George Jacoby

Summary

Affiliation: Lahey Clinic
Country: USA

Publications

  1. pmc Plasmid-determined AmpC-type beta-lactamases
    Alain Philippon
    Service de Bacteriologie, Université Paris V Hôpital Cochin, Paris, France
    Antimicrob Agents Chemother 46:1-11. 2002
  2. ncbi request reprint Mechanisms of resistance to quinolones
    George A Jacoby
    Lahey Clinic, Burlington, Massachusetts 01805, USA
    Clin Infect Dis 41:S120-6. 2005
  3. ncbi request reprint Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase
    Ari Robicsek
    Harvard Medical School, Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit St, GRJ 512, Boston, Massachusetts 02114, USA
    Nat Med 12:83-8. 2006
  4. pmc Beta-lactamase nomenclature
    George A Jacoby
    Lahey Clinic, 41 Mall Rd, Burlington, MA 01895, USA
    Antimicrob Agents Chemother 50:1123-9. 2006
  5. pmc Phylogenetic analysis of chromosomally determined qnr and related proteins
    George A Jacoby
    Lahey Clinic, Burlington, Massachusetts, USA
    Antimicrob Agents Chemother 57:1930-4. 2013
  6. ncbi request reprint The new beta-lactamases
    George A Jacoby
    Department of Infectious Diseases, Lahey Clinic, Burlington, Mass 01805, USA
    N Engl J Med 352:380-91. 2005
  7. pmc qnrB, another plasmid-mediated gene for quinolone resistance
    George A Jacoby
    Lahey Clinic, 41 Mall Road, Burlington, MA 01805, USA
    Antimicrob Agents Chemother 50:1178-82. 2006
  8. pmc Identification of extended-spectrum, AmpC, and carbapenem- hydrolyzing beta-lactamases in Escherichia coli and Klebsiella pneumoniae by disk tests
    George A Jacoby
    Lahey Clinic, Burlington, MA 01895, USA
    J Clin Microbiol 44:1971-6. 2006
  9. pmc qnr Gene nomenclature
    George Jacoby
    Lahey Clinic, Burlington, Massachusetts MA 01805, USA
    Antimicrob Agents Chemother 52:2297-9. 2008
  10. pmc AmpC beta-lactamases
    George A Jacoby
    Lahey Clinic, Burlington, Massachusetts 01805, USA
    Clin Microbiol Rev 22:161-82, Table of Contents. 2009

Research Grants

  1. PLASMID MEDIATED QUINOLONE RESISTANCE
    George Jacoby; Fiscal Year: 2001
  2. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2007

Detail Information

Publications32

  1. pmc Plasmid-determined AmpC-type beta-lactamases
    Alain Philippon
    Service de Bacteriologie, Université Paris V Hôpital Cochin, Paris, France
    Antimicrob Agents Chemother 46:1-11. 2002
  2. ncbi request reprint Mechanisms of resistance to quinolones
    George A Jacoby
    Lahey Clinic, Burlington, Massachusetts 01805, USA
    Clin Infect Dis 41:S120-6. 2005
    ..Although Qnr by itself produces only low-level resistance, its presence facilitates the selection of higher-level resistance mutations, thus contributing to the alarming increase in resistance to quinolones...
  3. ncbi request reprint Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase
    Ari Robicsek
    Harvard Medical School, Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit St, GRJ 512, Boston, Massachusetts 02114, USA
    Nat Med 12:83-8. 2006
    ....
  4. pmc Beta-lactamase nomenclature
    George A Jacoby
    Lahey Clinic, 41 Mall Rd, Burlington, MA 01895, USA
    Antimicrob Agents Chemother 50:1123-9. 2006
  5. pmc Phylogenetic analysis of chromosomally determined qnr and related proteins
    George A Jacoby
    Lahey Clinic, Burlington, Massachusetts, USA
    Antimicrob Agents Chemother 57:1930-4. 2013
    ..The related pentapeptide repeat protein-encoding mfpA gene is present in the genome of at least 19 species of Mycobacterium and 10 other Actinobacteria species. The native function of these genes is not yet known...
  6. ncbi request reprint The new beta-lactamases
    George A Jacoby
    Department of Infectious Diseases, Lahey Clinic, Burlington, Mass 01805, USA
    N Engl J Med 352:380-91. 2005
  7. pmc qnrB, another plasmid-mediated gene for quinolone resistance
    George A Jacoby
    Lahey Clinic, 41 Mall Road, Burlington, MA 01805, USA
    Antimicrob Agents Chemother 50:1178-82. 2006
    ....
  8. pmc Identification of extended-spectrum, AmpC, and carbapenem- hydrolyzing beta-lactamases in Escherichia coli and Klebsiella pneumoniae by disk tests
    George A Jacoby
    Lahey Clinic, Burlington, MA 01895, USA
    J Clin Microbiol 44:1971-6. 2006
    ..A relatively simple scheme was devised for distinguishing beta-lactamase types in clinical isolates with or without intact outer membrane porins...
  9. pmc qnr Gene nomenclature
    George Jacoby
    Lahey Clinic, Burlington, Massachusetts MA 01805, USA
    Antimicrob Agents Chemother 52:2297-9. 2008
  10. pmc AmpC beta-lactamases
    George A Jacoby
    Lahey Clinic, Burlington, Massachusetts 01805, USA
    Clin Microbiol Rev 22:161-82, Table of Contents. 2009
    ....
  11. pmc Temporal appearance of plasmid-mediated quinolone resistance genes
    George A Jacoby
    Lahey Clinic, Burlington, Massachusetts, USA
    Antimicrob Agents Chemother 53:1665-6. 2009
    ..None had the aac(6')-Ib-cr variant, qnrA, qnrS, qnrC, or qepA, but two strains collected in 1988 had qnrB alleles, making these the earliest known PMQR genes...
  12. pmc Citrobacter spp. as a source of qnrB Alleles
    George A Jacoby
    Lahey Clinic, Burlington, Massachusetts 01805 6208, USA
    Antimicrob Agents Chemother 55:4979-84. 2011
    ..The chromosome of Citrobacter is the likely source of plasmid-mediated qnrB...
  13. pmc Role of beta-lactamases and porins in resistance to ertapenem and other beta-lactams in Klebsiella pneumoniae
    George A Jacoby
    Lahey Clinic, Burlington, Mssachusetts 01805, USA
    Antimicrob Agents Chemother 48:3203-6. 2004
    ..From a wild-type strain producing ACT-1 beta-lactamase, ertapenem-resistant mutants for which the ertapenem MICs were up to 128 microg/ml and expression of outer membrane proteins was diminished could be selected...
  14. pmc Sequence of the MIR-1 beta-lactamase gene
    G A Jacoby
    Edith Nourse Rogers Memorial Veterans Hospital, Bedford, Massachusetts 01730, and Lahey Clinic, Burlington, Massachusetts 01805, USA
    Antimicrob Agents Chemother 43:1759-60. 1999
    ..blaMIR-1 is not part of a typical gene cassette but does lie near an element that could be involved in its capture on a plasmid...
  15. pmc Prevalence of plasmid-mediated quinolone resistance
    George A Jacoby
    Infectious Disease Department, Lahey Clinic, Burlington, Massachusetts, USA
    Antimicrob Agents Chemother 47:559-62. 2003
    ..This plasmid and one carrying the complete microcin B17 operon slightly decreased sparfloxacin susceptibility but had a much less protective effect than pMG252. Plasmid-mediated quinolone resistance was thus rare in the sample examined...
  16. ncbi request reprint Epidemiology of extended-spectrum beta-lactamases in Sofia, Bulgaria
    G A Jacoby
    Infectious Disease Department, Lahey Clinic, 41 Mall Road, Burlington, MA 01805, USA
    Eur J Clin Microbiol Infect Dis 22:385-8. 2003
  17. pmc Epidemiology of conjugative plasmid-mediated AmpC beta-lactamases in the United States
    M Alvarez
    Lahey Clinic, Burlington, and Edith Nourse Rogers Memorial Veterans Hospital, Bedford, Massachusetts, USA
    Antimicrob Agents Chemother 48:533-7. 2004
    ..and E. coli, are disseminated around the United States, and are not so easily distinguished from other enzymes that mediate resistance to oxyimino-beta-lactams...
  18. pmc Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyrase
    John H Tran
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114 2696, USA
    Antimicrob Agents Chemother 49:118-25. 2005
    ..Quinolones bind later in the catalytic cycle and stabilize a ternary complex consisting of the drug, gyrase, and DNA. By lowering gyrase binding to DNA, Qnr may reduce the amount of holoenzyme-DNA targets for quinolone inhibition...
  19. pmc Mechanism of plasmid-mediated quinolone resistance
    John H Tran
    Infectious Disease Department, Lahey Clinic, Burlington, MA 01805, USA
    Proc Natl Acad Sci U S A 99:5638-42. 2002
    ..Protection of topoisomerase IV, a secondary target of quinolone action in E. coli, was not evident. How Qnr protects DNA gyrase and the prevalence of this resistance mechanism in clinical isolates remains to be determined...
  20. pmc TEM-71, a novel plasmid-encoded, extended-spectrum beta-lactamase produced by a clinical isolate of Klebsiella pneumoniae
    J Kamile Rasheed
    Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Antimicrob Agents Chemother 46:2000-3. 2002
    ..0 and a substrate profile showing preferential hydrolysis of cefotaxime over ceftazidime. It differed from TEM-1 by two substitutions, Gly238Ser and Glu240Lys, and was under the control of the strong P4 promoter...
  21. pmc blaCTX-M-2 is located in an unusual class 1 integron (In35) which includes Orf513
    Sonia M Arduino
    Facultad de Medicina de la Universidad de Buenos Aires, Paraguay 2155 1121 Capital Federal, Argentina
    Antimicrob Agents Chemother 46:2303-6. 2002
    ..It is possible that bla(CTX-M-2) was acquired by plasmid pMAR-12 through an uncharacterized recombinational event in which Orf513 could be involved...
  22. pmc Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins
    Jean M Whichard
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 13:1681-8. 2007
    ..Nine Senftenberg isolates contained bla(OXA-1) contained bla(OXA-9). Further studies should address patient outcomes, risk factors, and resistance dissemination prevention strategies...
  23. ncbi request reprint The worldwide emergence of plasmid-mediated quinolone resistance
    Ari Robicsek
    Massachusetts General Hospital, Boston, MA 02114 2696, USA
    Lancet Infect Dis 6:629-40. 2006
    ....
  24. pmc Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme
    Chi Hye Park
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 2696, USA
    Antimicrob Agents Chemother 50:3953-5. 2006
    ..aac(6')-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli, equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes...
  25. ncbi request reprint Regional occurrence of plasmid-mediated SHV-7, an extended-spectrum beta-lactamase, in Enterobacter cloacae in Philadelphia Teaching Hospitals
    Matthew E Levison
    Division of Infectious Diseases, Drexel University College of Medicine, Philadelphia, PA, USA
    Clin Infect Dis 35:1551-4. 2002
    ..coli or K. pneumoniae in the United States, and we emphasize that, among Enterobacter cloacae strains, not all resistance to extended-spectrum cephalosporins is the result of hyperproduction of AmpC beta-lactamase...
  26. pmc Activities of newer quinolones against Escherichia coli and Klebsiella pneumoniae containing the plasmid-mediated quinolone resistance determinant qnr
    Minggui Wang
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Antimicrob Agents Chemother 48:1400-1. 2004
    ..Sitafloxacin, BAYy3118, and premafloxacin had higher activity in vitro than ciprofloxacin against transconjugants and donors containing qnr. The donors had higher quinolone MICs than the transconjugants...
  27. ncbi request reprint Interaction of plasmid and host quinolone resistance
    Luis Martinez-Martinez
    J Antimicrob Chemother 51:1037-9. 2003
  28. pmc Interaction of the plasmid-encoded quinolone resistance protein QnrA with Escherichia coli topoisomerase IV
    John H Tran
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    Antimicrob Agents Chemother 49:3050-2. 2005
    ..With a gel displacement assay, tagged QnrA was shown to bind to topoisomerase IV and its subunits in a reaction that did not depend on the presence of DNA, quinolone, or ATP...
  29. pmc Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, China
    Minggui Wang
    Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China
    Antimicrob Agents Chemother 47:2242-8. 2003
    ..coli from Shanghai and may contribute to the rapid increase in bacterial resistance to quinolones in China...
  30. pmc Emerging plasmid-mediated quinolone resistance associated with the qnr gene in Klebsiella pneumoniae clinical isolates in the United States
    Minggui Wang
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Antimicrob Agents Chemother 48:1295-9. 2004
    ..Plasmid-determined quinolone resistance contributes to the increasing quinolone resistance of K. pneumoniae isolates and to the linkage previously observed between resistance to quinolones and the latest beta-lactam antibiotics...
  31. pmc Mechanistic and structural analysis of aminoglycoside N-acetyltransferase AAC(6')-Ib and its bifunctional, fluoroquinolone-active AAC(6')-Ib-cr variant
    Matthew W Vetting
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 47:9825-35. 2008
    ..On the basis of kinetic properties, the pH dependence of the kinetic parameters, and structural information, we propose an acid/base-assisted reaction catalyzed by AAC(6')-Ib-wt and the AAC(6')-Ib-cr variant involving a ternary complex...
  32. pmc Beta-lactamase nomenclature
    George A Jacoby
    J Clin Microbiol 43:6220. 2005

Research Grants8

  1. PLASMID MEDIATED QUINOLONE RESISTANCE
    George Jacoby; Fiscal Year: 2001
    ..Understanding how qnr acts may help to curtail the rise in quinolone resistance and may also provide fundamental insights into aspects of DNA replication. ..
  2. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2007
    ....