Research Topics
Genomes and Genes
| Yun Cai LiuSummaryAffiliation: La Jolla Institute for Allergy and Immunology Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Immunity by ubiquitylation: a reversible process of modificationYun Cai Liu
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
Nat Rev Immunol 5:941-52. 2005..This Review covers recent progress in our understanding of protein ubiquitylation in the immune system...- Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylationChun Yang
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92130, USA
Mol Cell 21:135-41. 2006..Thus, in contrast to the activation pathway mediated by serine/threonine phosphorylation, tyrosine phosphorylation of Itch plays a negative role in modulating Itch-promoted ubiquitination... 
The E3 ubiquitin ligase Itch in T cell activation, differentiation, and toleranceYun Cai Liu
Division of Cell Biololgy, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
Semin Immunol 19:197-205. 2007....- Cbl and Cbl-b in T-cell regulationYun Cai Liu
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
Trends Immunol 23:140-3. 2002..The structural similarity and ubiquitous expression of Cbl and Cbl-b suggest, however, that they might also have overlapping functions in setting the thresholds for thymocyte selection and mature T-cell signaling... - Ubiquitin ligases and the immune responseYun Cai Liu
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
Annu Rev Immunol 22:81-127. 2004..This review discusses our current understanding of E3 Ub ligases in both innate and adaptive immunity. Such knowledge may facilitate the development of novel therapeutic approaches for immunological diseases... - Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligaseYuan Shao
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
EMBO Rep 4:425-31. 2003..Thus, Cbl negatively regulates Rap1 activation, probably through a proteolysis-independent E3-ubiquitin-ligase activity of Cbl that modulates protein-protein interactions... - Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase ItchMin Gao
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
Science 306:271-5. 2004..This pathway modulates cytokine production by effector T cells... - Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-bWenying Zhang
La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
J Biol Chem 278:23978-83. 2003..Thus, Cbl-b plays a negative role in Crk-L-C3G-mediated Rap1 and LFA-1 activation in T cells... - Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiationDeyu Fang
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
Nat Immunol 3:281-7. 2002..These results provide a molecular link between Itch deficiency and the aberrant activation of immune responses in itchy mice... - K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signalingHaining Huang
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
Immunity 33:60-70. 2010..Thus, the present study reveals unconventional K33-linked polyubiquitination in nonproteolytic regulation of cell-surface-receptor-mediated signal transduction... - Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylationYongli Bai
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
Mol Cell 15:825-31. 2004..This study reveals a previously unrecognized positive TGF-beta signaling pathway via proteolysis-independent ubiquitination... - Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammationK Venuprasad
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
J Clin Invest 116:1117-26. 2006..This study suggests that MEKK1-JNK signaling regulates Itch E3 ligase-mediated tolerogenic process in Th2 cells. These findings have therapeutic implications for allergic diseases... - Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cellsYohsuke Harada
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
J Exp Med 207:1381-91. 2010..This study reveals that Foxo factors promote transcription of the Foxp3 gene in induced T reg cells, and thus provides new mechanistic insight into Foxo-mediated T cell regulation... - Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1Satoshi Kojo
La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 106:17847-51. 2009..The study identifies an important signaling pathway linking Cbl-b-induced monoubiquitination to NFkappaB activation in NKT cell anergy induction, which may help design approaches for human cancer therapy... - Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy inductionMyung Shin Jeon
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
Immunity 21:167-77. 2004..Our results show a critical role for Cbl-b in the regulation of peripheral tolerance and anergy of T cells... - Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational changeEwen Gallagher
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
Proc Natl Acad Sci U S A 103:1717-22. 2006.... - Differential regulation of the B cell receptor-mediated signaling by the E3 ubiquitin ligase CblYuan Shao
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
J Biol Chem 279:43646-53. 2004.... - Regulation of immune responses by E3 ubiquitin-protein ligasesNan Fang
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, Calif, USA
Curr Dir Autoimmun 5:161-75. 2002 - Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defectMatthias Hundt
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
Immunity 24:513-22. 2006.... - Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signalingHyung Seung Jin
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 110:624-9. 2013..This study thus identifies an important role for protein neddylation in T-cell function, which may serve as a therapeutic target for inflammatory diseases... - The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1K Venuprasad
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
Nat Immunol 9:245-53. 2008..These results suggest TIEG and Itch contribute to a ubiquitin-dependent nonproteolytic pathway that regulates inducible Foxp3 expression and the control of allergic responses... - Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathwayYou Wei Zhang
Signal Transduction Program, The Burnham Institute, La Jolla, California 92037, USA
Mol Cell 19:607-18. 2005..Proteolysis of activated Chk1 may promote checkpoint termination under normal conditions, and may play an important role in the cytotoxic effects of CPT and related anticancer drugs... - Immune regulation by ubiquitin conjugationK Venuprasad
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
Adv Exp Med Biol 584:207-17. 2006 - The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itchAndreas Traweger
Institute of Molecular Biology, Austrian Academy of Sciences, 5020 Salzburg, Austria
J Biol Chem 277:10201-8. 2002..In addition, we provide evidence that Itch is specifically involved in the ubiquitination of occludin in vivo, and that the degradation of occludin is sensitive to proteasome inhibition... - The ubiquitin-protein ligase Itch regulates p73 stabilityMario Rossi
Department of Biology, University of Rome Tor Vergata, Rome, Italy
EMBO J 24:836-48. 2005..In conclusion, we have identified a key mechanism in the control of p73 protein levels both in normal as well as in stress conditions... - The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnoverLufen Chang
Division of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope, City of Hope National Medical Center, 1500 E Duarte Road, KCRB 3009, Duarte, CA 91010, USA
Cell 124:601-13. 2006..Thus, JNK antagonizes NF-kappaB during TNFalpha signaling by promoting the proteasomal elimination of c-FLIP(L)... - Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteinsVigo Heissmeyer
Center for Blood Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Nat Immunol 5:255-65. 2004..Our results define a complex molecular program that links gene transcription induced by calcium and calcineurin to a paradoxical impairment of signal transduction in anergic T cells... - The chaperone protein 14-3-3 interacts with 3BP2/SH3BP2 and regulates its adapter functionIsabelle Foucault
INSERM U343 and Laboratoire d Immunologie, hôpital de l Archet I, Nice 06202, France
J Biol Chem 278:7146-53. 2003..Indeed, a 3BP2 mutant protein incapable of binding 14-3-3 showed increased capacity to stimulate NFAT transcriptional activities, suggesting that 14-3-3 binding to 3BP2 negatively regulates 3BP2 adapter function in lymphocytes... - A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signallingVigo Heissmeyer
Department of Pathology, Harvard Medical School, CBR Institute for Biomedical Research, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
Novartis Found Symp 267:165-74; discussion 174-9. 2005..Thus Ca(2+)-calcineurin-NFAT signalling links gene transcription to a multi-step programme that leads to impaired signal transduction in anergic T cells...
Research Grants
- Cb1-b in T Cell Activation and ToleranceYun Cai Liu; Fiscal Year: 2006....
- Itch in T Cell Activation and ToleranceYun Cai Liu; Fiscal Year: 2007..The study on Itch is likely to shed light on the biological function of E3 ligases in the induction of T cell tolerance, and may provide insights for therapeutic intervention in immunological diseases. ..
- Itch in T Cell Activation and ToleranceYun Cai Liu; Fiscal Year: 2009..The study on Itch is likely to shed light on the biological function of E3 ligases in the induction of T cell tolerance, and may provide insights for therapeutic intervention in immunological diseases. ..
- Itch in T Cell Activation and ToleranceYun Cai Liu; Fiscal Year: 2010..The study on Itch is likely to shed light on the biological function of E3 ligases in the induction of T cell tolerance, and may provide insights for therapeutic intervention in immunological diseases. ..
- Mechanisms of protein ubiquitination in regulating airway inflammationYun Cai Liu; Fiscal Year: 2010..This proposal is to study the regulatory mechanisms to control excessive T cell activation. The knowledge gained from the proposed research will help design new therapeutic approaches for human allergic diseases. ..
- Itch in T Cell Activation and ToleranceYun Cai Liu; Fiscal Year: 2011..In addition to advancing basic biomedical knowledge, the expected outcomes will lay foundation to new therapeutic strategies. ..
- CBL IN T CELL ACTIVATIONYun Cai Liu; Fiscal Year: 2006..abstract_text> ..
- Regulation on Immune Responses by ItchYun Cai Liu; Fiscal Year: 2002..The study on Itch is likely to shed light on the biological function of E3 ligases in the immune system, and may provide insights for therapeutic intervention in immunological diseases. ..
- CBL IN T CELL ACTIVATIONYun Cai Liu; Fiscal Year: 2002..abstract_text> ..
- Mechanisms of protein ubiquitination in regulating airway inflammationYun Cai Liu; Fiscal Year: 2011..This proposal is to study the regulatory mechanisms to control excessive T cell activation. The knowledge gained from the proposed research will help design new therapeutic approaches for human allergic diseases. ..