Dirk Zajonc

Summary

Affiliation: La Jolla Institute for Allergy and Immunology
Country: USA

Publications

  1. pmc CD1 mediated T cell recognition of glycolipids
    Dirk M Zajonc
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Curr Opin Struct Biol 17:521-9. 2007
  2. pmc Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions
    Ivana Nemčovičová
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
    PLoS Pathog 9:e1003224. 2013
  3. pmc The Vα14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode
    Yali Li
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Exp Med 207:2383-93. 2010
  4. pmc Crystal structures of bovine CD1d reveal altered αGalCer presentation and a restricted A' pocket unable to bind long-chain glycolipids
    Jing Wang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
    PLoS ONE 7:e47989. 2012
  5. pmc Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens
    Enrico Girardi
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 13:851-6. 2012
  6. pmc Unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for NKT cells
    Enrico Girardi
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
    PLoS Biol 9:e1001189. 2011
  7. pmc The crystal structure of avian CD1 reveals a smaller, more primordial antigen-binding pocket compared to mammalian CD1
    Dirk M Zajonc
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:17925-30. 2008
  8. pmc Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells
    Bo Pei
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, California, USA
    Ann N Y Acad Sci 1253:68-79. 2012
  9. pmc Role of lipid trimming and CD1 groove size in cellular antigen presentation
    Tan Yun Cheng
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 25:2989-99. 2006
  10. pmc Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d
    Douglass Wu
    Department of Chemistry and Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:3972-7. 2006

Research Grants

Collaborators

Detail Information

Publications23

  1. pmc CD1 mediated T cell recognition of glycolipids
    Dirk M Zajonc
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Curr Opin Struct Biol 17:521-9. 2007
    ....
  2. pmc Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions
    Ivana Nemčovičová
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
    PLoS Pathog 9:e1003224. 2013
    ..Therefore, the breadth of UL141-mediated effects indicates that HCMV has evolved sophisticated strategies to evade the immune system by modulating multiple effector pathways...
  3. pmc The Vα14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode
    Yali Li
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Exp Med 207:2383-93. 2010
    ..We propose that the TCR of iNKT cells binds with a conserved footprint onto CD1d, regardless of the bound glycolipid antigen, and that for microbial antigens this unique binding mode requires TCR-initiated conformational changes...
  4. pmc Crystal structures of bovine CD1d reveal altered αGalCer presentation and a restricted A' pocket unable to bind long-chain glycolipids
    Jing Wang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
    PLoS ONE 7:e47989. 2012
    ..The altered αGalCer presentation by boCD1d also explains its lack of cross-activation of mouse iNKT cells and raises the interesting question of the nature and function of bovine lipid-reactive T cells...
  5. pmc Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens
    Enrico Girardi
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 13:851-6. 2012
    ..Type II NKT cell TCRs, therefore, recognize CD1d-sulfatide complexes by a distinct recognition mechanism characterized by the TCR-binding features of both iNKT cells and conventional peptide-reactive T cells...
  6. pmc Unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for NKT cells
    Enrico Girardi
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
    PLoS Biol 9:e1001189. 2011
    ..Therefore, our studies illuminate the mechanism of glycolipid recognition for antigens from important pathogens...
  7. pmc The crystal structure of avian CD1 reveals a smaller, more primordial antigen-binding pocket compared to mammalian CD1
    Dirk M Zajonc
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:17925-30. 2008
    ..Because birds and mammals share a common ancestor, but the rate of evolution is slower in birds than in mammals, the chCD1-2-binding groove probably represents a more primordial CD1-binding groove...
  8. pmc Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells
    Bo Pei
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, California, USA
    Ann N Y Acad Sci 1253:68-79. 2012
    ..In this review, we summarize progress on identifying the sources of microbe-derived glycolipid antigens recognized by NKT cells and the biochemical basis for their recognition...
  9. pmc Role of lipid trimming and CD1 groove size in cellular antigen presentation
    Tan Yun Cheng
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 25:2989-99. 2006
    ..Lipids are loaded in an intact form, so that they likely protrude through a portal near the bottom of the groove, which represents an escape hatch for long lipids from mycobacterial pathogens...
  10. pmc Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d
    Douglass Wu
    Department of Chemistry and Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:3972-7. 2006
    ....
  11. pmc Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity
    Dirk M Zajonc
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 202:1517-26. 2005
    ..These structure and binding data on sulfatide presentation by CD1d have important implications for the design of therapeutics that target T cells reactive for myelin glycolipids in autoimmune diseases of the central nervous system...
  12. ncbi request reprint Molecular mechanism of lipopeptide presentation by CD1a
    Dirk M Zajonc
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Immunity 22:209-19. 2005
    ..Thus, this structural study illustrates how a single chain lipid can be presented by CD1 and that the peptide moiety of the lipopeptide is recognized by the TCR...
  13. ncbi request reprint CD1 assembly and the formation of CD1-antigen complexes
    David L Hava
    Lymphocyte Biology Section, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Curr Opin Immunol 17:88-94. 2005
    ....
  14. ncbi request reprint T cell activation by lipopeptide antigens
    D Branch Moody
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Smith Building Room 514, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Science 303:527-31. 2004
    ..These studies identify a means of intracellular pathogen detection and identify lipopeptides as a biochemical class of antigens for T cells, which, like conventional peptides, have a potential for marked structural diversity...
  15. pmc pH-dependent interdomain tethers of CD1b regulate its antigen capture
    Miguel Relloso
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Smith Building Room 514, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Immunity 28:774-86. 2008
    ..We propose that ionic tethers act as molecular switches that respond to pH fluxes during endosomal recycling and regulate the conformation of the CD1 heavy chain to control the size and rate of antigens captured...
  16. pmc Two canine CD1a proteins are differentially expressed in skin
    Frank A Looringh van Beeck
    Department of Infectious Diseases and Immunology, University Utrecht, Yalelaan 1, 3584 CL, Utrecht, The Netherlands
    Immunogenetics 60:315-24. 2008
    ..cDNA sequencing and expressed sequence tag sequences confirmed the existence of a short, human CD1a-like cytoplasmic tail of four amino acids, of an intermediate length form of 15 amino acids, and of a long form of 31 amino acids...
  17. pmc Crystal structures of mouse CD1d-iGb3 complex and its cognate Valpha14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids
    Dirk M Zajonc
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    J Mol Biol 377:1104-16. 2008
    ..Thus, the same TCR may adopt alternative modes of recognition for these foreign and self-ligands for NKT cell activation...
  18. ncbi request reprint Structural characterization of mycobacterial phosphatidylinositol mannoside binding to mouse CD1d
    Dirk M Zajonc
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Immunol 177:4577-83. 2006
    ....
  19. ncbi request reprint Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria
    Yuki Kinjo
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    Nat Immunol 7:978-86. 2006
    ....
  20. pmc Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor
    Dirk M Zajonc
    Department of Molecular Biology and The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Immunol 6:810-8. 2005
    ....
  21. ncbi request reprint T-cell activation by lipopeptide antigens
    Ildiko Van Rhijn
    Division of Infection and Immunity, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Curr Opin Immunol 17:222-9. 2005
    ..These findings expand the range of known antigens for T cells and raise the intriguing possibility that CD1, similar to MHC class I and II molecules, enables T cells to discriminate among peptide sequences...
  22. ncbi request reprint Anatomy of CD1-lipid antigen complexes
    D Branch Moody
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Smith Building, Room 514, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 5:387-99. 2005
    ....
  23. ncbi request reprint Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A
    Dirk M Zajonc
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Immunol 4:808-15. 2003
    ..The headgroup is anchored in the A'-F' junction and protrudes into the F' pocket for TCR recognition. Because the A' pocket is narrow with a fixed terminus, it can act as a molecular 'ruler' to select alkyl chains of a particular length...

Research Grants3

  1. Structural Immunology of CD1 and CD1-TCR Complexes
    Dirk M Zajonc; Fiscal Year: 2010
    ..Understanding the functional properties of these cell types at a molecular level is crucial for the future development of novel chemotherapeutic agents or adjuvants to combat both diseases. ..
  2. Structural Immunology of CD1 and CD1-TCR Complexes
    Dirk Zajonc; Fiscal Year: 2009
    ..Understanding the functional properties of these cell types at a molecular level is crucial for the future development of novel chemotherapeutic agents or adjuvants to combat both diseases. ..