John Game

Summary

Affiliation: Lawrence Berkeley National Laboratory
Country: USA

Publications

  1. ncbi X-ray survival characteristics and genetic analysis for nine Saccharomyces deletion mutants that show altered radiation sensitivity
    John C Game
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Genetics 169:51-63. 2005
  2. ncbi The RAD6/BRE1 histone modification pathway in Saccharomyces confers radiation resistance through a RAD51-dependent process that is independent of RAD18
    John C Game
    Life Sciences Division, Lawrence Berkeley National Laboratory, CA 94720, USA
    Genetics 173:1951-68. 2006
  3. ncbi Excision of misincorporated ribonucleotides in DNA by RNase H (type 2) and FEN-1 in cell-free extracts
    Bjorn Rydberg
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:16654-9. 2002
  4. ncbi Use of a genome-wide approach to identify new genes that control resistance of Saccharomyces cerevisiae to ionizing radiation
    John C Game
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Radiat Res 160:14-24. 2003
  5. ncbi New genome-wide methods bring more power to yeast as a model organism
    John C Game
    Trends Pharmacol Sci 23:445-7. 2002

Research Grants

  1. Repair Pathways for Ionizing Radiation Damage Yeast
    John Game; Fiscal Year: 2006
  2. REPAIR PATHWAYS FOR IONIZING RADIATION DAMAGE IN YEAST
    John Game; Fiscal Year: 2002

Collaborators

Detail Information

Publications5

  1. ncbi X-ray survival characteristics and genetic analysis for nine Saccharomyces deletion mutants that show altered radiation sensitivity
    John C Game
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Genetics 169:51-63. 2005
    ..Struhl) in which this residue is replaced by other amino acids are also X-ray sensitive, which confirms that methylation of the lysine-79 residue is required for effective repair of radiation damage...
  2. ncbi The RAD6/BRE1 histone modification pathway in Saccharomyces confers radiation resistance through a RAD51-dependent process that is independent of RAD18
    John C Game
    Life Sciences Division, Lawrence Berkeley National Laboratory, CA 94720, USA
    Genetics 173:1951-68. 2006
    ..We conclude that IR resistance conferred by BRE1 and DOT1 is mediated through homologous recombinational repair, not postreplication repair, and confirm findings of a G1 checkpoint role for the RAD6/BRE1/DOT1 pathway...
  3. ncbi Excision of misincorporated ribonucleotides in DNA by RNase H (type 2) and FEN-1 in cell-free extracts
    Bjorn Rydberg
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:16654-9. 2002
    ....
  4. ncbi Use of a genome-wide approach to identify new genes that control resistance of Saccharomyces cerevisiae to ionizing radiation
    John C Game
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Radiat Res 160:14-24. 2003
    ..Our results emphasize that secondary mutations or deviations from euploidy can be a problem in screening this resource for sensitivity to ionizing radiation...
  5. ncbi New genome-wide methods bring more power to yeast as a model organism
    John C Game
    Trends Pharmacol Sci 23:445-7. 2002
    ..This significantly increases the power of yeast as a model system for studying human cellular responses to these agents, and for identifying human genes that are important in DNA repair and cancer...

Research Grants6

  1. Repair Pathways for Ionizing Radiation Damage Yeast
    John Game; Fiscal Year: 2006
    ..Recent and existing mutants will be studied in detail with this system to determine the molecular involvement of each gene in DSB repair, sister chromatid exchange and recombination between chromosomes. ..
  2. REPAIR PATHWAYS FOR IONIZING RADIATION DAMAGE IN YEAST
    John Game; Fiscal Year: 2002
    ..In a related aim, the order of gene function for RAD5O and RAD54 will be tested using different switching regimes with double mutants containing conditional alleles with differing permissive conditions. ..