Research Topics
| Jamie EberlingSummaryAffiliation: Lawrence Berkeley National Laboratory Country: USA Publications
Research Grants
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Detail Information
Publications
Preliminary evidence that estrogen protects against age-related hippocampal atrophyJ L Eberling
Department of Neurology and Center for Neuroscience, University of California, Davis, CA 95616, USA
Neurobiol Aging 24:725-32. 2003..These findings suggest a neuroprotective effect of estrogen...
Results from a phase I safety trial of hAADC gene therapy for Parkinson diseaseJ L Eberling
Department of Molecular Imaging and Neuroscience, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Neurology 70:1980-3. 2008..These studies led to the initiation of a phase I safety trial. Here we report the findings for the first cohort of five patients...- Dopamine transporter loss and clinical changes in MPTP-lesioned primatesJ L Eberling
Center for Functional Imaging, 55 121, Lawrence Berkeley National Laboratory, University of California, 1 Cyclotron Road, Berkeley, CA 94720, USA
Brain Res 832:184-7. 1999.... - Comparison of two methods for the analysis of [18F]6-fluoro-L-m-tyrosine PET dataJamie L Eberling
Center for Functional Imaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Neuroimage 23:358-63. 2004..These findings suggest that a simple ratio approach to analyzing FMT PET data may be a useful alternative to a kinetic approach especially for clinical applications... - Estrogen- and tamoxifen-associated effects on brain structure and functionJamie L Eberling
Department of Neurology and Center for Neuroscience, University of California, Davis, CA 95616, USA
Neuroimage 21:364-71. 2004..The ERT- group had hippocampal volumes that were intermediate to the other two groups. These findings provide physiological and anatomical evidence for neuroprotective effects of estrogen... - No effect of age and estrogen on aromatic L- amino acid decarboxylase activity in rhesus monkey brainJamie L Eberling
Department of Neurology, Center for Neuroscience, University of California, Davis, CA 94618, USA
Neurobiol Aging 23:479-83. 2002..In addition, FMT uptake did not differ from a group of young adult female monkeys at either time point. These findings may represent a compensatory up-regulation of aromatic L- amino acid decarboxylase (AADC) activity... - Oestrogen has neuroprotective effects and may reduce the risk of Alzheimer's diseaseJamie L Eberling
Center for Neuroscience, University of California, Davis, 1544 Newton Court, Davis, CA 95616, USA
Expert Opin Biol Ther 2:647-57. 2002..The role of oestrogen for the prevention or treatment of AD is not yet clear, but large, well-controlled, ongoing trials should provide definitive answers to many questions in the near future... - The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeysJamie L Eberling
Department of Neurology and Center for Neuroscience, University of California, Davis, 95616, USA
Exp Neurol 178:236-42. 2002..These findings show that GPI-1046 does not have regenerative effects in MPTP-treated primates and suggest that there may be species differences with respect to the trophic effects of GPI-1046 on nigrostriatal DA neurons... 
Safety and tolerability of putaminal AADC gene therapy for Parkinson diseaseC W Christine
Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Neurology 73:1662-9. 2009..These data prompted a clinical trial...- Clinical studies of cerebral blood flow in Alzheimer's diseaseW J Jagust
Center for Functional Imaging, Lawrence Berkeley Laboratory, University of California, Berkeley 94720, USA
Ann N Y Acad Sci 826:254-62. 1997..Taken together, these results show that while perfusion changes are important in AD, they are not clearly either primary or limiting... - Effect of estrogen on cerebral glucose metabolism in postmenopausal womenJ L Eberling
Center for Functional Imaging Lawrence Berkeley Laboratory, University of California, Berkeley, CA, USA
Neurology 55:875-7. 2000..The ERT- group showed metabolic ratios that were intermediate to the ERT+ and AD groups, although they did not show any signs of cognitive impairment. These findings show an effect of estrogen depletion on brain metabolic activity... - Tremor is associated with PET measures of nigrostriatal dopamine function in MPTP-lesioned monkeysJ L Eberling
Center for Functional Imaging, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mail Stop 55 121, Berkeley, California 94720, USA
Exp Neurol 165:342-6. 2000..In addition, K(i) values were significantly correlated with DA levels in both caudate and putamen. These findings support the idea that nigrostriatal degeneration contributes to rest tremor... - Brain structure and cognition in a community sample of elderly LatinosC C Wu
Department of Neurology, University of California-Davis Medical Center, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
Neurology 59:383-91. 2002..Because there is a synergistic effect between high WMH and hippocampal atrophy, interactions between vascular and degenerative processes may be important determinants of dementia... - Effects of subcortical cerebral infarction on cortical glucose metabolism and cognitive functionL T Kwan
Center for Functional Imaging, Lawrence Berkeley National Laboratory, Berkeley, Calif, USA
Arch Neurol 56:809-14. 1999..Taken together, both global and regional effects on cortical function mediate the production of clinical symptoms in patients with subcortical strokes... - Brain function and cognition in a community sample of elderly LatinosWilliam J Jagust
Department of Neurology, University of California Davis Medical Center, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
Neurology 59:378-83. 2002..This study was designed to extend this finding to individuals selected from a population-based cohort of Mexican Americans with a wide spectrum of cognitive ability... - A methodology for specifying PET VOI's using multimodality techniquesG J Klein
Center for Functional Imaging, Lawrence Berkeley National Laboratory, University of California, Berkeley 94720, USA
IEEE Trans Med Imaging 16:405-15. 1997..Quantification by this method allows calculation of radionuclide activity in the VOI's, as well as their statistical uncertainties and correlations. The methodology for this type of analysis and validation results are presented... - Enhanced cutaneous vascular response in AD subjects under donepezil therapyJonathan S Maltz
Department of Nuclear Medicine and Functional Imaging, Ernest O Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Neurobiol Aging 25:475-81. 2004..We sought to replicate these observations and further identify peripheral vascular components of AD pathology... - Overlesioned hemiparkinsonian non human primate model: correlation between clinical, neurochemical and histochemical changesYoshitsugu Oiwa
Center for Functional Imaging, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA, USA
Front Biosci 8:a155-66. 2003..Here we describe an animal model that can play an important role in understanding the symptoms and therapeutic basis of PD since different severities of parkinsonian symptoms can be mimicked... - Effects of white matter lesions and lacunes on cortical functionBruce R Reed
University of California Davis Alzheimer s Disease Center, Martinez, CA 94553, USA
Arch Neurol 61:1545-50. 2004..Whether small-vessel disease in fact predominantly affects the frontal lobes is not well documented... - Focal striatal dopamine may potentiate dyskinesias in parkinsonian monkeysKrystof S Bankiewicz
Department of Neurological Surgery, University of California San Francisco, Mission Center Building 0555, 1855 Folsom Street, Room 230, 94103, USA
Exp Neurol 197:363-72. 2006..This may be similar to focal dopaminergic activity in PD patients that developed off-drug or "runaway" dyskinesias following fetal mesencephalic grafts... - A dose-ranging study of AAV-hAADC therapy in Parkinsonian monkeysJohn R Forsayeth
Department of Neurosurgery, University of California at San Francisco, Room MCB 226, 1855 Folsom Street, San Francisco, CA 94103-0555, USA
Mol Ther 14:571-7. 2006..These findings have implications for the design and interpretation of clinical studies of AAV-hAADC gene therapy... - Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADCKrystof S Bankiewicz
Department of Neurosurgery, University of California at San Francisco, Room MCB 226, 1855 Folsom Street, San Francisco, CA 94103 0555, USA
Mol Ther 14:564-70. 2006..Introduction of this therapy into the clinic holds promise for Parkinson patients experiencing the motor complications that result from escalating l-Dopa requirements against a background of disease progression... - Correlates of memory function in community-dwelling elderly: the importance of white matter hyperintensitiesChristopher I Petkov
Center for Neuroscience, University of California at Davis, 95616, USA
J Int Neuropsychol Soc 10:371-81. 2004..We conclude that WMH are an important pathological substrate that affects certain memory functions in normal individuals and those with mild memory loss and discuss how tasks associated with WMH may rely upon frontal lobe function... - Imaging Interactions between Alzheimer's disease and cerebrovascular diseaseChristine C Wu
Department of Neurology, University of California-Davis, 4860 Y Street, Sacramento, CA 95616, USA
Ann N Y Acad Sci 977:403-10. 2002..In this article, we review two recent studies from our laboratory that use MRI and PET to begin to reveal the nature and mechanisms of the relationship between AD, CVD, and dementia...
Research Grants
- Effects of Chemotherapy on Brain FunctionJamie Eberling; Fiscal Year: 2007..They are also relevant to the overall mission of the NIH because of the negative impact that cognitive dysfunction has on quality of life. ..