Ichiro Kuwabara

Summary

Affiliation: La Jolla Institute for Allergy and Immunology
Country: USA

Publications

  1. ncbi request reprint Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release
    Ichiro Kuwabara
    Divisions of Allergy and Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 277:3487-97. 2002
  2. pmc Critical role of galectin-3 in phagocytosis by macrophages
    Hideki Sano
    Division of Allergy, La Jolla Institute for Allergy and Immunology, San Diego, California, USA
    J Clin Invest 112:389-97. 2003
  3. ncbi request reprint Sensitizing effect of galectin-7 in urothelial cancer to cisplatin through the accumulation of intracellular reactive oxygen species
    Yoshiyuki Matsui
    Department of Urology, Kyoto University, Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, Japan 606 8507
    Cancer Res 67:1212-20. 2007
  4. ncbi request reprint Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells
    Jurgen Kopitz
    Institut für Molekulare Pathologie, Klinikum der Ruprecht Karls Universtiät, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany
    Oncogene 22:6277-88. 2003
  5. pmc Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation
    Jun Saegusa
    Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, California 95816, USA
    J Invest Dermatol 128:2403-11. 2008
  6. doi request reprint Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7
    Yutaka Inagaki
    Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Isehara, Japan
    Gastroenterology 134:1180-90. 2008
  7. ncbi request reprint Galectins-3 and -7, but not galectin-1, play a role in re-epithelialization of wounds
    Zhiyi Cao
    Department of Ophthalmology, Center for Vision Research and The New England Eye Center, Davis, California 95616, USA
    J Biol Chem 277:42299-305. 2002
  8. ncbi request reprint Identification of peptide ligands for malignancy- and growth-regulating galectins using random phage-display and designed combinatorial peptide libraries
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University, Veterinarstr 13, 80539 Munchen, Germany
    Bioorg Med Chem 13:563-73. 2005
  9. ncbi request reprint Suppression of tumor growth by galectin-7 gene transfer
    Shugo Ueda
    Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, California 95817, USA
    Cancer Res 64:5672-6. 2004
  10. pmc An anti-apoptotic role for galectin-3 in diffuse large B-cell lymphomas
    Katrina K Hoyer
    Department of Pathology and Laboratory Medicine, University of California at Los Angeles School of Medicine, Los Angeles, California 90095 1732, USA
    Am J Pathol 164:893-902. 2004

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release
    Ichiro Kuwabara
    Divisions of Allergy and Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 277:3487-97. 2002
    ..Some of them are potentially contributory to this lectin's proapoptotic function and these include redox-related genes monoamine oxidase B, ryanodine receptor 2, and glutathione S-transferase Mu 3...
  2. pmc Critical role of galectin-3 in phagocytosis by macrophages
    Hideki Sano
    Division of Allergy, La Jolla Institute for Allergy and Immunology, San Diego, California, USA
    J Clin Invest 112:389-97. 2003
    ..Thus, galectin-3 may play an important role in both innate and adaptive immunity by contributing to phagocytic clearance of microorganisms and apoptotic cells...
  3. ncbi request reprint Sensitizing effect of galectin-7 in urothelial cancer to cisplatin through the accumulation of intracellular reactive oxygen species
    Yoshiyuki Matsui
    Department of Urology, Kyoto University, Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, Japan 606 8507
    Cancer Res 67:1212-20. 2007
    ..Galectin-7 is a candidate for a predictive marker of chemosensitivity against CDDP, and the targeted expression of galectin-7 might overcome the chemoresistance of urothelial cancer...
  4. ncbi request reprint Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells
    Jurgen Kopitz
    Institut für Molekulare Pathologie, Klinikum der Ruprecht Karls Universtiät, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany
    Oncogene 22:6277-88. 2003
    ..In addition to p53-linked proapoptotic activity intracellularly, galectin-7, acting as a lectin on the cell surface, appears to be capable of reducing cancer cell proliferation in susceptible systems...
  5. pmc Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation
    Jun Saegusa
    Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, California 95816, USA
    J Invest Dermatol 128:2403-11. 2008
    ..We conclude that endogenous galectin-3 is an anti-apoptotic molecule in keratinocytes functioning by suppressing ERK activation and enhancing AKT activation and may play a role in the development of apoptosis-related skin diseases...
  6. doi request reprint Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7
    Yutaka Inagaki
    Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Isehara, Japan
    Gastroenterology 134:1180-90. 2008
    ..Here, we propose a novel molecular mechanism by which HGF counter represses TGF-beta-stimulated profibrogenic signal transduction...
  7. ncbi request reprint Galectins-3 and -7, but not galectin-1, play a role in re-epithelialization of wounds
    Zhiyi Cao
    Department of Ophthalmology, Center for Vision Research and The New England Eye Center, Davis, California 95616, USA
    J Biol Chem 277:42299-305. 2002
    ..These findings have broad implications for developing novel therapeutic strategies for treating nonhealing wounds...
  8. ncbi request reprint Identification of peptide ligands for malignancy- and growth-regulating galectins using random phage-display and designed combinatorial peptide libraries
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University, Veterinarstr 13, 80539 Munchen, Germany
    Bioorg Med Chem 13:563-73. 2005
    ..Identification of peptide ligands for galectins with and without glycomimetic properties is thus possible. Our study documents the potential to combine the two library-based approaches for structural optimization of lead peptides...
  9. ncbi request reprint Suppression of tumor growth by galectin-7 gene transfer
    Shugo Ueda
    Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, California 95817, USA
    Cancer Res 64:5672-6. 2004
    ..Our results show that galectin-7 has a suppressive effect on tumor growth, suggesting that galectin-7 gene transfer or other means of specifically inducing galectin-7 expression may be a new approach for management of cancers...
  10. pmc An anti-apoptotic role for galectin-3 in diffuse large B-cell lymphomas
    Katrina K Hoyer
    Department of Pathology and Laboratory Medicine, University of California at Los Angeles School of Medicine, Los Angeles, California 90095 1732, USA
    Am J Pathol 164:893-902. 2004
    ..This pattern of expression suggests that aberrantly increased galectin-3 levels in specific B-cell populations may yield a protective advantage during transformation and/or progression of certain B-cell neoplasms...
  11. ncbi request reprint Functions of galectins in cell adhesion and chemotaxis
    Ichiro Kuwabara
    Department of Dermatology, University of California Davis, School of Medicine, 4645 Second Avenue, Sacramento, California 95817, USA
    Methods Enzymol 363:532-52. 2003
  12. ncbi request reprint Changes in galectin-7 and cytokeratin-19 expression during the progression of malignancy in thyroid tumors: diagnostic and biological implications
    Sandrine Rorive
    Laboratory of Pathology, Cliniques Universitaires de Bruxelles, Hopital Erasme, Belgium
    Mod Pathol 15:1294-301. 2002
    ....
  13. ncbi request reprint Analysis of selected blood and immune cell responses to carbohydrate-dependent surface binding of proto- and chimera-type galectins
    Alexander V Timoshenko
    Institute of Photobiology, National Academy of Sciences of Belarus, Minsk
    Mol Cell Biochem 250:139-49. 2003
    ..Within the family of galectins, the activity profiles depend on the target cell type and the individual galectin. Notably, proto-type galectins do not necessarily share a uniform capacity as elicitor...
  14. ncbi request reprint Craniopharyngioma: a case report and comparative galectin histochemical analysis
    Jan Plzak
    1st Faculty of Medicine, Institute of Anatomy, Charles University, Prague, Czech Republic
    Histochem J 34:117-22. 2002
    ....
  15. ncbi request reprint Galectin-7 as a potential mediator of corneal epithelial cell migration
    Zhiyi Cao
    New England Eye Center, Center for Vision Research and Department of Ophthalmology, Tufts University School of Medicine, Boston, MA 02111, USA
    Arch Ophthalmol 121:82-6. 2003
    ..To assess the role of a carbohydrate-binding protein, galectin-7, in reepithelialization of corneal wounds...