Klaus Ley


Affiliation: La Jolla Institute for Allergy and Immunology
Country: USA


  1. Li J, Ley K. Lymphocyte migration into atherosclerotic plaque. Arterioscler Thromb Vasc Biol. 2015;35:40-9 pubmed publisher
    ..Also, we review the role of their receptors CCR5, CCR6, CCR7, CXCR3, CXCR6, and CXCR2/CXCR4 and the role of the L-selectin in mouse models of atherosclerosis. ..
  2. Wolf D, Li J, Ley K. HGF Guides T Cells into the Heart. Immunity. 2015;42:979-81 pubmed publisher
    ..In this issue of Immunity, Komarowska et al. (2015) describe an autocrine loop that is initiated by cardiac-expressed hepatocyte growth factor to direct T cells into the heart during inflammation and cardiac transplant rejection. ..
  3. Marki A, Esko J, Pries A, Ley K. Role of the endothelial surface layer in neutrophil recruitment. J Leukoc Biol. 2015;98:503-15 pubmed publisher
    ..However, most previous studies considered either only the proadhesive or only the antiadhesive effects of the ESL. An integrated model for the role of the ESL in neutrophil rolling, arrest, and transmigration is needed. ..
  4. Wolf D, Zirlik A, Ley K. Beyond vascular inflammation--recent advances in understanding atherosclerosis. Cell Mol Life Sci. 2015;72:3853-69 pubmed publisher
    ..Ongoing work (J Clin Invest 123:27-36, 2013; Front Immunol 2013; Semin Immunol 31:95-101, 2009) suggests that it may be possible to develop antigen-specific immunomodulatory prevention and therapy-a vaccine against atherosclerosis. ..
  5. Li J, McArdle S, Gholami A, Kimura T, Wolf D, Gerhardt T, et al. CCR5+T-bet+FoxP3+ Effector CD4 T Cells Drive Atherosclerosis. Circ Res. 2016;118:1540-52 pubmed publisher
    ..CCR5(+)CD4 T cells express an unusual combination of transcription factors, FoxP3 and T-bet. Although CCR5Teff express FoxP3, we showed that they are not regulatory and adoptive transfer of these cells exacerbates atherosclerosis. ..
  6. Ley K, Laudanna C, Cybulsky M, Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol. 2007;7:678-89 pubmed
    ..This Review focuses on new aspects of one of the central paradigms of inflammation and immunity--the leukocyte adhesion cascade. ..
  7. Ley K, Zhang H. Dances with leukocytes: how tetraspanin-enriched microdomains assemble to form endothelial adhesive platforms. J Cell Biol. 2008;183:375-6 pubmed publisher
    ..Furthermore, convincing biochemical data suggest that these structures are distinct from lipid rafts. ..
  8. Ley K, Miller Y, Hedrick C. Monocyte and macrophage dynamics during atherogenesis. Arterioscler Thromb Vasc Biol. 2011;31:1506-16 pubmed publisher
    ..In this review, we discuss these and other processes associated with monocytic cell dynamics in the vascular wall and their role in the initiation and progression of atherosclerosis...
  9. Koltsova E, Sundd P, Zarpellon A, Ouyang H, Mikulski Z, Zampolli A, et al. Genetic deletion of platelet glycoprotein Ib alpha but not its extracellular domain protects from atherosclerosis. Thromb Haemost. 2014;112:1252-63 pubmed publisher
    ..Thus, atherosclerosis reduction in mice lacking GPIb? may not result from the defective GPIb?-ligand binding, but more likely is a consequence of functional defects of GPIb?-/- platelets and reduced blood platelet counts. ..


More Information


  1. Mikulski Z, Johnson R, Shaked I, Kim G, Nowyhed H, Goodman W, et al. SAMP1/YitFc mice develop ileitis via loss of CCL21 and defects in dendritic cell migration. Gastroenterology. 2015;148:783-793.e5 pubmed publisher
    ..Loss of CCL21 signaling and DC migration is required for development of ileitis in SAMP mice. Reagents such as R848, which activate DC migration to the MLN, may be developed as treatments for patients with Crohn's disease. ..
  2. Gerhardt T, Ley K. Monocyte trafficking across the vessel wall. Cardiovasc Res. 2015;107:321-30 pubmed publisher