Donglin Guo

Summary

Affiliation: Lankenau Institute for Medical Research
Country: USA

Publications

  1. doi request reprint Calcium-activated chloride current contributes to action potential alternations in left ventricular hypertrophy rabbit
    Donglin Guo
    Main Line Health Heart Ctr, Wynnewood, PA 19096, USA
    Am J Physiol Heart Circ Physiol 295:H97-H104. 2008
  2. doi request reprint Electrophysiological properties of HBI-3000: a new antiarrhythmic agent with multiple-channel blocking properties in human ventricular myocytes
    Donglin Guo
    Lankenau Institute for Medical Research and Main Line Health Heart Center, Wynnewood, PA 19096, USA
    J Cardiovasc Pharmacol 57:79-85. 2011
  3. ncbi request reprint L-type calcium current reactivation contributes to arrhythmogenesis associated with action potential triangulation
    Donglin Guo
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    J Cardiovasc Electrophysiol 18:196-203. 2007
  4. doi request reprint Increased late sodium current in left atrial myocytes of rabbits with left ventricular hypertrophy: its role in the genesis of atrial arrhythmias
    Donglin Guo
    Main Line Health Heart Center and Lankenau Inst, Medical Research, 100 Lancaster Ave, Wynnewood, PA 19096, USA
    Am J Physiol Heart Circ Physiol 298:H1375-81. 2010
  5. doi request reprint L-type calcium current recovery versus ventricular repolarization: preserved membrane-stabilizing mechanism for different QT intervals across species
    Donglin Guo
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    Heart Rhythm 5:271-9. 2008
  6. ncbi request reprint The QT and Tp-e intervals in left and right chest leads: comparison between patients with systemic and pulmonary hypertension
    Thinn Hlaing
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    J Electrocardiol 38:154-8. 2005
  7. doi request reprint Differentiating electrophysiological effects and cardiac safety of drugs based on the electrocardiogram: a blinded validation
    Tengxian Liu
    Lankenau Institute for Medical Research and Main Line Health Heart Center, 100 Lancaster Ave, Wynnewood, PA 19096, USA
    Heart Rhythm 9:1706-15. 2012
  8. doi request reprint Contribution of late sodium current (I(Na-L)) to rate adaptation of ventricular repolarization and reverse use-dependence of QT-prolonging agents
    Donglin Guo
    Lankenau Institute for Medical Research and Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    Heart Rhythm 8:762-9. 2011
  9. ncbi request reprint Phase 2 reentry as a trigger to initiate ventricular fibrillation during early acute myocardial ischemia
    Gan Xin Yan
    Main Line Health Heart Center and Lankenau Institute for Medical Research, 100 Lancaster Ave, Wynnewood, PA, 19096, USA
    Circulation 110:1036-41. 2004
  10. ncbi request reprint IL-6-overexpression brings about growth impairment potentially through a GH receptor defect
    Jaroslava Lieskovska
    Department of Developmental and Structural Biology, Public Health Research Institute, 225 Warren Street, Newark, NJ 07103, USA
    Growth Horm IGF Res 12:388-98. 2002

Collaborators

Detail Information

Publications10

  1. doi request reprint Calcium-activated chloride current contributes to action potential alternations in left ventricular hypertrophy rabbit
    Donglin Guo
    Main Line Health Heart Ctr, Wynnewood, PA 19096, USA
    Am J Physiol Heart Circ Physiol 295:H97-H104. 2008
    ..Our data indicate that abnormal intracellular Ca(2+) fluctuation may exert a strong feedback on the membrane I(Cl,Ca), leading to a beat-to-beat change in the net repolarizing current that manifests as T-wave alternans on the ECG...
  2. doi request reprint Electrophysiological properties of HBI-3000: a new antiarrhythmic agent with multiple-channel blocking properties in human ventricular myocytes
    Donglin Guo
    Lankenau Institute for Medical Research and Main Line Health Heart Center, Wynnewood, PA 19096, USA
    J Cardiovasc Pharmacol 57:79-85. 2011
    ..HBI-3000 may be a promising antiarrhythmic agent with low proarrhythmic risk...
  3. ncbi request reprint L-type calcium current reactivation contributes to arrhythmogenesis associated with action potential triangulation
    Donglin Guo
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    J Cardiovasc Electrophysiol 18:196-203. 2007
    ..AP triangulation has been shown to be an important predictor of drug-induced TdP...
  4. doi request reprint Increased late sodium current in left atrial myocytes of rabbits with left ventricular hypertrophy: its role in the genesis of atrial arrhythmias
    Donglin Guo
    Main Line Health Heart Center and Lankenau Inst, Medical Research, 100 Lancaster Ave, Wynnewood, PA 19096, USA
    Am J Physiol Heart Circ Physiol 298:H1375-81. 2010
    ..The I(Na-L) may serve as a potentially useful ionic target for antiarrhythmic drugs for the treatment of atrial arrhythmias in the setting of LVH...
  5. doi request reprint L-type calcium current recovery versus ventricular repolarization: preserved membrane-stabilizing mechanism for different QT intervals across species
    Donglin Guo
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    Heart Rhythm 5:271-9. 2008
    ..Long QT syndrome is associated with early after-depolarization (EAD) that may result in torsade de pointes (TdP). Interestingly, the corrected QT interval seems to be proportional to body mass across species under physiologic conditions...
  6. ncbi request reprint The QT and Tp-e intervals in left and right chest leads: comparison between patients with systemic and pulmonary hypertension
    Thinn Hlaing
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    J Electrocardiol 38:154-8. 2005
    ....
  7. doi request reprint Differentiating electrophysiological effects and cardiac safety of drugs based on the electrocardiogram: a blinded validation
    Tengxian Liu
    Lankenau Institute for Medical Research and Main Line Health Heart Center, 100 Lancaster Ave, Wynnewood, PA 19096, USA
    Heart Rhythm 9:1706-15. 2012
    ..However, the correlation of ECG ventricular waveforms with underlying ion actions is not well established and has been extensively debated...
  8. doi request reprint Contribution of late sodium current (I(Na-L)) to rate adaptation of ventricular repolarization and reverse use-dependence of QT-prolonging agents
    Donglin Guo
    Lankenau Institute for Medical Research and Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    Heart Rhythm 8:762-9. 2011
    ..Abnormal rate adaptation of ventricular repolarization is arrhythmogenic. There is controversy on the underlying ionic mechanisms for rate-dependent change in repolarization...
  9. ncbi request reprint Phase 2 reentry as a trigger to initiate ventricular fibrillation during early acute myocardial ischemia
    Gan Xin Yan
    Main Line Health Heart Center and Lankenau Institute for Medical Research, 100 Lancaster Ave, Wynnewood, PA, 19096, USA
    Circulation 110:1036-41. 2004
    ..The present study examined the role of phase 2 reentry in the initiation of VF during early myocardial ischemia...
  10. ncbi request reprint IL-6-overexpression brings about growth impairment potentially through a GH receptor defect
    Jaroslava Lieskovska
    Department of Developmental and Structural Biology, Public Health Research Institute, 225 Warren Street, Newark, NJ 07103, USA
    Growth Horm IGF Res 12:388-98. 2002
    ..We noted a twofold reduction of hepatic GHR mRNA in the transgenic mice. We therefore conclude that overexpression of IL-6 brings about growth impairment in part through a GH receptor defect...