Ugur Ozerdem

Summary

Affiliation: La Jolla Institute for Molecular Medicine
Country: USA

Publications

  1. pmc A simple method for measuring interstitial fluid pressure in cancer tissues
    Ugur Ozerdem
    La Jolla Institute for Molecular Medicine, 4570 Executive Drive, Suite 100, San Diego, California 92121, USA
    Microvasc Res 70:116-20. 2005
  2. pmc Targeting pericytes diminishes neovascularization in orthotopic uveal melanoma in nerve/glial antigen 2 proteoglycan knockout mouse
    Ugur Ozerdem
    La Jolla Institute for Molecular Medicine, San Diego, Calif, USA
    Ophthalmic Res 38:251-4. 2006
  3. ncbi request reprint Targeting of pericytes diminishes neovascularization and lymphangiogenesis in prostate cancer
    Ugur Ozerdem
    La Jolla Institute for Molecular Medicine, San Diego, California 92121, USA
    Prostate 66:294-304. 2006
  4. pmc Contribution of bone marrow-derived pericyte precursor cells to corneal vasculogenesis
    Ugur Ozerdem
    La Jolla Institute for Molecular Medicine, CA 92121, USA
    Invest Ophthalmol Vis Sci 46:3502-6. 2005
  5. pmc Early contribution of pericytes to angiogenic sprouting and tube formation
    Ugur Ozerdem
    La Jolla Institute for Molecular Medicine, Vascular Biology Division, 4570 Executive Drive, Suite 100, La Jolla, CA 92121, USA
    Angiogenesis 6:241-9. 2003
  6. pmc Pathological angiogenesis is reduced by targeting pericytes via the NG2 proteoglycan
    Ugur Ozerdem
    La Jolla Institute for Molecular Medicine, Vascular Biology Division, La Jolla, California, USA
    Angiogenesis 7:269-76. 2004
  7. pmc Targeting neovascular pericytes in neurofibromatosis type 1
    Ugur Ozerdem
    Vascular Biology Division, La Jolla Institute for Molecular Medicine, 4570 Executive Drive, Suite 100, San Diego, California, 92121, USA
    Angiogenesis 7:307-11. 2004
  8. ncbi request reprint NG2 proteoglycan expression by pericytes in pathological microvasculature
    Ugur Ozerdem
    Cancer Research Center, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Microvasc Res 63:129-34. 2002
  9. ncbi request reprint Plastic casting of embryonic, placental, and tumor vasculature in the mouse
    Ugur Ozerdem
    Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Microvasc Res 64:486-90. 2002
  10. pmc Reversal of cellular roles in angiogenesis: implications for anti-angiogenic therapy
    Daniela Virgintino
    La Jolla Institute for Molecular Medicine, San Diego, Calif, USA
    J Vasc Res 45:129-31. 2008

Collaborators

Detail Information

Publications17

  1. pmc A simple method for measuring interstitial fluid pressure in cancer tissues
    Ugur Ozerdem
    La Jolla Institute for Molecular Medicine, 4570 Executive Drive, Suite 100, San Diego, California 92121, USA
    Microvasc Res 70:116-20. 2005
    ..Knocking out NG2 proteoglycan on vasculogenic and angiogenic pericytes reduced interstitial fluid pressure in melanoma from +4.9 cm H2O to -0.4 cm H2O (P=0.0054 Mann-Whitney U test)...
  2. pmc Targeting pericytes diminishes neovascularization in orthotopic uveal melanoma in nerve/glial antigen 2 proteoglycan knockout mouse
    Ugur Ozerdem
    La Jolla Institute for Molecular Medicine, San Diego, Calif, USA
    Ophthalmic Res 38:251-4. 2006
    ..Inhibition of pericytes through NG2 proteoglycan decreased neovascularization and tumor end volume, rendering pericytes and NG2 proteoglycan potential cellular and molecular therapeutic targets in uveal melanoma...
  3. ncbi request reprint Targeting of pericytes diminishes neovascularization and lymphangiogenesis in prostate cancer
    Ugur Ozerdem
    La Jolla Institute for Molecular Medicine, San Diego, California 92121, USA
    Prostate 66:294-304. 2006
    ..The walls of capillaries in prostate cancer are composed of endothelial cells, and pericytes. NG2 is a transmembrane proteoglycan on nascent pericytes with a functional role in neovascularization...
  4. pmc Contribution of bone marrow-derived pericyte precursor cells to corneal vasculogenesis
    Ugur Ozerdem
    La Jolla Institute for Molecular Medicine, CA 92121, USA
    Invest Ophthalmol Vis Sci 46:3502-6. 2005
    ..In this investigation, multichannel laser scanning confocal microscopy and quantitative image analysis were used to study the fate of BM-derived hematopoietic precursor cells in corneal neovascularization...
  5. pmc Early contribution of pericytes to angiogenic sprouting and tube formation
    Ugur Ozerdem
    La Jolla Institute for Molecular Medicine, Vascular Biology Division, 4570 Executive Drive, Suite 100, La Jolla, CA 92121, USA
    Angiogenesis 6:241-9. 2003
    ..The ability to study these precocious contributions of pericytes to neovascularization depends heavily on the use of NG2 and PDGF beta -receptor as reliable early markers for activated pericytes...
  6. pmc Pathological angiogenesis is reduced by targeting pericytes via the NG2 proteoglycan
    Ugur Ozerdem
    La Jolla Institute for Molecular Medicine, Vascular Biology Division, La Jolla, California, USA
    Angiogenesis 7:269-76. 2004
    ..These experiments therefore demonstrate both the functional importance of NG2 in pericyte development and the feasibility of using pericytes as anti-angiogenic targets...
  7. pmc Targeting neovascular pericytes in neurofibromatosis type 1
    Ugur Ozerdem
    Vascular Biology Division, La Jolla Institute for Molecular Medicine, 4570 Executive Drive, Suite 100, San Diego, California, 92121, USA
    Angiogenesis 7:307-11. 2004
    ..Angiogenesis is accelerated in NF1 due to hyperproliferation of pericytes and endothelial cells. Mitotically activated NG2-positive pericytes, and endothelial cells may serve as potential therapeutic targets in NF1...
  8. ncbi request reprint NG2 proteoglycan expression by pericytes in pathological microvasculature
    Ugur Ozerdem
    Cancer Research Center, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Microvasc Res 63:129-34. 2002
  9. ncbi request reprint Plastic casting of embryonic, placental, and tumor vasculature in the mouse
    Ugur Ozerdem
    Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Microvasc Res 64:486-90. 2002
  10. pmc Reversal of cellular roles in angiogenesis: implications for anti-angiogenic therapy
    Daniela Virgintino
    La Jolla Institute for Molecular Medicine, San Diego, Calif, USA
    J Vasc Res 45:129-31. 2008
  11. ncbi request reprint The effect of prinomastat (AG3340), a synthetic inhibitor of matrix metalloproteinases, on uveal melanoma rabbit model
    Ugur Ozerdem
    Shiley Eye Center, University of California San Diego, 9415 Campus Point Drive, La Jolla, CA 92093 0946, USA
    Curr Eye Res 24:86-91. 2002
    ..We studied the effects of intravitreally administered prinomastat on the take rate and growth of uveal melanoma after xenograft implantation in rabbit uveal melanoma model...
  12. pmc A simple nonmydriatic self-retinal imaging procedure using a Kowa Genesis-D hand-held digital fundus camera
    Ugur Ozerdem
    La Jolla Bioengineering Institute, La Jolla, Calif 92037, USA
    Ophthalmic Res 42:125-7. 2009
    ..This simple technique will be useful to clinical physiologists conducting microgravity research, as well as for the studies of high-altitude medicine and aviation physiology...
  13. ncbi request reprint Effect of anti-cytomegalovirus therapy on the incidence of immune recovery uveitis in AIDS patients with healed cytomegalovirus retinitis
    Mi Kyoung Song
    Department of Ophthalmology, Shiley Eye Center, University of California San Diego, La Jolla, California 92093 0946, USA
    Am J Ophthalmol 136:696-702. 2003
    ..To determine the association between anticytomegalovirus (CMV) maintenance therapy after immune recovery and immune recovery uveitis in acquired immunodeficiency syndrome (AIDS) patients on highly active antiretroviral therapy (HAART)...
  14. pmc Measuring interstitial fluid pressure with fiberoptic pressure transducers
    Ugur Ozerdem
    La Jolla Bioengineering Institute, 505 Coast Boulevard, South Suite 406, La Jolla, California 92037, USA
    Microvasc Res 77:226-9. 2009
    ....
  15. pmc Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells
    Iiro Rajantie
    Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Blood 104:2084-6. 2004
    ..Thus, the major contribution of the BM to angiogenic processes is not endothelial, but may come from progenitors for periendothelial vascular mural and hematopoietic effector cells...
  16. ncbi request reprint A molecular mimic demonstrates that phosphorylated human prolactin is a potent anti-angiogenic hormone
    Eric Ueda
    Division of Biomedical Sciences, University of California, Riverside, CA 92521, USA
    Endocr Relat Cancer 13:95-111. 2006
    ..These findings suggest that circulating levels of phosphorylated PRL may influence the progression of cancer and, furthermore, that S179D PRL may be a useful anti-angiogenic therapeutic...
  17. pmc Ultrastructure of islet microcirculation, pericytes and the islet exocrine interface in the HIP rat model of diabetes
    Melvin R Hayden
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    Exp Biol Med (Maywood) 233:1109-23. 2008
    ..The transgenic human islet amyloid polypeptide (HIP) rat model of type 2 diabetes mellitus (T2DM) parallels the functional and structural changes in human islets with T2DM...

Research Grants2

  1. PERICYTES IN ANGIOGENESIS IN NEUROFIBROMATOSIS TYPE 1
    Ugur Ozerdem; Fiscal Year: 2003
    ..3) The investigators will examine the effect of the NF1-/- and NF1-/+ genotypes on microvascularization in embryonic development. The ability of NG2 ablation to rescue micro and macrovascular defects will be determined. ..
  2. Targeting Vasculogenesis and Interstitial Hypertension in Neurofibromatosis Type1
    Ugur Ozerdem; Fiscal Year: 2007
    ....