JAMES FELTON

Summary

Affiliation: Lawrence Livermore National Laboratory
Country: USA

Publications

  1. ncbi request reprint Human exposure to heterocyclic amine food mutagens/carcinogens: relevance to breast cancer
    James S Felton
    Molecular and Structural Biology Division, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
    Environ Mol Mutagen 39:112-8. 2002
  2. ncbi request reprint Mutagenic potency of food-derived heterocyclic amines
    James S Felton
    Chemistry, Materials and Life Sciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94551, USA
    Mutat Res 616:90-4. 2007
  3. ncbi request reprint A meat and potato war: implications for cancer etiology
    James S Felton
    Biosciences Directorate, Lawrence Livermore National Laboratory Livermore, CA 94551, USA
    Carcinogenesis 27:2367-70. 2006
  4. ncbi request reprint What do diet-induced changes in phase I and II enzymes tell us about prevention from exposure to heterocyclic amines?
    James S Felton
    Lawrence Livermore National Laboratory, Livermore, CA 94551, USA
    J Nutr 136:2683S-4S. 2006
  5. ncbi request reprint The impact of glucuronidation on the bioactivation and DNA adduction of the cooked-food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in vivo
    Michael A Malfatti
    Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA
    Carcinogenesis 26:2019-28. 2005
  6. ncbi request reprint Mutagenic activity and heterocyclic amine carcinogens in commercial pet foods
    Mark G Knize
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Mutat Res 539:195-201. 2003
  7. ncbi request reprint Formation and human risk of carcinogenic heterocyclic amines formed from natural precursors in meat
    Mark G Knize
    Biosciences Directorate, University of California, Lawrence Livermore National Laboratory 7000 East Avenue, Livermore, CA 94550, USA
    Nutr Rev 63:158-65. 2005
  8. ncbi request reprint The effect of UDP-glucuronosyltransferase 1A1 expression on the mutagenicity and metabolism of the cooked-food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in CHO cells
    Michael A Malfatti
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, P O Box 808, L 452, Livermore, CA 94551 9900, USA
    Mutat Res 570:205-14. 2005
  9. ncbi request reprint Human UDP-glucuronosyltransferase 1A1 is the primary enzyme responsible for the N-glucuronidation of N-hydroxy-PhIP in vitro
    Michael A Malfatti
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, P O Box 808, L 452, Livermore, California 94551, USA
    Chem Res Toxicol 17:1137-44. 2004
  10. ncbi request reprint Development and characterization of CHO repair-proficient cell lines for comparative mutagenicity and metabolism of heterocyclic amines from cooked food
    Rebekah W Wu
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, Livermore, CA 94551, USA
    Environ Mol Mutagen 41:7-13. 2003

Research Grants

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Human exposure to heterocyclic amine food mutagens/carcinogens: relevance to breast cancer
    James S Felton
    Molecular and Structural Biology Division, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
    Environ Mol Mutagen 39:112-8. 2002
    ..This work is suited to investigate individual exposure and risk, especially for breast cancer, from these potent dietary mutagens...
  2. ncbi request reprint Mutagenic potency of food-derived heterocyclic amines
    James S Felton
    Chemistry, Materials and Life Sciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94551, USA
    Mutat Res 616:90-4. 2007
    ..The other factor of 20 is not clearly understood but is downstream from the oxidation step. The application of QSAR (chemical characteristics) to biological principles related to mutagenesis is explored in this report...
  3. ncbi request reprint A meat and potato war: implications for cancer etiology
    James S Felton
    Biosciences Directorate, Lawrence Livermore National Laboratory Livermore, CA 94551, USA
    Carcinogenesis 27:2367-70. 2006
    ..What conclusion about risks from these dietary carcinogens can we make from the available scientific data?..
  4. ncbi request reprint What do diet-induced changes in phase I and II enzymes tell us about prevention from exposure to heterocyclic amines?
    James S Felton
    Lawrence Livermore National Laboratory, Livermore, CA 94551, USA
    J Nutr 136:2683S-4S. 2006
  5. ncbi request reprint The impact of glucuronidation on the bioactivation and DNA adduction of the cooked-food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in vivo
    Michael A Malfatti
    Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA
    Carcinogenesis 26:2019-28. 2005
    ..Tissues with reduced UGT1A activity can have a higher rate of PhIP activation and be more inclined to form DNA adducts compared with tissues with normal UGT1A activity...
  6. ncbi request reprint Mutagenic activity and heterocyclic amine carcinogens in commercial pet foods
    Mark G Knize
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Mutat Res 539:195-201. 2003
    ..From these findings it is hypothesized that there is a connection between dietary heterocyclic amines and cancer in animals consuming these foods...
  7. ncbi request reprint Formation and human risk of carcinogenic heterocyclic amines formed from natural precursors in meat
    Mark G Knize
    Biosciences Directorate, University of California, Lawrence Livermore National Laboratory 7000 East Avenue, Livermore, CA 94550, USA
    Nutr Rev 63:158-65. 2005
    ..Human cancer epidemiology studies related to the consumption of well-done meat products are listed and compared in this review...
  8. ncbi request reprint The effect of UDP-glucuronosyltransferase 1A1 expression on the mutagenicity and metabolism of the cooked-food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in CHO cells
    Michael A Malfatti
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, P O Box 808, L 452, Livermore, CA 94551 9900, USA
    Mutat Res 570:205-14. 2005
    ..These results clearly indicate that UGT1A1 plays a critical role in PhIP biotransformation, providing protection against PhIP-mediated cytotoxicity and mutagenicity...
  9. ncbi request reprint Human UDP-glucuronosyltransferase 1A1 is the primary enzyme responsible for the N-glucuronidation of N-hydroxy-PhIP in vitro
    Michael A Malfatti
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, P O Box 808, L 452, Livermore, California 94551, USA
    Chem Res Toxicol 17:1137-44. 2004
    ..This change will increase the susceptibility to the deleterious effects from PhIP exposure because the capacity to form nontoxic N-hydroxy-PhIP glucuronide conjugates will be diminished...
  10. ncbi request reprint Development and characterization of CHO repair-proficient cell lines for comparative mutagenicity and metabolism of heterocyclic amines from cooked food
    Rebekah W Wu
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, Livermore, CA 94551, USA
    Environ Mol Mutagen 41:7-13. 2003
    ....
  11. ncbi request reprint Impact of environmental exposures on the mutagenicity/carcinogenicity of heterocyclic amines
    James S Felton
    Biology and Biotechnology Research Program, L 452, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA
    Toxicology 198:135-45. 2004
    ..Numerous environmental chemicals found in food or the atmosphere can impact the exposure, metabolism, and cell proliferation response of heterocyclic amines...
  12. ncbi request reprint An in vitro model system to predict the bioaccessibility of heterocyclic amines from a cooked meat matrix
    Kristen S Kulp
    Biology and Biotechnology Research Program, PO Box 808, Lawrence Livermore National Laboratory, Livermore, CA 94551 9900, USA
    Food Chem Toxicol 41:1701-10. 2003
    ..These results may have important ramifications for human feeding studies, which assume that the total amount of each HA in the meat matrix is equally bioavailable...
  13. ncbi request reprint Chemical and biological differentiation of three human breast cancer cell types using time-of-flight secondary ion mass spectrometry
    Kristen S Kulp
    Biosciences Directorate and Chemistry and Material Sciences Directorate, P O Box 808, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
    Anal Chem 78:3651-8. 2006
    ..Ultimately, we anticipate characterizing rare chemical changes that may provide clues to single cell progression within carcinogenic and metastatic pathways...
  14. ncbi request reprint Factors affecting human heterocyclic amine intake and the metabolism of PhIP
    Mark G Knize
    Biology and Biotechnology Research Program, PO Box 808, Lawrence Livermore National Laboratory, Livermore, CA 94551 9900, USA
    Mutat Res 506:153-62. 2002
    ..This newly developed methodology will allow us to assess prevention strategies that reduce the possible risks associated with PhIP exposure...
  15. ncbi request reprint The urinary metabolite profile of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is predictive of colon DNA adducts after a low-dose exposure in humans
    Michael A Malfatti
    Lawrence Livermore National Laboratory, Livermore, California 94550, USA
    Cancer Res 66:10541-7. 2006
    ..Although it is difficult to make definite conclusions from a small data set, the results from this pilot study have encouraged further investigations using a much larger study group...
  16. ncbi request reprint PhIP carcinogenicity in breast cancer: computational and experimental evidence for competitive interactions with human estrogen receptor
    Brian J Bennion
    Biosciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, California 94551, USA
    Chem Res Toxicol 18:1528-36. 2005
    ..We propose that the mechanism for the tissue-specific carcinogenicity seen in the rat breast tumors and the presumptive human breast cancer associated with the consumption of well-done meat maybe mediated by this receptor activation...
  17. ncbi request reprint Insights into the o-acetylation reaction of hydroxylated heterocyclic amines by human arylamine N-acetyltransferases: a computational study
    Edmond Y Lau
    Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, California 94550, USA
    Chem Res Toxicol 19:1182-90. 2006
    ..Additionally, the quantum mechanical calculations show that the observed differences in mutagenic activity between N-OH MeIQx and N-OH PhIP are not related to their acetylation reaction with NAT...
  18. doi request reprint Preparation of single cells for imaging/profiling mass spectrometry
    Elena S F Berman
    Chemistry, Materials, Earth, and Life Sciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94550, USA
    J Am Soc Mass Spectrom 19:1230-6. 2008
    ..This preparation technique makes possible routine imaging/profiling MS analysis of individual cultured cells, allowing for understanding of molecular processes within individual cells...
  19. ncbi request reprint Highlights of the eighth international conference on carcinogenic/mutagenic N-substituted aryl compounds
    Elizabeth G Snyderwine
    Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD 20892 4258, USA
    Mutat Res 506:1-8. 2002
    ....
  20. pmc A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach
    Chi Chen
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Chem Res Toxicol 20:531-42. 2007
    ....
  21. pmc Identification of 2-amino-1,7-dimethylimidazo[4,5-g]quinoxaline: an abundant mutagenic heterocyclic aromatic amine formed in cooked beef
    Robert J Turesky
    Division of Environmental Disease Prevention, Wadsworth Center, New York State Department of Health, Albany, New York 12201, USA
    Chem Res Toxicol 20:520-30. 2007
    ..This newly discovered 7-MeIgQx molecule is one of the most abundant HAAs formed in cooked ground beef patties and pan-fried scrapings. The human health risk of 7-MeIgQx requires investigation...
  22. pmc Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
    Xiaochao Ma
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 3106, Bethesda, MD 20892, USA
    Carcinogenesis 28:732-7. 2007
    ..Because of the high inducibility of human CYP1A1, especially in cigarette smokers, the role of lung CYP1A1 in PhIP carcinogenesis should be considered. (237 words)...
  23. ncbi request reprint Environmental and chemical carcinogenesis
    Gerald N Wogan
    Biological Engineering Division, Massachusetts Institute of Technology, Room 26 009, Cambridge, MA 02139, USA
    Semin Cancer Biol 14:473-86. 2004
    ..These mutations presumably arise via DNA damage by environmental or endogenous agents, but it remains to be determined whether the acquisition of a mutator phenotype is a necessary event during tumor progression...

Research Grants5

  1. Quantifying the impact of diet on carcinogen exposure
    JAMES FELTON; Fiscal Year: 2003
    ..Once the impact of dietary factors is understood, then it will be possible to emphasize prevention strategies that will eliminate or modify the risk. ..
  2. DETERMINANTS OF DIETARY RISK OF HETEROCYCLIC AMINES
    JAMES FELTON; Fiscal Year: 2004
    ..abstract not provided ..
  3. CARCINOGENIC SIGNIFICANCE OF HETERCYCLIC AMINES
    JAMES FELTON; Fiscal Year: 2006
    ..All of these efforts should result in a much better understanding of the risk these carcinogenic compounds play in human cancer. Six Projects and four Cores are presented to accomplish these tasks...