Toshiaki Kawakami

Summary

Affiliation: La Jolla Institute for Allergy and Immunology
Country: USA

Publications

  1. doi request reprint Salmonella's masterful skill in mast cell suppression
    Toshiaki Kawakami
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA Laboratory for Allergic Disease, RIKEN Center for Integrative Medical Sciences IMS RCAI, Yokohama 230 0045, Japan Electronic address
    Immunity 39:996-8. 2013
  2. doi request reprint Phospholipase C-β in immune cells
    Toshiaki Kawakami
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA Laboratory of Allergic Disease, RIKEN Center for Integrative Medical Sciences IMS RCAI, Yokohama 230 0045, Japan Electronic address
    Adv Biol Regul 53:249-57. 2013
  3. pmc Mast cell survival and activation by IgE in the absence of antigen: a consideration of the biologic mechanisms and relevance
    Toshiaki Kawakami
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 175:4167-73. 2005
  4. pmc Mast cells in atopic dermatitis
    Toshiaki Kawakami
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Curr Opin Immunol 21:666-78. 2009
  5. ncbi request reprint [Regulation of mast cell survival and activation by monomeric IgE]
    Toshiaki Kawakami
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Arerugi 53:557-61. 2004
  6. ncbi request reprint Protein kinase C beta (PKC beta): normal functions and diseases
    Toshiaki Kawakami
    Division of Allergy, La Jolla Institute for Allergy and Immunology, Science Center Drive, San Diego, California 92121, USA
    J Biochem 132:677-82. 2002
  7. pmc The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn
    Hong Hong
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, CA 92037, USA
    Blood 110:2511-9. 2007
  8. pmc Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI
    Wenbin Xiao
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 175:6885-92. 2005
  9. ncbi request reprint Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases
    Jiro Kitaura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 174:4495-504. 2005
  10. pmc Mast cells are required for full expression of allergen/SEB-induced skin inflammation
    Tomoaki Ando
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    J Invest Dermatol 133:2695-705. 2013

Research Grants

  1. Regulation of asthma by Btk and family kinases
    Toshiaki Kawakami; Fiscal Year: 2007
  2. Mast cell regulation by PKC and Akt
    Toshiaki Kawakami; Fiscal Year: 2005
  3. IgE Regulation of Mast Cell Growth and Survival
    Toshiaki Kawakami; Fiscal Year: 2006
  4. ROLES OF PH DOMAINS IN MAST CELL SIGNAL TRANSDUCTION
    Toshiaki Kawakami; Fiscal Year: 2000
  5. PROTEIN TYROSINE KINASES AND MAST CELL ACTIVATION
    Toshiaki Kawakami; Fiscal Year: 2001

Collaborators

Detail Information

Publications52

  1. doi request reprint Salmonella's masterful skill in mast cell suppression
    Toshiaki Kawakami
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA Laboratory for Allergic Disease, RIKEN Center for Integrative Medical Sciences IMS RCAI, Yokohama 230 0045, Japan Electronic address
    Immunity 39:996-8. 2013
    ..In this issue of Immunity, Choi et al. (2013) demonstrate that the Salmonella Typhimurium-secreted protein tyrosine phosphatase, SptP, suppresses mast cell degranulation, which enables bacterial dissemination...
  2. doi request reprint Phospholipase C-β in immune cells
    Toshiaki Kawakami
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA Laboratory of Allergic Disease, RIKEN Center for Integrative Medical Sciences IMS RCAI, Yokohama 230 0045, Japan Electronic address
    Adv Biol Regul 53:249-57. 2013
    ..The SPS complex has important regulatory roles in tumorigenesis and immune cell activation. ..
  3. pmc Mast cell survival and activation by IgE in the absence of antigen: a consideration of the biologic mechanisms and relevance
    Toshiaki Kawakami
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 175:4167-73. 2005
    ....
  4. pmc Mast cells in atopic dermatitis
    Toshiaki Kawakami
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Curr Opin Immunol 21:666-78. 2009
    ..Numerous animal models have been used to study this epidemic disease. Here we review the recent progress to synthesize our current understanding of this disease and potential mechanisms for a mast cell's role in the disease...
  5. ncbi request reprint [Regulation of mast cell survival and activation by monomeric IgE]
    Toshiaki Kawakami
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Arerugi 53:557-61. 2004
  6. ncbi request reprint Protein kinase C beta (PKC beta): normal functions and diseases
    Toshiaki Kawakami
    Division of Allergy, La Jolla Institute for Allergy and Immunology, Science Center Drive, San Diego, California 92121, USA
    J Biochem 132:677-82. 2002
    ..Their involvement in disorders due to pertubations in these signaling systems, i.e., immunodeficiencies and diabetes, is also reviewed. Finally, patterns of PKC action in these and other biologic systems are discussed...
  7. pmc The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn
    Hong Hong
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, CA 92037, USA
    Blood 110:2511-9. 2007
    ..Thus, this study has revealed a hierarchical regulation among SFK members to fine-tune mast cell activation...
  8. pmc Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI
    Wenbin Xiao
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 175:6885-92. 2005
    ..Furthermore, Lyn-mediated negative regulation was shown to be exerted via the FcepsilonRI beta-ITAM...
  9. ncbi request reprint Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases
    Jiro Kitaura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 174:4495-504. 2005
    ..Thus, binding of HC IgEs to Fc epsilon RI induces adhesion of mast cells to fibronectin by modulating cellular activation signals in a unique fashion...
  10. pmc Mast cells are required for full expression of allergen/SEB-induced skin inflammation
    Tomoaki Ando
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    J Invest Dermatol 133:2695-705. 2013
    ..Therefore, this clinically relevant model provides mechanistic insights into the pathogenic mechanism of human AD. ..
  11. ncbi request reprint Early divergence of Fc epsilon receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival
    Jiro Kitaura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 173:4317-23. 2004
    ..Collectively, signals emanated from IgE-bound FcepsilonRI for receptor up-regulation and internalization are shown to diverge at the receptor or receptor-proximal levels from those for other biological outcomes...
  12. ncbi request reprint Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion
    Yuko Kawakami
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 279:47720-5. 2004
    ..Therefore, PKCbetaII appears to work as a cell type- and stimulus-specific PDK2...
  13. pmc Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease
    Wenbin Xiao
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Blood 116:6003-13. 2010
    ..Therefore, we identify a novel Lyn/PLC-β3-mediated regulatory mechanism of SHP-1 and Stat5 activities...
  14. pmc Phospholipase C-β3 regulates FcɛRI-mediated mast cell activation by recruiting the protein phosphatase SHP-1
    Wenbin Xiao
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Immunity 34:893-904. 2011
    ..Thus, we have defined a PLC-β3- and SHP-1-mediated signaling pathway for FcɛRI-mediated cytokine production...
  15. pmc Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5
    Wenbin Xiao
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    J Clin Invest 118:924-34. 2008
    ..Thus, this study has defined a myeloproliferative transformation-sensitive signaling pathway, composed of Lyn/Hck, SHIP, autocrine/paracrine cytokines, and Stat5, that regulates HSC differentiation and M2 macrophage programming...
  16. ncbi request reprint Dysregulation of Src family kinases in mast cells from epilepsy-resistant ASK versus epilepsy-prone EL mice
    Jiro Kitaura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 178:455-62. 2007
    ....
  17. pmc Pivotal advance: IgE accelerates in vitro development of mast cells and modifies their phenotype
    Jun ichi Kashiwakura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Leukoc Biol 84:357-67. 2008
    ..Therefore, our results suggest that monomeric IgEs, especially HC IgEs, not only promote mast cell development but also modulate the mast cell phenotype...
  18. pmc A minor catalytic activity of Src family kinases is sufficient for maximal activation of mast cells via the high-affinity IgE receptor
    Michael Poderycki
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 184:84-93. 2010
    ..Furthermore, the data suggest that both positive and negative regulatory functions of Lyn are predominantly carried out by its catalytic activity and not an adaptor function...
  19. pmc Short Stat5-interacting peptide derived from phospholipase C-β3 inhibits hematopoietic cell proliferation and myeloid differentiation
    Hiroki Yasudo
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
    PLoS ONE 6:e24995. 2011
    ....
  20. pmc Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3
    Yuko Kawakami
    Divisions of Cell Biology and Molecular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 103:153-8. 2006
    ..These negative regulatory functions of Btk in dendritic cells appear to be mediated mainly through autocrine secretion of IL-10 and subsequent activation of Stat3...
  21. pmc Polyclonal IgE induces mast cell survival and cytokine production
    Jun ichi Kashiwakura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, CA, USA
    Allergol Int 58:411-9. 2009
    ..However, no studies have been performed on the effects of polyclonal IgE molecules. Here, we tested whether polyclonal mouse and human IgE molecules affect survival and cytokine production in mast cells...
  22. pmc IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion
    Jiro Kitaura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10 355 Science Center Dr, San Diego, CA 92121, USA
    Blood 105:3222-9. 2005
    ..In mouse experiments, naive mast cells are attracted to IgE, and IgE-sensitized mast cells are attracted to antigen. Therefore, IgE and antigen are implicated in mast cell accumulation at allergic tissue sites with local high IgE levels...
  23. pmc Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5
    Wenbin Xiao
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Cancer Cell 16:161-71. 2009
    ..The same mechanism for malignant transformation seems to be operative in other human lymphoid and myeloid malignancies. Thus, PLC-beta3 is likely a tumor suppressor...
  24. doi request reprint Critical role for mast cell stat5 activity in skin inflammation
    Tomoaki Ando
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Cell Rep 6:366-76. 2014
    ..Therefore, STAT5 regulatory mechanisms in mast cells are important for AD pathogenesis. ..
  25. pmc Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy
    Jun chi Kashiwakura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    J Clin Invest 122:218-28. 2012
    ..These results indicate that HRF has a proinflammatory role in asthma and skin immediate hypersensitivity, leading us to suggest HRF as a potential therapeutic target...
  26. ncbi request reprint IgE regulation of mast cell survival and function
    Toshiaki Kawakami
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Novartis Found Symp 271:100-7; discussion 108-14, 145-51. 2005
    ..Consistent with receptor aggregation induced by monomeric IgE, other means of receptor aggregation, e.g. IgE+antigen and IgE+anti-IgE, can also induce survival and other events in unique ranges of stimulation intensity...
  27. pmc Costimulation of mast cells by 4-1BB, a member of the tumor necrosis factor receptor superfamily, with the high-affinity IgE receptor
    Hajime Nishimoto
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA
    Blood 106:4241-8. 2005
    ..Therefore, FcepsilonRI-inducible 4-1BB plays a costimulatory function together with FcepsilonRI stimulation...
  28. pmc Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI
    Jiro Kitaura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:12911-6. 2003
    ..In hybridoma-transplanted mice, mucosal mast cell numbers correlate with serum IgE levels. Therefore, survival effects of IgE could contribute to the pathogenesis of allergic disease...
  29. pmc Protective murine and human monoclonal antibodies against eczema vaccinatum
    Yoshiaki Tomimori
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology LIAI, La Jolla, CA, USA
    Antivir Ther 16:67-75. 2011
    ..Eczema vaccinatum is the most common severe pathology associated with smallpox vaccination (vaccinia virus), occurring at high rates among individuals with a previous history of atopic dermatitis (atopic eczema)...
  30. pmc JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis
    Monica Guma
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Pathology, Division of Rheumatology, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 107:22122-7. 2010
    ..Hence, JNK1 controls mast cell degranulation and FcγR-triggered IL-1β production, in addition to regulating cytokine and matrix metalloproteinase biosynthesis, and is an attractive therapeutic target in inflammatory arthritis...
  31. pmc Inhibition of NK cell activity by IL-17 allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatum
    Yuko Kawakami
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Exp Med 206:1219-25. 2009
    ..Given low NK cell activities and increased IL-17 expression in atopic dermatitis patients, these results can explain the increased susceptibility of atopic dermatitis patients to eczema vaccinatum...
  32. ncbi request reprint Techniques to study Fc epsilonRI signaling
    Yuko Kawakami
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA, USA
    Methods Mol Biol 315:175-89. 2006
    ..As signal transduction is highly dependent on protein-protein interactions, we will describe experimental details of co-immunoprecipitation methods that are used to confirm such interactions...
  33. pmc Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma
    Riaz I Zuberi
    Division of Allergy, La Jolla Institute of Allergy and Immunology, San Diego, California, USA
    Am J Pathol 165:2045-53. 2004
    ..We conclude that galectin-3 may play an important role in the pathogenesis of asthma and inhibitors of this lectin may prove useful for treatment of this disease...
  34. ncbi request reprint An improved mouse model of atopic dermatitis and suppression of skin lesions by an inhibitor of Tec family kinases
    Yuko Kawakami
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Allergol Int 56:403-9. 2007
    ..We attempted to develop an improved method to induce an animal model of atopic dermatitis and to use it to evaluate the efficacy of a Tec family kinase inhibitor...
  35. doi request reprint Monomeric IgE and mast cell development, survival and function
    Jun ichi Kashiwakura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Adv Exp Med Biol 716:29-46. 2011
    ....
  36. pmc Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens
    Jun ichi Kashiwakura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Science, Itabashi ku, Tokyo, Japan
    Allergy Asthma Immunol Res 4:332-40. 2012
    ..In this study, we investigated whether IgEs recognize autoantigens and whether IgEs' binding of autoantigens correlates with difference s in HC versus PC properties...
  37. ncbi request reprint Regulation of mast-cell and basophil function and survival by IgE
    Toshiaki Kawakami
    Division of Allergy, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Nat Rev Immunol 2:773-86. 2002
    ..So, the binding of IgE to Fc epsilon RI might influence mast-cell and basophil survival directly or indirectly, and can also regulate cellular function...
  38. pmc A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps
    Katja Branitzki-Heinemann
    Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA
    Biochem J 446:159-63. 2012
    ....
  39. pmc A Ras activation pathway dependent on Syk phosphorylation of protein kinase C
    Yuko Kawakami
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:9470-5. 2003
    ..By recruiting the Grb-2/Sos complex to the plasma membrane, these conventional PKC isoforms contribute to the full activation of the Ras/extracellular signal-regulated kinase signaling pathway in FcepsilonRI-stimulated mast cells...
  40. ncbi request reprint Regulation of outside-in signaling in platelets by integrin-associated protein kinase C beta
    Charito S Buensuceso
    Hematology Oncology Division, Department of Medicine, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 280:644-53. 2005
    ..Furthermore, the studies extend the concept of alpha(IIb)beta(3) as a scaffold for multiple protein kinases that regulate the platelet actin cytoskeleton...
  41. ncbi request reprint Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells
    Hidetoshi Kumagai
    Division of Hematopoietic Factors, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, 6 1 Shirokanedai 4 chome, Minato ku, Tokyo 108 8639, Japan
    Biochem Biophys Res Commun 307:719-29. 2003
    ..These findings suggest that a new pair of ITIM/ITAM-bearing receptors, LMIR1 and 2, regulate mast cell-mediated inflammatory responses through yet to be defined ligand(s)...
  42. ncbi request reprint PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling
    Thomas T Su
    The Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Nat Immunol 3:780-6. 2002
    ..Together, these data define an essential role for PKC-beta in BCR survival signaling and highlight PKC-beta as a key therapeutic target for B-lineage malignancies...
  43. ncbi request reprint G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells
    Attila Mocsai
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143 0134, USA
    Blood 101:4155-63. 2003
    ..We conclude that, in contrast to previous reports, Syk does not play a major role in GPCR signaling...
  44. ncbi request reprint O-methylated catechins from tea leaves inhibit multiple protein kinases in mast cells
    Mari Maeda-Yamamoto
    National Institute of Vegetable and Tea Science, National Agriculture Research Organization, and School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    J Immunol 172:4486-92. 2004
    ..These observations for the first time have revealed the molecular mechanisms of antiallergic effects of tea-derived catechins...
  45. ncbi request reprint Partial depletion of intracellular ATP mediates the stress-survival function of the PCPH oncoprotein
    Juan A Recio
    Laboratory of Experimental Carcinogenesis, Department of Radiation Medicine, Georgetown University Medical Center, Washington, DC 20007, USA
    Cancer Res 62:2690-4. 2002
    ..Treatment with adenosine or nucleoside analogues may thus enhance the response to radiation or chemotherapy of tumors that express the PCPH oncogene...
  46. ncbi request reprint Role of the FcepsilonRI beta-chain ITAM as a signal regulator for mast cell activation with monomeric IgE
    Satoshi Nunomura
    Division of Molecular Cell Immunology and Allergology, Nihon University School of Medicine, Itabashi ku, Tokyo 173 8910, Japan
    Int Immunol 17:685-94. 2005
    ..These findings for the first time revealed the unique functions of the beta-chain ITAM in both chemical mediator release and cytokine production of mast cells upon monomeric IgE stimulation...
  47. doi request reprint Human IgE+ and IgE- are not equivalent to mouse highly cytokinergic IgE
    Liping Xie
    Johns Hopkins Asthma and Allergy Center at Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 121:1027-33. 2008
    ..Recently, there have been reports of monomeric highly cytokinergic IgEs causing mediator release, cytokine release, and phosphorylation events in cultured rodent and human mast cells in the absence of antigen...
  48. ncbi request reprint Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response
    Kentaro Matsuda
    Department of Pathology, Stanford University School of Medicine, CA 94305 5324, USA
    J Allergy Clin Immunol 116:1357-63. 2005
    ..Mouse monoclonal IgE antibodies can promote the survival of mouse bone marrow-derived cultured mast cells and induce the cells to secrete mediators in the absence of known specific antigen...
  49. pmc Development, migration, and survival of mast cells
    Yoshimichi Okayama
    Research Unit for Allergy Transcriptome, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama, Japan
    Immunol Res 34:97-115. 2006
    ..Recent studies also demonstrated that monomeric IgE binding to FcepsilonRI can enhance mast-cell survival. In this review we discuss the factors that regulate mast cell development, migration, and survival...
  50. ncbi request reprint Fer and Fps/Fes participate in a Lyn-dependent pathway from FcepsilonRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation
    Christian M Udell
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    J Biol Chem 281:20949-57. 2006
    ..Thus, Lyn and Fer/Fps kinases cooperate to phosphorylate Pecam-1 and activate Shp1/Shp2 phosphatases that function in part to limit mast cell activation...
  51. ncbi request reprint Role of galectin-3 in mast cell functions: galectin-3-deficient mast cells exhibit impaired mediator release and defective JNK expression
    Huan Yuan Chen
    Department of Dermatology, School of Medicine, University of California Davis, Sacramento, CA 95817, USA
    J Immunol 177:4991-7. 2006
    ..All together, these results point to an important role of galectin-3 in mast cell biology...
  52. pmc Quantitative time-resolved phosphoproteomic analysis of mast cell signaling
    Lulu Cao
    Department of Chemistry, Brown University, Providence, RI 02912, USA
    J Immunol 179:5864-76. 2007
    ....

Research Grants24

  1. Regulation of asthma by Btk and family kinases
    Toshiaki Kawakami; Fiscal Year: 2007
    ..This is a poorly explored area in DC biology. Our efforts will hopefully identify novel targets for pharmaceutical intervention to treat asthma and other immune diseases. ..
  2. Mast cell regulation by PKC and Akt
    Toshiaki Kawakami; Fiscal Year: 2005
    ..Given the critical importance of PKC in degranulation and other activation events, these studies are also likely to provide an opportunity for novel therapeutic modalities aimed at allergic diseases. ..
  3. IgE Regulation of Mast Cell Growth and Survival
    Toshiaki Kawakami; Fiscal Year: 2006
    ..abstract_text> ..
  4. ROLES OF PH DOMAINS IN MAST CELL SIGNAL TRANSDUCTION
    Toshiaki Kawakami; Fiscal Year: 2000
    ....
  5. PROTEIN TYROSINE KINASES AND MAST CELL ACTIVATION
    Toshiaki Kawakami; Fiscal Year: 2001
    ..Particularly, interactions of Btk with Src PTKs and ERK might suggest positive and negative, respectively, feedback mechanisms for FceRI induced mast cell activation. ..