Janet Sawicki

Summary

Affiliation: Lankenau Institute for Medical Research
Country: USA

Publications

  1. ncbi request reprint Regulated expression of diphtheria toxin in prostate cancer cells
    Weidan Peng
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    Mol Ther 6:537-45. 2002
  2. ncbi request reprint Evidence for stem cells in cultures of mouse prostate epithelial cells
    Janet A Sawicki
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096 3425, USA
    Prostate 50:46-53. 2002
  3. pmc Fetal microchimerism and cancer
    Janet A Sawicki
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    Cancer Res 68:9567-9. 2008
  4. pmc Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis
    Yu Hung Huang
    Lankenau Institute for Medical Research, 100 E Lancaster Avenue, Wynnewood, PA 19096 3450, USA
    Proc Natl Acad Sci U S A 106:3426-30. 2009
  5. ncbi request reprint Human coxsackie adenovirus receptor (CAR) expression in transgenic mouse prostate tumors enhances adenoviral delivery of genes
    Yunhua Bao
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    Prostate 64:401-7. 2005
  6. pmc Nanoparticle-delivered suicide gene therapy effectively reduces ovarian tumor burden in mice
    Yu Hung Huang
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    Cancer Res 69:6184-91. 2009
  7. ncbi request reprint Capturing and profiling adult hair follicle stem cells
    Rebecca J Morris
    Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nat Biotechnol 22:411-7. 2004
  8. pmc A polymer library approach to suicide gene therapy for cancer
    Daniel G Anderson
    Department of Chemical Engineering and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 101:16028-33. 2004
  9. ncbi request reprint Rapid optimization of gene delivery by parallel end-modification of poly(beta-amino ester)s
    Gregory T Zugates
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Mol Ther 15:1306-12. 2007
  10. ncbi request reprint Nanoparticulate delivery of suicide DNA to murine prostate and prostate tumors
    Weidan Peng
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    Prostate 67:855-62. 2007

Research Grants

Collaborators

  • KATHERINE ANNA RAUEN
  • Rebecca Morris
  • Lisa Shantz
  • Lily Wu
  • G Cotsarelis
  • Weidan Peng
  • Daniel G Anderson
  • Yu Hung Huang
  • Robert Langer
  • Yunhua Bao
  • Gregory T Zugates
  • Robert F Padera
  • Naushad Hossain
  • Amy Verbitsky
  • Catherine S Coleman
  • Geoffrey Cole
  • Charles Dunton
  • David Holtz
  • Jordan J Green
  • David A Bumcrot
  • Michael R Chernick
  • Kevin Love
  • Michael Goldberg
  • Andreas Zumbuehl
  • Siddharth Jhunjhunwala
  • Jiping Chen
  • Anat Kohn
  • Akin Akinc
  • Robert Padera
  • Yongjun Guo
  • Louis C Megosh
  • Anthony E Pegg
  • THOMAS G O'BRIEN

Detail Information

Publications12

  1. ncbi request reprint Regulated expression of diphtheria toxin in prostate cancer cells
    Weidan Peng
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    Mol Ther 6:537-45. 2002
    ....
  2. ncbi request reprint Evidence for stem cells in cultures of mouse prostate epithelial cells
    Janet A Sawicki
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096 3425, USA
    Prostate 50:46-53. 2002
    ..Primary cultures of mouse prostatic epithelial cells were studied to identify cells having stem cell characteristics...
  3. pmc Fetal microchimerism and cancer
    Janet A Sawicki
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    Cancer Res 68:9567-9. 2008
    ..For example, fetal microchimerism has been implicated in autoimmune disease, wound healing, and cancer. Studies of this phenomenon may provide a novel perspective on cancer in women, including in breast, ovarian, and lung cancers...
  4. pmc Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis
    Yu Hung Huang
    Lankenau Institute for Medical Research, 100 E Lancaster Avenue, Wynnewood, PA 19096 3450, USA
    Proc Natl Acad Sci U S A 106:3426-30. 2009
    ..These results suggest that lipidoid-formulated CLDN3 siRNA has potential as a therapeutic for ovarian cancer...
  5. ncbi request reprint Human coxsackie adenovirus receptor (CAR) expression in transgenic mouse prostate tumors enhances adenoviral delivery of genes
    Yunhua Bao
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    Prostate 64:401-7. 2005
    ..Their use in pre-clinical testing of adenovirally-delivered gene therapies, however, is limited because of restricted cell surface expression of Coxsackie adenovirus receptor (CAR) in mice...
  6. pmc Nanoparticle-delivered suicide gene therapy effectively reduces ovarian tumor burden in mice
    Yu Hung Huang
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    Cancer Res 69:6184-91. 2009
    ..p. administration of polymeric nanoparticles to deliver DT-A encoding DNA, combined with transcriptional regulation to target gene expression to ovarian tumor cells, holds promise as an effective therapy for advanced-stage ovarian cancer...
  7. ncbi request reprint Capturing and profiling adult hair follicle stem cells
    Rebecca J Morris
    Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nat Biotechnol 22:411-7. 2004
    ..Ultimately, these findings provide potential targets for the treatment of hair loss and other disorders of skin and hair...
  8. pmc A polymer library approach to suicide gene therapy for cancer
    Daniel G Anderson
    Department of Chemical Engineering and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 101:16028-33. 2004
    ..Because C32 transfects tumors locally at high levels, transfects healthy muscle poorly, and displays no toxicity, it may provide a vehicle for the local treatment of cancer...
  9. ncbi request reprint Rapid optimization of gene delivery by parallel end-modification of poly(beta-amino ester)s
    Gregory T Zugates
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Mol Ther 15:1306-12. 2007
    ..The rapid end-modification strategy presented here has led to the discovery of many effective polymers for gene delivery and may be a useful method to develop and optimize cationic polymers for gene therapy...
  10. ncbi request reprint Nanoparticulate delivery of suicide DNA to murine prostate and prostate tumors
    Weidan Peng
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    Prostate 67:855-62. 2007
    ..Here, we demonstrate the effectiveness of a prostate-specific, locally delivered gene therapy for the targeted killing of prostate cells...
  11. ncbi request reprint Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation
    Lisa M Shantz
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Carcinogenesis 23:657-64. 2002
    ....
  12. ncbi request reprint Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis
    Catherine S Coleman
    Department of Cellular and Molecular Physiology, The Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, PO Box 850, Hershey, PA 17033, USA
    Carcinogenesis 23:359-64. 2002
    ..These results suggest that activation of polyamine catabolism leading to increases in putrescine and N1-acetylspermidine may play a key role in chemically induced mouse skin neoplasia...

Research Grants11

  1. Targeted Death of Prostatic Cancer Cells
    Janet Sawicki; Fiscal Year: 2003
    ..We expect our investigations will lead to the development of a novel gene therapy for prostate cancer patients that will effectively arrest the development of recurrent tumors. ..
  2. Targeting Nanoparticle DNA Delivery to Prostate Tumors
    Janet Sawicki; Fiscal Year: 2007
    ....
  3. Targeted Nanoparticle DNA Therapy for Ovarian Cancer
    Janet A Sawicki; Fiscal Year: 2010
    ..Targeted nanotherapy, used alone or as an adjuvant therapy, should lead to a more effective treatment for patients with metastatic ovarian cancer. ..
  4. Targeting Nanoparticle DNA Delivery to Prostate Tumors
    Janet A Sawicki; Fiscal Year: 2010
    ....