Research Topics
| S V CostesSummaryAffiliation: Lawrence Berkeley National Laboratory Country: USA Publications
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Detail Information
Publications
Intensity-based signal separation algorithm for accurate quantification of clustered centrosomes in tissue sectionsMarkus C Fleisch
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Microsc Res Tech 69:964-72. 2006..This was done by taking into account baseline centrosome amplification and proliferation rates measured in the tissue. Using this technique, the authors showed that 20-30% of cells have amplified centrosomes in Tp53 null mammary tumors...
Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organizationS V Costes
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Mutat Res 704:78-87. 2010..Thus, heritable persistent RIF spanning over tens of Mbp may reflect persistent changes in the transcriptome of a large progeny of cells. Such model opens the door to a "non-DNA-centric view" of radiation-induced phenotypes...
Rapid and automated multidimensional fluorescence microscopy profiling of 3D human breast culturesCatherine C Park
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Integr Biol (Camb) 5:681-91. 2013..Such tools have therefore the potential to further characterize cell culture populations after cancer treatment and identify novel phenotypes of resistance...- Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studiesRituparna Mukhopadhyay
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Breast Cancer Res 12:R11. 2010..We investigated whether ionizing radiation, which increases breast cancer risk in women, affects the rate of vHMEC outgrowth... - Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domainsSylvain V Costes
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
PLoS Comput Biol 3:e155. 2007..These data suggest that DNA damage-induced foci are restricted to certain regions of the nucleus of human epithelial cells. It is possible that DNA lesions are collected in these nuclear sub-domains for more efficient repair... - Automatic and quantitative measurement of protein-protein colocalization in live cellsSylvain V Costes
Image Analysis Laboratory, National Cancer Institute, Frederick, Maryland, USA
Biophys J 86:3993-4003. 2004..25 x 10(-3) s(-1). More generally, this algorithm can be used to answer a variety of biological questions involving protein-protein interactions or co-compartmentalization and can be generalized to colocalization of more than two colors... - A systems biology approach to multicellular and multi-generational radiation responsesMary Helen Barcellos-Hoff
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Building 74 355, Berkeley, CA 94705, USA
Mutat Res 597:32-8. 2006.... - Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblastsSylvain V Costes
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Radiat Res 165:505-15. 2006..Thus, even though double-strand breaks and radiation-induced foci are correlated, the dynamic nature of both contradicts their accepted equivalence for low doses of different radiation qualities... - Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modelingJonathan Tang
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Integr Biol (Camb) 3:408-21. 2011..Our simulations suggest that overexpression of AKT-1 must also perturb cell-cell and cell-ECM communication, reminding us that extracellular context can dictate cellular behavior... - Targeted and nontargeted effects of ionizing radiation that impact genomic instabilityChristopher A Maxwell
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Cancer Res 68:8304-11. 2008..Together, these studies show that radiation deregulates centrosome stability, which underlies genomic instability in normal human epithelial cells, and that this can be opposed by radiation-induced TGFbeta signaling... - Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transitionKumari L Andarawewa
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
Cancer Res 67:8662-70. 2007..Together, these data show that the interactions between radiation-induced signaling pathways elicit heritable phenotypes that could contribute to neoplastic progression... - In vivo HIV-1 Rev multimerization in the nucleolus and cytoplasm identified by fluorescence resonance energy transferDirk Daelemans
Human Retrovirus Section, Basic Research Laboratory and Image Analysis Laboratory, Science Application International Corporation, NCI-Frederick, Frederick, Maryland 21702-1201, USA
J Biol Chem 279:50167-75. 2004..Our results show that Rev multimerizes in the nucleolus of living cells, suggesting an important role of the nucleolus in nucleocytoplasmic transport... - Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeletonDalit Barkan
Laboratory of Cell Biology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Cancer Res 68:6241-50. 2008..Targeting this process may provide therapeutic strategies for inhibition of the dormant-to-proliferative metastatic switch... - Human CD8+ T cells store RANTES in a unique secretory compartment and release it rapidly after TcR stimulationMarta Catalfamo
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 20:219-30. 2004..These results show that CD8+ T cells have two distinct TcR-regulated secretory compartments characterized by different mobilization kinetics, effector molecules, and biological function... - Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivoDirk Daelemans
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium
Mol Cell Biol 25:728-39. 2005..CRM1 is able to bind Rev cargo in the nucleolus, and upon RanGTP binding a functional export complex is produced that is exported to the cytoplasm...