S V Costes

Summary

Affiliation: Lawrence Berkeley National Laboratory
Country: USA

Publications

  1. ncbi request reprint Intensity-based signal separation algorithm for accurate quantification of clustered centrosomes in tissue sections
    Markus C Fleisch
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Microsc Res Tech 69:964-72. 2006
  2. doi request reprint Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization
    S V Costes
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Mutat Res 704:78-87. 2010
  3. pmc Rapid and automated multidimensional fluorescence microscopy profiling of 3D human breast cultures
    Catherine C Park
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Integr Biol (Camb) 5:681-91. 2013
  4. pmc Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies
    Rituparna Mukhopadhyay
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Breast Cancer Res 12:R11. 2010
  5. pmc Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains
    Sylvain V Costes
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS Comput Biol 3:e155. 2007
  6. pmc Automatic and quantitative measurement of protein-protein colocalization in live cells
    Sylvain V Costes
    Image Analysis Laboratory, National Cancer Institute, Frederick, Maryland, USA
    Biophys J 86:3993-4003. 2004
  7. ncbi request reprint A systems biology approach to multicellular and multi-generational radiation responses
    Mary Helen Barcellos-Hoff
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Building 74 355, Berkeley, CA 94705, USA
    Mutat Res 597:32-8. 2006
  8. ncbi request reprint Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts
    Sylvain V Costes
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Radiat Res 165:505-15. 2006
  9. doi request reprint Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling
    Jonathan Tang
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Integr Biol (Camb) 3:408-21. 2011
  10. doi request reprint Targeted and nontargeted effects of ionizing radiation that impact genomic instability
    Christopher A Maxwell
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cancer Res 68:8304-11. 2008

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Intensity-based signal separation algorithm for accurate quantification of clustered centrosomes in tissue sections
    Markus C Fleisch
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Microsc Res Tech 69:964-72. 2006
    ..This was done by taking into account baseline centrosome amplification and proliferation rates measured in the tissue. Using this technique, the authors showed that 20-30% of cells have amplified centrosomes in Tp53 null mammary tumors...
  2. doi request reprint Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization
    S V Costes
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Mutat Res 704:78-87. 2010
    ..Thus, heritable persistent RIF spanning over tens of Mbp may reflect persistent changes in the transcriptome of a large progeny of cells. Such model opens the door to a "non-DNA-centric view" of radiation-induced phenotypes...
  3. pmc Rapid and automated multidimensional fluorescence microscopy profiling of 3D human breast cultures
    Catherine C Park
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Integr Biol (Camb) 5:681-91. 2013
    ..Such tools have therefore the potential to further characterize cell culture populations after cancer treatment and identify novel phenotypes of resistance...
  4. pmc Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies
    Rituparna Mukhopadhyay
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Breast Cancer Res 12:R11. 2010
    ..We investigated whether ionizing radiation, which increases breast cancer risk in women, affects the rate of vHMEC outgrowth...
  5. pmc Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains
    Sylvain V Costes
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS Comput Biol 3:e155. 2007
    ..These data suggest that DNA damage-induced foci are restricted to certain regions of the nucleus of human epithelial cells. It is possible that DNA lesions are collected in these nuclear sub-domains for more efficient repair...
  6. pmc Automatic and quantitative measurement of protein-protein colocalization in live cells
    Sylvain V Costes
    Image Analysis Laboratory, National Cancer Institute, Frederick, Maryland, USA
    Biophys J 86:3993-4003. 2004
    ..25 x 10(-3) s(-1). More generally, this algorithm can be used to answer a variety of biological questions involving protein-protein interactions or co-compartmentalization and can be generalized to colocalization of more than two colors...
  7. ncbi request reprint A systems biology approach to multicellular and multi-generational radiation responses
    Mary Helen Barcellos-Hoff
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Building 74 355, Berkeley, CA 94705, USA
    Mutat Res 597:32-8. 2006
    ....
  8. ncbi request reprint Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts
    Sylvain V Costes
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Radiat Res 165:505-15. 2006
    ..Thus, even though double-strand breaks and radiation-induced foci are correlated, the dynamic nature of both contradicts their accepted equivalence for low doses of different radiation qualities...
  9. doi request reprint Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling
    Jonathan Tang
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Integr Biol (Camb) 3:408-21. 2011
    ..Our simulations suggest that overexpression of AKT-1 must also perturb cell-cell and cell-ECM communication, reminding us that extracellular context can dictate cellular behavior...
  10. doi request reprint Targeted and nontargeted effects of ionizing radiation that impact genomic instability
    Christopher A Maxwell
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cancer Res 68:8304-11. 2008
    ..Together, these studies show that radiation deregulates centrosome stability, which underlies genomic instability in normal human epithelial cells, and that this can be opposed by radiation-induced TGFbeta signaling...
  11. ncbi request reprint Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition
    Kumari L Andarawewa
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Cancer Res 67:8662-70. 2007
    ..Together, these data show that the interactions between radiation-induced signaling pathways elicit heritable phenotypes that could contribute to neoplastic progression...
  12. ncbi request reprint In vivo HIV-1 Rev multimerization in the nucleolus and cytoplasm identified by fluorescence resonance energy transfer
    Dirk Daelemans
    Human Retrovirus Section, Basic Research Laboratory and Image Analysis Laboratory, Science Application International Corporation, NCI Frederick, Frederick, Maryland 21702 1201, USA
    J Biol Chem 279:50167-75. 2004
    ..Our results show that Rev multimerizes in the nucleolus of living cells, suggesting an important role of the nucleolus in nucleocytoplasmic transport...
  13. pmc Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton
    Dalit Barkan
    Laboratory of Cell Biology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 68:6241-50. 2008
    ..Targeting this process may provide therapeutic strategies for inhibition of the dormant-to-proliferative metastatic switch...
  14. ncbi request reprint Human CD8+ T cells store RANTES in a unique secretory compartment and release it rapidly after TcR stimulation
    Marta Catalfamo
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 20:219-30. 2004
    ..These results show that CD8+ T cells have two distinct TcR-regulated secretory compartments characterized by different mobilization kinetics, effector molecules, and biological function...
  15. pmc Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo
    Dirk Daelemans
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium
    Mol Cell Biol 25:728-39. 2005
    ..CRM1 is able to bind Rev cargo in the nucleolus, and upon RanGTP binding a functional export complex is produced that is exported to the cytoplasm...