Michael Croft

Summary

Affiliation: La Jolla Institute for Allergy and Immunology
Country: USA

Publications

  1. ncbi request reprint Peptide-specific CD8 T regulatory cells use IFN-gamma to elaborate TGF-beta-based suppression
    Lara Myers
    Division of Immunology, University of Connecticut Health Center, Farmington, CT 06032, USA
    J Immunol 174:7625-32. 2005
  2. pmc Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells
    Seung Woo Lee
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Nat Immunol 9:917-26. 2008
  3. pmc Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment
    Damien Bresson
    Diabetes Center, Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Autoimmun 37:342-51. 2011
  4. pmc Clinical targeting of the TNF and TNFR superfamilies
    Michael Croft
    Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    Nat Rev Drug Discov 12:147-68. 2013
  5. pmc TNF superfamily in inflammatory disease: translating basic insights
    Michael Croft
    La Jolla Institute for Allergy and Immunology, Division of Immune Regulation, 9420 Athena Circle, La Jolla, CA 92037, USA
    Trends Immunol 33:144-52. 2012
  6. pmc Control of immunity by the TNFR-related molecule OX40 (CD134)
    Michael Croft
    La Jolla Institute for Allergy and Immunology, California 92037, USA
    Annu Rev Immunol 28:57-78. 2010
  7. pmc The role of TNF superfamily members in T-cell function and diseases
    Michael Croft
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA
    Nat Rev Immunol 9:271-85. 2009
  8. ncbi request reprint The evolving crosstalk between co-stimulatory and co-inhibitory receptors: HVEM-BTLA
    Michael Croft
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Trends Immunol 26:292-4. 2005
  9. pmc The significance of OX40 and OX40L to T-cell biology and immune disease
    Michael Croft
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Immunol Rev 229:173-91. 2009
  10. ncbi request reprint Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?
    Michael Croft
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Nat Rev Immunol 3:609-20. 2003

Research Grants

  1. Regulation of T Cell Tolerance by OX40
    Michael Croft; Fiscal Year: 2006
  2. The Role of 4-IBB in T Cell and APC Interactions
    Michael Croft; Fiscal Year: 2007
  3. TNFR Members in T Cell Immunity to Vaccinia
    Michael Croft; Fiscal Year: 2007
  4. The Molecular Basis of OX40 on CD4 T Cells
    Michael Croft; Fiscal Year: 2009
  5. The Role of 4-1BB in T Cell and APC Interactions
    Michael Croft; Fiscal Year: 2009
  6. The Molecular Basis of OX40 on CD4 T Cells
    Michael Croft; Fiscal Year: 2010
  7. The Role of 4-1BB in T Cell and APC Interactions
    Michael Croft; Fiscal Year: 2010
  8. TNFR Members in T Cell Immunity to Vaccinia
    Michael Croft; Fiscal Year: 2010
  9. Regulation of T Cell Tolerance by OX40
    Michael Croft; Fiscal Year: 2010
  10. The Molecular Basis of OX40 on CD4 T Cells
    Michael Croft; Fiscal Year: 2007

Detail Information

Publications82

  1. ncbi request reprint Peptide-specific CD8 T regulatory cells use IFN-gamma to elaborate TGF-beta-based suppression
    Lara Myers
    Division of Immunology, University of Connecticut Health Center, Farmington, CT 06032, USA
    J Immunol 174:7625-32. 2005
    ..Ultimately, this mechanism may permit regulation of pathogenic Th1 responses by CD8 T regulatory cells...
  2. pmc Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells
    Seung Woo Lee
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Nat Immunol 9:917-26. 2008
    ..Thus, 4-1BB and 4-1BBL have a previously unknown function in limiting myelopoiesis and the development of dendritic cells...
  3. pmc Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment
    Damien Bresson
    Diabetes Center, Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Autoimmun 37:342-51. 2011
    ....
  4. pmc Clinical targeting of the TNF and TNFR superfamilies
    Michael Croft
    Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    Nat Rev Drug Discov 12:147-68. 2013
    ....
  5. pmc TNF superfamily in inflammatory disease: translating basic insights
    Michael Croft
    La Jolla Institute for Allergy and Immunology, Division of Immune Regulation, 9420 Athena Circle, La Jolla, CA 92037, USA
    Trends Immunol 33:144-52. 2012
    ..Here, we examine recent data regarding the potential of these molecules as targets for therapy of autoimmune and inflammatory disease...
  6. pmc Control of immunity by the TNFR-related molecule OX40 (CD134)
    Michael Croft
    La Jolla Institute for Allergy and Immunology, California 92037, USA
    Annu Rev Immunol 28:57-78. 2010
    ....
  7. pmc The role of TNF superfamily members in T-cell function and diseases
    Michael Croft
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA
    Nat Rev Immunol 9:271-85. 2009
    ..Here, I explore how blocking or inducing the signalling pathways that are triggered by these different interactions can be an effective way to modulate immune responses...
  8. ncbi request reprint The evolving crosstalk between co-stimulatory and co-inhibitory receptors: HVEM-BTLA
    Michael Croft
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Trends Immunol 26:292-4. 2005
    ..However, two studies have now provided a new perspective in this already complex area, showing not only a crosstalk between these superfamilies but potentially between co-stimulatory and co-inhibitory receptors...
  9. pmc The significance of OX40 and OX40L to T-cell biology and immune disease
    Michael Croft
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Immunol Rev 229:173-91. 2009
    ....
  10. ncbi request reprint Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?
    Michael Croft
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Nat Rev Immunol 3:609-20. 2003
    ..The roles of these molecules in initiating and sustaining the T-cell response and in promoting long-lived immunity are discussed...
  11. ncbi request reprint Costimulation of T cells by OX40, 4-1BB, and CD27
    Michael Croft
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Cytokine Growth Factor Rev 14:265-73. 2003
    ..This review will focus on recent studies of these molecules and discuss their implications...
  12. doi request reprint Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1
    Tobias Boettler
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037
    J Immunol 191:5026-35. 2013
    ..The effect of the OX40 agonist was dependent on IL-2 signaling and the timing of OX40 stimulation. Collectively, our data demonstrate that excessive OX40 signaling can result in deleterious consequences in the setting of LCMV infection. ..
  13. ncbi request reprint OX40 costimulation promotes persistence of cytomegalovirus-specific CD8 T Cells: A CD4-dependent mechanism
    Ian R Humphreys
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 179:2195-202. 2007
    ..Collectively, these results indicate manipulation of OX40 may be useful in improving cellular immunotherapy regimes for treatment of persistent virus infections...
  14. pmc Preferential use of B7.2 and not B7.1 in priming of vaccinia virus-specific CD8 T cells
    Shahram Salek-Ardakani
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, San Diego, CA 92037, USA
    J Immunol 182:2909-18. 2009
    ..2 is the major ligand for the CD28 receptor on VACV-specific CD8 T cells, that B7.2 can promote efficient CD8 T cell priming without B7.1, and that B7.1 and B7.2 can be differentially utilized during antiviral responses...
  15. pmc Antagonism of airway tolerance by endotoxin/lipopolysaccharide through promoting OX40L and suppressing antigen-specific Foxp3+ T regulatory cells
    Wei Duan
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 181:8650-9. 2008
    ..Targeting OX40L then has the potential to improve the efficacy of Ag immunotherapy to promote tolerance...
  16. ncbi request reprint Functional dichotomy between OX40 and 4-1BB in modulating effector CD8 T cell responses
    Seung Woo Lee
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 177:4464-72. 2006
    ..OX40 can positively regulate effector function and late accumulation/survival, whereas 4-1BB can initially operate in a negative manner to limit primary CD8 responses...
  17. ncbi request reprint Costimulation of CD8 T cell responses by OX40
    Pratima Bansal-Pakala
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 172:4821-5. 2004
    ..Thus, OX40 is one of the costimulatory molecules that can contribute signals to regulate the accumulation of Ag-reactive CD8 cells during immune responses...
  18. pmc CD4+ cells are required for chronic eosinophilic lung inflammation but not airway remodeling
    Taylor A Doherty
    La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Am J Physiol Lung Cell Mol Physiol 296:L229-35. 2009
    ....
  19. pmc Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8(+) T cells
    Ian R Humphreys
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
    Eur J Immunol 40:2762-8. 2010
    ..These data highlight the dual nature of the 4-1BB/4-1BBL system in mediating both stimulatory and inhibitory cosignaling activities during the generation of anti-MCMV immunity...
  20. pmc SLAT regulates Th1 and Th2 inflammatory responses by controlling Ca2+/NFAT signaling
    Stéphane Bécart
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    J Clin Invest 117:2164-75. 2007
    ..Thus, SLAT is required for thymic DN1 cell expansion, T cell activation, and Th1 and Th2 inflammatory responses...
  21. pmc Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance
    Pejman Soroosh
    Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Exp Med 210:775-88. 2013
    ..Therefore, lung-resident tissue MØs have regulatory functions, and strategies to target these cells might hold promise for prevention or treatment of allergic asthma...
  22. pmc Costimulation of mast cells by 4-1BB, a member of the tumor necrosis factor receptor superfamily, with the high-affinity IgE receptor
    Hajime Nishimoto
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA
    Blood 106:4241-8. 2005
    ..Therefore, FcepsilonRI-inducible 4-1BB plays a costimulatory function together with FcepsilonRI stimulation...
  23. pmc The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling
    Taylor A Doherty
    Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Med 17:596-603. 2011
    ....
  24. pmc B cell-specific expression of B7-2 is required for follicular Th cell function in response to vaccinia virus
    Samira Salek-Ardakani
    Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, San Diego, CA 92037, USA
    J Immunol 186:5294-303. 2011
    ..Our data provide new insight into the source and nature of molecules required for T(FH) cells to direct GC B cell responses...
  25. ncbi request reprint Differential regulation of Th2 and Th1 lung inflammatory responses by protein kinase C theta
    Shahram Salek-Ardakani
    Division Molecular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, La Jolla, CA 92121, USA
    J Immunol 173:6440-7. 2004
    ..These data suggest that PKCtheta can play roles in aspects of both Th2 and Th1 responses, but lung inflammation induced by Th2 cells is more dependent on this protein kinase than lung inflammation induced by Th1 cells...
  26. ncbi request reprint Vaccination with dendritic cells pulsed with apoptotic tumors in combination with anti-OX40 and anti-4-1BB monoclonal antibodies induces T cell-mediated protective immunity in Her-2/neu transgenic mice
    Camilo Cuadros
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Int J Cancer 116:934-43. 2005
    ....
  27. ncbi request reprint TNF receptor-associated factor 5 limits the induction of Th2 immune responses
    Takanori So
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 172:4292-7. 2004
    ..These results suggest that TRAF5 can limit the induction of Th2 responses, and that TRAF5 can play a role in modulating responses driven by OX40 costimulation...
  28. pmc Correlates of protection efficacy induced by vaccinia virus-specific CD8+ T-cell epitopes in the murine intranasal challenge model
    Magdalini Moutaftsi
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
    Eur J Immunol 39:717-22. 2009
    ..However, binding affinity partially predicted protection efficacy and ultimately epitope immunogenicity and recognition of infected cells offered the best correlation...
  29. pmc Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival
    Jianxun Song
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 180:7240-8. 2008
    ..Thus, OX40 signals regulate T cell number and viability through the NF-kappaB1 pathway that controls expression and activity of intracellular targets for proliferation and survival...
  30. ncbi request reprint Enhanced CD4 T cell responsiveness in the absence of 4-1BB
    Seung Woo Lee
    La Jolla Institute for Allergy and Immunology, Division of Molecular Immunology, San Diego, CA 92121, USA
    J Immunol 174:6803-8. 2005
    ..These results demonstrate that the absence of 4-1BB can make CD4 T cells hyperresponsive to protein Ag in vivo, suggesting a new unappreciated negative regulatory role of 4-1BB when expressed on a T cell...
  31. pmc The adaptor molecule MyD88 directly promotes CD8 T cell responses to vaccinia virus
    Yuan Zhao
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 182:6278-86. 2009
    ..Together, our results highlight an important role for MyD88 in initial antiviral CD8 T cell responses and suggest that targeting this pathway may be useful in promoting and sustaining anti-VACV immunity...
  32. pmc STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria
    Taylor A Doherty
    Dept of Medicine, Univ of California San Diego, Biomedical Sciences Bldg, La Jolla, CA 92093 0635, USA
    Am J Physiol Lung Cell Mol Physiol 303:L577-88. 2012
    ..Thus several transcription factor pathways (STAT6, GATA-3, and ETS-1) may contribute to NHC proliferation and Th2-type responses in Alternaria-induced asthma...
  33. pmc Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness
    Taylor A Doherty
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0635, USA
    J Immunol 188:2622-9. 2012
    ..This may provide some insight into the uniquely pathogenic aspects of Alternaria-associated asthma...
  34. ncbi request reprint Cooperation between CD4 and CD8 T cells for anti-tumor activity is enhanced by OX40 signals
    Aihua Song
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92037, USA
    Eur J Immunol 37:1224-32. 2007
    ..OX40 therefore represents an important signal for allowing effective cooperation between CD4 and CD8 cells and for promoting cell interplay and tumor rejection where CD8 activity is limiting...
  35. ncbi request reprint Protein kinase Ctheta controls Th1 cells in experimental autoimmune encephalomyelitis
    Shahram Salek-Ardakani
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 175:7635-41. 2005
    ..These data provide evidence of a pivotal role for PKCtheta in the generation and effector function of autoimmune Th1 cells...
  36. pmc Cutting edge: 4-1BB controls regulatory activity in dendritic cells through promoting optimal expression of retinal dehydrogenase
    Seung Woo Lee
    Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 189:2697-701. 2012
    ..Thus, our data demonstrate a novel activity of 4-1BB in controlling RALDH expression and the regulatory activity of DC...
  37. pmc Inducible CD4+LAP+Foxp3- regulatory T cells suppress allergic inflammation
    Wei Duan
    Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA 920370, USA
    J Immunol 187:6499-507. 2011
    ..Taken together, we concluded that inducible Ag-specific LAP(+) Tregs can suppress asthmatic lung inflammation and constitute a mediator of airway tolerance together with Foxp3(+) Tregs...
  38. pmc OX40 drives protective vaccinia virus-specific CD8 T cells
    Shahram Salek-Ardakani
    Division of Molecular Immunology, La JollaInstitute for Allergy and Immunology, San Diego, CA 92037, USA
    J Immunol 181:7969-76. 2008
    ..These data suggest that unique costimulatory pathways might control alternate antiviral CD8 responses, demonstrating the plasticity of the immune response in utilizing different mechanisms to achieve similar ultimate goals...
  39. pmc Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment
    Takanori So
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 103:3740-5. 2006
    ....
  40. ncbi request reprint Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion
    Jianxun Song
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Immunity 22:621-31. 2005
    ..Thus, sustained Survivin expression from costimulatory signaling maintains T cell division over time and regulates the extent of clonal expansion...
  41. ncbi request reprint Tumor necrosis factor/tumor necrosis factor receptor family members that positively regulate immunity
    Takanori So
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California, USA
    Int J Hematol 83:1-11. 2006
    ..This review summarizes aspects of these TNF/TNFR interactions that are potentially important to immune responses...
  42. pmc OX40 facilitates control of a persistent virus infection
    Tobias Boettler
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
    PLoS Pathog 8:e1002913. 2012
    ..Consequently, OX40-deficient mice fail to control LCMV clone 13 infection over time, highlighting the importance of this signaling pathway during persistent viral infection...
  43. pmc Cytomegalovirus exploits IL-10-mediated immune regulation in the salivary glands
    Ian R Humphreys
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Exp Med 204:1217-25. 2007
    ..Collectively, the results indicate that modulating effector T cell differentiation can counteract pathogen exploitation of the mucosa, thus limiting persistent virus replication and transmission...
  44. pmc Hypercostimulation through 4-1BB distorts homeostasis of immune cells
    Seung Woo Lee
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 182:6753-62. 2009
    ....
  45. pmc Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice
    Yoshihiko Tanaka
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA
    Blood 106:1286-95. 2005
    ..Thus, Vav1 is selectively required for IL-4 and c-Maf expression, a requirement reflecting, at least in part, the dependence of c-Maf expression on Ca2+/NFAT signaling...
  46. pmc Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling
    Dae Jin Song
    Department of Medicine, University of California San Diego, San Diego, CA 92093, USA
    J Immunol 183:5333-41. 2009
    ....
  47. pmc The TNFR family members OX40 and CD27 link viral virulence to protective T cell vaccines in mice
    Shahram Salek-Ardakani
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    J Clin Invest 121:296-307. 2011
    ..Our results suggest that the virulence of a virus dictates costimulatory receptor usage to determine the level of protective CD8+ T cell immunity...
  48. ncbi request reprint Prevention of diabetes in NOD mice at a late stage by targeting OX40/OX40 ligand interactions
    Syamasundar V Pakala
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Eur J Immunol 34:3039-46. 2004
    ..These studies show that OX40/OX40L interactions form a late checkpoint in diabetes development and suggest that these molecules are realistic targets for therapeutic intervention...
  49. pmc Nitric oxide modulates TGF-beta-directive signals to suppress Foxp3+ regulatory T cell differentiation and potentiate Th1 development
    Seung Woo Lee
    Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 186:6972-80. 2011
    ....
  50. ncbi request reprint OX40 and Bcl-xL promote the persistence of CD8 T cells to recall tumor-associated antigen
    Aihua Song
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 175:3534-41. 2005
    ..These data demonstrate that OX40 and Bcl-x(L) can control survival of primed CD8 T cells and provide new insights into both regulation of CD8 immunity and control of tumors...
  51. ncbi request reprint Defective T cell priming associated with aging can be rescued by signaling through 4-1BB (CD137)
    Pratima Bansal-Pakala
    Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 169:5005-9. 2002
    ..These studies demonstrate that 4-1BB, and potentially other costimulatory members of the TNFR family, are targets for therapies aimed at augmenting weak T cell responses in elderly immunocompromised individuals...
  52. ncbi request reprint The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes
    Jianxun Song
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    Nat Immunol 8:64-73. 2007
    ..Moreover, expression of aurora B restored Cd28-/- T cell proliferation and promoted inflammation in vivo. These data identify aurora B, along with survivin and mTOR, as a regulator of the G1-S checkpoint in T cells...
  53. ncbi request reprint The costimulation-regulated duration of PKB activation controls T cell longevity
    Jianxun Song
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Nat Immunol 5:150-8. 2004
    ..Thus, sustained and periodic PKB signaling has an integral role in regulating T cell longevity...
  54. pmc Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production
    Taylor A Doherty
    Department of Medicine, University of California, La Jolla, CA 92093 0635, USA
    J Allergy Clin Immunol 132:205-13. 2013
    ..Cysteinyl leukotrienes (CysLTs) contribute to asthma pathogenesis, in part through cysteinyl leukotriene receptor 1 (CysLT1R). Recently discovered lineage-negative type 2 innate lymphoid cells (ILC2s) potently produce IL-5 and IL-13...
  55. pmc Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cells
    Takanori So
    Divisions of Molecular Immunology and Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:2903-8. 2011
    ..Thus, by recruiting TCR-related intracellular molecules into the TRAF2 complex, OX40 provides the T cell with a high level of NF-κB activity needed for longevity...
  56. pmc Innate signals from Nod2 block respiratory tolerance and program T(H)2-driven allergic inflammation
    Wei Duan
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Allergy Clin Immunol 126:1284-93.e10. 2010
    ..Airway tolerance is critical for protecting the lung from inflammatory disease driven by allergens. However, factors that disrupt tolerance processes and then lead to susceptibility to developing allergic asthma remain elusive...
  57. pmc Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation
    Motti Gerlic
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:7808-13. 2013
    ..Altogether, these findings reveal a unique viral mechanism for evading host innate immune responses...
  58. pmc Dispensable role for 4-1BB and 4-1BBL in development of vaccinia virus-specific CD8 T cells
    Yuan Zhao
    La Jolla Institute for Allergy and Immunology, Division of Immune Regulation, 9420 Athena Circle, La Jolla, San Diego, CA 92037, USA
    Immunol Lett 141:220-6. 2012
    ..Thus, our data demonstrate that 4-1BB and 4-1BBL do not play a strong or dominant role in driving the generation of high frequencies of VACV-specific CD8 T cells...
  59. pmc The antigen presentation function of bone marrow-derived mast cells is spatiotemporally restricted to a subset expressing high levels of cell surface FcepsilonRI and MHC II
    Jian Gong
    Department of Allergy and Immunology, IgE Therapeutics, Inc, San Diego, CA, USA
    BMC Immunol 11:34. 2010
    ..Evidence is presented for a novel surface FcepsilonRIhi , MHC II +, and c-kit + pure mast cell subset, temporally restricted as antigen-presenting cells in the immune axis of T-cell activation...
  60. pmc Immune regulation and control of regulatory T cells by OX40 and 4-1BB
    Takanori So
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Cytokine Growth Factor Rev 19:253-62. 2008
    ..This review specifically focuses on recent studies of regulatory T cells, and regulatory or suppressive activity, that are modulated by OX40 or 4-1BB...
  61. pmc Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation
    K Venuprasad
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Clin Invest 116:1117-26. 2006
    ..This study suggests that MEKK1-JNK signaling regulates Itch E3 ligase-mediated tolerogenic process in Th2 cells. These findings have therapeutic implications for allergic diseases...
  62. pmc Herpesvirus entry mediator (TNFRSF14) regulates the persistence of T helper memory cell populations
    Pejman Soroosh
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Exp Med 208:797-809. 2011
    ..Collectively, our results demonstrate a critical role of HVEM signals in the persistence of large pools of memory CD4 T cells...
  63. pmc Targeting OX40 promotes lung-resident memory CD8 T cell populations that protect against respiratory poxvirus infection
    Shahram Salek-Ardakani
    La Jolla Institute for Allergy and Immunology, Division of Immune Regulation, 9420 Athena Circle, San Diego, CA 92037, USA
    J Virol 85:9051-9. 2011
    ..These data suggest that agonists to the OX40 costimulatory receptor represent potential candidates for incorporation into vaccines for respiratory viruses...
  64. pmc Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3
    Yuko Kawakami
    Divisions of Cell Biology and Molecular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 103:153-8. 2006
    ..These negative regulatory functions of Btk in dendritic cells appear to be mediated mainly through autocrine secretion of IL-10 and subsequent activation of Stat3...
  65. ncbi request reprint Regulation of CD4 T cell memory by OX40 (CD134)
    Shahram Salek-Ardakani
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Vaccine 24:872-83. 2006
    ..In this review we discuss these new developments in the context of past research and current models for the generation, persistence, and re-activation of memory T cells...
  66. pmc Virtual optimization of nasal insulin therapy predicts immunization frequency to be crucial for diabetes protection
    Georgia Fousteri
    Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Diabetes 59:3148-58. 2010
    ..Development of antigen-specific strategies to treat or prevent type 1 diabetes has been slow and difficult because of the lack of experimental tools and defined biomarkers that account for the underlying therapeutic mechanisms...
  67. ncbi request reprint Cutting edge: OX40 inhibits TGF-beta- and antigen-driven conversion of naive CD4 T cells into CD25+Foxp3+ T cells
    Takanori So
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 179:1427-30. 2007
    ..These data identify OX40 as a negative regulator of Foxp3 and suggest that OX40 can concomitantly promote effector T cell generation while antagonizing the differentiation of adaptive Foxp3(+) regulatory T cells...
  68. pmc Deficiency of the cyclin kinase inhibitor p21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoimmunity
    Brian R Lawson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 199:547-57. 2004
    ..Thus, modulation of the cell cycle pathway may be a novel approach to reduce apoptosis-resistant pathogenic lymphocytes and to ameliorate systemic autoimmunity...
  69. pmc Nasal cardiac myosin peptide treatment and OX40 blockade protect mice from acute and chronic virally-induced myocarditis
    Georgia Fousteri
    Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Autoimmun 36:210-20. 2011
    ..Altogether, these results chart the way for novel prevention and intervention strategies for viral myocarditis...
  70. pmc CD8 T cells are essential for recovery from a respiratory vaccinia virus infection
    John Goulding
    Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, San Diego, CA 92037, USA
    J Immunol 189:2432-40. 2012
    ....
  71. pmc Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice
    Georgia Fousteri
    Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Diabetes 61:1169-79. 2012
    ..They suggest that once central tolerance is bypassed, autoreactive cells arriving in the periphery do not by default follow solely a pathogenic fate upon activation...
  72. pmc Preferential replication of vaccinia virus in the ovaries is independent of immune regulation through IL-10 and TGF-β
    Yuan Zhao
    La Jolla Institute for Allergy and Immunology, Division of Immune Regulation, La Jolla, California 92037, USA
    Viral Immunol 24:387-96. 2011
    ..Collectively, the results indicate that preferential replication of VACV in the ovaries may not be dependent on immune suppressive mechanisms in this tissue...
  73. pmc OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation
    Shahram Salek-Ardakani
    La Jolla Institute for Allergy and Immunology, Division of Immunochemistry, 10355 Science Center Dr, San Diego, CA 92121, USA
    J Exp Med 198:315-24. 2003
    ..Thus, OX40-OX40L interactions are pivotal to the efficiency of recall responses regulated by memory Th2 cells...
  74. pmc Tumor necrosis factor receptor/tumor necrosis factor family members in antiviral CD8 T-cell immunity
    Shahram Salek-Ardakani
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    J Interferon Cytokine Res 30:205-18. 2010
    ..In this review, we discuss their control of the generation, persistence, and reactivation of CD8 T cells during virus infection...
  75. doi request reprint 4-1BB as a therapeutic target for human disease
    Seung Woo Lee
    Molecular Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California, 92037, USA
    Adv Exp Med Biol 647:120-9. 2009
    ..In this review, we will summarize the results of basic research on 4-1BB and 4-1BB immunotherapy of disease and provide some potential mechanistic insights into the many stimulatory and regulatory functions of 4-1BB...
  76. pmc OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling
    Takanori So
    Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 186:3547-55. 2011
    ..Therefore, OX40 primarily functions to augment PKB signaling in T cells by enhancing the amount of PI3K and PKB available to the TCR. This highlights a quantitative role of this TNFR family second signal to supplement signal 1...
  77. ncbi request reprint Vaccinia virus-specific CD4+ T cell responses target a set of antigens largely distinct from those targeted by CD8+ T cell responses
    Magdalini Moutaftsi
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 178:6814-20. 2007
    ..Taken together, these results highlight fundamental differences in immunodominance of CD4(+) and CD8(+) T cell responses to a complex pathogen...
  78. ncbi request reprint 4-1BB (CD137) controls the clonal expansion and survival of CD8 T cells in vivo but does not contribute to the development of cytotoxicity
    David Cooper
    Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Eur J Immunol 32:521-9. 2002
    ..These findings demonstrate that 4-1BB contributes to clonal expansion, survival, and development of Tc1 cells when protein antigen is encountered by primary CD8 T cells in an inflammatory environment in vivo...
  79. ncbi request reprint Combined CD137 (4-1BB) and adjuvant therapy generates a developing pool of peptide-specific CD8 memory T cells
    Lara Myers
    Department of Immunology, School of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Int Immunol 18:325-33. 2006
    ..Taken together, the data indicate that CD137 and adjuvant combined therapy is an efficacious vaccine strategy for immunization with non-replicating inert antigen...
  80. ncbi request reprint CD4 T cell priming in dendritic cell-deficient mice
    Paola Castiglioni
    Department of Medicine and Cancer Center, University of California San Diego, 9500 Gilman Drive, La Jolla CA 92093 0837, USA
    Int Immunol 15:127-36. 2003
    ..These data demonstrate that CD4( +) T cells can be primed in the absence of functional DC and suggest that relB may gauge the T cell response in vivo...
  81. ncbi request reprint CD28, TNF receptor, and IL-12 are critical for CD4-independent cross-priming of therapeutic antitumor CD8+ T cells
    Hong Ming Hu
    Laboratory of Molecular and Tumor Immunology, Robert W Franz Cancer Research Center, Earle A Chiles Research Institute, Providence Cancer Center and Providence Portland Medical Center, OR 97213, USA
    J Immunol 169:4897-904. 2002
    ..Thus, cross-priming of therapeutic CD8(+) T cells by a tumor vaccine transduced with GM-CSF requires TNFR, IL-12, and CD28 signaling...
  82. ncbi request reprint CD134 Costimulation Couples the CD137 Pathway to Induce Production of Supereffector CD8 T Cells That Become IL-7 Dependent
    Seung Joo Lee
    Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 179:2203-14. 2007
    ..Therefore, dual costimulation through CD137 and CD134 drives production and survival of supereffector CD8 T cells through a distinct IL-7-dependent pathway...

Research Grants33

  1. Regulation of T Cell Tolerance by OX40
    Michael Croft; Fiscal Year: 2006
    ..These studies will show the role of 0X40 in determining peripheral tolerance in both CD4 and CD8 compartments, and whether 0X40 is a viable target for reversing the tolerance process in disease. ..
  2. The Role of 4-IBB in T Cell and APC Interactions
    Michael Croft; Fiscal Year: 2007
    ..Moreover, it will aid in defining how T cell responses can be effectively targeted for vaccination or therapeutic purposes depending on the type of T cell and the stage in the life of the T cell. ..
  3. TNFR Members in T Cell Immunity to Vaccinia
    Michael Croft; Fiscal Year: 2007
    ....
  4. The Molecular Basis of OX40 on CD4 T Cells
    Michael Croft; Fiscal Year: 2009
    ....
  5. The Role of 4-1BB in T Cell and APC Interactions
    Michael Croft; Fiscal Year: 2009
    ..abstract_text> ..
  6. The Molecular Basis of OX40 on CD4 T Cells
    Michael Croft; Fiscal Year: 2010
    ....
  7. The Role of 4-1BB in T Cell and APC Interactions
    Michael Croft; Fiscal Year: 2010
    ..abstract_text> ..
  8. TNFR Members in T Cell Immunity to Vaccinia
    Michael Croft; Fiscal Year: 2010
    ....
  9. Regulation of T Cell Tolerance by OX40
    Michael Croft; Fiscal Year: 2010
    ..By understanding how OX40 controls the balance of effector/pathogenic T cells and regulatory T cells that suppress immune responses, this will aid in future strategies that might target human disease. ..
  10. The Molecular Basis of OX40 on CD4 T Cells
    Michael Croft; Fiscal Year: 2007
    ..abstract_text> ..
  11. OX-40 AND 4-IBB IN CD4 T CELL AND APC INTERACTIONS
    Michael Croft; Fiscal Year: 2001
    ..Finally, the role of Ox-40/Ox-40L and 4-1BB/4-1BBL interactions in collagen-induced arthritis will be tested. ..
  12. The Molecular Basis of OX40 on CD4 T Cells
    Michael Croft; Fiscal Year: 2003
    ..abstract_text> ..
  13. The Molecular Basis of OX40 on CD4 T Cells
    Michael Croft; Fiscal Year: 2006
    ..abstract_text> ..
  14. The Molecular Basis of OX40 on CD4 T Cells
    Michael Croft; Fiscal Year: 2011
    ....