Affiliation: Lawrence Berkeley National Laboratory
- DNA repair: dynamic defenders against cancer and agingJILL O FUSS
Department of Molecular Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
PLoS Biol 4:e203. 2006
- DNA double-strand break and chromosomal rejoining defects with misrejoining in Nijmegen breakage syndrome cellsJanice M Pluth
Lawrence Berkeley National Laboratory, Life Sciences Division, One Cyclotron Road, Berkeley, CA 94720, United States
DNA Repair (Amst) 7:108-18. 2008..This work provides both molecular and cytological evidence that NBS1-deficient cells have defects in DSB processing and reveals that these molecular events can be manifest cytologically...
- Dose-dependent misrejoining of radiation-induced DNA double-strand breaks in human fibroblasts: experimental and theoretical study for high- and low-LET radiationBjorn Rydberg
Lawrence Berkeley National Laboratory, Life Sciences Division, Berkeley, California 94720, USA berydberg lbl gov
Radiat Res 163:526-34. 2005..Radiat. Res. 158, 568-580, 2002). The discrepancy may indicate inadequacies in the chromosome model, for example insufficient chromosomal overlap, but may also be partly due to differences between fibroblasts and lymphocytes...
- Spatial distribution and yield of DNA double-strand breaks induced by 3-7 MeV helium ions in human fibroblastsBjorn Rydberg
Lawrence Berkeley National Laboratory, Life Sciences Division, Department of Radiation Biology and DNA Repair, Berkeley, California 94720, USA
Radiat Res 158:32-42. 2002..When the calculation is performed to include fragments larger than 0.1 kbp (to correspond to the experimental measurements), there is good agreement between experiment and theory...
- Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repairLi Fan
Life Sciences Division, Department of Molecular Biology, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Mol Cell 22:27-37. 2006..Together, these results provide an unexpected mechanism of DNA unwinding with implications for XPB damage verification in nucleotide excision repair...
- Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne SyndromeAltaf H Sarker
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mail Stop 74R157, Berkeley, California 94720, USA
Mol Cell 20:187-98. 2005..Together, these results implicate coordinated recognition of stalled transcription by XPG and CSB in TCR initiation and suggest that TFIIH-dependent remodeling of stalled RNAPII without release may be sufficient to allow repair...
- Comparative TFIIS-mediated transcript cleavage by mammalian RNA polymerase II arrested at a lesion in different transcription systemsVirginia S Kalogeraki
Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 94305 5020, USA
DNA Repair (Amst) 4:1075-87. 2005..Our results suggest that the extent of TFIIS-mediated transcript cleavage is a well-orchestrated process, depending upon other factors (or their effects on RNAPII), in addition to TFIIS itself...
- Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progressionJunhua Wang
Life Sciences Division, Department of Molecular Biology, Lawrence Berkeley National Laboratory, Mail Stop 74 157, 1 Cyclotron Road, Berkeley, CA 94720, USA
DNA Repair (Amst) 4:556-70. 2005....
- The single-strand DNA binding activity of human PC4 prevents mutagenesis and killing by oxidative DNA damageJen Yeu Wang
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655
Mol Cell Biol 24:6084-93. 2004..We discuss the possible requirement for PC4 in either global or transcription-coupled repair of oxidative DNA damage to mediate the release of XPG bound to its substrate...
- Transcription-coupled repair of 8-oxoguanine in human cellsFlorence Le Page
Division of Life Sciences, CEA, 92265 Fontenay aux Roses, France
Methods Enzymol 353:536-47. 2002
- XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutationsLi Fan
Department of Molecular Biology, Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Cell 133:789-800. 2008..These results provide a foundation for understanding disease consequences of mutations in XPD and related 4Fe-4S helicases including FancJ...