J M Mullin

Summary

Affiliation: Lankenau Institute for Medical Research
Country: USA

Publications

  1. ncbi Keynote review: epithelial and endothelial barriers in human disease
    James M Mullin
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Drug Discov Today 10:395-408. 2005
  2. ncbi Modification of tight junction structure and permeability by nutritional means
    James M Mullin
    Lankenau Institute for Medical Research, Princeton University, Wynnewood, PA 19096, USA
    Ann N Y Acad Sci 1165:99-112. 2009
  3. ncbi Proton pump inhibitors: actions and reactions
    James M Mullin
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096 3450, USA
    Drug Discov Today 14:647-60. 2009
  4. ncbi Epithelial barriers, compartmentation, and cancer
    J M Mullin
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Sci STKE 2004:pe2. 2004
  5. ncbi Ras mutation impairs epithelial barrier function to a wide range of nonelectrolytes
    James M Mullin
    The Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA
    Mol Biol Cell 16:5538-50. 2005
  6. ncbi Transepithelial leak in Barrett's esophagus
    J M Mullin
    Lankenau Institute for Medical Research, Director of Research, Division of Gastroenterology, Lankenau Hospital, 100 Lancaster Avenue, Wynnewood, Pennsylvania, USA
    Dig Dis Sci 51:2326-36. 2006
  7. ncbi Increased tight junction permeability can result from protein kinase C activation/translocation and act as a tumor promotional event in epithelial cancers
    J M Mullin
    Lankenau Medical Research Center, 100 Lancaster Avenue, Wynnewood, Pennsylvania 19096, USA
    Ann N Y Acad Sci 915:231-6. 2000
  8. ncbi Activation of NF-kappaB is necessary for the restoration of the barrier function of an epithelium undergoing TNF-alpha-induced apoptosis
    A P Soler
    The Lankenau Medical Research Center, Wynnewood, PA 19096, USA
    Eur J Cell Biol 78:56-66. 1999
  9. ncbi Regulation of protein kinase C-delta and -epsilon isoforms by phorbol ester treatment of LLC-PK1 renal epithelia
    H Clarke
    Lankenau Medical Research Center, Wynnewood, Pennsylvania, USA
    Kidney Int 58:1004-15. 2000
  10. ncbi The transient increase of tight junction permeability induced by bryostatin 1 correlates with rapid downregulation of protein kinase C-alpha
    H Clarke
    Lankenau Medical Research Institute, 100 Lancaster Avenue, Wynnewood, Pennsylvania 19096, USA
    Exp Cell Res 261:239-49. 2000

Research Grants

  1. Colon Barrier Breakdown in the Elderly
    James Mullin; Fiscal Year: 2005

Collaborators

  • A P Soler
  • H Clarke
  • Mary Kay Francis
  • D M Klurfeld
  • J B Meddings
  • J B Smith
  • Simon A Lewis
  • P J Morin
  • Ch Sell
  • Melissa Gabello
  • Lisa J Murray
  • Mary Carmen Valenzano
  • C W Marano
  • Burhan Hameed
  • M Gabello
  • Arivudainambi Ramalingam
  • M Carmen Valenzano
  • M C Valenzano
  • David S Rudolph
  • S Skrovanek
  • Giancarlo Mercogliano
  • James J Thornton
  • Gemma J Feldman
  • Erika Rendon-Huerta
  • L A Garulacan
  • Akihiro Ko
  • E Peter Zurbach
  • P Zurbach
  • Xuexuan Wang
  • M Barr
  • James C Underwood
  • Christopher P Farrell
  • Melissa Morgan
  • Aaron P Martin
  • Owen Tully
  • Mary C Valenzano
  • Marysue Whitby
  • Michael P Ryan
  • David M Smith
  • Jon J Verrechio
  • J David Schmidt
  • Leesa E Gillooley
  • Susan E Trembeth
  • Rupal Kothari
  • N Ginanni
  • C Trace
  • S M Goldman
  • F P Sutter
  • L Igidbashian
  • K V Laughlin
  • G A Reichard

Detail Information

Publications27

  1. ncbi Keynote review: epithelial and endothelial barriers in human disease
    James M Mullin
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Drug Discov Today 10:395-408. 2005
    ..Specific effects on the tight junction are found to be integral to bacterial invasion and tumor progression...
  2. ncbi Modification of tight junction structure and permeability by nutritional means
    James M Mullin
    Lankenau Institute for Medical Research, Princeton University, Wynnewood, PA 19096, USA
    Ann N Y Acad Sci 1165:99-112. 2009
    ..The implications of being able to enhance epithelial TJ barrier function by nutritional means are discussed, particularly in light of the ability of methionine-restrictive diets to enhance life span and forestall age-related morbidity...
  3. ncbi Proton pump inhibitors: actions and reactions
    James M Mullin
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096 3450, USA
    Drug Discov Today 14:647-60. 2009
    ..The ubiquity of the various types of H(+), K(+)-ATPase could also contribute to non-gastric effects. PPIs may influence physiology in other ways, such as inducing transepithelial leak...
  4. ncbi Epithelial barriers, compartmentation, and cancer
    J M Mullin
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Sci STKE 2004:pe2. 2004
    ....
  5. ncbi Ras mutation impairs epithelial barrier function to a wide range of nonelectrolytes
    James M Mullin
    The Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA
    Mol Biol Cell 16:5538-50. 2005
    ..These selective changes in permeability may influence tumorigenesis by the types of solutes now able to cross the epithelial barrier...
  6. ncbi Transepithelial leak in Barrett's esophagus
    J M Mullin
    Lankenau Institute for Medical Research, Director of Research, Division of Gastroenterology, Lankenau Hospital, 100 Lancaster Avenue, Wynnewood, Pennsylvania, USA
    Dig Dis Sci 51:2326-36. 2006
    ....
  7. ncbi Increased tight junction permeability can result from protein kinase C activation/translocation and act as a tumor promotional event in epithelial cancers
    J M Mullin
    Lankenau Medical Research Center, 100 Lancaster Avenue, Wynnewood, Pennsylvania 19096, USA
    Ann N Y Acad Sci 915:231-6. 2000
    ..Tight junctional leakiness is therefore a promotional event that would be unique to epithelial cancers...
  8. ncbi Activation of NF-kappaB is necessary for the restoration of the barrier function of an epithelium undergoing TNF-alpha-induced apoptosis
    A P Soler
    The Lankenau Medical Research Center, Wynnewood, PA 19096, USA
    Eur J Cell Biol 78:56-66. 1999
    ..These data demonstrate that NF-kappaB activation is required for the maintenance of the barrier function of an epithelium undergoing TNF-induced apoptosis...
  9. ncbi Regulation of protein kinase C-delta and -epsilon isoforms by phorbol ester treatment of LLC-PK1 renal epithelia
    H Clarke
    Lankenau Medical Research Center, Wynnewood, Pennsylvania, USA
    Kidney Int 58:1004-15. 2000
    ..Protein kinase C (PKC) has been observed to play a role in both processes. This study examines the subcellular distribution and down-regulation of PKC-delta and PKC-epsilon isoforms in phorbol ester-treated LLC-PK1 epithelia...
  10. ncbi The transient increase of tight junction permeability induced by bryostatin 1 correlates with rapid downregulation of protein kinase C-alpha
    H Clarke
    Lankenau Medical Research Institute, 100 Lancaster Avenue, Wynnewood, Pennsylvania 19096, USA
    Exp Cell Res 261:239-49. 2000
    ..Due to its transient effect on tight junction permeability, bryostatin 1 offers a novel pharmacological tool to investigate junctional physiology...
  11. ncbi Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets
    H Clarke
    Lankenau Medical Research Center, Wynnewood, PA 19096, USA
    J Cell Sci 113:3187-96. 2000
    ....
  12. ncbi Increased tight junctional permeability is associated with the development of colon cancer
    A P Soler
    The Lankenau Medical Research Center, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Carcinogenesis 20:1425-31. 1999
    ..These results showed that increased TJ permeability of the colon epithelium and consequently a decrease in epithelial barrier function precede the development of colon tumors...
  13. ncbi Restriction of sulfur-containing amino acids alters claudin composition and improves tight junction barrier function
    S Skrovanek
    The Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1046-55. 2007
    ..The functional result of these structural changes was improved barrier function, as evidenced by increased transepithelial electrical resistance and decreased transepithelial (paracellular) diffusion of D-mannitol...
  14. ncbi Protein kinase C activation increases transepithelial transport of biologically active insulin
    J M Mullin
    The Lankenau Medical Research Center, Wynnewood, Pennsylvania 19096, USA
    Cancer Res 58:1641-5. 1998
    ..The dramatically enhanced permeability of macromolecules across epithelial cell layers undergoing protein kinase C activation may play a significant role in epithelial cancer, immunology, and drug delivery...
  15. ncbi Effects of apical vs. basolateral palytoxin on LLC-PK1 renal epithelia
    J M Mullin
    Lankenau Medical Research Center, Wynnewood, Pennsylvania 19096
    Am J Physiol 260:C1201-11. 1991
    ..It also adds to a growing literature suggesting the existence of Na(+)-K(+)-ATPase in the apical cell surface of epithelia under certain conditions...
  16. ncbi Esomeprazole induces upper gastrointestinal tract transmucosal permeability increase
    J M Mullin
    The Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA
    Aliment Pharmacol Ther 28:1317-25. 2008
    ..In a previous work, we observed that a transmucosal, upper gastrointestinal (GI) leak exists in Barrett's oesophagus (BO) patients. PPI medications are commonly used by Barrett's patients...
  17. ncbi Omeprazole induces gastric permeability to digoxin
    M Gabello
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Dig Dis Sci 55:1255-63. 2010
    ....
  18. ncbi Phorbol ester treatment increases paracellular permeability across IEC-18 gastrointestinal epithelium in vitro
    C W Marano
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    Dig Dis Sci 46:1490-9. 2001
    ....
  19. ncbi Plasma concentrations of soluble tumor necrosis factor receptor I and tumor necrosis factor during cardiopulmonary bypass
    C W Marano
    Lankenau Institute for Medical Research, Department of Surgery, Lankenau Hospital, Wynnewood, Pennsylvania 19096, USA
    Ann Thorac Surg 70:1313-8. 2000
    ..Despite their postulated roles as modulators of TNF bioavailability, soluble TNF receptors have not been characterized in patients undergoing this procedure and is the focus of this study...
  20. ncbi Age- and diet-related increase in transepithelial colon permeability of Fischer 344 rats
    J M Mullin
    Lankenau Institute for Medical Research, Lankenau Hospital, Wynnewood, Pennsylvania 19096, USA
    Dig Dis Sci 47:2262-70. 2002
    ..The potential effect of such increased leakiness on the increased frequency of colon cancer in older individuals is discussed...
  21. ncbi Indocyanine green alters transepithelial electrical parameters of the distal colon
    Burhan Hameed
    Division of Gastroenterology, Lankenau Hospital, Wynnewood, Pennsylvania 19096, USA
    Dig Dis Sci 49:1381-6. 2004
    ..ICG should not be considered inert in vivo. Leakage of ICG from the vascular space into the interstitial fluid space will likely result in tissue morbidity...
  22. ncbi Dietary methionine restriction improves colon tight junction barrier function and alters claudin expression pattern
    Arivudainambi Ramalingam
    Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA
    Am J Physiol Cell Physiol 299:C1028-35. 2010
    ..Overall, our data suggest that reduction in dietary intake of methionine results in improved epithelial barrier function by inducing altered TJ protein composition...
  23. ncbi Omeprazole induces gastric transmucosal permeability to the peptide bradykinin
    Melissa Gabello
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    World J Gastroenterol 16:1097-103. 2010
    ..To investigate omeprazole-induced transepithelial gastric leak and its effects on the permeability of the peptides bradykinin and oxytocin...
  24. ncbi Absence of Na+/sugar cotransport activity in Barrett's metaplasia
    Lisa J Murray
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, United States
    World J Gastroenterol 14:1365-9. 2008
    ..To evaluate the presence of Na+-dependent, active, sugar transport in Barrett's epithelia as an intestinal biomarker, based on the well-documented, morphological intestinal phenotype of Barrett's esophagus (BE)...
  25. ncbi Transmucosal gastric leak induced by proton pump inhibitors
    Lisa J Murray
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Dig Dis Sci 54:1408-17. 2009
    ..Because PPIs are so widely used and are assumed to be innocuous, this transmucosal gastric leak must be further investigated, as it may carry considerable biomedical implications...
  26. ncbi Comparison of three integral tight junction barrier proteins in Barrett's epithelium versus normal esophageal epithelium
    Erika Rendon-Huerta
    Am J Gastroenterol 98:1901-3. 2003
  27. ncbi Occludin: structure, function and regulation
    Gemma J Feldman
    Department of Pharmacology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Adv Drug Deliv Rev 57:883-917. 2005
    ..Disruption of occludin regulation is an important aspect of a number of diseases. Strategies to prevent and/or reverse occludin downregulation may be an important therapeutic target...

Research Grants1

  1. Colon Barrier Breakdown in the Elderly
    James Mullin; Fiscal Year: 2005
    ..Changes in membrane composition/fluidity are known to affect paracellular permeability in general, and tight junction proteins specifically. ..