Research Topics
Genomes and Genes | Jimmie E FataSummaryAffiliation: Lawrence Berkeley National Laboratory Country: USA Publications
| Collaborators
|
Detail Information
Publications
Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymesJimmie E Fata
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
Breast Cancer Res 6:1-11. 2004..How these morphogenic pathways are integrated in the normal gland and how they become dysregulated and subverted in the progression of breast cancer also remain largely unanswered questions...
Functional BMP receptor in endocardial cells is required in atrioventricular cushion mesenchymal cell formation in chickHiroto Okagawa
Department of Cell Biology and Anatomy and Cardiovascular Developmental Biology Center, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA
Dev Biol 306:179-92. 2007..These results provide evidence that BMP signaling through the AV endocardium is required for the EMT and the activation of the BMP receptor in the endocardium can promote AV EMT in the chick...- The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epitheliumJimmie E Fata
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Dev Biol 306:193-207. 2007..Our findings indicate that expression of morphogenetic effectors, proliferation, and cell-type decisions during mammary organoid morphogenesis are intimately dependent on the duration of activation of MAPK(ERK1,2) activation... - Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instabilityDerek C Radisky
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Nature 436:123-7. 2005..These findings identify a previously undescribed pathway in which a component of the breast tumour microenvironment alters cellular structure in culture and tissue structure in vivo, leading to malignant transformation... - Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cellsMarcia V Fournier
Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Cancer Res 69:4545-52. 2009..This interaction thus seems to be a critical integrator of proliferative and morphogenetic signaling in breast epithelial cells... - Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2Hong Liu
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 103:4134-9. 2006.... - Epimorphin overexpression in the mouse mammary gland promotes alveolar hyperplasia and mammary adenocarcinomaJamie L Bascom
Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Cancer Res 65:8617-21. 2005..This study reveals another pathway in which overexpression and alteration of a normal morphogenic process promote the development of cancer in the mammary gland... - Metalloproteinase axes increase beta-catenin signaling in primary mouse mammary epithelial cells lacking TIMP3Carlo V Hojilla
Ontario Cancer Institute, 610 University Avenue Toronto, Ontario M5G2M9, Canada
J Cell Sci 120:1050-60. 2007..Recombinant TIMP1, TIMP3 and TIMP4 inhibited ductal elongation whereas TIMP2 promoted this process... - Insulin-like growth factor-II regulates PTEN expression in the mammary glandRoger A Moorehead
Ontario Cancer Institute University Health Network, University of Toronto, Toronto, Ontario M5G 2M9, Canada
J Biol Chem 278:50422-7. 2003..Thus, we have identified a novel negative feedback loop within the PI3K pathway where IGF-II induces PTEN expression to modulate its physiologic effects... - Circulating hormones and estrous stage predict cellular and stromal remodeling in murine uterusGeoffrey A Wood
Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
Reproduction 133:1035-44. 2007....