STEPHEN PHILIP SCHOENBERGER

Summary

Affiliation: La Jolla Institute for Allergy and Immunology
Country: USA

Publications

  1. ncbi T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    S P Schoenberger
    Department of Immunohematology and Blood Bank, University Hospital Leiden, The Netherlands
    Nature 393:480-3. 1998
  2. ncbi Efficient direct priming of tumor-specific cytotoxic T lymphocyte in vivo by an engineered APC
    S P Schoenberger
    Department of Immunohematology and Blood Bank, University Hospital Leiden, The Netherlands
    Cancer Res 58:3094-100. 1998
  3. ncbi Cross-priming of CTL responses in vivo does not require antigenic peptides in the endoplasmic reticulum of immunizing cells
    S P Schoenberger
    Department of Immunohematology and Blood Bank, University Hospital Leiden, The Netherlands
    J Immunol 161:3808-12. 1998
  4. ncbi Stimulation via CD40 can substitute for CD4 T cell function in preventing reactivation of a latent herpesvirus
    S R Sarawar
    Divisions of Molecular Immunology and Immune Regulation, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 98:6325-9. 2001
  5. ncbi B7-mediated costimulation of CD4 T cells constrains cytomegalovirus persistence
    Ramon Arens
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Virol 85:390-6. 2011

Research Grants

  1. Programming of CD8+ T Cell Tolerance by B Cell APC
    Stephen Schoenberger; Fiscal Year: 2007
  2. TRAIL-mediated regulation of T help for CTL
    Stephen Schoenberger; Fiscal Year: 2009
  3. TRAIL-mediated regulation of T help for CTL
    Stephen Schoenberger; Fiscal Year: 2007
  4. MANIPULATION OF CD40 CD40L IN CTL BASED IMMUNOTHERAPY
    Stephen Schoenberger; Fiscal Year: 2004
  5. Programming of CD8+ T Cell Tolerance by B Cell APC
    STEPHEN PHILIP SCHOENBERGER; Fiscal Year: 2010

Collaborators

  • R Offringa
  • E Goulmy
  • S R Sarawar
  • Ramon Arens
  • Min J Her
  • Andrea Loewendorf
  • Carl F Ware
  • Edith Janssen
  • Chris A Benedict
  • Kirsten Schneider-Ohrum
  • Geoffrey R Shellam

Detail Information

Publications5

  1. ncbi T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    S P Schoenberger
    Department of Immunohematology and Blood Bank, University Hospital Leiden, The Netherlands
    Nature 393:480-3. 1998
    ..Blockade of CD40L inhibits CTL priming; this inhibition is overcome by signalling through CD40. CD40-CD40L interactions are therefore vital in the delivery of T-cell help for CTL priming...
  2. ncbi Efficient direct priming of tumor-specific cytotoxic T lymphocyte in vivo by an engineered APC
    S P Schoenberger
    Department of Immunohematology and Blood Bank, University Hospital Leiden, The Netherlands
    Cancer Res 58:3094-100. 1998
    ....
  3. ncbi Cross-priming of CTL responses in vivo does not require antigenic peptides in the endoplasmic reticulum of immunizing cells
    S P Schoenberger
    Department of Immunohematology and Blood Bank, University Hospital Leiden, The Netherlands
    J Immunol 161:3808-12. 1998
    ..These results indicate that, although purified peptide/glycoprotein 96 complexes are potent immunogens, the mechanism of CTL cross-priming in vivo does not depend upon antigenic peptides in the ER of immunizing cells...
  4. ncbi Stimulation via CD40 can substitute for CD4 T cell function in preventing reactivation of a latent herpesvirus
    S R Sarawar
    Divisions of Molecular Immunology and Immune Regulation, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 98:6325-9. 2001
    ....
  5. ncbi B7-mediated costimulation of CD4 T cells constrains cytomegalovirus persistence
    Ramon Arens
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Virol 85:390-6. 2011
    ..Together, these data reveal a requirement for B7-mediated signaling in regulating the CMV-specific CD4 T cell response and establishing host-virus equilibrium...

Research Grants13

  1. Programming of CD8+ T Cell Tolerance by B Cell APC
    Stephen Schoenberger; Fiscal Year: 2007
    ..The results of these studies will shed important new light on the APC function of normal and transformed B cells, and will allow the development of much-needed new strategies for enhancement of immune responses to B cell tumors. ..
  2. TRAIL-mediated regulation of T help for CTL
    Stephen Schoenberger; Fiscal Year: 2009
    ....
  3. TRAIL-mediated regulation of T help for CTL
    Stephen Schoenberger; Fiscal Year: 2007
    ....
  4. MANIPULATION OF CD40 CD40L IN CTL BASED IMMUNOTHERAPY
    Stephen Schoenberger; Fiscal Year: 2004
    ..It is hoped that this project will result in a superior animal model in which to explore factors that influence the balance between tumor control and autoimmunity in CTL-based immunotherapy. ..
  5. Programming of CD8+ T Cell Tolerance by B Cell APC
    STEPHEN PHILIP SCHOENBERGER; Fiscal Year: 2010
    ..The results of these studies will shed important new light on the APC function of normal and transformed B cells, and will allow the development of much-needed new strategies for enhancement of immune responses to B cell tumors. ..