M J Bissell

Summary

Affiliation: Lawrence Berkeley National Laboratory
Country: USA

Publications

  1. pmc Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening
    Jordi Alcaraz
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977R225A, Berkeley, CA 94720, USA
    Integr Biol (Camb) 3:1153-66. 2011
  2. pmc Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia
    Jordi Alcaraz
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    EMBO J 27:2829-38. 2008
  3. pmc Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function
    Ren Xu
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Cell Biol 184:57-66. 2009
  4. pmc Epimorphin mediates mammary luminal morphogenesis through control of C/EBPbeta
    Y Hirai
    Life Science Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    J Cell Biol 153:785-94. 2001
  5. pmc Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells
    Hong Liu
    Life Science Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA 94720, USA
    J Cell Biol 164:603-12. 2004
  6. pmc NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals
    Sabine Becker-Weimann
    Life Sciences Division, Lawrence Berkeley National Laboratory1, Berkeley, CA
    Oncotarget 4:2010-20. 2013
  7. pmc Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer
    Rachel L Dusek
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Center for Clinical Sciences Research Room 1255, 269 Campus Drive, Stanford, CA 94305, USA
    Breast Cancer Res 14:R65. 2012
  8. pmc β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib
    Catherine Huang
    Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77054, USA
    Breast Cancer Res 13:R84. 2011
  9. pmc Myoepithelial cells: good fences make good neighbors
    Melissa C Adriance
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Breast Cancer Res 7:190-7. 2005
  10. pmc Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes
    Jimmie E Fata
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Breast Cancer Res 6:1-11. 2004

Research Grants

Detail Information

Publications119 found, 100 shown here

  1. pmc Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening
    Jordi Alcaraz
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977R225A, Berkeley, CA 94720, USA
    Integr Biol (Camb) 3:1153-66. 2011
    ....
  2. pmc Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia
    Jordi Alcaraz
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    EMBO J 27:2829-38. 2008
    ..Our data indicate that tissue-specific gene expression is controlled by both the tissues' unique biochemical milieu and mechanical properties, processes involved in maintenance of tissue integrity and protection against tumorigenesis...
  3. pmc Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function
    Ren Xu
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Cell Biol 184:57-66. 2009
    ..These results underscore the crucial role of continuous laminin signaling and polarized tissue architecture in maintenance of transcription factor activation, chromatin organization, and tissue-specific gene expression...
  4. pmc Epimorphin mediates mammary luminal morphogenesis through control of C/EBPbeta
    Y Hirai
    Life Science Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    J Cell Biol 153:785-94. 2001
    ..Together, our studies demonstrate a role for EPM in luminal morphogenesis through control of C/EBPbeta expression...
  5. pmc Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells
    Hong Liu
    Life Science Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA 94720, USA
    J Cell Biol 164:603-12. 2004
    ..These findings reveal key events of the PI3K pathway that play distinct roles to maintain tissue polarity and that when disrupted are instrumental in the malignant phenotype...
  6. pmc NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals
    Sabine Becker-Weimann
    Life Sciences Division, Lawrence Berkeley National Laboratory1, Berkeley, CA
    Oncotarget 4:2010-20. 2013
    ....
  7. pmc Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer
    Rachel L Dusek
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Center for Clinical Sciences Research Room 1255, 269 Campus Drive, Stanford, CA 94305, USA
    Breast Cancer Res 14:R65. 2012
    ..Given that p63 is essential for proper mammary gland development and that cell adhesion is fundamental for ensuring the proper architecture and function of the mammary epithelium, here we investigate Perp function in the mammary gland...
  8. pmc β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib
    Catherine Huang
    Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77054, USA
    Breast Cancer Res 13:R84. 2011
    ..The β1 integrin resides on the membrane of the breast cancer cell, activating several elements of breast tumor progression including proliferation and survival...
  9. pmc Myoepithelial cells: good fences make good neighbors
    Melissa C Adriance
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Breast Cancer Res 7:190-7. 2005
    ....
  10. pmc Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes
    Jimmie E Fata
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Breast Cancer Res 6:1-11. 2004
    ..How these morphogenic pathways are integrated in the normal gland and how they become dysregulated and subverted in the progression of breast cancer also remain largely unanswered questions...
  11. pmc Estrogen and progesterone receptors have distinct roles in the establishment of the hyperplastic phenotype in PR-A transgenic mice
    Marina Simian
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Breast Cancer Res 11:R72. 2009
    ..Our objective was to determine the roles of estrogen (E) and progesterone (P) in the genesis of mammary hyperplasias/preneoplasias in PR-A transgenics...
  12. pmc Evaluation of normalization methods for cDNA microarray data by k-NN classification
    Wei Wu
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    BMC Bioinformatics 6:191. 2005
    ..However, to date there have been few published systematic evaluations of these techniques for removing variations arising from dye biases in the context of downstream, higher-order analytical tasks such as classification...
  13. pmc Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
    Mina J Bissell
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Nat Med 17:320-9. 2011
    ..We also include a discussion of how this information is being tailored for clinical use...
  14. pmc Polarity determination in breast tissue: desmosomal adhesion, myoepithelial cells, and laminin 1
    Mina J Bissell
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Breast Cancer Res 5:117-9. 2003
    ..Two recent papers have shed some light onto this intriguing problem in mammary gland biology. The results point to desmosomes and laminin 1 as having crucial roles. However, some questions remain...
  15. pmc Tissue architecture: the ultimate regulator of breast epithelial function
    Mina J Bissell
    Department of Cell and Molecular Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Curr Opin Cell Biol 15:753-62. 2003
  16. pmc The organizing principle: microenvironmental influences in the normal and malignant breast
    Mina J Bissell
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Differentiation 70:537-46. 2002
    ..How this context determines functional integrity, and how its loss can lead to malignancy, appears to have much to do with tissue structure and polarity...
  17. pmc Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?
    Mina J Bissell
    Department Cancer Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Cancer Cell 7:17-23. 2005
  18. pmc Modelling molecular mechanisms of breast cancer and invasion: lessons from the normal gland
    M J Bissell
    Division of Life Sciences, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Biochem Soc Trans 35:18-22. 2007
    ....
  19. pmc Putting tumours in context
    M J Bissell
    Division of Life Sciences, Lawrence Berkeley National Laboratory, Berkeley, California 99720, USA
    Nat Rev Cancer 1:46-54. 2001
    ..Investigation of this process might provide new insights into the mechanisms of tumorigenesis and could also lead to new therapeutic targets...
  20. pmc Expression of autoactivated stromelysin-1 in mammary glands of transgenic mice leads to a reactive stroma during early development
    N Thomasset
    Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Am J Pathol 153:457-67. 1998
    ..This, together with increased transgene expression, led to basement membrane disruption starting by day 15 of pregnancy. We propose that the highly reactive stroma provides a prelude to breast epithelial tumors observed in these animals...
  21. pmc The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells
    M Simian
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley 94720, USA
    Development 128:3117-31. 2001
    ..These results provide direct evidence for a crucial role of MMPs in branching in mammary epithelium and suggest that, in addition to epimorphin, MMP activity is a minimum requirement for branching morphogenesis in the mammary gland...
  22. pmc A novel pathway for mammary epithelial cell invasion induced by the helix-loop-helix protein Id-1
    P Y Desprez
    Department of Cell and Molecular Biology, Life Sciences Division, Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Mol Cell Biol 18:4577-88. 1998
    ..This Id-1-regulated invasive phenotype could contribute to involution of the mammary gland and possibly to the development of invasive breast cancer...
  23. pmc Epimorphin functions as a key morphoregulator for mammary epithelial cells
    Y Hirai
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Cell Biol 140:159-69. 1998
    ..These results suggest that epimorphin is the primary morphogen in the mammary gland but that growth factors are necessary to achieve the appropriate cell numbers for the resulting morphogenesis to be visualized...
  24. pmc Trichostatin A inhibits beta-casein expression in mammary epithelial cells
    P Pujuguet
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Cell Biochem 83:660-70. 2001
    ..These results are discussed in combination with previous work showing that TSA mediates the differentiation of many types of cancer cells but inhibits differentiation of some nonmalignant cell types...
  25. pmc Division of labor among the alpha6beta4 integrin, beta1 integrins, and an E3 laminin receptor to signal morphogenesis and beta-casein expression in mammary epithelial cells
    J Muschler
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Mol Biol Cell 10:2817-28. 1999
    ..These results elucidate the multiplicity of cell-extracellular matrix interactions required to integrate cell structure and signaling and ultimately permit normal cell function...
  26. pmc The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis
    M D Sternlicht
    Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Cell 98:137-46. 1999
    ..The premalignant and malignant lesions have stereotyped genomic changes unlike those seen in other murine mammary cancer models. These data indicate that Str1 influences tumor initiation and alters neoplastic risk...
  27. pmc Extracellular matrix remodeling and the regulation of epithelial-stromal interactions during differentiation and involution
    Z Werb
    Laboratory of Radiobiology and Environmental Health, University of California, San Francisco, USA
    Kidney Int Suppl 54:S68-74. 1996
    ....
  28. pmc Extracellular matrix regulates whey acidic protein gene expression by suppression of TGF-alpha in mouse mammary epithelial cells: studies in culture and in transgenic mice
    C Q Lin
    Life Science Division, Lawrence Berkeley Laboratories, Berkeley, California 94720, USA
    J Cell Biol 129:1115-26. 1995
    ..These results provide a clear example of cooperation among lactogenic hormones, ECM, and locally acting growth factors in regulation of tissue-specific gene expression...
  29. pmc Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression
    C J Sympson
    Life Sciences Division, Lawrence Berkeley Laboratory, Berkeley, California 94720
    J Cell Biol 125:681-93. 1994
    ..We conclude that the balance of ECM-degrading enzymes with their inhibitors, and the associated regulation of ECM structure, is crucial for tissue-specific gene expression and morphogenesis in vivo...
  30. pmc Localization of 9E3/CEF-4 in avian tissues: expression is absent in Rous sarcoma virus-induced tumors but is stimulated by injury
    M Martins Green
    Cell and Molecular Biology Division, Lawrence Berkeley Laboratory, Berkeley, California 94720
    J Cell Biol 110:581-95. 1990
    ..Finally, expression in conjunction with high collagen levels and in wounded tissues may point to a role in wound response and/or repair, possibly via alteration of extracellular matrix...
  31. pmc Extracellular matrix, nuclear and chromatin structure, and gene expression in normal tissues and malignant tumors: a work in progress
    Virginia A Spencer
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Adv Cancer Res 97:275-94. 2007
    ..Here, we will discuss some key findings that may provide insights into mechanisms through which ECM could influence gene transcription and how tumor cells acquire the ability to overcome these levels of control...
  32. pmc Apical polarity in three-dimensional culture systems: where to now?
    Jamie L Inman
    Lawrence Berkeley National Laboratory, Division of Life Sciences, 1 Cyclotron Road, Berkeley, CA 94720, USA
    J Biol 9:2. 2010
    ....
  33. pmc Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: the role of extracellular matrix and its degrading enzymes
    M J Bissell
    Cancer Biology Department, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, 94720, USA
    Cold Spring Harb Symp Quant Biol 70:343-56. 2005
    ..These findings illustrate how normal tissue structure controls the response to extracellular signals so as to preserve tissue specificity and growth status...
  34. pmc The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter
    M D Sternlicht
    Department of Anatomy, University of California, 513 Parnassus Avenue, HSW 1301, San Francisco, California, CA 94143 0452, USA
    Oncogene 19:1102-13. 2000
    ..Thus by altering the cellular microenvironment, stromelysin-1 can act as a natural tumor promoter and enhance cancer susceptibility...
  35. ncbi request reprint Proliferation and polarity in breast cancer: untying the Gordian knot
    Hong Liu
    Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cell Cycle 4:646-9. 2005
    ....
  36. ncbi request reprint Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive properties
    A Lochter
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    J Biol Chem 272:5007-15. 1997
    ..Thus misregulation of stromelysin-1 expression appears to be an important aspect of mammary tumor cell progression to an invasive phenotype...
  37. pmc Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways
    L R Lund
    Laboratory of Radiobiology and Environmental Health, University of California, San Francisco 94143 0750, USA
    Development 122:181-93. 1996
    ....
  38. pmc Disruption of 3D tissue integrity facilitates adenovirus infection by deregulating the coxsackievirus and adenovirus receptor
    M Anders
    Cancer Research Institute, Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 100:1943-8. 2003
    ..Disruption of this organization by changes in the microenvironment, including malignant transformation, leads to up-regulation of CAR, thus enhancing the cell's susceptibility to adenovirus infection...
  39. ncbi request reprint Tumors are unique organs defined by abnormal signaling and context
    D Radisky
    Life Science Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Semin Cancer Biol 11:87-95. 2001
    ..We propose that anticancer research might be more effective if aimed at eradicating the cause of abnormality rather than just treating the end result...
  40. pmc Collagen-IV and laminin-1 regulate estrogen receptor alpha expression and function in mouse mammary epithelial cells
    Virginia Novaro
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Cell Sci 116:2975-86. 2003
    ....
  41. ncbi request reprint Homeostasis in the breast: it takes a village
    Aylin Rizki
    Lawrence Berkeley National Laboratory, Life Sciences Division, Department of Cancer Biology, One Cyclotron Road, Mail stop 83 101, Berkeley, California 94720, USA
    Cancer Cell 6:1-2. 2004
    ....
  42. ncbi request reprint Tenascin-C inhibits extracellular matrix-dependent gene expression in mammary epithelial cells. Localization of active regions using recombinant tenascin fragments
    P L Jones
    Life Sciences Division, Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA
    J Cell Sci 108:519-27. 1995
    ....
  43. pmc Functional culture models to study mechanisms governing apoptosis in normal and malignant mammary epithelial cells
    V M Weaver
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley 94720, USA
    J Mammary Gland Biol Neoplasia 4:193-201. 1999
    ..These models could now be used to investigate how the basement membrane represses apoptosis in normal cells, and how breast cancers become death-resistant...
  44. pmc Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation
    Celeste M Nelson
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977 225A, Berkeley, CA 94720, USA
    Semin Cancer Biol 15:342-52. 2005
    ..We propose the need for engineered tissues that faithfully recapitulate their native structures to allow a greater understanding of tissue function, dysfunction, and potential therapeutic intervention...
  45. pmc Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures
    Celeste M Nelson
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Science 314:298-300. 2006
    ..These results reveal that tissue geometry can control organ morphogenesis by defining the local cellular microenvironment, a finding that has relevance to control of invasion and metastasis...
  46. pmc A human breast cell model of preinvasive to invasive transition
    Aylin Rizki
    Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Cancer Res 68:1378-87. 2008
    ..This model provides a new tool for dissection of mechanisms by which preinvasive breast cells could acquire invasiveness in a metaplastic context...
  47. pmc Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells
    Masahiko Itoh
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cancer Res 67:4759-66. 2007
    ..Thus, Rap1 acts as a central regulator of breast architecture, with normal levels of activation instructing polarity during acinar morphogenesis, and increased activation inducing tumor formation and progression to malignancy...
  48. pmc Three-dimensional culture models of normal and malignant breast epithelial cells
    Genee Y Lee
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nat Methods 4:359-65. 2007
    ..Alternatively, the 3D 'on-top' assay, in which cells are cultured on top of a thin lrECM gel overlaid with a dilute solution of lrECM, may be used as described in Box 2 (Fig. 1 and Fig. 2)...
  49. pmc Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture
    Ju Han
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS Comput Biol 6:e1000684. 2010
    ..Specifically, PPARgamma has been associated with the invasive stellate morphological phenotype, which corresponds to triple-negative pathobiology. PPARgamma has been validated through two supporting biological assays...
  50. pmc Breast cancer cells in three-dimensional culture display an enhanced radioresponse after coordinate targeting of integrin alpha5beta1 and fibronectin
    Jin Min Nam
    Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Cancer Res 70:5238-48. 2010
    ..Our findings offer preclinical validation of fibronectin and alpha5beta1-integrin as targets for breast cancer therapy...
  51. pmc Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis
    Bryony S Wiseman
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    J Cell Biol 162:1123-33. 2003
    ..Nevertheless, the mammary gland is able to develop lactational competence in MMP mutant mice. Thus, specific MMPs refine the mammary branching pattern by distinct mechanisms during mammary gland branching morphogenesis...
  52. pmc AZU-1: a candidate breast tumor suppressor and biomarker for tumor progression
    H M Chen
    Lawrence Berkeley National Laboratory, Life Sciences Division, Berkeley, California 94720, USA
    Mol Biol Cell 11:1357-67. 2000
    ..These results indicate that AZU-1 is a candidate breast tumor suppressor that may exert its effects by promoting correct tissue morphogenesis...
  53. pmc Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices
    Ren Xu
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977 225A, Berkeley, CA 94720, USA
    Cancer Metastasis Rev 28:167-76. 2009
    ..Cancer occurs when these dynamic interactions go awry for an extended time...
  54. pmc p53-dependent integration of telomere and growth factor deprivation signals
    Alain Beliveau
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 104:4431-6. 2007
    ..Our findings provide a previously unrecognized mechanistic explanation for the observation that ectopically expressed hTERT conveys growth advantages to cells, without having to postulate nontelomeric functions for the enzyme...
  55. pmc Targeting TACE-dependent EGFR ligand shedding in breast cancer
    Paraic A Kenny
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    J Clin Invest 117:337-45. 2007
    ....
  56. pmc Tumor engineering: the other face of tissue engineering
    Cyrus M Ghajar
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 8206, USA
    Tissue Eng Part A 16:2153-6. 2010
    ....
  57. pmc Is CD133 a marker of metastatic colon cancer stem cells?
    Mark A Labarge
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Clin Invest 118:2021-4. 2008
    ..In light of these new findings, the popular notion that CD133 is a marker of colon CSCs may need to be revised...
  58. pmc The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium
    Jimmie E Fata
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Dev Biol 306:193-207. 2007
    ..Our findings indicate that expression of morphogenetic effectors, proliferation, and cell-type decisions during mammary organoid morphogenesis are intimately dependent on the duration of activation of MAPK(ERK1,2) activation...
  59. pmc Gene expression in the third dimension: the ECM-nucleus connection
    Virginia A Spencer
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977R225A, Berkeley, CA 94720, USA
    J Mammary Gland Biol Neoplasia 15:65-71. 2010
    ....
  60. pmc Unraveling the microenvironmental influences on the normal mammary gland and breast cancer
    Britta Weigelt
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977 225A, Berkeley, CA 94720, USA
    Semin Cancer Biol 18:311-21. 2008
    ....
  61. pmc HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment
    Britta Weigelt
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California Berkeley, Mailstop 977R225A, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Breast Cancer Res Treat 122:35-43. 2010
    ....
  62. pmc Of microenvironments and mammary stem cells
    Mark A Labarge
    Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Stem Cell Rev 3:137-46. 2007
    ..These studies together create a robust portrait of mammary gland biology and identify the location of the stem cell niche, elucidate a developmental hierarchy, and suggest how the niche might be manipulated for therapeutic benefit...
  63. pmc Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging
    Cyrus M Ghajar
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 8206, USA
    Histochem Cell Biol 130:1105-18. 2008
    ....
  64. pmc Polo-like kinase 1 is involved in invasion through extracellular matrix
    Aylin Rizki
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Cancer Res 67:11106-10. 2007
    ..These results support a role for the involvement of PLK1 in the invasion process and point to this pathway as a potential therapeutic target for preinvasive and invasive breast carcinoma treatment...
  65. pmc Targeting the tumor microenvironment
    Paraic A Kenny
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Front Biosci 12:3468-74. 2007
    ..In this article, we describe some of the "druggable" targets and processes within the tumor microenvironment and review the approaches being taken to disrupt these interactions...
  66. ncbi request reprint Malignant mammary cells acquire independence from extracellular context for regulation of estrogen receptor alpha
    Virginia Novaro
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, and Dipartimento di Patologia generale, Seconda Universita degli Studi di Napoli, Napoli, Italy
    Clin Cancer Res 10:402S-9S. 2004
    ..Evidence is presented to show the relevance of the cross-talk between different signaling pathways in the constitution of a functional tissue organization and how this integration may be disrupted in the malignant phenotype...
  67. ncbi request reprint Epimorphin overexpression in the mouse mammary gland promotes alveolar hyperplasia and mammary adenocarcinoma
    Jamie L Bascom
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cancer Res 65:8617-21. 2005
    ..This study reveals another pathway in which overexpression and alteration of a normal morphogenic process promote the development of cancer in the mammary gland...
  68. pmc The organization of tight junctions in epithelia: implications for mammary gland biology and breast tumorigenesis
    Masahiko Itoh
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Mammary Gland Biol Neoplasia 8:449-62. 2003
    ..Many of these components are regulated during mammary gland development and pregnancy cycles, and several have received much attention as possible "tumor suppressors" during progression to breast cancer...
  69. pmc Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
    Derek C Radisky
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nature 436:123-7. 2005
    ..These findings identify a previously undescribed pathway in which a component of the breast tumour microenvironment alters cellular structure in culture and tissue structure in vivo, leading to malignant transformation...
  70. pmc Automated local bright feature image analysis of nuclear protein distribution identifies changes in tissue phenotype
    David W Knowles
    Biophysics and Cancer Biology Departments, Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 103:4445-50. 2006
    ..We believe that this quantitative analysis will have additional applications for classifying normal and pathological tissues...
  71. pmc Modeling tissue-specific signaling and organ function in three dimensions
    Karen L Schmeichel
    Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 83 101, CA 94720, USA
    J Cell Sci 116:2377-88. 2003
    ..Furthermore the experimental accessibility afforded by these tissue-specific 3D models has implications for the design and development of cancer therapies...
  72. pmc Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2
    Hong Liu
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 103:4134-9. 2006
    ....
  73. ncbi request reprint A role for dystroglycan in epithelial polarization: loss of function in breast tumor cells
    John Muschler
    Division of Life Sciences, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cancer Res 62:7102-9. 2002
    ..These data point to DG as an important mediator of normal cell responses to the basement membrane, and as a significant variable in carcinoma cells, in which its frequent loss can contribute to aberrant cell behavior...
  74. pmc Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts
    Fei Wang
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Natl Cancer Inst 94:1494-503. 2002
    ..We have now used this assay to identify reversion and/or death requirements of several more aggressive human breast cancer cell lines...
  75. pmc Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer
    Celeste M Nelson
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Annu Rev Cell Dev Biol 22:287-309. 2006
    ..We expand on the concept of "dynamic reciprocity" to present an integrated view of development, cancer, and aging and posit that genes are like the keys on a piano: Although they are essential, it is the context that makes the music...
  76. ncbi request reprint Cancer. Respect thy neighbor!
    Derek C Radisky
    Division of Life Sciences, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Science 303:775-7. 2004
  77. pmc Depletion of nuclear actin is a key mediator of quiescence in epithelial cells
    Virginia A Spencer
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977R225A, Berkeley, CA 94720, USA
    J Cell Sci 124:123-32. 2011
    ..These data indicate a novel role for nuclear β-actin in growth arrest of epithelial cells and underscore the importance of the integrity of the basement membrane in homeostasis...
  78. pmc Ensemble attribute profile clustering: discovering and characterizing groups of genes with similar patterns of biological features
    J R Semeiks
    Life Sciences Division MS 977 225A, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    BMC Bioinformatics 7:147. 2006
    ....
  79. ncbi request reprint Inflammation is responsible for the development of wound-induced tumors in chickens infected with Rous sarcoma virus
    M Martins Green
    Laboratory of Cell and Molecular Biology, Lawrence Berkeley Laboratory, Berkeley, California 94720
    Cancer Res 54:4334-41. 1994
    ..These inflammatory mediators play a critical role in providing the conducive environment for oncogene integration and activation, and subsequent development of tumors.(ABSTRACT TRUNCATED AT 400 WORDS)..
  80. ncbi request reprint Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition
    Kumari L Andarawewa
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Cancer Res 67:8662-70. 2007
    ..Together, these data show that the interactions between radiation-induced signaling pathways elicit heritable phenotypes that could contribute to neoplastic progression...
  81. pmc Extracellular matrix-regulated gene expression requires cooperation of SWI/SNF and transcription factors
    Ren Xu
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 282:14992-9. 2007
    ..Thus, extracellular matrix- and prolactin-regulated transcription of the mammary-specific casein genes requires the concerted action of chromatin remodeling enzymes and transcription factors...
  82. pmc Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cells
    Marcia V Fournier
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Cancer Res 69:4545-52. 2009
    ..This interaction thus seems to be a critical integrator of proliferative and morphogenetic signaling in breast epithelial cells...
  83. pmc Delivering the message: epimorphin and mammary epithelial morphogenesis
    Derek C Radisky
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Trends Cell Biol 13:426-34. 2003
    ..We conclude with a review of recent studies that suggest similar morphogenic roles for epimorphin in other glandular organs...
  84. pmc The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression
    Paraic A Kenny
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Mol Oncol 1:84-96. 2007
    ..We further demonstrate that consistent differences in genes encoding signal transduction proteins emerge when even tumor cells are cultured in 3D microenvironments...
  85. pmc Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis
    Connie S Chen
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 284:6877-84. 2009
    ..These results provide a dramatic demonstration of the use of structural information about one molecule to define a functional motif of a second molecule that is related at the sequence level but highly divergent functionally...
  86. pmc Controlled microaspiration for high-pressure freezing: a new method for ultrastructural preservation of fragile and sparse tissues for TEM and electron tomography
    W J Triffo
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mail Stop Donner, Berkeley, CA 94720, USA
    J Microsc 230:278-87. 2008
    ..We illustrate the potential for correlative light and electron microscopy as well as electron tomography...
  87. pmc Communication between the cell membrane and the nucleus: role of protein compartmentalization
    S A Lelièvre
    Lawrence Berkeley National Laboratory, Life Sciences Division, Berkeley, CA 94708, USA
    J Cell Biochem Suppl 30:250-63. 1998
    ....
  88. pmc Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition
    Olga K Mirzoeva
    Department of Medicine, Division of Gastroenterology, University of California, San Francisco, California 94115, USA
    Cancer Res 69:565-72. 2009
    ....
  89. pmc Quis custodiet ipsos custodies: who watches the watchmen?
    Cyrus M Ghajar
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 8206, USA
    Am J Pathol 174:1996-9. 2009
    ..This Commentary highlights two articles in this issue of the American Journal of Pathology, discussing the implications of stromal expression of caveolin-1 in breast cancer...
  90. pmc Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments
    Mark A Labarge
    Lawrence Berkeley National Laboratory, Division of Life Sciences, Berkeley, CA 94720, USA
    Integr Biol (Camb) 1:70-9. 2009
    ..We report on the functional ability of those proteins of the mammary gland that maintain quiescence, maintain the progenitor state, and guide progenitor differentiation towards myoepithelial and luminal lineages...
  91. pmc Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells
    Celeste M Nelson
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Cell Biochem 105:25-33. 2008
    ..Our data reveal a previously unanticipated cell shape-dependent mechanism that controls this key phenotypic alteration and provide insight into the distinct mechanisms activated by different EMT-inducing agents...
  92. pmc Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer
    Marcia V Fournier
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cancer Res 66:7095-102. 2006
    ..This study represents a novel unsupervised approach to identifying breast cancer markers that may be of use clinically...
  93. pmc Self-organization of engineered epithelial tubules by differential cellular motility
    Hidetoshi Mori
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:14890-5. 2009
    ..These results indicate that differential directional persistence can give rise to patterns within model developing tissues...
  94. pmc Biomechanical approaches for studying integration of tissue structure and function in mammary epithelia
    Jordi Alcaraz
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Mammary Gland Biol Neoplasia 9:361-74. 2004
    ....
  95. pmc Order and disorder: the role of extracellular matrix in epithelial cancer
    Derek Radisky
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Cancer Invest 20:139-53. 2002
  96. pmc Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins
    Ariel R Krakowski
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 102:12437-42. 2005
    ....
  97. pmc Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma
    Ole William Petersen
    Structural Cell Biology Unit, Department of Medical Anatomy, Section A, The Panum Institute, Copenhagen, Denmark
    Am J Pathol 162:391-402. 2003
    ..We conclude that breast cancer can generate its own nonmalignant stroma and that one function for this is that of a reciprocal interaction with epithelial tumor cells to facilitate tumor growth...
  98. pmc The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells
    Sara R Hamilton
    London Regional Cancer Program, London Health Sciences Centre, and the University of Western Ontario, London, and Department of Cardiovascular Research, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 282:16667-80. 2007
    ..Therefore, an effect of CD44 on tumor cell motility may depend in part on its ability to partner with additional proteins, such as cell surface Rhamm...
  99. pmc beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium
    Valerie M Weaver
    Department of Pathology and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cancer Cell 2:205-16. 2002
    ..These results indicate that integrin-induced polarity may drive tumor cell resistance to apoptosis-inducing agents via effects on NFkappaB...
  100. ncbi request reprint Proteolytic enzymes and altered glycosylation modulate dystroglycan function in carcinoma cells
    Jarnail Singh
    California Pacific Medical Center Research Institute, San Francisco, California 94115, USA
    Cancer Res 64:6152-9. 2004
    ....

Research Grants23

  1. Conference on Tumor Induction and Progression
    Mina Bissell; Fiscal Year: 2005
    ..We need to capture more brilliant minds to enter this area. In this first Keystone meeting on tumor microenvironment, we propose to unravel the excitement and the promise of the field. ..
  2. DEFINITION OF MICROENVIRONMENT IN BREAST CANCER
    Mina Bissell; Fiscal Year: 2005
    ..As loss of appropriate integration of these signals could lead to malignancy, our results may yield new markers and therapeutic strategies to limit or reverse breast tumor progression. ..
  3. DEFINITION OF MICROENVIRONMENT IN BREAST CANCER
    Mina Bissell; Fiscal Year: 2006
    ..As loss of appropriate integration of these signals could lead to malignancy, our results may yield new markers and therapeutic strategies to limit or reverse breast tumor progression. ..
  4. DEFINITION OF MICROENVIRONMENT IN BREAST CANCER
    Mina Bissell; Fiscal Year: 2006
    ..As loss of appropriate integration of these signals could lead to malignancy, our results may yield new markers and therapeutic strategies to limit or reverse breast tumor progression. ..
  5. DEFINITION OF MICROENVIRONMENT IN BREAST CANCER
    Mina Bissell; Fiscal Year: 2007
    ..As loss of appropriate integration of these signals could lead to malignancy, our results may yield new markers and therapeutic strategies to limit or reverse breast tumor progression. ..
  6. DEFINITION OF MICROENVIRONMENT IN BREAST CANCER
    Mina Bissell; Fiscal Year: 2006
    ..As loss of appropriate integration of these signals could lead to malignancy, our results may yield new markers and therapeutic strategies to limit or reverse breast tumor progression. ..
  7. DEFINITION OF MICROENVIRONMENT IN BREAST CANCER
    Mina Bissell; Fiscal Year: 2004
    ..As loss of appropriate integration of these signals could lead to malignancy, our results may yield new markers and therapeutic strategies to limit or reverse breast tumor progression. ..
  8. DEFINITION OF MICROENVIRONMENT IN BREAST CANCER
    Mina Bissell; Fiscal Year: 2003
    ..Since the loss of proper interaction and integration of these pathways could lead to malignant conversion, the results may form the basis of new intervention and therapies in breast cancer. ..
  9. DEFINITION OF MICROENVIRONMENT IN BREAST CANCER
    Mina Bissell; Fiscal Year: 2003
    ..Since the loss of proper interaction and integration of these pathways could lead to malignant conversion, the results may form the basis of new intervention and therapies in breast cancer. ..
  10. DEFINITION OF MICROENVIRONMENT IN BREAST CANCER
    Mina Bissell; Fiscal Year: 1999
    ..Since the loss of proper interaction and integration of these pathways could lead to malignant conversion, the results may form the basis of new intervention and therapies in breast cancer. ..
  11. DEFINITION OF MICROENVIRONMENT IN BREAST CANCER
    Mina Bissell; Fiscal Year: 2000
    ..Since the loss of proper interaction and integration of these pathways could lead to malignant conversion, the results may form the basis of new intervention and therapies in breast cancer. ..
  12. DEFINITION OF MICROENVIRONMENT IN BREAST CANCER
    Mina Bissell; Fiscal Year: 2001
    ..Since the loss of proper interaction and integration of these pathways could lead to malignant conversion, the results may form the basis of new intervention and therapies in breast cancer. ..
  13. DEFINITION OF MICROENVIRONMENT IN BREAST CANCER
    Mina Bissell; Fiscal Year: 2001
    ..Since the loss of proper interaction and integration of these pathways could lead to malignant conversion, the results may form the basis of new intervention and therapies in breast cancer. ..
  14. DEFINITION OF MICROENVIRONMENT IN BREAST CANCER
    Mina Bissell; Fiscal Year: 2002
    ..Since the loss of proper interaction and integration of these pathways could lead to malignant conversion, the results may form the basis of new intervention and therapies in breast cancer. ..
  15. 12th International ISD Conference: Cancer & Development
    Mina Bissell; Fiscal Year: 2002
    ..abstract_text> ..
  16. DEFINITION OF MICROENVIRONMENT IN BREAST CANCER
    Mina Bissell; Fiscal Year: 2003
    ..Since the loss of proper interaction and integration of these pathways could lead to malignant conversion, the results may form the basis of new intervention and therapies in breast cancer. ..
  17. Bioengineering 3-D Models for Organ-Specific Cancer Therapy in Lung and Breast
    Mina Bissell; Fiscal Year: 2007
    ..Moreover, elucidating similarities and differences in breast and airway epithelium will facilitate discovery and design of novel tissuespecific therapies. ..