Doug Green

Summary

Affiliation: La Jolla Institute for Allergy and Immunology
Country: USA

Publications

  1. pmc Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis
    Jean Ehrland Ricci
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Cell Biol 160:65-75. 2003
  2. ncbi Apoptotic pathways: ten minutes to dead
    Douglas R Green
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Cell 121:671-4. 2005
  3. ncbi Early work on the role of mitochondria, an interview with Doug Green
    Doug Green
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA
    Cell Death Differ 11:S119-21. 2004
  4. ncbi Activation-induced cell death in T cells
    Douglas R Green
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Immunol Rev 193:70-81. 2003
  5. ncbi The pathophysiology of mitochondrial cell death
    Douglas R Green
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Science 305:626-9. 2004
  6. pmc Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses
    Nathalie M Droin
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Mol Cell Biol 23:7638-47. 2003
  7. ncbi Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
    Jerry E Chipuk
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Science 303:1010-4. 2004
  8. ncbi Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis
    Diana Spierings
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Science 310:66-7. 2005
  9. ncbi BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
    Tomomi Kuwana
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Mol Cell 17:525-35. 2005
  10. ncbi PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
    Jerry E Chipuk
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Science 309:1732-5. 2005

Collaborators

Detail Information

Publications69

  1. pmc Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis
    Jean Ehrland Ricci
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Cell Biol 160:65-75. 2003
    ....
  2. ncbi Apoptotic pathways: ten minutes to dead
    Douglas R Green
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Cell 121:671-4. 2005
    ..The emerging, if preliminary, perspective these new studies provide may represent either a refinement of our views of how cells die or, perhaps, the beginnings of what amounts to a reformulation of our ideas...
  3. ncbi Early work on the role of mitochondria, an interview with Doug Green
    Doug Green
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA
    Cell Death Differ 11:S119-21. 2004
  4. ncbi Activation-induced cell death in T cells
    Douglas R Green
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Immunol Rev 193:70-81. 2003
    ..Induction of nonlymphoid FasL in this manner may serve as a sensing mechanism for immune cell infiltration, which contributes to peripheral deletion...
  5. ncbi The pathophysiology of mitochondrial cell death
    Douglas R Green
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Science 305:626-9. 2004
    ..The general rules governing the pathophysiology of MOMP and controversial issues regarding its regulation are discussed...
  6. pmc Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses
    Nathalie M Droin
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Mol Cell Biol 23:7638-47. 2003
    ..These results support a role for Egr family members in nonlymphoid expression of FasL, TRAIL, and TNF...
  7. ncbi Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
    Jerry E Chipuk
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Science 303:1010-4. 2004
    ..We propose that when p53 accumulates in the cytosol, it can function analogously to the BH3-only subset of proapoptotic Bcl-2 proteins to activate Bax and trigger apoptosis...
  8. ncbi Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis
    Diana Spierings
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Science 310:66-7. 2005
    ....
  9. ncbi BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
    Tomomi Kuwana
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Mol Cell 17:525-35. 2005
    ..In this model, the simple inhibition of antiapoptotic functions is insufficient to induce apoptosis unless a direct activator of Bax or Bak is present...
  10. ncbi PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
    Jerry E Chipuk
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Science 309:1732-5. 2005
    ..Mutant Bcl-xL that bound p53, but not PUMA, rendered cells resistant to p53-induced apoptosis irrespective of PUMA expression. Thus, PUMA couples the nuclear and cytoplasmic proapoptotic functions of p53...
  11. ncbi Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release
    Ichiro Kuwabara
    Divisions of Allergy and Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 277:3487-97. 2002
    ..Some of them are potentially contributory to this lectin's proapoptotic function and these include redox-related genes monoamine oxidase B, ryanodine receptor 2, and glutathione S-transferase Mu 3...
  12. ncbi In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis
    Shine Tu
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA
    Nat Cell Biol 8:72-7. 2006
    ..This approach unambiguously identifies the apical caspase activated in response to apoptotic stimuli, and establishes caspase-2 as a proximal mediator of heat shock-induced apoptosis...
  13. pmc Nonlymphoid Fas ligand in peptide-induced peripheral lymphocyte deletion
    Michael J Pinkoski
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 99:16174-9. 2002
    ..These data demonstrate that nonlymphoid FasL is expressed in response to peripheral T cell activation and participates in the regulation of T cells that infiltrate peripheral tissues...
  14. ncbi Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane
    Tomomi Kuwana
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Cell 111:331-42. 2002
    ..We conclude that mitochondrial protein release in apoptosis can be mediated by supramolecular openings in the outer mitochondrial membrane, promoted by BH3/Bax/lipid interaction and directly inhibited by Bcl-x(L)...
  15. pmc The role of ARK in stress-induced apoptosis in Drosophila cells
    Katja C Zimmermann
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Cell Biol 156:1077-87. 2002
    ..These results demonstrate the central role of ARK in stress-induced apoptosis, which appears to act independently of cytochrome c. Apoptosis induced by Reaper or Grim can proceed via a distinct pathway, independent of ARK...
  16. ncbi Tumor necrosis factor alpha up-regulates non-lymphoid Fas-ligand following superantigen-induced peripheral lymphocyte activation
    Michael J Pinkoski
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 277:42380-5. 2002
    ....
  17. ncbi Lymphocyte apoptosis: refining the paths to perdition
    Michael J Pinkoski
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Curr Opin Hematol 9:43-9. 2002
    ..In addition, the intricacies of the mitochondrial role in apoptosis are starting to unravel with reports of novel proteins, such as Smac/DIABLO, and old proteins, such as heat shock proteins, playing new roles in regulating cell death...
  18. ncbi Confocal restricted-height imaging of suspension cells (CRISC) in a PDMS microdevice during apoptosis
    Cristina Munoz-Pinedo
    La Jolla Institute for Allergy and Immunology, San Diego, CA, USA
    Lab Chip 5:628-33. 2005
    ....
  19. ncbi Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription
    Jerry E Chipuk
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Cancer Cell 4:371-81. 2003
    ..Hence, pharmacologic p53 modulators can activate a transcription-independent apoptotic program...
  20. ncbi Correlated three-dimensional light and electron microscopy reveals transformation of mitochondria during apoptosis
    Mei G Sun
    Department of Biology, San Diego State University, San Diego, CA 92182 4614, USA
    Nat Cell Biol 9:1057-65. 2007
    ..Swelling occurs only late in apoptosis after release of cytochrome c and loss of the mitochondrial membrane potential...
  21. ncbi Duration of CTL activation regulates IL-2 production required for autonomous clonal expansion
    Diana C J Spierings
    La Jolla Institute for Allergy and Immunology, San Diego, CA, USA
    Eur J Immunol 36:1707-17. 2006
    ..These results indicate that the nature and duration of antigenic stimulation regulate the autonomy of CTL expansion via the production of autocrine IL-2...
  22. ncbi Apoptosis: letting slip the dogs of war
    Beni B Wolf
    Department of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Curr Biol 12:R177-9. 2002
    ....
  23. ncbi Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
    Ulrich Maurer
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Mol Cell 21:749-60. 2006
    ..The results demonstrate that the control of MCL-1 stability by GSK-3 is an important mechanism for the regulation of apoptosis by growth factors, PI3K, and AKT...
  24. ncbi CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death
    Edith M Janssen
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Nature 434:88-93. 2005
    ..Regulation of Trail expression can therefore account for the role of CD4+ T cells in the generation of CD8+ T cell memory and represents a novel mechanism for controlling adaptive immune responses...
  25. ncbi Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain
    Jean Ehrland Ricci
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Cell 117:773-86. 2004
    ..Therefore, caspase cleavage of NDUFS1 is required for several mitochondrial changes associated with apoptosis...
  26. pmc Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death
    Christine Bonzon
    Department of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Mol Biol Cell 17:2150-7. 2006
    ..The data are consistent with a model in which Caspase-2 induces apoptosis via cleavage of Bid at D59 and the subsequent engagement of the mitochondrial (intrinsic) pathway...
  27. ncbi Role of Bcl-2 family members in immunity and disease
    Nathalie M Droin
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Biochim Biophys Acta 1644:179-88. 2004
    ..In this review, we describe current knowledge of the functions of different Bcl-2 members and their potential roles in disease and immunity...
  28. ncbi Cytoplasmic p53: bax and forward
    Jerry E Chipuk
    La Jolla Institute for Allergy and Immunology, Division of Cellular Immunology, San Diego, California 92121, USA
    Cell Cycle 3:429-31. 2004
    ..In parallel, p53 can release pro-apoptotic Bcl-2 proteins sequestered by Bcl-x(L). These data suggest that cytoplasmic p53 functions analogously to the BH3-only proteins, a subset of pro-apoptotic Bcl-2 proteins...
  29. ncbi Apoptosis in the regulation of immune responses
    Michael J Pinkoski
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California, USA
    J Rheumatol Suppl 74:19-25. 2005
    ..Concepts reviewed here include caspase activation, death pathways, and crosstalk between death ligands and their receptors...
  30. ncbi The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways
    Emmanuel Dejardin
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Immunity 17:525-35. 2002
    ..In contrast, IKKalpha controls the induction by LTbetaR ligation of chemokines and cytokines involved in lymphoid organogenesis, including SLC, BLC, ELC, SDF1, and BAFF...
  31. ncbi A unified model for apical caspase activation
    Kelly M Boatright
    The Program in Apoptosis and Cell Death Research, Burnham Institute, 10901 North Torrey Pines Road, University of California, San Diego, La Jolla, CA 92037, USA
    Mol Cell 11:529-41. 2003
    ..We propose a unified caspase activation hypothesis whereby apical caspases are activated by dimerization of monomeric zymogens...
  32. ncbi Death and NF-kappaB in T cell activation: life at the edge
    Douglas R Green
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Mol Cell 11:551-2. 2003
    ..Nuclear Factor kappa-B appears to be required to prevent p73-induced apoptosis triggered by primary T cell activation. Here we explore what this state of affairs might do for the regulation of the immune system...
  33. pmc The multidomain proapoptotic molecules Bax and Bak are directly activated by heat
    Lisa J Pagliari
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 102:17975-80. 2005
    ..Our results support an emerging paradigm, wherein the activation of Bax or Bak and the blockade of antiapoptotic Bcl-2 proteins are pivotal steps in the mitochondrial pathway of apoptosis...
  34. ncbi Metalloproteinase shedding of Fas ligand regulates beta-amyloid neurotoxicity
    Douglas W Ethell
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Curr Biol 12:1595-600. 2002
    ..These findings suggest that factors that affect metalloproteinase-mediated shedding of FasL may play a role in the etiology of Alzheimer's disease and may provide an avenue for therapeutic intervention...
  35. ncbi Do inducers of apoptosis trigger caspase-independent cell death?
    Jerry E Chipuk
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Nat Rev Mol Cell Biol 6:268-75. 2005
    ..Here, we present recent findings and discuss the physiological relevance of caspase-independent cell death...
  36. ncbi And all of a sudden it's over: mitochondrial outer-membrane permeabilization in apoptosis
    Nigel J Waterhouse
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Biochimie 84:113-21. 2002
    ..It is still unclear how these proteins are released from the mitochondria. Recent advances in our knowledge of mitochondrial outer-membrane permeabilization and the consequences of this event on mitochondria will be discussed...
  37. pmc A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid
    Shailaja Kasibhatla
    Maxim Pharmaceuticals, Inc, 6650 Nancy Ridge Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 102:12095-100. 2005
    ..In summary, GA binding to TfR induces a unique signal leading to rapid apoptosis of tumor cells. These results suggest that GA may provide an additional approach for targeting the TfR and its use in cancer therapy...
  38. ncbi Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice
    Maya Saleh
    Department of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Nature 440:1064-8. 2006
    ..In mice, caspase-12 deficiency confers resistance to sepsis and its presence exerts a dominant-negative suppressive effect on caspase-1, resulting in enhanced vulnerability to bacterial infection and septic mortality...
  39. ncbi Regulation of arthritis by p53: critical role of adaptive immunity
    Egle Simelyte
    University of California, San Diego, School of Medicine, La Jolla, CA, USA
    Arthritis Rheum 52:1876-84. 2005
    ..To determine if adaptive immune responses or synovial effector functions are responsible for this effect, passive models of arthritis were studied in p53 wild-type and knockout mice...
  40. ncbi p53's believe it or not: lessons on transcription-independent death
    Jerry E Chipuk
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    J Clin Immunol 23:355-61. 2003
    ..Here we will explore what is currently known about TIPA learned from various p53 mutants and truncations, along with discussing several proposed mechanisms...
  41. ncbi A matter of life and death
    Douglas R Green
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Cancer Cell 1:19-30. 2002
    ..The secondary traits of diverse neoplasms are a consequence of cell proliferation, tissue expansion, and other outcomes of this platform...
  42. ncbi Overview: apoptotic signaling pathways in the immune system
    Douglas R Green
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Immunol Rev 193:5-9. 2003
  43. ncbi HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cells
    Karuppiah Muthumani
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:37820-31. 2002
    ..Bcl-2 overexpressing cells succumb to Vpr-induced apoptosis. These studies illustrate that Vpr induces a mitochondria-dependent apoptotic pathway that is distinct from apoptosis driven by the Fas-FasL pathway...
  44. ncbi Uptake of apoptotic antigen-coupled cells by lymphoid dendritic cells and cross-priming of CD8(+) T cells produce active immune unresponsiveness
    Thomas A Ferguson
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 168:5589-95. 2002
    ..The results provide a mechanism for a well-established method of inducing immunologic unresponsiveness...
  45. ncbi At the gates of death
    Douglas R Green
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Cell 9:328-30. 2006
    ..Here, we discuss an emerging view, proposed by Certo et al. in this issue of Cancer Cell, on how these interactions result in MOMP and apoptosis...
  46. pmc Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration
    Cristina Munoz-Pinedo
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 103:11573-8. 2006
    ..The timing and extent of AIF release makes it unlikely that it is involved in the induction of apoptosis, either upstream or downstream of mitochondrial outer membrane permeabilization...
  47. ncbi Role of proteolysis in caspase-8 activation and stabilization
    Cristina Pop
    Program in Apoptosis and Cell Death Research, The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 46:4398-407. 2007
    ..Autoproteolysis of caspase-8 may be a mechanism for increasing the lifetime of the dimeric enzyme following dissociation from its activating complex at the cell membrane...
  48. ncbi GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation
    Anna Colell
    Department of Cell Death and Proliferation, Institut d Investigacions Biomediques de Barcelona IIBB CSIC, IDIBAPS, 08036 Barcelona, Spain
    Cell 129:983-97. 2007
    ..Therefore, GAPDH mediates an elevation in glycolysis and enhanced autophagy that cooperate to protect cells from CICD...
  49. pmc Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein
    Hirotaka Kazama
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 631101, USA
    Immunity 29:21-32. 2008
    ..Similarly, blocking sites of oxidation in HMGB1 prevented tolerance induction by apoptotic cells. These results suggest that caspase-orchestrated mitochondrial events determine the impact of apoptotic cells on the immune response...
  50. pmc Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization
    Ann Cassidy-Stone
    Section of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616, USA
    Dev Cell 14:193-204. 2008
    ..Our findings raise the interesting possibility that mdivi-1 represents a class of therapeutics for stroke, myocardial infarction, and neurodegenerative diseases...
  51. doi Cytochrome c: functions beyond respiration
    Yong Ling P Ow
    The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario M5G 2C1, Canada
    Nat Rev Mol Cell Biol 9:532-42. 2008
    ..As well as its role in canonical intrinsic apoptosis, cytochrome c amplifies signals that are generated by other apoptotic pathways and participates in certain non-apoptotic functions...
  52. ncbi Cell death and immune privilege
    Thomas A Ferguson
    Department of Ophthalmology and Visual Sciences, Department of Pathology, Washington University School of Medicine, 660 S Euclid, Box 8096, St Louis, MO 63110, USA
    Int Rev Immunol 21:153-72. 2002
    ..In these organs immune responses either do not proceed, or proceed in a manner different from other areas; thus, they are called "immunologically privileged." Here a functioning immune response can be the culprit that leads to disease...
  53. pmc HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation
    Karuppiah Muthumani
    University of Pennsylvania School of Medicine, Department of Pathology and Laboratory Medicine 422 Curie Blvd, Philadelphia, PA 19104, USA
    Blood 106:2059-68. 2005
    ..Therefore, a linear pathway for Nef-induced FasL expression that encompasses p38 and AP-1 has been elucidated. Furthermore, chemical inhibition of the p38 pathway attenuates HIV-1-mediated bystander killing of CD8 cells in vitro...
  54. ncbi RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100
    Emmanuel Derudder
    Laboratoire Oncogenese, Differenciation et Transduction du Signal, CNRS UPR 9079, Institut Andre Lwoff, 7 rue Guy Moquet, 94801 Villejuif, France
    J Biol Chem 278:23278-84. 2003
    ....
  55. ncbi Minimal BH3 peptides promote cell death by antagonizing anti-apoptotic proteins
    Carole Moreau
    INSERM U419, Nantes, France
    J Biol Chem 278:19426-35. 2003
    ..Thus, BH3 domains do not necessarily activate multidomain pro-apoptotic proteins directly but promote apoptosis by releasing active multidomain pro-apoptotic proteins from their anti-apoptotic counterparts...
  56. pmc Pharmacological manipulation of cell death: clinical applications in sight?
    Douglas R Green
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Clin Invest 115:2610-7. 2005
    ....
  57. ncbi The suicide in the thymus, a twisted trail
    Douglas R Green
    Nat Immunol 4:207-8. 2003
  58. ncbi Dynamic regulation of FoxP3 expression controls the balance between CD4+ T cell activation and cell death
    Deborah J Kasprowicz
    Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    Eur J Immunol 35:3424-32. 2005
    ..Concomitant with differentiation is a loss of FoxP3 mRNA and protein. These data demonstrate that FoxP3 levels regulate T cell function, and that FoxP3 itself is dynamically regulated during effector T cell differentiation...
  59. pmc How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
    Jerry E Chipuk
    St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Trends Cell Biol 18:157-64. 2008
    ....
  60. pmc Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation
    Clare L Scott
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Cell Biol 164:89-96. 2004
    ..Moreover, loss of Apaf-1 did not promote oncogene-induced transformation of mouse embryo fibroblasts. Thus, Apaf-1 and caspase-9 do not suppress c-myc-induced lymphomagenesis and embryo fibroblast transformation...
  61. pmc Measuring apoptosis at the single cell level
    Lisa Bouchier-Hayes
    Department of Immunology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Methods 44:222-8. 2008
    ..We discuss these techniques here and highlight the advantages and drawbacks of using such approaches to study apoptosis...
  62. pmc A survivor hits the breaks
    Douglas R Green
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mol Cell 29:411-2. 2008
    ..In this issue of Molecular Cell, Wang et al. (2008) propose another function for Bcl2: the inhibition of DNA repair by nonhomologous end-joining...
  63. ncbi Mitochondria, apoptosis and autoimmunity
    Michael J Pinkoski
    Medical Research Council, Toxicology Unit, Leicester, UK
    Curr Dir Autoimmun 9:55-73. 2006
    ....
  64. doi Fas Bim boom!
    Douglas R Green
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Immunity 28:141-3. 2008
    ..New findings by Hughes et al. (2008), Hutcheson et al. (2008), and Weant et al. (2008) highlight the roles of apoptosis regulators Bim and Fas in the contraction phase of T cell responses and reveal consequences of failure of this process...
  65. ncbi Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils
    Isabelle Daigle
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Nat Med 8:61-7. 2002
    ..Thus, we provide molecular and functional evidence for negative signaling by death receptors...
  66. ncbi Presence of a transcriptionally active glucocorticoid receptor alpha in lens epithelial cells
    Eric R James
    Department of Ophthalmology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA
    Invest Ophthalmol Vis Sci 44:5269-76. 2003
    ..The purpose of this study was to determine whether lens epithelial cells (LECs) contain a glucocorticoid receptor (GR) that is transcriptionally active and that is able to induce production of known glucocorticoid-inducible proteins...
  67. ncbi Remodeling for demolition: changes in mitochondrial ultrastructure during apoptosis
    John C Reed
    The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell 9:1-3. 2002
    ..Both events are induced by proapoptotic members of the Bcl-2 family and appear to be separable...
  68. ncbi Granzyme A: the road less traveled
    Michael J Pinkoski
    Nat Immunol 4:106-8. 2003
  69. ncbi Life, death, BH3 profiles, and the salmon mousse
    Douglas R Green
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 12:97-9. 2007
    ....