Research Topics
| Dirk ZajoncSummaryAffiliation: La Jolla Institute for Allergy and Immunology Country: USA Publications
Research Grants
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Detail Information
Publications
CD1 mediated T cell recognition of glycolipidsDirk M Zajonc
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
Curr Opin Struct Biol 17:521-9. 2007....- The crystal structure of avian CD1 reveals a smaller, more primordial antigen-binding pocket compared to mammalian CD1Dirk M Zajonc
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 105:17925-30. 2008..Because birds and mammals share a common ancestor, but the rate of evolution is slower in birds than in mammals, the chCD1-2-binding groove probably represents a more primordial CD1-binding groove... - Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cellsBo Pei
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, California, USA
Ann N Y Acad Sci 1253:68-79. 2012..In this review, we summarize progress on identifying the sources of microbe-derived glycolipid antigens recognized by NKT cells and the biochemical basis for their recognition... - Role of lipid trimming and CD1 groove size in cellular antigen presentationTan Yun Cheng
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
EMBO J 25:2989-99. 2006..Lipids are loaded in an intact form, so that they likely protrude through a portal near the bottom of the groove, which represents an escape hatch for long lipids from mycobacterial pathogens... - Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1dDouglass Wu
Department of Chemistry and Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 103:3972-7. 2006.... - Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunityDirk M Zajonc
Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Exp Med 202:1517-26. 2005..These structure and binding data on sulfatide presentation by CD1d have important implications for the design of therapeutics that target T cells reactive for myelin glycolipids in autoimmune diseases of the central nervous system... 
CD1 assembly and the formation of CD1-antigen complexesDavid L Hava
Lymphocyte Biology Section, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
Curr Opin Immunol 17:88-94. 2005....- T cell activation by lipopeptide antigensD Branch Moody
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Smith Building Room 514, 1 Jimmy Fund Way, Boston, MA 02115, USA
Science 303:527-31. 2004..These studies identify a means of intracellular pathogen detection and identify lipopeptides as a biochemical class of antigens for T cells, which, like conventional peptides, have a potential for marked structural diversity... - Molecular mechanism of lipopeptide presentation by CD1aDirk M Zajonc
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Immunity 22:209-19. 2005..Thus, this structural study illustrates how a single chain lipid can be presented by CD1 and that the peptide moiety of the lipopeptide is recognized by the TCR... - pH-dependent interdomain tethers of CD1b regulate its antigen captureMiguel Relloso
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Smith Building Room 514, 1 Jimmy Fund Way, Boston, MA 02115, USA
Immunity 28:774-86. 2008..We propose that ionic tethers act as molecular switches that respond to pH fluxes during endosomal recycling and regulate the conformation of the CD1 heavy chain to control the size and rate of antigens captured... - Two canine CD1a proteins are differentially expressed in skinFrank A Looringh van Beeck
Department of Infectious Diseases and Immunology, University Utrecht, Yalelaan 1, 3584 CL, Utrecht, The Netherlands
Immunogenetics 60:315-24. 2008..cDNA sequencing and expressed sequence tag sequences confirmed the existence of a short, human CD1a-like cytoplasmic tail of four amino acids, of an intermediate length form of 15 amino acids, and of a long form of 31 amino acids... - Crystal structures of mouse CD1d-iGb3 complex and its cognate Valpha14 T cell receptor suggest a model for dual recognition of foreign and self glycolipidsDirk M Zajonc
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
J Mol Biol 377:1104-16. 2008..Thus, the same TCR may adopt alternative modes of recognition for these foreign and self-ligands for NKT cell activation... - Structure and function of a potent agonist for the semi-invariant natural killer T cell receptorDirk M Zajonc
Department of Molecular Biology and The Scripps Research Institute, La Jolla, California 92037, USA
Nat Immunol 6:810-8. 2005.... - Structural characterization of mycobacterial phosphatidylinositol mannoside binding to mouse CD1dDirk M Zajonc
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Immunol 177:4577-83. 2006.... - Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteriaYuki Kinjo
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
Nat Immunol 7:978-86. 2006.... - Anatomy of CD1-lipid antigen complexesD Branch Moody
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Smith Building, Room 514, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
Nat Rev Immunol 5:387-99. 2005.... - T-cell activation by lipopeptide antigensIldiko Van Rhijn
Division of Infection and Immunity, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
Curr Opin Immunol 17:222-9. 2005..These findings expand the range of known antigens for T cells and raise the intriguing possibility that CD1, similar to MHC class I and II molecules, enables T cells to discriminate among peptide sequences... - Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 ADirk M Zajonc
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Immunol 4:808-15. 2003..The headgroup is anchored in the A'-F' junction and protrudes into the F' pocket for TCR recognition. Because the A' pocket is narrow with a fixed terminus, it can act as a molecular 'ruler' to select alkyl chains of a particular length...
Research Grants
- Structural Immunology of CD1 and CD1-TCR ComplexesDirk M Zajonc; Fiscal Year: 2010..Understanding the functional properties of these cell types at a molecular level is crucial for the future development of novel chemotherapeutic agents or adjuvants to combat both diseases. ..