Jimmie E Fata

Summary

Affiliation: Lawrence Berkeley National Laboratory
Country: USA

Publications

  1. pmc Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes
    Jimmie E Fata
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Breast Cancer Res 6:1-11. 2004
  2. pmc The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium
    Jimmie E Fata
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Dev Biol 306:193-207. 2007
  3. pmc Functional BMP receptor in endocardial cells is required in atrioventricular cushion mesenchymal cell formation in chick
    Hiroto Okagawa
    Department of Cell Biology and Anatomy and Cardiovascular Developmental Biology Center, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA
    Dev Biol 306:179-92. 2007
  4. pmc Epimorphin is a novel regulator of the progesterone receptor isoform-a
    Jamie L Bascom
    Authors Affiliations Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California Mayo Clinic Cancer Center, Jacksonville, Florida College of Staten Island, City University of New York, Staten Island, New York and Department of Bioscience, Kwansei Gakuin University, Sanda, Japan
    Cancer Res 73:5719-29. 2013
  5. pmc Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
    Derek C Radisky
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nature 436:123-7. 2005
  6. pmc Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2
    Hong Liu
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 103:4134-9. 2006
  7. pmc Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cells
    Marcia V Fournier
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Cancer Res 69:4545-52. 2009
  8. ncbi request reprint Epimorphin overexpression in the mouse mammary gland promotes alveolar hyperplasia and mammary adenocarcinoma
    Jamie L Bascom
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cancer Res 65:8617-21. 2005
  9. ncbi request reprint Metalloproteinase axes increase beta-catenin signaling in primary mouse mammary epithelial cells lacking TIMP3
    Carlo V Hojilla
    Ontario Cancer Institute, 610 University Avenue Toronto, Ontario M5G2M9, Canada
    J Cell Sci 120:1050-60. 2007
  10. ncbi request reprint Insulin-like growth factor-II regulates PTEN expression in the mammary gland
    Roger A Moorehead
    Ontario Cancer Institute University Health Network, University of Toronto, Toronto, Ontario M5G 2M9, Canada
    J Biol Chem 278:50422-7. 2003

Collaborators

Detail Information

Publications11

  1. pmc Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes
    Jimmie E Fata
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Breast Cancer Res 6:1-11. 2004
    ..How these morphogenic pathways are integrated in the normal gland and how they become dysregulated and subverted in the progression of breast cancer also remain largely unanswered questions...
  2. pmc The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium
    Jimmie E Fata
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Dev Biol 306:193-207. 2007
    ..Our findings indicate that expression of morphogenetic effectors, proliferation, and cell-type decisions during mammary organoid morphogenesis are intimately dependent on the duration of activation of MAPK(ERK1,2) activation...
  3. pmc Functional BMP receptor in endocardial cells is required in atrioventricular cushion mesenchymal cell formation in chick
    Hiroto Okagawa
    Department of Cell Biology and Anatomy and Cardiovascular Developmental Biology Center, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA
    Dev Biol 306:179-92. 2007
    ..These results provide evidence that BMP signaling through the AV endocardium is required for the EMT and the activation of the BMP receptor in the endocardium can promote AV EMT in the chick...
  4. pmc Epimorphin is a novel regulator of the progesterone receptor isoform-a
    Jamie L Bascom
    Authors Affiliations Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California Mayo Clinic Cancer Center, Jacksonville, Florida College of Staten Island, City University of New York, Staten Island, New York and Department of Bioscience, Kwansei Gakuin University, Sanda, Japan
    Cancer Res 73:5719-29. 2013
    ..These findings elucidate a hitherto unknown transcriptional regulator of Pgr-a, and shed light on how overexpression of Epim leads to malignancy...
  5. pmc Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
    Derek C Radisky
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nature 436:123-7. 2005
    ..These findings identify a previously undescribed pathway in which a component of the breast tumour microenvironment alters cellular structure in culture and tissue structure in vivo, leading to malignant transformation...
  6. pmc Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2
    Hong Liu
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 103:4134-9. 2006
    ....
  7. pmc Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cells
    Marcia V Fournier
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Cancer Res 69:4545-52. 2009
    ..This interaction thus seems to be a critical integrator of proliferative and morphogenetic signaling in breast epithelial cells...
  8. ncbi request reprint Epimorphin overexpression in the mouse mammary gland promotes alveolar hyperplasia and mammary adenocarcinoma
    Jamie L Bascom
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cancer Res 65:8617-21. 2005
    ..This study reveals another pathway in which overexpression and alteration of a normal morphogenic process promote the development of cancer in the mammary gland...
  9. ncbi request reprint Metalloproteinase axes increase beta-catenin signaling in primary mouse mammary epithelial cells lacking TIMP3
    Carlo V Hojilla
    Ontario Cancer Institute, 610 University Avenue Toronto, Ontario M5G2M9, Canada
    J Cell Sci 120:1050-60. 2007
    ..Recombinant TIMP1, TIMP3 and TIMP4 inhibited ductal elongation whereas TIMP2 promoted this process...
  10. ncbi request reprint Insulin-like growth factor-II regulates PTEN expression in the mammary gland
    Roger A Moorehead
    Ontario Cancer Institute University Health Network, University of Toronto, Toronto, Ontario M5G 2M9, Canada
    J Biol Chem 278:50422-7. 2003
    ..Thus, we have identified a novel negative feedback loop within the PI3K pathway where IGF-II induces PTEN expression to modulate its physiologic effects...
  11. ncbi request reprint Circulating hormones and estrous stage predict cellular and stromal remodeling in murine uterus
    Geoffrey A Wood
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
    Reproduction 133:1035-44. 2007
    ....