HILDE MC CHEROUTRE

Summary

Affiliation: La Jolla Institute for Allergy and Immunology
Country: USA

Publications

  1. pmc Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes
    Daniel Mucida
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 14:281-9. 2013
  2. pmc Mucosal memory CD8⁺ T cells are selected in the periphery by an MHC class I molecule
    Yujun Huang
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 12:1086-95. 2011
  3. pmc CD4 CTL: living up to the challenge
    Hilde Cheroutre
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA Electronic address
    Semin Immunol 25:273-81. 2013
  4. pmc Crosstalk between adaptive and innate immune cells leads to high quality immune protection at the mucosal borders
    Hilde Cheroutre
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92037, USA
    Adv Exp Med Biol 785:43-7. 2013
  5. ncbi request reprint Mucosal T lymphocytes--peacekeepers and warriors
    Hilde Cheroutre
    The La Jolla Institute for Allergy and Immunology, San Diego, CA, USA
    Springer Semin Immunopathol 27:147-65. 2005
  6. ncbi request reprint Mucosal effector memory T cells: the other side of the coin
    H Cheroutre
    The La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Cell Mol Life Sci 62:2853-66. 2005
  7. ncbi request reprint Acquired and natural memory T cells join forces at the mucosal front line
    Hilde Cheroutre
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Nat Rev Immunol 4:290-300. 2004
  8. ncbi request reprint Starting at the beginning: new perspectives on the biology of mucosal T cells
    Hilde Cheroutre
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Annu Rev Immunol 22:217-46. 2004
  9. doi request reprint Doubting the TCR coreceptor function of CD8alphaalpha
    Hilde Cheroutre
    La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Immunity 28:149-59. 2008
  10. pmc The thymus chapter in the life of gut-specific intra epithelial lymphocytes
    Hilde Cheroutre
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9240 Athena Circle, La Jolla, CA 92037, USA
    Curr Opin Immunol 20:185-91. 2008

Research Grants

  1. Uncovering the Missing Link that Determines Susceptibility to Autoimmunity
    Hilde Cheroutre; Fiscal Year: 2009
  2. Selective Instructions for Memory Precursor T Cells
    Hilde Cheroutre; Fiscal Year: 2009
  3. Mucosal immune regulation by CD8aa+ cells
    Hilde Cheroutre; Fiscal Year: 2009
  4. Mucosal immune regulation by CD8aa+ cells
    Hilde Cheroutre; Fiscal Year: 2007
  5. Selective Instructions for Memory Precursor T Cells
    Hilde Cheroutre; Fiscal Year: 2006
  6. Selective Instructions for Memory Precursor T Cells
    Hilde Cheroutre; Fiscal Year: 2005
  7. Inhibition of Immune Responses by CD8alphaalpha-TL
    Hilde Cheroutre; Fiscal Year: 2004
  8. Regulation and mechanism of agonist selection
    Hilde Cheroutre; Fiscal Year: 2005
  9. Mucosal immune regulation by CD8aa+ cells
    HILDE MC CHEROUTRE; Fiscal Year: 2010
  10. Inhibition of Immune Responses by CD8alphaalpha-TL
    Hilde Cheroutre; Fiscal Year: 2002

Collaborators

Detail Information

Publications39

  1. pmc Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes
    Daniel Mucida
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 14:281-9. 2013
    ..This unexpected plasticity resulted in the post-thymic termination of the helper T cell program and the functional differentiation of distinct MHC class II-restricted CD4(+) cytotoxic T lymphocytes...
  2. pmc Mucosal memory CD8⁺ T cells are selected in the periphery by an MHC class I molecule
    Yujun Huang
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 12:1086-95. 2011
    ....
  3. pmc CD4 CTL: living up to the challenge
    Hilde Cheroutre
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA Electronic address
    Semin Immunol 25:273-81. 2013
    ....
  4. pmc Crosstalk between adaptive and innate immune cells leads to high quality immune protection at the mucosal borders
    Hilde Cheroutre
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92037, USA
    Adv Exp Med Biol 785:43-7. 2013
    ..Therefore, the generation of mucosal effector memory is controlled by an innate-adaptive crosstalk that provides for host defense at the body's largest interface...
  5. ncbi request reprint Mucosal T lymphocytes--peacekeepers and warriors
    Hilde Cheroutre
    The La Jolla Institute for Allergy and Immunology, San Diego, CA, USA
    Springer Semin Immunopathol 27:147-65. 2005
    ..Others, however, particularly subsets residing permanently in the epithelium, are intestine-specific T cell subpopulations generated by an atypical differentiation pathway...
  6. ncbi request reprint Mucosal effector memory T cells: the other side of the coin
    H Cheroutre
    The La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Cell Mol Life Sci 62:2853-66. 2005
    ..This review will discuss new insights into T cell memory. We will focus in particular on the generation and function of effector memory CD8 T cells at the intestinal mucosa, which represents one of the largest entry sites for pathogens...
  7. ncbi request reprint Acquired and natural memory T cells join forces at the mucosal front line
    Hilde Cheroutre
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Nat Rev Immunol 4:290-300. 2004
  8. ncbi request reprint Starting at the beginning: new perspectives on the biology of mucosal T cells
    Hilde Cheroutre
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Annu Rev Immunol 22:217-46. 2004
    ....
  9. doi request reprint Doubting the TCR coreceptor function of CD8alphaalpha
    Hilde Cheroutre
    La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Immunity 28:149-59. 2008
    ..Together, these observations indicate that CD8alphaalpha on T cells marks a differentiation stage and that it likely functions as a TCR corepressor to negatively regulate T cell activation...
  10. pmc The thymus chapter in the life of gut-specific intra epithelial lymphocytes
    Hilde Cheroutre
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9240 Athena Circle, La Jolla, CA 92037, USA
    Curr Opin Immunol 20:185-91. 2008
    ..This review will discuss the contributions of the thymus in shaping the various intestinal IEL sublineages...
  11. pmc The light and dark sides of intestinal intraepithelial lymphocytes
    Hilde Cheroutre
    Laboratory of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    Nat Rev Immunol 11:445-56. 2011
    ..In this Review, we address how the unique development and functions of intestinal IELs allow them to achieve this balance...
  12. ncbi request reprint IELs: enforcing law and order in the court of the intestinal epithelium
    Hilde Cheroutre
    The La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Immunol Rev 206:114-31. 2005
    ....
  13. ncbi request reprint Thymic differentiation of TCR alpha beta(+) CD8 alpha alpha(+) IELs
    Florence Lambolez
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Immunol Rev 215:178-88. 2007
    ..Therefore, the increased understanding of the developmental origin of TCR alpha beta(+) CD8 alpha alpha(+) IELs may help us to understand how they participate in immune regulation and protection in the intestine...
  14. ncbi request reprint Identification of pre- and postselection TCRalphabeta+ intraepithelial lymphocyte precursors in the thymus
    Denise Gangadharan
    La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA
    Immunity 25:631-41. 2006
    ....
  15. pmc Intestinal T cells: facing the mucosal immune dilemma with synergy and diversity
    Femke van Wijk
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Semin Immunol 21:130-8. 2009
    ..This review will focus on the unique features of mucosal T cell subsets that reside in the epithelium and lamina propria of the gut...
  16. ncbi request reprint The CD8 isoform CD8alphaalpha is not a functional homologue of the TCR co-receptor CD8alphabeta
    Denise Gangadharan
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Curr Opin Immunol 16:264-70. 2004
    ....
  17. ncbi request reprint CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors
    Loui T Madakamutil
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Science 304:590-3. 2004
    ..Thus, memory precursors can be identified among primary effector cells and are selected for survival and differentiation by CD8alphaalpha...
  18. ncbi request reprint Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    Daniel Mucida
    La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Science 317:256-60. 2007
    ..These findings indicate that a common metabolite can regulate the balance between pro- and anti-inflammatory immunity...
  19. pmc NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells
    Dirk Elewaut
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA
    J Exp Med 197:1623-33. 2003
    ....
  20. pmc Mucosal T cells in gut homeostasis and inflammation
    Femke van Wijk
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Expert Rev Clin Immunol 6:559-66. 2010
    ..In this article, we will discuss the specialized properties of mucosal T cells in the context of immune homeostasis and inflammation...
  21. ncbi request reprint Precursors of functional MHC class I- or class II-restricted CD8alphaalpha(+) T cells are positively selected in the thymus by agonist self-peptides
    Andrew J Leishman
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Immunity 16:355-64. 2002
    ..Our data define a distinct agonist-dependent, positive selection process in the thymus, and they suggest a function for CD8alphaalpha distinct from the conventional TCR coreceptor function of CD8alphabeta or CD4...
  22. ncbi request reprint Regulation of mucosal immune responses by recombinant interleukin 10 produced by intestinal epithelial cells in mice
    Hilde De Winter
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Gastroenterology 122:1829-41. 2002
    ..Interleukin (IL)-10 is a cytokine with anti-inflammatory properties. The aim of this study was to explore the effect of a site-specific delivery of IL-10 on intestinal immune responses...
  23. pmc IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    Sergei Grivennikov
    Laboratory of Gene Regulation and Signal Transduction, UCSD School of Medicine, University of California San Diego, La Jolla, CA 92093 0723, USA
    Cancer Cell 15:103-13. 2009
    ..Thus, the NF-kappaB-IL-6-Stat3 cascade is an important regulator of the proliferation and survival of tumor-initiating IECs...
  24. ncbi request reprint Molecular basis for the high affinity interaction between the thymic leukemia antigen and the CD8alphaalpha molecule
    Antoine Attinger
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 174:3501-7. 2005
    ..These data indicate that small changes in the alpha3 domain of class I molecules potentially can have profound physiologic consequences...
  25. ncbi request reprint Functional dichotomy between OX40 and 4-1BB in modulating effector CD8 T cell responses
    Seung Woo Lee
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 177:4464-72. 2006
    ..OX40 can positively regulate effector function and late accumulation/survival, whereas 4-1BB can initially operate in a negative manner to limit primary CD8 responses...
  26. ncbi request reprint Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses
    Timothy L Denning
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 178:4230-9. 2007
    ..Collectively, these data underscore the fact that, while TCRalphabeta(+)CD8alphaalpha IEL resemble TCRgammadelta(+) IEL, they are a unique population of cells with regulated Ag reactivity that could have regulatory function...
  27. pmc Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells
    Seung Woo Lee
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Nat Immunol 9:917-26. 2008
    ..Thus, 4-1BB and 4-1BBL have a previously unknown function in limiting myelopoiesis and the development of dendritic cells...
  28. pmc From the diet to the nucleus: vitamin A and TGF-beta join efforts at the mucosal interface of the intestine
    Daniel Mucida
    La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Semin Immunol 21:14-21. 2009
    ....
  29. pmc Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
    Masako Murai
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 10:1178-84. 2009
    ..Our data indicate that IL-10 released from myeloid cells acts in a paracrine manner on T(reg) cells to maintain Foxp3 expression...
  30. pmc TGFbeta and retinoic acid intersect in immune-regulation
    Daniel Mucida
    La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    Cell Adh Migr 1:142-4. 2007
    ..A vitamin A metabolite, retinoic acid (RA), was recently identified as a key modulator of TGFbeta-driven- immune deviation capable of suppressing T(H)17 differentiation while promoting Foxp3(+)Treg generation.(6-10)...
  31. ncbi request reprint The crystal structure of a TL/CD8alphaalpha complex at 2.1 A resolution: implications for modulation of T cell activation and memory
    Yiwei Liu
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Immunity 18:205-15. 2003
    ..At the same time, the TL/CD8alphaalpha interaction is strengthened through subtle structure changes in the TL alpha3 domain. Thus, TL functions to sequester and redirect CD8alphaalpha away from the TCR, modifying lck-dependent signaling...
  32. ncbi request reprint Peptide-independent folding and CD8 alpha alpha binding by the nonclassical class I molecule, thymic leukemia antigen
    Dominique A Weber
    Department of Pathology, School of Medicine, Emory University, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Immunol 169:5708-14. 2002
    ..Our results also show that CD8alphaalpha binding is not dependent on either TL-associated peptide or TL glycosylation...
  33. doi request reprint Ultimately, it matters where, when, and what they'll meet
    Hilde Cheroutre
    Gastroenterology 134:1249-51. 2008
  34. pmc Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance
    Maya F Kotturi
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 181:2124-33. 2008
    ..Thus, our results indicate that an intrinsic property of the epitope (MHC binding affinity) and an intrinsic property of the host (naive precursor frequency) jointly dictate the immunodominance hierarchy of CD8(+) T cell responses...
  35. pmc Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma
    Katrina K Hoyer
    Department of Pathology and Laboratory Medicine, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, and AIDS Institute, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 99:14392-7. 2002
    ..Together these data demonstrate that TCL1 is a powerful oncogene that, when overexpressed in both B and T cells, predominantly yields mature B cell lymphomas...
  36. ncbi request reprint In IBD eight can come before four
    Hilde Cheroutre
    Gastroenterology 131:667-70. 2006
  37. ncbi request reprint Overexpression of interleukin-10 by activated T lymphocytes inhibits atherosclerosis in LDL receptor-deficient Mice by altering lymphocyte and macrophage phenotypes
    Laura J Pinderski
    Department of Medicine, University of California Los Angeles, USA
    Circ Res 90:1064-71. 2002
    ..These studies demonstrate that T lymphocyte IL-10 can influence the function of other immune cells to reduce the development of advanced atherosclerotic lesions in mice...
  38. ncbi request reprint The complementarity-determining region-like loops of CD8 alpha interact differently with beta 2-microglobulin of the class I molecules H-2Kb and thymic leukemia antigen, while similarly with their alpha 3 domains
    Lesley Devine
    Department of Laboratory Medicine and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 168:3881-6. 2002
    ....

Research Grants20

  1. Uncovering the Missing Link that Determines Susceptibility to Autoimmunity
    Hilde Cheroutre; Fiscal Year: 2009
    ..Our proposed study will explore a novel strategy to prevent and/or treat autoimmunity. Hepatic stellate cells will be used as natural, regulatory, antigen-presenting cells to assure the efficient ge ..
  2. Selective Instructions for Memory Precursor T Cells
    Hilde Cheroutre; Fiscal Year: 2009
    ..Understanding the basic mechanism of CDS memory formation to viruses and other pathogenic agents is highly relevant to the biodefense needs facing the United States today. ..
  3. Mucosal immune regulation by CD8aa+ cells
    Hilde Cheroutre; Fiscal Year: 2009
    ..Understanding mucosal immune regulation will undoubtedly impact our knowledge to advance medical treatments not only for intestinal related diseases but for health improvement in general. ..
  4. Mucosal immune regulation by CD8aa+ cells
    Hilde Cheroutre; Fiscal Year: 2007
    ..Understanding mucosal immune regulation will undoubtedly impact our knowledge to advance medical treatments not only for intestinal related diseases but for health improvement in general. ..
  5. Selective Instructions for Memory Precursor T Cells
    Hilde Cheroutre; Fiscal Year: 2006
    ..Understanding the basic mechanism of CDS memory formation to viruses and other pathogenic agents is highly relevant to the biodefense needs facing the United States today. ..
  6. Selective Instructions for Memory Precursor T Cells
    Hilde Cheroutre; Fiscal Year: 2005
    ..Understanding the basic mechanism of CDS memory formation to viruses and other pathogenic agents is highly relevant to the biodefense needs facing the United States today. ..
  7. Inhibition of Immune Responses by CD8alphaalpha-TL
    Hilde Cheroutre; Fiscal Year: 2004
    ..Therefore, the mechanisms outlined here could have implications for cancer and other diseases that extend beyond the mucosa. ..
  8. Regulation and mechanism of agonist selection
    Hilde Cheroutre; Fiscal Year: 2005
    ....
  9. Mucosal immune regulation by CD8aa+ cells
    HILDE MC CHEROUTRE; Fiscal Year: 2010
    ..Understanding mucosal immune regulation will undoubtedly impact our knowledge to advance medical treatments not only for intestinal related diseases but for health improvement in general. ..
  10. Inhibition of Immune Responses by CD8alphaalpha-TL
    Hilde Cheroutre; Fiscal Year: 2002
    ..Therefore, the mechanisms outlined here could have implications for cancer and other diseases that extend beyond the mucosa. ..
  11. Inhibition of Immune Responses by CD8alphaalpha-TL
    Hilde Cheroutre; Fiscal Year: 2003
    ..Therefore, the mechanisms outlined here could have implications for cancer and other diseases that extend beyond the mucosa. ..
  12. Regulation and mechanism of agonist selection
    Hilde Cheroutre; Fiscal Year: 2007
    ....
  13. Selective Instructions for Memory Precursor T Cells
    Hilde Cheroutre; Fiscal Year: 2007
    ..Understanding the basic mechanism of CDS memory formation to viruses and other pathogenic agents is highly relevant to the biodefense needs facing the United States today. ..
  14. Regulation and mechanism of agonist selection
    Hilde Cheroutre; Fiscal Year: 2004
    ....
  15. Regulation and mechanism of agonist selection
    Hilde Cheroutre; Fiscal Year: 2006
    ....
  16. Mucosal immune regulation by CD8aa+ cells
    Hilde Cheroutre; Fiscal Year: 2006
    ..Understanding mucosal immune regulation will undoubtedly impact our knowledge to advance medical treatments not only for intestinal related diseases but for health improvement in general. ..
  17. Inhibition of Immune Responses by CD8alphaalpha-TL
    Hilde Cheroutre; Fiscal Year: 2001
    ..Therefore, the mechanisms outlined here could have implications for cancer and other diseases that extend beyond the mucosa. ..