Urs Christen

Summary

Affiliation: La Jolla Institute for Allergy and Immunology
Country: USA

Publications

  1. ncbi Manipulating the type 1 vs type 2 balance in type 1 diabetes
    Urs Christen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Immunol Res 30:309-25. 2004
  2. ncbi Apoptosis of autoreactive CD8 lymphocytes as a potential mechanism for the abrogation of type 1 diabetes by islet-specific TNF-alpha expression at a time when the autoimmune process is already ongoing
    Urs Christen
    Departments of Neuropharmacology and Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 958:166-9. 2002
  3. ncbi Infections and autoimmunity--good or bad?
    Urs Christen
    Immune Regulation Laboratory, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 174:7481-6. 2005
  4. ncbi IP-10 and type 1 diabetes: a question of time and location
    Urs Christen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA, USA
    Autoimmunity 37:273-82. 2004
  5. ncbi IP-10 and type 1 diabetes: a question of time and location
    Urs Christen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA, USA
    Autoimmunity 37:273-82. 2004
  6. ncbi Initiation of autoimmunity
    Urs Christen
    Immune Regulation Laboratory, Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Curr Opin Immunol 16:759-67. 2004
  7. ncbi Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease
    Urs Christen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 171:6838-45. 2003
  8. ncbi SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes
    Ana Maria Barral
    La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Autoimmun 27:166-73. 2006
  9. ncbi Islet-specific expression of CXCL10 causes spontaneous islet infiltration and accelerates diabetes development
    Antje Rhode
    Immune Regulation Laboratory, Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 175:3516-24. 2005
  10. ncbi Different diabetogenic potential of autoaggressive CD8+ clones associated with IFN-gamma-inducible protein 10 (CXC chemokine ligand 10) production but not cytokine expression, cytolytic activity, or homing characteristics
    Mette Ejrnaes
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 174:2746-55. 2005

Research Grants

Collaborators

Detail Information

Publications31

  1. ncbi Manipulating the type 1 vs type 2 balance in type 1 diabetes
    Urs Christen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Immunol Res 30:309-25. 2004
    ..In this review we will focus on the pathogenesis of T1D in a virus-induced transgenic mouse model and discuss possibilities of how an aggressive type 1-dominated immune response can be restrained and autoimmunity be abrogated...
  2. ncbi Apoptosis of autoreactive CD8 lymphocytes as a potential mechanism for the abrogation of type 1 diabetes by islet-specific TNF-alpha expression at a time when the autoimmune process is already ongoing
    Urs Christen
    Departments of Neuropharmacology and Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 958:166-9. 2002
    ..Here we provide a model of how experienced autoaggressive CD8 lymphocytes are dying by apoptosis as a result of beta cell-specific TNF-alpha expression at a time when the autoimmune process is already ongoing...
  3. ncbi Infections and autoimmunity--good or bad?
    Urs Christen
    Immune Regulation Laboratory, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 174:7481-6. 2005
    ..Knowledge of mechanisms that underlie either positive or negative effects of infections on autoimmunity will facilitate exploration of molecular details for prospective clinical studies in the future...
  4. ncbi IP-10 and type 1 diabetes: a question of time and location
    Urs Christen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA, USA
    Autoimmunity 37:273-82. 2004
    ....
  5. ncbi IP-10 and type 1 diabetes: a question of time and location
    Urs Christen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA, USA
    Autoimmunity 37:273-82. 2004
    ....
  6. ncbi Initiation of autoimmunity
    Urs Christen
    Immune Regulation Laboratory, Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Curr Opin Immunol 16:759-67. 2004
    ....
  7. ncbi Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease
    Urs Christen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 171:6838-45. 2003
    ....
  8. ncbi SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes
    Ana Maria Barral
    La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Autoimmun 27:166-73. 2006
    ..Thus, SOCS expression renders beta-cells resistant to CTL attack in a mouse model of T1D...
  9. ncbi Islet-specific expression of CXCL10 causes spontaneous islet infiltration and accelerates diabetes development
    Antje Rhode
    Immune Regulation Laboratory, Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 175:3516-24. 2005
    ..Our results indicate that CXCL10 expression accelerates the autoimmune process by enhancing the migration of Ag-specific lymphocytes to their target site...
  10. ncbi Different diabetogenic potential of autoaggressive CD8+ clones associated with IFN-gamma-inducible protein 10 (CXC chemokine ligand 10) production but not cytokine expression, cytolytic activity, or homing characteristics
    Mette Ejrnaes
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 174:2746-55. 2005
    ..Thus, secretion of IFN-gamma-inducible protein-10 by autoaggressive CD8(+) lymphocytes might determine their diabetogenic capacity by affecting recruitment of cells to the insulitic lesion...
  11. pmc A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes
    Urs Christen
    Immune Regulation Lab, Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Clin Invest 114:1290-8. 2004
    ..Sequential heterologous viral infections might therefore act in concert to precipitate clinical autoimmune disease, even if single exposure to a viral mimic does not always cause sufficient tissue destruction...
  12. ncbi Minimal impact of a de novo-expressed beta-cell autoantigen on spontaneous diabetes development in NOD mice
    Marianne M Martinic
    Immune Regulation Lab DI 3, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Diabetes 56:1059-68. 2007
    ..Thus, autoreactivity toward de novo-expressed beta-cell autoantigens will not accelerate autoimmunity unless large numbers of antigen-experienced autoreactive T-cells expressing the appropriate chemokine receptors are present...
  13. ncbi Virally induced inflammation triggers fratricide of Fas-ligand-expressing beta-cells
    Urs Christen
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California, USA
    Diabetes 53:591-6. 2004
    ..Expression of Fas-L therefore might not be protective in situations in which viral inflammation can be expected, resulting in Fas induction on the targeted cell itself...
  14. ncbi CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors
    Loui T Madakamutil
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Science 304:590-3. 2004
    ..Thus, memory precursors can be identified among primary effector cells and are selected for survival and differentiation by CD8alphaalpha...
  15. ncbi Virally induced inflammation and therapeutic avenues in type 1 diabetes
    Urs Christen
    Immune Regulation Laboratory, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Endocrinol Metab Clin North Am 33:45-58, viii. 2004
  16. ncbi Transgenic animal models for type 1 diabetes: linking a tetracycline-inducible promoter with a virus-inducible mouse model
    Urs Christen
    Department of Immune Regulation, IR 3, La Jolla Institute for Allergy and Immunology, San Diego, CA, USA
    Transgenic Res 11:587-95. 2002
    ....
  17. pmc Molecular anatomy of antigen-specific CD8(+) T cell engagement and synapse formation in vivo
    Dorian B McGavern
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Immunol 3:918-25. 2002
    ..In addition, we have established an in vivo approach for assessing the intricacies of antigen-specific T cell activation, migration, engagement, memory and other defining elements of adaptive immunity...
  18. pmc Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies
    Mette Ejrnaes
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Clin Dev Immunol 13:337-47. 2006
    ..First, we review recent findings that blockade of IL-10/IL-10R interaction can resolve chronic viral infection and second, we reflect on how neutralization of the chemokine CXCL10 can abrogate virus-induced type 1 diabetes...
  19. pmc Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient
    Urs Christen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Clin Invest 113:74-84. 2004
    ..Thus, virally induced proinflammatory cytokines and chemokines can influence the ongoing autoaggressive process beneficially at the preclinical stage, if produced at the correct location, time, and levels...
  20. ncbi Induction, acceleration or prevention of autoimmunity by molecular mimicry
    Urs Christen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA
    Mol Immunol 40:1113-20. 2004
    ..Already activated autoreactive cells might be easier re-activated and primed for effector functions by cross-reactive ligands than naive lymphocytes...
  21. pmc Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies
    Mette Ejrnaes
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Clin Dev Immunol 13:67-77. 2006
    ..First, we review recent findings that blockade of IL-10/IL-10R interaction can resolve chronic viral infection and second, we reflect on how neutralization of the chemokine CXCL10 can abrogate virus-induced type 1 diabetes...
  22. ncbi Cytokines and chemokines in virus-induced autoimmunity
    Urs Christen
    The Scripts Research Institute, Division of Virology, La Jolla, California, USA
    Adv Exp Med Biol 520:203-20. 2003
  23. ncbi CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
    Edith M Janssen
    Division of Cellular Immunology and Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Nature 421:852-6. 2003
    ..Our results demonstrate that T-cell help is 'programmed' into CD8+ T cells during priming, conferring on these cells a hallmark of immune response memory: the capacity for functional expansion on re-encounter with antigen...
  24. pmc Functional redundancy of CXCR3/CXCL10 signaling in the recruitment of diabetogenic cytotoxic T lymphocytes to pancreatic islets in a virally induced autoimmune diabetes model
    Ken T Coppieters
    Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Diabetes 62:2492-9. 2013
    ..Our present data in a viral mouse model challenge the notion that specific blockade of the CXCL10/CXCR3 chemokine axis halts T1D onset and progression. ..
  25. pmc Discrete proteolysis of focal contact and adherens junction components in Porphyromonas gingivalis-infected oral keratinocytes: a strategy for cell adhesion and migration disabling
    Edith Hintermann
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Infect Immun 70:5846-56. 2002
    ..Furthermore, they illustrate a new pathogenetic paradigm of infection whereby bacteria may disrupt the integrity of epithelia...
  26. ncbi Chemokines as drug targets in type 1 diabetes
    Urs Christen
    Pharmazentrum Frankfurt, Zentrum fur Arzneimittelforschung, Entwicklung und Sicherheit ZAFES, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Endocr Metab Immune Disord Drug Targets 7:7-12. 2007
    ..This review focuses on blocking of chemokines in animal models of type 1 diabetes and discusses the possible applications of such treatments in human autoimmune disease...
  27. pmc Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease
    Robert S Fujinami
    Department of Neurology, University of Utah School of Medicine, 30 N 1900 E, 3R330 SOM, Salt Lake City, UT 84132 2305, USA
    Clin Microbiol Rev 19:80-94. 2006
    ..These mechanisms are discussed in the context of multiple sclerosis, myocarditis, and diabetes, three immune-medicated diseases often linked with virus infections...
  28. ncbi Viral infection--a cure for type 1 diabetes?
    Edith Hintermann
    Pharmazentrum frankfurt ZAFES, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Curr Med Chem 14:2048-52. 2007
    ....
  29. ncbi Animal models for autoimmune hepatitis
    Urs Christen
    Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Autoimmun Rev 6:306-11. 2007
    ..However, most models were only successful in causing a transient form of hepatic damage and often used rather complex ways of disease induction...
  30. ncbi Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages
    Itamar Goren
    Pharmazentrum Frankfurt, ZAFES, Institut fur Allgemeine Pharmakologie und Toxikologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Invest Dermatol 127:2259-67. 2007
    ....
  31. pmc Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection
    Martin Holdener
    Pharmazentrum Frankfurt Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit, Johann Wolfgang Goethe University, 60590 Frankfurt am Main, Germany
    J Exp Med 205:1409-22. 2008
    ..Our novel model system should be instrumental for studying mechanisms involved in the initiation, propagation, and precipitation of virus-induced autoimmune liver diseases...

Research Grants1

  1. Development of an animal model for autoimmune hepatitis
    Urs Christen; Fiscal Year: 2007
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