depressed repair of alkylation damage by metals in vivo...
  13. ncbi request reprint Protein-protein interactions involving DNA glycosylases
    Bo Hang
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Chem Res Toxicol 16:1181-95. 2003
  14. ncbi request reprint NEIL2 protects against oxidative DNA damage induced by sidestream smoke in human cells
    Altaf H Sarker
    Department of Cancer and DNA Damage Responses, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS ONE 9:e90261. 2014
    ....
  15. pmc HDL mimetic peptide ATI-5261 forms an oligomeric assembly in solution that dissociates to monomers upon dilution
    Ying Zheng
    Life Sciences Division, Lawrence Berkeley National Laboratory, Donner Laboratory, University of California, Berkeley, Berkeley, California 94720, United States
    Biochemistry 50:4068-76. 2011
    ..Optimizing self-association behavior and secondary structure may prove useful for improving the translatability and efficacy of apolipoprotein mimetic peptides...
  16. ncbi request reprint The p-benzoquinone DNA adducts derived from benzene are highly mutagenic
    Zhongwen Xie
    Graduate Center for Toxicology, University of Kentucky, Lexington, 40536, USA
    DNA Repair (Amst) 4:1399-409. 2005
    ..When the lesion becomes incompatible in accommodating a base opposite the lesion in DNA, translesion synthesis occurs by a less efficient lesion loop-out mechanism, resulting in avoiding copying the damaged base and leading to deletion...
  17. ncbi request reprint Synthesis of the fully protected phosphoramidite of the benzene-DNA adduct, N2-(4-Hydroxyphenyl)-2'-deoxyguanosine and incorporation of the later into DNA oligomers
    Ahmed Chenna
    Monogram Biosciences Inc, South San Francisco, California, USA
    Nucleosides Nucleotides Nucleic Acids 27:979-91. 2008
    ..The oligomers were purified by reverse-phase HPLC. Enzymatic hydrolysis and HPLC analysis confirmed the presence of this adduct in the oligomers...

Research Grants5

  1. HUMAN ENZYME REPAIR OF EXOCYCLIC ADDUCTS
    Bo Hang; Fiscal Year: 2001
    ..4) To purify to homogeneity recently identified or other new human glycosylase, characterize the activities and obtain protein micro-sequencing information. ..
  2. Enzyme Repair of Exocyclic Adducts
    Bo Hang; Fiscal Year: 2003
    ..abstract_text> ..
  3. BIOCHEMICAL MECHANISM OF EXOCYCLIC ADDUCTS IN CANCER
    Bo Hang; Fiscal Year: 2004
    ..By using these exocyclic adducts, which have incremental changes in chemical structure, information will be gained on how structure affects function. ..
  4. Enzyme Repair of Excoyclic Adducts
    Bo Hang; Fiscal Year: 2004
    ..abstract_text> ..
  5. Enzyme Repair of Excoyclic Adducts
    Bo Hang; Fiscal Year: 2005
    ..abstract_text> ..