Yun Cai Liu

Summary

Affiliation: La Jolla Institute for Allergy and Immunology
Country: USA

Publications

  1. ncbi request reprint Immunity by ubiquitylation: a reversible process of modification
    Yun Cai Liu
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Nat Rev Immunol 5:941-52. 2005
  2. ncbi request reprint Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation
    Chun Yang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92130, USA
    Mol Cell 21:135-41. 2006
  3. pmc The E3 ubiquitin ligase Itch in T cell activation, differentiation, and tolerance
    Yun Cai Liu
    Division of Cell Biololgy, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Semin Immunol 19:197-205. 2007
  4. ncbi request reprint Cbl and Cbl-b in T-cell regulation
    Yun Cai Liu
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Trends Immunol 23:140-3. 2002
  5. ncbi request reprint Ubiquitin ligases and the immune response
    Yun Cai Liu
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Annu Rev Immunol 22:81-127. 2004
  6. ncbi request reprint Regulation of immune responses by E3 ubiquitin-protein ligases
    Nan Fang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, Calif, USA
    Curr Dir Autoimmun 5:161-75. 2002
  7. pmc Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase
    Yuan Shao
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    EMBO Rep 4:425-31. 2003
  8. pmc K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling
    Haining Huang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Immunity 33:60-70. 2010
  9. ncbi request reprint Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch
    Min Gao
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Science 306:271-5. 2004
  10. ncbi request reprint Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation
    Deyu Fang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Nat Immunol 3:281-7. 2002

Research Grants

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Immunity by ubiquitylation: a reversible process of modification
    Yun Cai Liu
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Nat Rev Immunol 5:941-52. 2005
    ..This Review covers recent progress in our understanding of protein ubiquitylation in the immune system...
  2. ncbi request reprint Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation
    Chun Yang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92130, USA
    Mol Cell 21:135-41. 2006
    ..Thus, in contrast to the activation pathway mediated by serine/threonine phosphorylation, tyrosine phosphorylation of Itch plays a negative role in modulating Itch-promoted ubiquitination...
  3. pmc The E3 ubiquitin ligase Itch in T cell activation, differentiation, and tolerance
    Yun Cai Liu
    Division of Cell Biololgy, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Semin Immunol 19:197-205. 2007
    ....
  4. ncbi request reprint Cbl and Cbl-b in T-cell regulation
    Yun Cai Liu
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Trends Immunol 23:140-3. 2002
    ..The structural similarity and ubiquitous expression of Cbl and Cbl-b suggest, however, that they might also have overlapping functions in setting the thresholds for thymocyte selection and mature T-cell signaling...
  5. ncbi request reprint Ubiquitin ligases and the immune response
    Yun Cai Liu
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Annu Rev Immunol 22:81-127. 2004
    ..This review discusses our current understanding of E3 Ub ligases in both innate and adaptive immunity. Such knowledge may facilitate the development of novel therapeutic approaches for immunological diseases...
  6. ncbi request reprint Regulation of immune responses by E3 ubiquitin-protein ligases
    Nan Fang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, Calif, USA
    Curr Dir Autoimmun 5:161-75. 2002
  7. pmc Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase
    Yuan Shao
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    EMBO Rep 4:425-31. 2003
    ..Thus, Cbl negatively regulates Rap1 activation, probably through a proteolysis-independent E3-ubiquitin-ligase activity of Cbl that modulates protein-protein interactions...
  8. pmc K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling
    Haining Huang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Immunity 33:60-70. 2010
    ..Thus, the present study reveals unconventional K33-linked polyubiquitination in nonproteolytic regulation of cell-surface-receptor-mediated signal transduction...
  9. ncbi request reprint Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch
    Min Gao
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Science 306:271-5. 2004
    ..This pathway modulates cytokine production by effector T cells...
  10. ncbi request reprint Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation
    Deyu Fang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Nat Immunol 3:281-7. 2002
    ..These results provide a molecular link between Itch deficiency and the aberrant activation of immune responses in itchy mice...
  11. ncbi request reprint Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-b
    Wenying Zhang
    La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 278:23978-83. 2003
    ..Thus, Cbl-b plays a negative role in Crk-L-C3G-mediated Rap1 and LFA-1 activation in T cells...
  12. pmc Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation
    K Venuprasad
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Clin Invest 116:1117-26. 2006
    ..This study suggests that MEKK1-JNK signaling regulates Itch E3 ligase-mediated tolerogenic process in Th2 cells. These findings have therapeutic implications for allergic diseases...
  13. pmc Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells
    Yohsuke Harada
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Exp Med 207:1381-91. 2010
    ..This study reveals that Foxo factors promote transcription of the Foxp3 gene in induced T reg cells, and thus provides new mechanistic insight into Foxo-mediated T cell regulation...
  14. ncbi request reprint Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation
    Yongli Bai
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Mol Cell 15:825-31. 2004
    ..This study reveals a previously unrecognized positive TGF-beta signaling pathway via proteolysis-independent ubiquitination...
  15. pmc Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1
    Satoshi Kojo
    La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:17847-51. 2009
    ..The study identifies an important signaling pathway linking Cbl-b-induced monoubiquitination to NFkappaB activation in NKT cell anergy induction, which may help design approaches for human cancer therapy...
  16. pmc Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change
    Ewen Gallagher
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Proc Natl Acad Sci U S A 103:1717-22. 2006
    ....
  17. ncbi request reprint Immune regulation by ubiquitin conjugation
    K Venuprasad
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Adv Exp Med Biol 584:207-17. 2006
  18. ncbi request reprint Differential regulation of the B cell receptor-mediated signaling by the E3 ubiquitin ligase Cbl
    Yuan Shao
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 279:43646-53. 2004
    ....
  19. ncbi request reprint Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction
    Myung Shin Jeon
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Immunity 21:167-77. 2004
    ..Our results show a critical role for Cbl-b in the regulation of peripheral tolerance and anergy of T cells...
  20. pmc Regulation of T cell function by the ubiquitin-specific protease USP9X via modulating the Carma1-Bcl10-Malt1 complex
    Yoon Park
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:9433-8. 2013
    ..These results demonstrate that USP9X is a crucial positive regulator of the TCR signaling pathway and is required for T-cell function through the modulation of CBM complex formation...
  21. pmc Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling
    Hyung Seung Jin
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:624-9. 2013
    ..This study thus identifies an important role for protein neddylation in T-cell function, which may serve as a therapeutic target for inflammatory diseases...
  22. ncbi request reprint Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect
    Matthias Hundt
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Immunity 24:513-22. 2006
    ....
  23. pmc The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1
    K Venuprasad
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    Nat Immunol 9:245-53. 2008
    ..These results suggest TIEG and Itch contribute to a ubiquitin-dependent nonproteolytic pathway that regulates inducible Foxp3 expression and the control of allergic responses...
  24. ncbi request reprint Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway
    You Wei Zhang
    Signal Transduction Program, The Burnham Institute, La Jolla, California 92037, USA
    Mol Cell 19:607-18. 2005
    ..Proteolysis of activated Chk1 may promote checkpoint termination under normal conditions, and may play an important role in the cytotoxic effects of CPT and related anticancer drugs...
  25. ncbi request reprint The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells
    Nengming Xiao
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 15:657-66. 2014
    ..The defective TFH differentiation of Itch(-/-) T cells was rectified by deletion of Foxo1. Thus, our results indicate that Itch acts as an essential positive regulator in the differentiation of TFH cells. ..
  26. pmc Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN-λ and elevated secretion of Cxcl10
    Christoph Burkart
    Moores Cancer Center, University of California San Diego, La Jolla, CA, USA
    EMBO Mol Med 5:967-82. 2013
    ..Taken together, our data suggest that targeting Usp18 may be a viable approach to boost antitumour immunity while suppressing the protumour activity of the immune system. ..
  27. pmc The ubiquitin-protein ligase Itch regulates p73 stability
    Mario Rossi
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    EMBO J 24:836-48. 2005
    ..In conclusion, we have identified a key mechanism in the control of p73 protein levels both in normal as well as in stress conditions...
  28. ncbi request reprint The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itch
    Andreas Traweger
    Institute of Molecular Biology, Austrian Academy of Sciences, 5020 Salzburg, Austria
    J Biol Chem 277:10201-8. 2002
    ..In addition, we provide evidence that Itch is specifically involved in the ubiquitination of occludin in vivo, and that the degradation of occludin is sensitive to proteasome inhibition...
  29. ncbi request reprint The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover
    Lufen Chang
    Division of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope, City of Hope National Medical Center, 1500 E Duarte Road, KCRB 3009, Duarte, CA 91010, USA
    Cell 124:601-13. 2006
    ..Thus, JNK antagonizes NF-kappaB during TNFalpha signaling by promoting the proteasomal elimination of c-FLIP(L)...
  30. ncbi request reprint A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling
    Vigo Heissmeyer
    Department of Pathology, Harvard Medical School, CBR Institute for Biomedical Research, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Novartis Found Symp 267:165-74; discussion 174-9. 2005
    ..Thus Ca(2+)-calcineurin-NFAT signalling links gene transcription to a multi-step programme that leads to impaired signal transduction in anergic T cells...
  31. ncbi request reprint Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
    Vigo Heissmeyer
    Center for Blood Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Nat Immunol 5:255-65. 2004
    ..Our results define a complex molecular program that links gene transcription induced by calcium and calcineurin to a paradoxical impairment of signal transduction in anergic T cells...
  32. ncbi request reprint The chaperone protein 14-3-3 interacts with 3BP2/SH3BP2 and regulates its adapter function
    Isabelle Foucault
    INSERM U343 and Laboratoire d Immunologie, hôpital de l Archet I, Nice 06202, France
    J Biol Chem 278:7146-53. 2003
    ..Indeed, a 3BP2 mutant protein incapable of binding 14-3-3 showed increased capacity to stimulate NFAT transcriptional activities, suggesting that 14-3-3 binding to 3BP2 negatively regulates 3BP2 adapter function in lymphocytes...

Research Grants23

  1. Mechanisms of protein ubiquitination in regulating airway inflammation
    Yun Cai Liu; Fiscal Year: 2011
    ..This proposal is to study the regulatory mechanisms to control excessive T cell activation. The knowledge gained from the proposed research will help design new therapeutic approaches for human allergic diseases. ..
  2. CBL IN T CELL ACTIVATION
    Yun Cai Liu; Fiscal Year: 1999
    ..abstract_text> ..
  3. Itch in T Cell Activation and Tolerance
    Yun Cai Liu; Fiscal Year: 2006
    ..The study on Itch is likely to shed light on the biological function of E3 ligases in the induction of T cell tolerance, and may provide insights for therapeutic intervention in immunological diseases. ..
  4. Cb1-b in T Cell Activation and Tolerance
    Yun Cai Liu; Fiscal Year: 2006
    ....
  5. Itch in T Cell Activation and Tolerance
    Yun Cai Liu; Fiscal Year: 2007
    ..The study on Itch is likely to shed light on the biological function of E3 ligases in the induction of T cell tolerance, and may provide insights for therapeutic intervention in immunological diseases. ..
  6. Itch in T Cell Activation and Tolerance
    Yun Cai Liu; Fiscal Year: 2009
    ..The study on Itch is likely to shed light on the biological function of E3 ligases in the induction of T cell tolerance, and may provide insights for therapeutic intervention in immunological diseases. ..
  7. Mechanisms of protein ubiquitination in regulating airway inflammation
    Yun Cai Liu; Fiscal Year: 2009
    ..This proposal is to study the regulatory mechanisms to control excessive T cell activation. The knowledge gained from the proposed research will help design new therapeutic approaches for human allergic diseases. ..
  8. Itch in T Cell Activation and Tolerance
    Yun Cai Liu; Fiscal Year: 2010
    ..The study on Itch is likely to shed light on the biological function of E3 ligases in the induction of T cell tolerance, and may provide insights for therapeutic intervention in immunological diseases. ..
  9. Mechanisms of protein ubiquitination in regulating airway inflammation
    Yun Cai Liu; Fiscal Year: 2010
    ..This proposal is to study the regulatory mechanisms to control excessive T cell activation. The knowledge gained from the proposed research will help design new therapeutic approaches for human allergic diseases. ..
  10. Itch in T Cell Activation and Tolerance
    Yun Cai Liu; Fiscal Year: 2011
    ..In addition to advancing basic biomedical knowledge, the expected outcomes will lay foundation to new therapeutic strategies. ..
  11. CBL IN T CELL ACTIVATION
    Yun Cai Liu; Fiscal Year: 2006
    ..abstract_text> ..
  12. Cb1-b in T Cell Activation and Tolerance
    Yun Cai Liu; Fiscal Year: 2005
    ....
  13. CBL IN T CELL ACTIVATION
    Yun Cai Liu; Fiscal Year: 2005
    ..abstract_text> ..
  14. CBL IN T CELL ACTIVATION
    Yun Cai Liu; Fiscal Year: 2000
    ..abstract_text> ..
  15. CBL IN T CELL ACTIVATION
    Yun Cai Liu; Fiscal Year: 2001
    ..abstract_text> ..
  16. Regulation on Immune Responses by Itch
    Yun Cai Liu; Fiscal Year: 2002
    ..The study on Itch is likely to shed light on the biological function of E3 ligases in the immune system, and may provide insights for therapeutic intervention in immunological diseases. ..
  17. Cb1-b in T Cell Activation and Tolerance
    Yun Cai Liu; Fiscal Year: 2002
    ....
  18. CBL IN T CELL ACTIVATION
    Yun Cai Liu; Fiscal Year: 2002
    ..abstract_text> ..
  19. CBL IN T CELL ACTIVATION
    Yun Cai Liu; Fiscal Year: 2003
    ..abstract_text> ..
  20. Cb1-b in T Cell Activation and Tolerance
    Yun Cai Liu; Fiscal Year: 2003
    ....
  21. Cb1-b in T Cell Activation and Tolerance
    Yun Cai Liu; Fiscal Year: 2004
    ....
  22. CBL IN T CELL ACTIVATION
    Yun Cai Liu; Fiscal Year: 2004
    ..abstract_text> ..