Jamie Eberling

Summary

Affiliation: Lawrence Berkeley National Laboratory
Country: USA

Publications

  1. ncbi request reprint Comparison of two methods for the analysis of [18F]6-fluoro-L-m-tyrosine PET data
    Jamie L Eberling
    Center for Functional Imaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Neuroimage 23:358-63. 2004
  2. ncbi request reprint Preliminary evidence that estrogen protects against age-related hippocampal atrophy
    J L Eberling
    Department of Neurology and Center for Neuroscience, University of California, Davis, CA 95616, USA
    Neurobiol Aging 24:725-32. 2003
  3. doi request reprint Results from a phase I safety trial of hAADC gene therapy for Parkinson disease
    J L Eberling
    Department of Molecular Imaging and Neuroscience, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Neurology 70:1980-3. 2008
  4. ncbi request reprint Dopamine transporter loss and clinical changes in MPTP-lesioned primates
    J L Eberling
    Center for Functional Imaging, 55 121, Lawrence Berkeley National Laboratory, University of California, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Brain Res 832:184-7. 1999
  5. ncbi request reprint Estrogen- and tamoxifen-associated effects on brain structure and function
    Jamie L Eberling
    Department of Neurology and Center for Neuroscience, University of California, Davis, CA 95616, USA
    Neuroimage 21:364-71. 2004
  6. ncbi request reprint No effect of age and estrogen on aromatic L- amino acid decarboxylase activity in rhesus monkey brain
    Jamie L Eberling
    Department of Neurology, Center for Neuroscience, University of California, Davis, CA 94618, USA
    Neurobiol Aging 23:479-83. 2002
  7. ncbi request reprint Oestrogen has neuroprotective effects and may reduce the risk of Alzheimer's disease
    Jamie L Eberling
    Center for Neuroscience, University of California, Davis, 1544 Newton Court, Davis, CA 95616, USA
    Expert Opin Biol Ther 2:647-57. 2002
  8. ncbi request reprint The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys
    Jamie L Eberling
    Department of Neurology and Center for Neuroscience, University of California, Davis, 95616, USA
    Exp Neurol 178:236-42. 2002
  9. pmc Safety and tolerability of putaminal AADC gene therapy for Parkinson disease
    C W Christine
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Neurology 73:1662-9. 2009
  10. ncbi request reprint Clinical studies of cerebral blood flow in Alzheimer's disease
    W J Jagust
    Center for Functional Imaging, Lawrence Berkeley Laboratory, University of California, Berkeley 94720, USA
    Ann N Y Acad Sci 826:254-62. 1997

Research Grants

  1. Effects of Chemotherapy on Brain Function
    Jamie Eberling; Fiscal Year: 2007

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Comparison of two methods for the analysis of [18F]6-fluoro-L-m-tyrosine PET data
    Jamie L Eberling
    Center for Functional Imaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Neuroimage 23:358-63. 2004
    ..These findings suggest that a simple ratio approach to analyzing FMT PET data may be a useful alternative to a kinetic approach especially for clinical applications...
  2. ncbi request reprint Preliminary evidence that estrogen protects against age-related hippocampal atrophy
    J L Eberling
    Department of Neurology and Center for Neuroscience, University of California, Davis, CA 95616, USA
    Neurobiol Aging 24:725-32. 2003
    ..These findings suggest a neuroprotective effect of estrogen...
  3. doi request reprint Results from a phase I safety trial of hAADC gene therapy for Parkinson disease
    J L Eberling
    Department of Molecular Imaging and Neuroscience, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Neurology 70:1980-3. 2008
    ..These studies led to the initiation of a phase I safety trial. Here we report the findings for the first cohort of five patients...
  4. ncbi request reprint Dopamine transporter loss and clinical changes in MPTP-lesioned primates
    J L Eberling
    Center for Functional Imaging, 55 121, Lawrence Berkeley National Laboratory, University of California, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Brain Res 832:184-7. 1999
    ....
  5. ncbi request reprint Estrogen- and tamoxifen-associated effects on brain structure and function
    Jamie L Eberling
    Department of Neurology and Center for Neuroscience, University of California, Davis, CA 95616, USA
    Neuroimage 21:364-71. 2004
    ..The ERT- group had hippocampal volumes that were intermediate to the other two groups. These findings provide physiological and anatomical evidence for neuroprotective effects of estrogen...
  6. ncbi request reprint No effect of age and estrogen on aromatic L- amino acid decarboxylase activity in rhesus monkey brain
    Jamie L Eberling
    Department of Neurology, Center for Neuroscience, University of California, Davis, CA 94618, USA
    Neurobiol Aging 23:479-83. 2002
    ..In addition, FMT uptake did not differ from a group of young adult female monkeys at either time point. These findings may represent a compensatory up-regulation of aromatic L- amino acid decarboxylase (AADC) activity...
  7. ncbi request reprint Oestrogen has neuroprotective effects and may reduce the risk of Alzheimer's disease
    Jamie L Eberling
    Center for Neuroscience, University of California, Davis, 1544 Newton Court, Davis, CA 95616, USA
    Expert Opin Biol Ther 2:647-57. 2002
    ..The role of oestrogen for the prevention or treatment of AD is not yet clear, but large, well-controlled, ongoing trials should provide definitive answers to many questions in the near future...
  8. ncbi request reprint The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys
    Jamie L Eberling
    Department of Neurology and Center for Neuroscience, University of California, Davis, 95616, USA
    Exp Neurol 178:236-42. 2002
    ..These findings show that GPI-1046 does not have regenerative effects in MPTP-treated primates and suggest that there may be species differences with respect to the trophic effects of GPI-1046 on nigrostriatal DA neurons...
  9. pmc Safety and tolerability of putaminal AADC gene therapy for Parkinson disease
    C W Christine
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Neurology 73:1662-9. 2009
    ..These data prompted a clinical trial...
  10. ncbi request reprint Clinical studies of cerebral blood flow in Alzheimer's disease
    W J Jagust
    Center for Functional Imaging, Lawrence Berkeley Laboratory, University of California, Berkeley 94720, USA
    Ann N Y Acad Sci 826:254-62. 1997
    ..Taken together, these results show that while perfusion changes are important in AD, they are not clearly either primary or limiting...
  11. ncbi request reprint Effect of estrogen on cerebral glucose metabolism in postmenopausal women
    J L Eberling
    Center for Functional Imaging Lawrence Berkeley Laboratory, University of California, Berkeley, CA, USA
    Neurology 55:875-7. 2000
    ..The ERT- group showed metabolic ratios that were intermediate to the ERT+ and AD groups, although they did not show any signs of cognitive impairment. These findings show an effect of estrogen depletion on brain metabolic activity...
  12. ncbi request reprint Tremor is associated with PET measures of nigrostriatal dopamine function in MPTP-lesioned monkeys
    J L Eberling
    Center for Functional Imaging, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mail Stop 55 121, Berkeley, California 94720, USA
    Exp Neurol 165:342-6. 2000
    ..In addition, K(i) values were significantly correlated with DA levels in both caudate and putamen. These findings support the idea that nigrostriatal degeneration contributes to rest tremor...
  13. ncbi request reprint Brain structure and cognition in a community sample of elderly Latinos
    C C Wu
    Department of Neurology, University of California Davis Medical Center, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
    Neurology 59:383-91. 2002
    ..The authors measured these variables in a population-based cohort of older Mexican Americans with a wide spectrum of cognitive ability, ranging from normal cognition to dementia...
  14. pmc Effects of subcortical cerebral infarction on cortical glucose metabolism and cognitive function
    L T Kwan
    Center for Functional Imaging, Lawrence Berkeley National Laboratory, Berkeley, Calif, USA
    Arch Neurol 56:809-14. 1999
    ..Taken together, both global and regional effects on cortical function mediate the production of clinical symptoms in patients with subcortical strokes...
  15. ncbi request reprint Brain function and cognition in a community sample of elderly Latinos
    William J Jagust
    Department of Neurology, University of California Davis Medical Center, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
    Neurology 59:378-83. 2002
    ..This study was designed to extend this finding to individuals selected from a population-based cohort of Mexican Americans with a wide spectrum of cognitive ability...
  16. ncbi request reprint A methodology for specifying PET VOI's using multimodality techniques
    G J Klein
    Center for Functional Imaging, Lawrence Berkeley National Laboratory, University of California, Berkeley 94720, USA
    IEEE Trans Med Imaging 16:405-15. 1997
    ..Quantification by this method allows calculation of radionuclide activity in the VOI's, as well as their statistical uncertainties and correlations. The methodology for this type of analysis and validation results are presented...
  17. ncbi request reprint Enhanced cutaneous vascular response in AD subjects under donepezil therapy
    Jonathan S Maltz
    Department of Nuclear Medicine and Functional Imaging, Ernest O Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Neurobiol Aging 25:475-81. 2004
    ..We sought to replicate these observations and further identify peripheral vascular components of AD pathology...
  18. ncbi request reprint Overlesioned hemiparkinsonian non human primate model: correlation between clinical, neurochemical and histochemical changes
    Yoshitsugu Oiwa
    Center for Functional Imaging, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA, USA
    Front Biosci 8:a155-66. 2003
    ..Here we describe an animal model that can play an important role in understanding the symptoms and therapeutic basis of PD since different severities of parkinsonian symptoms can be mimicked...
  19. ncbi request reprint Effects of white matter lesions and lacunes on cortical function
    Bruce R Reed
    University of California Davis Alzheimer s Disease Center, Martinez, CA 94553, USA
    Arch Neurol 61:1545-50. 2004
    ..Whether small-vessel disease in fact predominantly affects the frontal lobes is not well documented...
  20. pmc Focal striatal dopamine may potentiate dyskinesias in parkinsonian monkeys
    Krystof S Bankiewicz
    Department of Neurological Surgery, University of California San Francisco, Mission Center Building 0555, 1855 Folsom Street, Room 230, 94103, USA
    Exp Neurol 197:363-72. 2006
    ..This may be similar to focal dopaminergic activity in PD patients that developed off-drug or "runaway" dyskinesias following fetal mesencephalic grafts...
  21. pmc A dose-ranging study of AAV-hAADC therapy in Parkinsonian monkeys
    John R Forsayeth
    Department of Neurosurgery, University of California at San Francisco, Room MCB 226, 1855 Folsom Street, San Francisco, CA 94103-0555, USA
    Mol Ther 14:571-7. 2006
    ..These findings have implications for the design and interpretation of clinical studies of AAV-hAADC gene therapy...
  22. ncbi request reprint Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC
    Krystof S Bankiewicz
    Department of Neurosurgery, University of California at San Francisco, Room MCB 226, 1855 Folsom Street, San Francisco, CA 94103 0555, USA
    Mol Ther 14:564-70. 2006
    ..Introduction of this therapy into the clinic holds promise for Parkinson patients experiencing the motor complications that result from escalating l-Dopa requirements against a background of disease progression...
  23. ncbi request reprint Correlates of memory function in community-dwelling elderly: the importance of white matter hyperintensities
    Christopher I Petkov
    Center for Neuroscience, University of California at Davis, 95616, USA
    J Int Neuropsychol Soc 10:371-81. 2004
    ..We conclude that WMH are an important pathological substrate that affects certain memory functions in normal individuals and those with mild memory loss and discuss how tasks associated with WMH may rely upon frontal lobe function...
  24. ncbi request reprint Imaging Interactions between Alzheimer's disease and cerebrovascular disease
    Christine C Wu
    Department of Neurology, University of California Davis, 4860 Y Street, Sacramento, CA 95616, USA
    Ann N Y Acad Sci 977:403-10. 2002
    ..In this article, we review two recent studies from our laboratory that use MRI and PET to begin to reveal the nature and mechanisms of the relationship between AD, CVD, and dementia...

Research Grants3

  1. Effects of Chemotherapy on Brain Function
    Jamie Eberling; Fiscal Year: 2007
    ..They are also relevant to the overall mission of the NIH because of the negative impact that cognitive dysfunction has on quality of life. ..