Research Topics
| Huynh Hoa BuiSummaryAffiliation: La Jolla Institute for Allergy and Immunology Country: USA Publications
| Collaborators
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Detail Information
Publications
Predicting population coverage of T-cell epitope-based diagnostics and vaccinesHuynh Hoa Bui
La Jolla Institute for Allergy and Immunology, Division of Vaccine Discovery, 3030 Bunker Hill Street, Suite 326, San Diego, CA 92109, USA
BMC Bioinformatics 7:153. 2006..Thus, without careful consideration, a vaccine or diagnostic with ethnically biased population coverage could result...
Vaccinia virus-specific CD4+ T cell responses target a set of antigens largely distinct from those targeted by CD8+ T cell responsesMagdalini Moutaftsi
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
J Immunol 178:6814-20. 2007..Taken together, these results highlight fundamental differences in immunodominance of CD4(+) and CD8(+) T cell responses to a complex pathogen...- A multivalent and cross-protective vaccine strategy against arenaviruses associated with human diseaseMaya F Kotturi
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
PLoS Pathog 5:e1000695. 2009..In conclusion, the set of identified epitopes allows broad, non-ethnically biased coverage of all 7 viral species targeted by our studies... - Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccinesHuynh Hoa Bui
La Jolla Institute for Allergy and Immunology, Division of Vaccine Discovery, 9420 Athena Circle, La Jolla, CA 92037, USA
BMC Bioinformatics 8:361. 2007..In both cases, concrete information pertaining to the degree of conservancy of the epitope(s) considered is crucial... - Polyfunctional CD4+ T cell responses to a set of pathogenic arenaviruses provide broad population coverageMaya F Kotturi
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California, 92037 USA
Immunome Res 6:4. 2010.... - A community resource benchmarking predictions of peptide binding to MHC-I moleculesBjoern Peters
La Jolla Institute for Allergy and Immunology, San Diego, California, USA
PLoS Comput Biol 2:e65. 2006.... - A quantitative analysis of the variables affecting the repertoire of T cell specificities recognized after vaccinia virus infectionErika Assarsson
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
J Immunol 178:7890-901. 2007..This suggested that additional factors, including immunoregulatory mechanisms, restrict the repertoire of T cell specificities after vaccinia infection by a factor of at least 10... - A roadmap for the immunomics of category A-C pathogensAlessandro Sette
La Jolla Institute for Allegy and Immunology, San Diego, CA 92121, USA
Immunity 22:155-61. 2005..Herein is an account of the meeting and its results... - Immune epitope database analysis resource (IEDB-AR)Qing Zhang
Immune Epitope Database and Analysis Resource IEDB AR, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
Nucleic Acids Res 36:W513-8. 2008..New functionalities have been added to most of the previously implemented tools, and a total of eight new tools were added, including two B-cell epitope prediction tools, four T-cell epitope prediction tools and two analysis tools... - Curation of complex, context-dependent immunological dataRandi Vita
La Jolla Institute for Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, California, USA
BMC Bioinformatics 7:341. 2006..The Immune Epitope Database and Analysis Resource (IEDB) is dedicated to capturing, housing and analyzing complex immune epitope related data http://www.immuneepitope.org... - Ab and T cell epitopes of influenza A virus, knowledge and opportunitiesHuynh Hoa Bui
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 104:246-51. 2007..At the same time, the analysis illustrates gaps in our collective knowledge that should inspire directions for further study of immunity against the influenza A virus... - Towards a consensus on datasets and evaluation metrics for developing B-cell epitope prediction toolsJason A Greenbaum
Immune Epitope Database and Analysis Resource IEDB, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
J Mol Recognit 20:75-82. 2007..By developing common datasets, standardized data formats, and the means with which to consolidate information, we hope to greatly enhance the development of B-cell epitope prediction tools... - Immunomic analysis of the repertoire of T-cell specificities for influenza A virus in humansErika Assarsson
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
J Virol 82:12241-51. 2008..These results enable further functional studies of T-cell responses during influenza virus infection and provide a potential base for the development of a universal influenza vaccine... - ElliPro: a new structure-based tool for the prediction of antibody epitopesJulia Ponomarenko
San Diego Supercomputer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
BMC Bioinformatics 9:514. 2008..The aim of this work was to implement that method as a web-tool and evaluate its performance on discontinuous epitopes known from the structures of antibody-protein complexes... - WATGEN: an algorithm for modeling water networks at protein-protein interfacesHuynh Hoa Bui
Division of Vaccine Discovery, La Jolla Institute of Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA
J Comput Chem 28:2241-51. 2007..Based on these data, we conclude that WATGEN can accurately predict the location of water molecules at a protein-peptide interface, and this may be of value for understanding the energetics and specificity of biomolecular association... - Characterization of the peptide-binding specificity of Mamu-A*11 results in the identification of SIV-derived epitopes and interspecies cross-reactivityAlessandro Sette
La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
Immunogenetics 57:53-68. 2005..This is the first detailed description of mouse-macaque interspecies cross-reactivity, potentially useful in testing novel vaccines in mice and macaques... - Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applicationsHuynh-Hoa Bui
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, CA 92109, USA
Immunogenetics 57:304-14. 2005..MHC binding predictions based on ARB matrices were made available at http://epitope.liai.org:8080/matrix web server... - HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulationCarla Oseroff
La Jolla Institute for Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, CA 92109, USA
Proc Natl Acad Sci U S A 102:13980-5. 2005..Finally, most epitopes were highly conserved among vaccinia virus Western Reserve, variola major and modified vaccinia Ankara, supporting their potential use in vaccine and diagnostic applications... - Structural prediction of peptides binding to MHC class I moleculesHuynh-Hoa Bui
Department of Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089, USA
Proteins 63:43-52. 2006..In summary, PePSSI is capable of rapid and accurate prediction of peptide-MHC binding conformations, which may in turn allow estimation of MHCI-peptide binding affinity... - A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virusMagdalini Moutaftsi
La Jolla Institute for Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, California 92109, USA
Nat Biotechnol 24:817-9. 2006..This approach reveals the breadth of T-cell responses to vaccinia, a widely studied murine viral infection model, and may provide a tool for developing comprehensive antigenic maps of any complex pathogen... - Chronic lymphocytic choriomeningitis virus infection actively down-regulates CD4+ T cell responses directed against a broad range of epitopesBianca R Mothe
Department of Biological Sciences, California State University, San Marcos, California 92096, USA
J Immunol 179:1058-67. 2007..Thus, multiple mechanisms may be involved in the impairment of helper responses in the setting of early persistent infection... - HLA-A*0201, HLA-A*1101, and HLA-B*0702 transgenic mice recognize numerous poxvirus determinants from a wide variety of viral gene productsValerie Pasquetto
La Jolla Institute for Allergy and Immunology, San Diego, CA 92109, USA
J Immunol 175:5504-15. 2005..These findings have implications for the design of new smallpox vaccines and the understanding of immune responses to large DNA viruses in general... - The design and implementation of the immune epitope database and analysis resourceBjoern Peters
La Jolla Institute of Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, CA 92109, USA
Immunogenetics 57:326-36. 2005..quot; We describe how we plan to capture, structure, and store this information, what query interfaces we will make available to the public, and what additional predictive and analytical tools we will provide... - The immune epitope database and analysis resource: from vision to blueprintBjoern Peters
La Jolla Institute of Allergy and Immunology, San Diego, California, USA
PLoS Biol 3:e91. 2005 - HLA-A2-restricted protection against lethal lymphocytic choriomeningitisJason Botten
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, SP30 2020, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Virol 81:2307-17. 2007....