JOEL CHASIS

Summary

Affiliation: Lawrence Berkeley National Laboratory
Country: USA

Publications

  1. ncbi request reprint Erythroblastic islands: specialized microenvironmental niches for erythropoiesis
    Joel Anne Chasis
    Life Sciences Division, University of California, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Curr Opin Hematol 13:137-41. 2006
  2. pmc Erythroblastic islands: niches for erythropoiesis
    Joel Anne Chasis
    Life Sciences Division, University of California, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Blood 112:470-8. 2008
  3. ncbi request reprint Novel secreted isoform of adhesion molecule ICAM-4: potential regulator of membrane-associated ICAM-4 interactions
    Gloria Lee
    Life Sciences Division, University of California, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Blood 101:1790-7. 2003
  4. ncbi request reprint Two distinct domains of protein 4.1 critical for assembly of functional nuclei in vitro
    Sharon Wald Krauss
    Department of Subcellular Structure, Life Sciences Division, University of California, Lawrence Berkeley National Laboratory, 94720, USA
    J Biol Chem 277:44339-46. 2002
  5. ncbi request reprint Two protein 4.1 domains essential for mitotic spindle and aster microtubule dynamics and organization in vitro
    Sharon Wald Krauss
    Lawrence Berkeley National Laboratory, Life Sciences Division, University of California, Berkeley 94720, USA
    J Biol Chem 279:27591-8. 2004
  6. pmc Nuclear substructure reorganization during late-stage erythropoiesis is selective and does not involve caspase cleavage of major nuclear substructural proteins
    Sharon Wald Krauss
    Life Sciences Division, University of California Lawrence Berkeley National Laboratory, Bldg 74, 1 Cyclotron Rd, Berkeley, CA 94720, USA
    Blood 106:2200-5. 2005
  7. pmc Targeted gene deletion demonstrates that the cell adhesion molecule ICAM-4 is critical for erythroblastic island formation
    Gloria Lee
    Life Sciences Division, University of California, Lawrence Berkeley National Laboratory, Bldg 74, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Blood 108:2064-71. 2006
  8. ncbi request reprint Peptides based on alphaV-binding domains of erythrocyte ICAM-4 inhibit sickle red cell-endothelial interactions and vaso-occlusion in the microcirculation
    Dhananjay K Kaul
    Dept of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Cell Physiol 291:C922-30. 2006
  9. pmc Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane
    Marcela Salomao
    Red Cell Physiology Laboratory and Membrane Biochemistry Laboratory, New York Blood Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 105:8026-31. 2008
  10. pmc The Laminin 511/521-binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3
    Tosti J Mankelow
    Bristol Institute for Transfusion Sciences, National Blood Service, Southmead Road, Bristol, United Kingdom
    Blood 110:3398-406. 2007

Research Grants

  1. NOVEL FUNCTIONS OF RED CELL PROTEINS LU AND LW
    Joel A Chasis; Fiscal Year: 2010
  2. NOVEL FUNCTIONS OF RED CELL PROTEINS LU AND LW
    JOEL CHASIS; Fiscal Year: 2009
  3. NOVEL FUNCTIONS OF RED CELL PROTEINS LU AND LW
    JOEL CHASIS; Fiscal Year: 2007
  4. NOVEL FUNCTIONS OF RED CELL PROTEINS LU AND LW
    JOEL CHASIS; Fiscal Year: 2003
  5. GORDON CONFERENCE ON THE RED CELL
    JOEL CHASIS; Fiscal Year: 2003

Detail Information

Publications10

  1. ncbi request reprint Erythroblastic islands: specialized microenvironmental niches for erythropoiesis
    Joel Anne Chasis
    Life Sciences Division, University of California, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Curr Opin Hematol 13:137-41. 2006
    ..This review focuses on current understanding of molecular mechanisms operating within erythroblastic islands including cell-cell adhesion, regulatory feedback, and central macrophage function...
  2. pmc Erythroblastic islands: niches for erythropoiesis
    Joel Anne Chasis
    Life Sciences Division, University of California, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Blood 112:470-8. 2008
    ..Coupling of historical, current, and future insights will be essential to understand the tightly regulated production of red cells both in steady state and stress erythropoiesis...
  3. ncbi request reprint Novel secreted isoform of adhesion molecule ICAM-4: potential regulator of membrane-associated ICAM-4 interactions
    Gloria Lee
    Life Sciences Division, University of California, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Blood 101:1790-7. 2003
    ..We postulate that secretion of this newly described isoform, ICAM-4S, may modulate binding of membrane-associated ICAM-4 and could thus play a critical regulatory role in erythroblast molecular attachments...
  4. ncbi request reprint Two distinct domains of protein 4.1 critical for assembly of functional nuclei in vitro
    Sharon Wald Krauss
    Department of Subcellular Structure, Life Sciences Division, University of California, Lawrence Berkeley National Laboratory, 94720, USA
    J Biol Chem 277:44339-46. 2002
    ..1R. Our data establish that protein 4.1 is essential for nuclear assembly and identify two distinct 4.1 domains, initially characterized in cytoskeletal interactions, that have crucial and versatile functions in nuclear assembly...
  5. ncbi request reprint Two protein 4.1 domains essential for mitotic spindle and aster microtubule dynamics and organization in vitro
    Sharon Wald Krauss
    Lawrence Berkeley National Laboratory, Life Sciences Division, University of California, Berkeley 94720, USA
    J Biol Chem 279:27591-8. 2004
    ..These investigations underscore an important functional context for protein 4.1 in microtubule morphogenesis and highlight a previously unappreciated role for 4.1 in cell division...
  6. pmc Nuclear substructure reorganization during late-stage erythropoiesis is selective and does not involve caspase cleavage of major nuclear substructural proteins
    Sharon Wald Krauss
    Life Sciences Division, University of California Lawrence Berkeley National Laboratory, Bldg 74, 1 Cyclotron Rd, Berkeley, CA 94720, USA
    Blood 106:2200-5. 2005
    ..These findings imply that nuclear condensation and extrusion during terminal erythroid differentiation involve novel mechanisms that do not entail major activation of apoptotic machinery...
  7. pmc Targeted gene deletion demonstrates that the cell adhesion molecule ICAM-4 is critical for erythroblastic island formation
    Gloria Lee
    Life Sciences Division, University of California, Lawrence Berkeley National Laboratory, Bldg 74, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Blood 108:2064-71. 2006
    ....
  8. ncbi request reprint Peptides based on alphaV-binding domains of erythrocyte ICAM-4 inhibit sickle red cell-endothelial interactions and vaso-occlusion in the microcirculation
    Dhananjay K Kaul
    Dept of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Cell Physiol 291:C922-30. 2006
    ..Thus peptides or small molecule mimetics of ICAM-4 may have therapeutic potential...
  9. pmc Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane
    Marcela Salomao
    Red Cell Physiology Laboratory and Membrane Biochemistry Laboratory, New York Blood Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 105:8026-31. 2008
    ....
  10. pmc The Laminin 511/521-binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3
    Tosti J Mankelow
    Bristol Institute for Transfusion Sciences, National Blood Service, Southmead Road, Bristol, United Kingdom
    Blood 110:3398-406. 2007
    ..These studies imply that structural flexibility of Lutheran may be essential for its interaction with Laminin and present a novel opportunity for the development of therapeutics for sickle cell disease...

Research Grants10

  1. NOVEL FUNCTIONS OF RED CELL PROTEINS LU AND LW
    Joel A Chasis; Fiscal Year: 2010
    ..They are also relevant to diseases associated with bone marrow fibrosis and abnormal red blood cell production. ..
  2. NOVEL FUNCTIONS OF RED CELL PROTEINS LU AND LW
    JOEL CHASIS; Fiscal Year: 2009
    ..They are also relevant to diseases associated with bone marrow fibrosis and abnormal red blood cell production. ..
  3. NOVEL FUNCTIONS OF RED CELL PROTEINS LU AND LW
    JOEL CHASIS; Fiscal Year: 2007
    ..Successful accomplishment of these aims will further our goals of developing a mechanistic understanding of normal erythropoiesis and the pathophysiology of sickle cell disease which could lead to novel therapeutic modalities . ..
  4. NOVEL FUNCTIONS OF RED CELL PROTEINS LU AND LW
    JOEL CHASIS; Fiscal Year: 2003
    ....
  5. GORDON CONFERENCE ON THE RED CELL
    JOEL CHASIS; Fiscal Year: 2003
    ..approaches/interests combined with the richness of discussions of previous Red Cell Gordon Conferences has led to numerous productive collaborations and fostered new developments in these important areas of basic and clinical research ..