MITCHELL E KRONENBERG

Summary

Affiliation: La Jolla Institute for Allergy and Immunology
Country: USA

Publications

  1. pmc NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells
    Dirk Elewaut
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA
    J Exp Med 197:1623-33. 2003
  2. pmc Co-receptor choice by V alpha14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection
    Isaac Engel
    La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Exp Med 207:1015-29. 2010
  3. pmc The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Valpha14i NKT cells
    Dirk Elewaut
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA
    J Exp Med 198:1133-46. 2003
  4. pmc Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
    Yuki Kinjo
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 12:966-74. 2011
  5. pmc BTLA interaction with HVEM expressed on CD8(+) T cells promotes survival and memory generation in response to a bacterial infection
    Marcos W Steinberg
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
    PLoS ONE 8:e77992. 2013
  6. pmc Binding and antigen presentation of ceramide-containing glycolipids by soluble mouse and human CD1d molecules
    O V Naidenko
    Department of Microbiology and Immunology and the Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Exp Med 190:1069-80. 1999
  7. ncbi request reprint Acid test: lipid antigens get into the groove
    Mitchell Kronenberg
    La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Immunity 28:727-9. 2008
  8. ncbi request reprint Regulation of immunity by self-reactive T cells
    Mitchell Kronenberg
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Nature 435:598-604. 2005
  9. ncbi request reprint Frontline T cells: gammadelta T cells and intraepithelial lymphocytes
    Mitchell Kronenberg
    La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Immunol Rev 215:5-7. 2007
  10. pmc Activation or anergy: NKT cells are stunned by alpha-galactosylceramide
    Barbara A Sullivan
    La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Clin Invest 115:2328-9. 2005

Research Grants

  1. The role of LIGHT in Colitis Pathogenesis
    Mitchell Kronenberg; Fiscal Year: 2007
  2. Development and Function of NKT Cells
    Mitchell Kronenberg; Fiscal Year: 2007
  3. NKT Cell Recognition of Streptococcus Pneumoniae
    Mitchell Kronenberg; Fiscal Year: 2007
  4. Indirect recognition of microbes by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2007
  5. Recognition of bacterial antigens by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2007
  6. The role of LIGHT in Colitis Pathogenesis
    Mitchell Kronenberg; Fiscal Year: 2006
  7. Recognition of bacterial antigens by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2006
  8. Antigen Presentation Pathway by CD1 Molecules
    Mitchell Kronenberg; Fiscal Year: 2006
  9. 2007 Immunobiology and Immunochemistry Gordon Research Conference
    Mitchell Kronenberg; Fiscal Year: 2007
  10. Recognition of bacterial antigens by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2010

Detail Information

Publications67

  1. pmc NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells
    Dirk Elewaut
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA
    J Exp Med 197:1623-33. 2003
    ....
  2. pmc Co-receptor choice by V alpha14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection
    Isaac Engel
    La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Exp Med 207:1015-29. 2010
    ....
  3. pmc The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Valpha14i NKT cells
    Dirk Elewaut
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA
    J Exp Med 198:1133-46. 2003
    ....
  4. pmc Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
    Yuki Kinjo
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 12:966-74. 2011
    ..Our results show how microbial lipids position the sugar for recognition by the invariant TCR and, most notably, extend the range of microbes recognized by this conserved TCR to several clinically important bacteria...
  5. pmc BTLA interaction with HVEM expressed on CD8(+) T cells promotes survival and memory generation in response to a bacterial infection
    Marcos W Steinberg
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
    PLoS ONE 8:e77992. 2013
    ....
  6. pmc Binding and antigen presentation of ceramide-containing glycolipids by soluble mouse and human CD1d molecules
    O V Naidenko
    Department of Microbiology and Immunology and the Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Exp Med 190:1069-80. 1999
    ....
  7. ncbi request reprint Acid test: lipid antigens get into the groove
    Mitchell Kronenberg
    La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Immunity 28:727-9. 2008
    ..How do CD1 molecules load lipid antigens? In this issue of Immunity, Relloso et al. (2008) uncover how lysosomal pH targets amino acids in CD1b, causing it to open and attain a conformation more receptive to lipid antigens...
  8. ncbi request reprint Regulation of immunity by self-reactive T cells
    Mitchell Kronenberg
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Nature 435:598-604. 2005
    ..Subpopulations of self-reactive T cells have a strong influence on self tolerance and may represent targets for therapeutic intervention to control a variety of autoimmune diseases, tumour growth and infection...
  9. ncbi request reprint Frontline T cells: gammadelta T cells and intraepithelial lymphocytes
    Mitchell Kronenberg
    La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Immunol Rev 215:5-7. 2007
  10. pmc Activation or anergy: NKT cells are stunned by alpha-galactosylceramide
    Barbara A Sullivan
    La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Clin Invest 115:2328-9. 2005
    ....
  11. ncbi request reprint Synergistic costimulation by both B7 molecules regulates colitis pathogenesis
    Gisen Kim
    La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Ann N Y Acad Sci 1072:233-41. 2006
    ..While a full block of costimulation may prevent autoimmunity, our data indicate, surprisingly, that a partial block may in some cases augment disease...
  12. ncbi request reprint Presenting fats with SAPs
    Mitchell Kronenberg
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Nat Immunol 5:126-7. 2004
  13. pmc Innate-like recognition of microbes by invariant natural killer T cells
    Mitchell Kronenberg
    La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Curr Opin Immunol 21:391-6. 2009
    ..The means by which iNKT cells influence other cell types and overall host defense are likewise diverse, illustrating the flexibility and functional diversity of this T lymphocyte sublineage...
  14. ncbi request reprint On the road: progress in finding the unique pathway of invariant NKT cell differentiation
    Mitchell Kronenberg
    La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Curr Opin Immunol 19:186-93. 2007
    ....
  15. ncbi request reprint The unconventional lifestyle of NKT cells
    Mitchell Kronenberg
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Nat Rev Immunol 2:557-68. 2002
  16. pmc Natural killer T cells: know thyself
    Mitchell Kronenberg
    La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:5713-4. 2007
  17. ncbi request reprint Toward an understanding of NKT cell biology: progress and paradoxes
    Mitchell Kronenberg
    La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Annu Rev Immunol 23:877-900. 2005
    ..Despite this uncertainty, many investigators are hopeful that immune therapies can be developed based on NKT cell stimulation...
  18. ncbi request reprint Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    Daniel Mucida
    La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Science 317:256-60. 2007
    ..These findings indicate that a common metabolite can regulate the balance between pro- and anti-inflammatory immunity...
  19. pmc Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo
    Jennifer L Matsuda
    La Jolla Institute for Allergy and Immunology, and Division of Biological Sciences, University of California, San Diego, CA, USA
    Proc Natl Acad Sci U S A 100:8395-400. 2003
    ....
  20. pmc Mechanisms for glycolipid antigen-driven cytokine polarization by Valpha14i NKT cells
    Barbara A Sullivan
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 184:141-53. 2010
    ..Therefore, we suggest that the pharmacokinetic properties of glycolipids are a major determinant of cytokine skewing, suggesting a pathway for designing therapeutic glycolipids for modulating invariant NKT cell responses...
  21. pmc The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition
    Stephane Sidobre
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 101:12254-9. 2004
    ..Overall, these findings emphasize the distinct properties of glycosphingolipid antigen recognition by Valpha14i NKT cells...
  22. ncbi request reprint Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria
    Yuki Kinjo
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    Nat Immunol 7:978-86. 2006
    ....
  23. ncbi request reprint Surprisingly minor influence of TRAV11 (Valpha14) polymorphism on NK T-receptor mCD1/alpha-galactosylceramide binding kinetics
    Bee Cheng Sim
    IMM1, Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Immunogenetics 54:874-83. 2003
    ..These differences are minor compared with differences between agonist and antagonist ligands in other TCR systems, suggesting that it is unlikely that TCR polymorphism explains the defect in NK T cells in the autoimmune mouse strains...
  24. ncbi request reprint Invariant NKT cells amplify the innate immune response to lipopolysaccharide
    Niranjana A Nagarajan
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Immunol 178:2706-13. 2007
    ....
  25. ncbi request reprint Paradoxical effect of reduced costimulation in T cell-mediated colitis
    Gisen Kim
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Immunol 178:5563-70. 2007
    ..The consequent inhibitory effect of full CTLA-4 expression, induced by IL-2, may slow colitis, even in the absence of regulatory T cells...
  26. ncbi request reprint Thymic differentiation of TCR alpha beta(+) CD8 alpha alpha(+) IELs
    Florence Lambolez
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Immunol Rev 215:178-88. 2007
    ..Therefore, the increased understanding of the developmental origin of TCR alpha beta(+) CD8 alpha alpha(+) IELs may help us to understand how they participate in immune regulation and protection in the intestine...
  27. ncbi request reprint Homeostasis of V alpha 14i NKT cells
    Jennifer L Matsuda
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Nat Immunol 3:966-74. 2002
    ....
  28. pmc Natural Sphingomonas glycolipids vary greatly in their ability to activate natural killer T cells
    Yuki Kinjo
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Chem Biol 15:654-64. 2008
    ....
  29. ncbi request reprint Recognition of bacterial glycosphingolipids by natural killer T cells
    Yuki Kinjo
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, 10355 Science Center Drive, San Diego, California 92121, USA
    Nature 434:520-5. 2005
    ....
  30. ncbi request reprint CD1 tetramers: a powerful tool for the analysis of glycolipid-reactive T cells
    Stephane Sidobre
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    J Immunol Methods 268:107-21. 2002
    ....
  31. ncbi request reprint Regulation of mucosal immune responses by recombinant interleukin 10 produced by intestinal epithelial cells in mice
    Hilde De Winter
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Gastroenterology 122:1829-41. 2002
    ..Interleukin (IL)-10 is a cytokine with anti-inflammatory properties. The aim of this study was to explore the effect of a site-specific delivery of IL-10 on intestinal immune responses...
  32. pmc CD1 mediated T cell recognition of glycolipids
    Dirk M Zajonc
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Curr Opin Struct Biol 17:521-9. 2007
    ....
  33. ncbi request reprint Role of NKT cells in the digestive system. IV. The role of canonical natural killer T cells in mucosal immunity and inflammation
    Gerhard Wingender
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92037, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1-8. 2008
    ..In this review, we will focus on the role of both of these canonical NKT cell populations in the mucosal tissues of the intestine...
  34. ncbi request reprint Cutting edge: CD4+CD25+ regulatory T cells impaired for intestinal homing can prevent colitis
    Timothy L Denning
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 174:7487-91. 2005
    ..These data demonstrate that Treg can prevent colitis by inhibiting the accumulation of tissue-seeking effector cells and that Treg accumulation in the intestine is dispensable for colitis suppression...
  35. ncbi request reprint Mucosal T lymphocytes--peacekeepers and warriors
    Hilde Cheroutre
    The La Jolla Institute for Allergy and Immunology, San Diego, CA, USA
    Springer Semin Immunopathol 27:147-65. 2005
    ..Others, however, particularly subsets residing permanently in the epithelium, are intestine-specific T cell subpopulations generated by an atypical differentiation pathway...
  36. ncbi request reprint Expansion of human Valpha24+ NKT cells by repeated stimulation with KRN7000
    Paul R Rogers
    Research Laboratory, Gemini Science, Inc, 10355 Science Center Drive, San Diego, CA, 92121, USA
    J Immunol Methods 285:197-214. 2004
    ..This expansion method may be useful for proof-of-concept studies involving adoptive transfer of ex vivo-expanded NKT cells as a new therapeutic option for cancer and autoimmune diseases...
  37. ncbi request reprint The Third Way: Progress on pathways of antigen processing and presentation by CD1
    Anna P Lawton
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Immunol Cell Biol 82:295-306. 2004
    ..This suggests that the CD1 antigen presenting system, which diverged early in vertebrate evolution from MHC antigen presenting molecules, is a simpler system with a character closer to the primordial antigen presenting function...
  38. ncbi request reprint The mouse CD1d cytoplasmic tail mediates CD1d trafficking and antigen presentation by adaptor protein 3-dependent and -independent mechanisms
    Anna P Lawton
    Division of Developmental Immunology, Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 174:3179-86. 2005
    ..Our results emphasize that multiple steps, including interactions with the adaptors AP-2 and AP-3, are required for normal trafficking of mCD1d and that these different steps are mediated by only a few cytoplasmic amino acids...
  39. pmc Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d
    Douglass Wu
    Department of Chemistry and Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:3972-7. 2006
    ....
  40. pmc T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment
    Timothy C Cheung
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 183:7286-96. 2009
    ..We suggest that the HVEM-BTLA cis-complex competitively inhibits HVEM activation by ligands expressed in the surrounding microenvironment, thus helping maintain T cells in the naive state...
  41. ncbi request reprint The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex
    Stephane Sidobre
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 169:1340-8. 2002
    ..These unique properties are consistent with the coreceptor-independent action of the V alpha 14 TCR and may be related to the intense response to alpha-GalCer by NKT cells in vivo...
  42. pmc Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals
    Aaron J Tyznik
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 181:4452-6. 2008
    ..Consequently, iNKT cells have the ability to respond to a variety of microbes, including viruses, in an Ag-independent manner, suggesting they may play a broad role in antipathogen defenses despite their limited TCR repertoire...
  43. pmc Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells
    Douglass Wu
    Department of Chemistry and The Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:1351-6. 2005
    ..Because alpha-GalCer is a marine-sponge-derived ligand, our study here shows that bacterium-derived antigens are also able to stimulate mouse and human NKT cells...
  44. doi request reprint Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice
    Michael J Barnes
    Department of Genetics, Scripps Research Institute, La Jolla, CA, USA
    J Immunol 184:3743-54. 2010
    ..These data establish Gimap5 as a key regulator of hematopoietic integrity and lymphocyte homeostasis...
  45. ncbi request reprint Precursors of functional MHC class I- or class II-restricted CD8alphaalpha(+) T cells are positively selected in the thymus by agonist self-peptides
    Andrew J Leishman
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Immunity 16:355-64. 2002
    ..Our data define a distinct agonist-dependent, positive selection process in the thymus, and they suggest a function for CD8alphaalpha distinct from the conventional TCR coreceptor function of CD8alphabeta or CD4...
  46. pmc Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1
    Satoshi Kojo
    La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:17847-51. 2009
    ..The study identifies an important signaling pathway linking Cbl-b-induced monoubiquitination to NFkappaB activation in NKT cell anergy induction, which may help design approaches for human cancer therapy...
  47. ncbi request reprint Activation of natural killer T cells by glycolipids
    Emmanuel Tupin
    La Jolla Institute for Allergy and Immunology, San Diego, California, USA
    Methods Enzymol 417:185-201. 2006
    ....
  48. ncbi request reprint Molecular basis for the high affinity interaction between the thymic leukemia antigen and the CD8alphaalpha molecule
    Antoine Attinger
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 174:3501-7. 2005
    ..These data indicate that small changes in the alpha3 domain of class I molecules potentially can have profound physiologic consequences...
  49. ncbi request reprint Carboxylated glycans mediate colitis through activation of NF-kappa B
    Geetha Srikrishna
    Glycobiology Program, The Burnham Institute, La Jolla, CA 92037, USA
    J Immunol 175:5412-22. 2005
    ..It specifically blocked activation of NF-kappaB p65 in lamina propria cells of colitic mice and in activated macrophages. These results indicate that carboxylate-glycan-dependent pathways contribute to the early onset of colitis...
  50. ncbi request reprint The unique role of natural killer T cells in the response to microorganisms
    Emmanuel Tupin
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA
    Nat Rev Microbiol 5:405-17. 2007
    ..This indirect sensing of infection, by responding to cytokines from activated dendritic cells, allows NKT cells to react to a broad range of infectious agents...
  51. pmc Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency
    Gerhard Wingender
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 185:2721-9. 2010
    ..Therefore, unlike NK cells, which rely mostly on perforin/granzyme-mediated mechanisms, the Ag-specific cytotoxicity of iNKT cells in vivo is largely restricted to the CD95/CD178 pathway...
  52. ncbi request reprint Infection, autoimmunity, and glycolipids: T cells detect microbes through self-recognition
    Mitchell Kronenberg
    La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Immunity 22:657-9. 2005
    ..This mechanism also may provide a connection between infection and autoimmunity...
  53. pmc Unconventional ligand activation of herpesvirus entry mediator signals cell survival
    Timothy C Cheung
    Divisions of Molecular Immunology and Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:6244-9. 2009
    ..Moreover, Btla(-/-) T cells survived poorly following activation but were rescued with BTLA-Fc, indicating HVEM-BTLA bidirectional signaling may serve as a critical cell-survival system for lymphoid and epithelial cells...
  54. pmc Transcriptional regulator Id2 controls survival of hepatic NKT cells
    Laurel A Monticelli
    Division of Biology, University of California San Diego, La Jolla, CA 92093 0377, USA
    Proc Natl Acad Sci U S A 106:19461-6. 2009
    ..Thus, Id2 was necessary to establish a hepatic iNKT cell population, defining a role for Id2 and implicating the Id targets, E protein transcription factors, in the regulation of iNKT cell homeostasis...
  55. pmc Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
    Masako Murai
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 10:1178-84. 2009
    ..Our data indicate that IL-10 released from myeloid cells acts in a paracrine manner on T(reg) cells to maintain Foxp3 expression...
  56. doi request reprint Carbohydrate specificity of the recognition of diverse glycolipids by natural killer T cells
    Dirk M Zajonc
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Immunol Rev 230:188-200. 2009
    ..Recent investigations from our laboratories as well as studies from other groups have provided important information on the structural basis for NKT-cell specificity...
  57. ncbi request reprint Natural killer T cells: natural or unnatural regulators of autoimmunity?
    Kirsten J L Hammond
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Curr Opin Immunol 15:683-9. 2003
    ..Although current controversy surrounds the importance of NKT cells and their modes of action, they represent a potentially important clinical target...
  58. ncbi request reprint Invariant natural killer cells in the response to bacteria: the advent of specific antigens
    Gerhard Wingender
    La Jolla Institute for Allergy and Immunology LIAI, Division of Developmental Immunology, San Diego, CA 92037, USA
    Future Microbiol 1:325-40. 2006
    ....
  59. ncbi request reprint Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses
    Timothy L Denning
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 178:4230-9. 2007
    ..Collectively, these data underscore the fact that, while TCRalphabeta(+)CD8alphaalpha IEL resemble TCRgammadelta(+) IEL, they are a unique population of cells with regulated Ag reactivity that could have regulatory function...
  60. pmc A crucial role for HVEM and BTLA in preventing intestinal inflammation
    Marcos W Steinberg
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Exp Med 205:1463-76. 2008
    ..Our experiments emphasize the antiinflammatory role of HVEM and the importance of HVEM expression by innate immune cells in preventing runaway inflammation in the intestine...
  61. pmc Spontaneous colitis occurrence in transgenic mice with altered B7-mediated costimulation
    Gisen Kim
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 181:5278-88. 2008
    ..This model provides an important tool for examining how B7 molecules and their effects on CTLA-4 modulate T cell function and the development of inflammatory diseases...
  62. pmc Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners
    Marcos W Steinberg
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Semin Immunopathol 31:207-21. 2009
    ..Despite complexity, experiments we and others are carrying out are establishing rules for understanding when and in what cell types these molecules contribute to intestinal inflammation...
  63. ncbi request reprint CD1 and MHC II find different means to the same end
    Barbara A Sullivan
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Trends Immunol 26:282-8. 2005
    ..Recent experimental evidence has illuminated these unique aspects of the CD1 antigen-presentation pathway...
  64. pmc Regulation of inflammation, autoimmunity, and infection immunity by HVEM-BTLA signaling
    Jr Wen Shui
    La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, San Diego, CA 92037, USA
    J Leukoc Biol 89:517-23. 2011
    ..Here, we will summarize the current view about how HVEM-BTLA signaling is involved in the regulation of mucosal inflammation, autoimmunity, and infection immunity...
  65. pmc Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells
    Jing Wang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:1535-40. 2010
    ..Therefore, our data reveal the biochemical basis for the high degree of antigenic specificity of iNKT cells for certain fatty acids, and they suggest how microbes could alter fatty acid biosynthesis as an immune evasion mechanism...
  66. pmc The Vα14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode
    Yali Li
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Exp Med 207:2383-93. 2010
    ..We propose that the TCR of iNKT cells binds with a conserved footprint onto CD1d, regardless of the bound glycolipid antigen, and that for microbial antigens this unique binding mode requires TCR-initiated conformational changes...

Research Grants40

  1. The role of LIGHT in Colitis Pathogenesis
    Mitchell Kronenberg; Fiscal Year: 2007
    ..The experimental results derived from the proposed experiments could provide important insights into the mechanisms for the beneficial and potentially harmful effects of such a blockade. ..
  2. Development and Function of NKT Cells
    Mitchell Kronenberg; Fiscal Year: 2007
    ..This knowledge may lead to immune based therapies that specifically target these cells for treatment of cancer and other diseases. ..
  3. NKT Cell Recognition of Streptococcus Pneumoniae
    Mitchell Kronenberg; Fiscal Year: 2007
    ..The results from these studies should help in understanding iNKT cell biology and the response to S. pneumoniae, which could lead to the development of more effective vaccines against this organism. ..
  4. Indirect recognition of microbes by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2007
    ....
  5. Recognition of bacterial antigens by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2007
    ....
  6. The role of LIGHT in Colitis Pathogenesis
    Mitchell Kronenberg; Fiscal Year: 2006
    ..The experimental results derived from the proposed experiments could provide important insights into the mechanisms for the beneficial and potentially harmful effects of such a blockade. ..
  7. Recognition of bacterial antigens by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2006
    ....
  8. Antigen Presentation Pathway by CD1 Molecules
    Mitchell Kronenberg; Fiscal Year: 2006
    ..The results from these studies will aid in our understanding of lipid antigen presentation, and they should help in the design of lipid antigen-based vaccines and in attempts to alter immune regulation by stimulating NK T cells. ..
  9. 2007 Immunobiology and Immunochemistry Gordon Research Conference
    Mitchell Kronenberg; Fiscal Year: 2007
    ..Participation by women and under represented minorities is actively sought. In this application, we seek support for this important and prestigious conference. ..
  10. Recognition of bacterial antigens by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2010
    ..abstract_text> ..
  11. Indirect recognition of microbes by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2009
    ..abstract_text> ..
  12. Recognition of bacterial antigens by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2009
    ..abstract_text> ..
  13. The role of LIGHT in Colitis Pathogenesis
    Mitchell Kronenberg; Fiscal Year: 2005
    ..The experimental results derived from the proposed experiments could provide important insights into the mechanisms for the beneficial and potentially harmful effects of such a blockade. ..
  14. Antigen Presentation Pathway by CD1 Molecules
    Mitchell Kronenberg; Fiscal Year: 2005
    ..The results from these studies will aid in our understanding of lipid antigen presentation, and they should help in the design of lipid antigen-based vaccines and in attempts to alter immune regulation by stimulating NK T cells. ..
  15. MOLECULAR BASIS FOR NK T CELL RECOGNITION AND FUNCTION
    Mitchell Kronenberg; Fiscal Year: 2001
    ..abstract_text> ..
  16. ANTIGEN PRESENTATION AND IMMUNE REGULATION BY CD1
    Mitchell Kronenberg; Fiscal Year: 2001
    ..Suck knowledge could lead to novel immune therapies for cancer and autoimmune disease. ..
  17. ANTIGEN PRESENTATION BY CD1 MOLECULES
    Mitchell Kronenberg; Fiscal Year: 2000
    ....
  18. ANTIGEN PRESENTATION AND IMMUNE REGULATION BY CD1
    Mitchell Kronenberg; Fiscal Year: 2000
    ..Suck knowledge could lead to novel immune therapies for cancer and autoimmune disease. ..
  19. MOLECULAR BASIS FOR NK T CELL RECOGNITION AND FUNCTION
    Mitchell Kronenberg; Fiscal Year: 2000
    ..abstract_text> ..
  20. ANTIGEN PRESENTING FUNCTION OF THE TL AND CD1 MOLECULES
    Mitchell Kronenberg; Fiscal Year: 1999
    ....
  21. ANTIGEN PRESENTATION BY CD1 MOLECULES
    Mitchell Kronenberg; Fiscal Year: 1999
    ....
  22. Antigen Presentation Pathway by CD1 Molecules
    Mitchell Kronenberg; Fiscal Year: 2002
    ..The results from these studies will aid in our understanding of lipid antigen presentation, and they should help in the design of lipid antigen-based vaccines and in attempts to alter immune regulation by stimulating NK T cells. ..
  23. ANTIGEN PRESENTATION AND IMMUNE REGULATION BY CD1
    Mitchell Kronenberg; Fiscal Year: 2002
    ..Suck knowledge could lead to novel immune therapies for cancer and autoimmune disease. ..
  24. Role of LIGHT in Colitis Pathogenesis
    Mitchell Kronenberg; Fiscal Year: 2004
    ..The experimental results derived from the proposed experiments could provide important insights into the mechanisms for the beneficial and potentially harmful effects of such a blockade. ..
  25. MOLECULAR BASIS FOR NK T CELL RECOGNITION AND FUNCTION
    Mitchell Kronenberg; Fiscal Year: 2004
    ..abstract_text> ..
  26. ANTIGEN PRESENTATION AND IMMUNE REGULATION BY CD1
    Mitchell Kronenberg; Fiscal Year: 2004
    ..Suck knowledge could lead to novel immune therapies for cancer and autoimmune disease. ..
  27. Antigen Presentation Pathway by CD1 Molecules
    Mitchell Kronenberg; Fiscal Year: 2004
    ..The results from these studies will aid in our understanding of lipid antigen presentation, and they should help in the design of lipid antigen-based vaccines and in attempts to alter immune regulation by stimulating NK T cells. ..
  28. MOLECULAR BASIS FOR NK T CELL RECOGNITION AND FUNCTION
    Mitchell Kronenberg; Fiscal Year: 2003
    ..abstract_text> ..
  29. ANTIGEN PRESENTATION AND IMMUNE REGULATION BY CD1
    Mitchell Kronenberg; Fiscal Year: 2003
    ..Suck knowledge could lead to novel immune therapies for cancer and autoimmune disease. ..
  30. Antigen Presentation Pathway by CD1 Molecules
    Mitchell Kronenberg; Fiscal Year: 2003
    ..The results from these studies will aid in our understanding of lipid antigen presentation, and they should help in the design of lipid antigen-based vaccines and in attempts to alter immune regulation by stimulating NK T cells. ..
  31. MOLECULAR BASIS FOR NK T CELL RECOGNITION AND FUNCTION
    Mitchell Kronenberg; Fiscal Year: 2002
    ..abstract_text> ..
  32. Indirect recognition of microbes by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2010
    ..abstract_text> ..