Affiliation: La Jolla Institute for Allergy and Immunology
- Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c releaseIchiro Kuwabara
Divisions of Allergy and Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
J Biol Chem 277:3487-97. 2002..Some of them are potentially contributory to this lectin's proapoptotic function and these include redox-related genes monoamine oxidase B, ryanodine receptor 2, and glutathione S-transferase Mu 3...
- Critical role of galectin-3 in phagocytosis by macrophagesHideki Sano
Division of Allergy, La Jolla Institute for Allergy and Immunology, San Diego, California, USA
J Clin Invest 112:389-97. 2003..Thus, galectin-3 may play an important role in both innate and adaptive immunity by contributing to phagocytic clearance of microorganisms and apoptotic cells...
- Sensitizing effect of galectin-7 in urothelial cancer to cisplatin through the accumulation of intracellular reactive oxygen speciesYoshiyuki Matsui
Department of Urology, Kyoto University, Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, Japan 606 8507
Cancer Res 67:1212-20. 2007..Galectin-7 is a candidate for a predictive marker of chemosensitivity against CDDP, and the targeted expression of galectin-7 might overcome the chemoresistance of urothelial cancer...
- Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cellsJurgen Kopitz
Institut für Molekulare Pathologie, Klinikum der Ruprecht Karls Universtiät, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany
Oncogene 22:6277-88. 2003..In addition to p53-linked proapoptotic activity intracellularly, galectin-7, acting as a lectin on the cell surface, appears to be capable of reducing cancer cell proliferation in susceptible systems...
- Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activationJun Saegusa
Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, California 95816, USA
J Invest Dermatol 128:2403-11. 2008..We conclude that endogenous galectin-3 is an anti-apoptotic molecule in keratinocytes functioning by suppressing ERK activation and enhancing AKT activation and may play a role in the development of apoptosis-related skin diseases...
- Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7Yutaka Inagaki
Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Isehara, Japan
Gastroenterology 134:1180-90. 2008..Here, we propose a novel molecular mechanism by which HGF counter represses TGF-beta-stimulated profibrogenic signal transduction...
- Galectins-3 and -7, but not galectin-1, play a role in re-epithelialization of woundsZhiyi Cao
Department of Ophthalmology, Center for Vision Research and The New England Eye Center, Davis, California 95616, USA
J Biol Chem 277:42299-305. 2002..These findings have broad implications for developing novel therapeutic strategies for treating nonhealing wounds...
- Identification of peptide ligands for malignancy- and growth-regulating galectins using random phage-display and designed combinatorial peptide librariesSabine Andre
Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University, Veterinarstr 13, 80539 Munchen, Germany
Bioorg Med Chem 13:563-73. 2005..Identification of peptide ligands for galectins with and without glycomimetic properties is thus possible. Our study documents the potential to combine the two library-based approaches for structural optimization of lead peptides...
- Suppression of tumor growth by galectin-7 gene transferShugo Ueda
Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, California 95817, USA
Cancer Res 64:5672-6. 2004..Our results show that galectin-7 has a suppressive effect on tumor growth, suggesting that galectin-7 gene transfer or other means of specifically inducing galectin-7 expression may be a new approach for management of cancers...
- An anti-apoptotic role for galectin-3 in diffuse large B-cell lymphomasKatrina K Hoyer
Department of Pathology and Laboratory Medicine, University of California at Los Angeles School of Medicine, Los Angeles, California 90095 1732, USA
Am J Pathol 164:893-902. 2004..This pattern of expression suggests that aberrantly increased galectin-3 levels in specific B-cell populations may yield a protective advantage during transformation and/or progression of certain B-cell neoplasms...
- Functions of galectins in cell adhesion and chemotaxisIchiro Kuwabara
Department of Dermatology, University of California Davis, School of Medicine, 4645 Second Avenue, Sacramento, California 95817, USA
Methods Enzymol 363:532-52. 2003
- Changes in galectin-7 and cytokeratin-19 expression during the progression of malignancy in thyroid tumors: diagnostic and biological implicationsSandrine Rorive
Laboratory of Pathology, Cliniques Universitaires de Bruxelles, Hopital Erasme, Belgium
Mod Pathol 15:1294-301. 2002....
- Analysis of selected blood and immune cell responses to carbohydrate-dependent surface binding of proto- and chimera-type galectinsAlexander V Timoshenko
Institute of Photobiology, National Academy of Sciences of Belarus, Minsk
Mol Cell Biochem 250:139-49. 2003..Within the family of galectins, the activity profiles depend on the target cell type and the individual galectin. Notably, proto-type galectins do not necessarily share a uniform capacity as elicitor...
- Craniopharyngioma: a case report and comparative galectin histochemical analysisJan Plzak
1st Faculty of Medicine, Institute of Anatomy, Charles University, Prague, Czech Republic
Histochem J 34:117-22. 2002....
- Galectin-7 as a potential mediator of corneal epithelial cell migrationZhiyi Cao
New England Eye Center, Center for Vision Research and Department of Ophthalmology, Tufts University School of Medicine, Boston, MA 02111, USA
Arch Ophthalmol 121:82-6. 2003..To assess the role of a carbohydrate-binding protein, galectin-7, in reepithelialization of corneal wounds...