PRISCILLA COOPER

Summary

Affiliation: Lawrence Berkeley National Laboratory
Country: USA

Publications

  1. pmc DNA repair: dynamic defenders against cancer and aging
    JILL O FUSS
    Department of Molecular Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    PLoS Biol 4:e203. 2006
  2. ncbi request reprint DNA double-strand break and chromosomal rejoining defects with misrejoining in Nijmegen breakage syndrome cells
    Janice M Pluth
    Lawrence Berkeley National Laboratory, Life Sciences Division, One Cyclotron Road, Berkeley, CA 94720, United States
    DNA Repair (Amst) 7:108-18. 2008
  3. ncbi request reprint Dose-dependent misrejoining of radiation-induced DNA double-strand breaks in human fibroblasts: experimental and theoretical study for high- and low-LET radiation
    Bjorn Rydberg
    Lawrence Berkeley National Laboratory, Life Sciences Division, Berkeley, California 94720, USA berydberg lbl gov
    Radiat Res 163:526-34. 2005
  4. ncbi request reprint Spatial distribution and yield of DNA double-strand breaks induced by 3-7 MeV helium ions in human fibroblasts
    Bjorn Rydberg
    Lawrence Berkeley National Laboratory, Life Sciences Division, Department of Radiation Biology and DNA Repair, Berkeley, California 94720, USA
    Radiat Res 158:32-42. 2002
  5. ncbi request reprint Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair
    Li Fan
    Life Sciences Division, Department of Molecular Biology, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Mol Cell 22:27-37. 2006
  6. ncbi request reprint Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome
    Altaf H Sarker
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mail Stop 74R157, Berkeley, California 94720, USA
    Mol Cell 20:187-98. 2005
  7. ncbi request reprint Comparative TFIIS-mediated transcript cleavage by mammalian RNA polymerase II arrested at a lesion in different transcription systems
    Virginia S Kalogeraki
    Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 94305 5020, USA
    DNA Repair (Amst) 4:1075-87. 2005
  8. ncbi request reprint Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression
    Junhua Wang
    Life Sciences Division, Department of Molecular Biology, Lawrence Berkeley National Laboratory, Mail Stop 74 157, 1 Cyclotron Road, Berkeley, CA 94720, USA
    DNA Repair (Amst) 4:556-70. 2005
  9. pmc The single-strand DNA binding activity of human PC4 prevents mutagenesis and killing by oxidative DNA damage
    Jen Yeu Wang
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655
    Mol Cell Biol 24:6084-93. 2004
  10. ncbi request reprint Transcription-coupled repair of 8-oxoguanine in human cells
    Florence Le Page
    Division of Life Sciences, CEA, 92265 Fontenay aux Roses, France
    Methods Enzymol 353:536-47. 2002

Research Grants

Collaborators

Detail Information

Publications11

  1. pmc DNA repair: dynamic defenders against cancer and aging
    JILL O FUSS
    Department of Molecular Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    PLoS Biol 4:e203. 2006
  2. ncbi request reprint DNA double-strand break and chromosomal rejoining defects with misrejoining in Nijmegen breakage syndrome cells
    Janice M Pluth
    Lawrence Berkeley National Laboratory, Life Sciences Division, One Cyclotron Road, Berkeley, CA 94720, United States
    DNA Repair (Amst) 7:108-18. 2008
    ..This work provides both molecular and cytological evidence that NBS1-deficient cells have defects in DSB processing and reveals that these molecular events can be manifest cytologically...
  3. ncbi request reprint Dose-dependent misrejoining of radiation-induced DNA double-strand breaks in human fibroblasts: experimental and theoretical study for high- and low-LET radiation
    Bjorn Rydberg
    Lawrence Berkeley National Laboratory, Life Sciences Division, Berkeley, California 94720, USA berydberg lbl gov
    Radiat Res 163:526-34. 2005
    ..Radiat. Res. 158, 568-580, 2002). The discrepancy may indicate inadequacies in the chromosome model, for example insufficient chromosomal overlap, but may also be partly due to differences between fibroblasts and lymphocytes...
  4. ncbi request reprint Spatial distribution and yield of DNA double-strand breaks induced by 3-7 MeV helium ions in human fibroblasts
    Bjorn Rydberg
    Lawrence Berkeley National Laboratory, Life Sciences Division, Department of Radiation Biology and DNA Repair, Berkeley, California 94720, USA
    Radiat Res 158:32-42. 2002
    ..When the calculation is performed to include fragments larger than 0.1 kbp (to correspond to the experimental measurements), there is good agreement between experiment and theory...
  5. ncbi request reprint Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair
    Li Fan
    Life Sciences Division, Department of Molecular Biology, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Mol Cell 22:27-37. 2006
    ..Together, these results provide an unexpected mechanism of DNA unwinding with implications for XPB damage verification in nucleotide excision repair...
  6. ncbi request reprint Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome
    Altaf H Sarker
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mail Stop 74R157, Berkeley, California 94720, USA
    Mol Cell 20:187-98. 2005
    ..Together, these results implicate coordinated recognition of stalled transcription by XPG and CSB in TCR initiation and suggest that TFIIH-dependent remodeling of stalled RNAPII without release may be sufficient to allow repair...
  7. ncbi request reprint Comparative TFIIS-mediated transcript cleavage by mammalian RNA polymerase II arrested at a lesion in different transcription systems
    Virginia S Kalogeraki
    Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 94305 5020, USA
    DNA Repair (Amst) 4:1075-87. 2005
    ..Our results suggest that the extent of TFIIS-mediated transcript cleavage is a well-orchestrated process, depending upon other factors (or their effects on RNAPII), in addition to TFIIS itself...
  8. ncbi request reprint Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression
    Junhua Wang
    Life Sciences Division, Department of Molecular Biology, Lawrence Berkeley National Laboratory, Mail Stop 74 157, 1 Cyclotron Road, Berkeley, CA 94720, USA
    DNA Repair (Amst) 4:556-70. 2005
    ....
  9. pmc The single-strand DNA binding activity of human PC4 prevents mutagenesis and killing by oxidative DNA damage
    Jen Yeu Wang
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655
    Mol Cell Biol 24:6084-93. 2004
    ..We discuss the possible requirement for PC4 in either global or transcription-coupled repair of oxidative DNA damage to mediate the release of XPG bound to its substrate...
  10. ncbi request reprint Transcription-coupled repair of 8-oxoguanine in human cells
    Florence Le Page
    Division of Life Sciences, CEA, 92265 Fontenay aux Roses, France
    Methods Enzymol 353:536-47. 2002
  11. pmc XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations
    Li Fan
    Department of Molecular Biology, Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell 133:789-800. 2008
    ..These results provide a foundation for understanding disease consequences of mutations in XPD and related 4Fe-4S helicases including FancJ...

Research Grants23

  1. DOUBLE STRAND BREAK MISREJOINING IN MAMMALIAM CELLS
    PRISCILLA COOPER; Fiscal Year: 2003
    ..abstract_text> ..
  2. MECHANISMS FOR REPAIR OF RADIATION DAMAGE IN HUMAN CELLS
    PRISCILLA COOPER; Fiscal Year: 2005
    ..These studies will advance our understanding of how cells cope with cellular oxidative damage to DNA. ..
  3. GORDON RESEARCH CONFERENCE ON MAMMALIAN DNA REPAIR
    PRISCILLA COOPER; Fiscal Year: 2007
    ..Primary consideration for admittance will be given to those individuals who are expected to contribute actively to discussion and presentation of unpublished results. ..
  4. Mechanisms for Transcription-Coupled Repair in Human Cells
    PRISCILLA COOPER; Fiscal Year: 2009
    ..These studies address key mechanisms for maintaining genomic integrity and function in the face of cellular and environmental oxidative DNA damage ..
  5. Mechanisms for Transcription-Coupled Repair in Human Cells
    Priscilla K Cooper; Fiscal Year: 2010
    ..These studies address key mechanisms for maintaining genomic integrity and function in the face of cellular and environmental oxidative DNA damage ..
  6. MECHANISMS FOR REPAIR OF RADIATION DAMAGE IN HUMAN CELLS
    PRISCILLA COOPER; Fiscal Year: 2000
    ....
  7. Mechanisms for Transcription-Coupled Repair in Human Cells
    PRISCILLA COOPER; Fiscal Year: 2007
    ..These studies address key mechanisms for maintaining genomic integrity and function in the face of cellular and environmental oxidative DNA damage. ..