Amnon Altman

Summary

Affiliation: La Jolla Institute for Allergy and Immunology
Country: USA

Publications

  1. ncbi Protein kinase C-theta (PKCtheta): new perspectives on its functions in T cell biology
    Rina Barouch-Bentov
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Adv Exp Med Biol 584:1-13. 2006
  2. ncbi Role for protein kinase Ctheta (PKCtheta) in TCR/CD28-mediated signaling through the canonical but not the non-canonical pathway for NF-kappaB activation
    Yingqiu Li
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 280:1217-23. 2005
  3. pmc Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylation
    Konstantina Nika
    Program of Inflammation, Infectious and Inflammatory Disease Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Mol Cell Biol 26:1806-16. 2006
  4. ncbi Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect
    Matthias Hundt
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Immunity 24:513-22. 2006
  5. ncbi Filamin A is required for T cell activation mediated by protein kinase C-theta
    Keitaro Hayashi
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 177:1721-8. 2006
  6. pmc Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C
    Martin Villalba
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Cell Biol 157:253-63. 2002
  7. pmc A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28
    Kok Fai Kong
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 12:1105-12. 2011
  8. pmc Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells
    M Villalba
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Cell Biol 155:331-8. 2001
  9. ncbi Protein kinase C-theta (PKCtheta): it's all about location, location, location
    Amnon Altman
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Immunol Rev 192:53-63. 2003
  10. ncbi Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death
    Amnon Altman
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, Science Center Dr, San Diego, CA 92121, USA
    J Biochem 132:841-6. 2002

Collaborators

Detail Information

Publications49

  1. ncbi Protein kinase C-theta (PKCtheta): new perspectives on its functions in T cell biology
    Rina Barouch-Bentov
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Adv Exp Med Biol 584:1-13. 2006
  2. ncbi Role for protein kinase Ctheta (PKCtheta) in TCR/CD28-mediated signaling through the canonical but not the non-canonical pathway for NF-kappaB activation
    Yingqiu Li
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 280:1217-23. 2005
    ..PKC acts solely within the canonical pathway to activate NF-kappaB, and PKC deficiency impacts upon p100/p52 processing in a manner that is independent of NF-kappaB-induced kinase...
  3. pmc Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylation
    Konstantina Nika
    Program of Inflammation, Infectious and Inflammatory Disease Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Mol Cell Biol 26:1806-16. 2006
    ..This represents a novel mechanism for the active immune synapse recruitment and activation of a phosphatase in TCR signaling...
  4. ncbi Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect
    Matthias Hundt
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Immunity 24:513-22. 2006
    ....
  5. ncbi Filamin A is required for T cell activation mediated by protein kinase C-theta
    Keitaro Hayashi
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 177:1721-8. 2006
    ....
  6. pmc Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C
    Martin Villalba
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Cell Biol 157:253-63. 2002
    ..These results provide evidence that a nonconventional PI3-K- and Vav-dependent pathway mediates the selective membrane recruitment and, possibly, activation of PKCtheta in T cells...
  7. pmc A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28
    Kok Fai Kong
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 12:1105-12. 2011
    ....
  8. pmc Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells
    M Villalba
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Cell Biol 155:331-8. 2001
    ..Therefore, Vav is necessary, but not sufficient, to regulate lipid rafts clustering and polarization at the IS, suggesting that additional signals are required...
  9. ncbi Protein kinase C-theta (PKCtheta): it's all about location, location, location
    Amnon Altman
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Immunol Rev 192:53-63. 2003
    ..Additional work is required to identify the immediate targets of PKCtheta and its immune functions in vivo. This work is likely to validate PKCtheta as an attractive drug target...
  10. ncbi Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death
    Amnon Altman
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, Science Center Dr, San Diego, CA 92121, USA
    J Biochem 132:841-6. 2002
    ..Resolution of these questions could open the way to the development of selective PKC theta inhibitors, which may have therapeutic potential in immunological diseases and in cancer...
  11. ncbi Positive feedback regulation of PLCgamma1/Ca(2+) signaling by PKCtheta in restimulated T cells via a Tec kinase-dependent pathway
    Amnon Altman
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Eur J Immunol 34:2001-11. 2004
    ..Moreover, they identify Tec as a key point downstream of PKCtheta, where TCR- and PKCtheta-induced signaling pathways, leading to AP-1 versus NF-kappaB activation, diverge in T cells...
  12. ncbi Protein kinase Ctheta: a new essential superstar on the T-cell stage
    A Altman
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Immunol Today 21:567-73. 2000
    ..Among these, the nuclear factor-kappaB (NF-kappaB) signaling cascade appears to be the most critical target of PKCtheta in the T-cell receptor/CD28 costimulatory pathway that leads to T-cell activation...
  13. pmc SLAT regulates Th1 and Th2 inflammatory responses by controlling Ca2+/NFAT signaling
    Stéphane Bécart
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    J Clin Invest 117:2164-75. 2007
    ..Thus, SLAT is required for thymic DN1 cell expansion, T cell activation, and Th1 and Th2 inflammatory responses...
  14. pmc Tyrosine-phosphorylation-dependent translocation of the SLAT protein to the immunological synapse is required for NFAT transcription factor activation
    Stéphane Bécart
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Immunity 29:704-19. 2008
    ..Therefore, tyrosine-phosphorylation-mediated relocalization of SLAT to the site of antigen recognition is required for SLAT to exert its pivotal role in NFAT-dependent CD4(+) T cell differentiation...
  15. pmc Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice
    Yoshihiko Tanaka
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA
    Blood 106:1286-95. 2005
    ..Thus, Vav1 is selectively required for IL-4 and c-Maf expression, a requirement reflecting, at least in part, the dependence of c-Maf expression on Ca2+/NFAT signaling...
  16. ncbi Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76
    Celine Charvet
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 280:15289-99. 2005
    ..Altogether, our data show that TCR-induced association of Vav3 with SLP-76 is required for its membrane/IS localization and function...
  17. pmc SWAP-70-like adapter of T cells: a novel Lck-regulated guanine nucleotide exchange factor coordinating actin cytoskeleton reorganization and Ca2+ signaling in T cells
    Stéphane Bécart
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
    Immunol Rev 232:319-33. 2009
    ..Future work will aim to dissect the interacting partners of SLAT and may thus shed light on the poorly understood events that coordinate and link actin cytoskeleton reorganization to Ca2+ signaling and gene transcription in T cells...
  18. pmc SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway
    Yingqiu Li
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    EMBO J 23:1112-22. 2004
    ..These results define SPAK as a substrate and target of PKCtheta in a TCR/CD28-induced signaling pathway leading selectively to AP-1 (but not NF-kappaB) activation...
  19. ncbi Guanine exchange-dependent and -independent effects of Vav1 on integrin-induced T cell spreading
    Miguel Angel del Pozo
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 170:41-7. 2003
    ..In contrast, a point mutation in the SH2 domain of Vav1 abolished this synergistic effect. Therefore, our results suggest a new regulatory effect of Vav1 in T cell spreading, which is independent of its guanine exchange factor activity...
  20. ncbi Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells
    Rina Barouch-Bentov
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 175:5126-34. 2005
    ....
  21. pmc Protein kinase C-η controls CTLA-4-mediated regulatory T cell function
    Kok Fai Kong
    1 Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA 2
    Nat Immunol 15:465-72. 2014
    ..These results reveal a CTLA-4-PKC-η signaling axis required for contact-dependent suppression and implicate this pathway as a potential cancer immunotherapy target. ..
  22. pmc SLAT/Def6 plays a critical role in the development of Th17 cell-mediated experimental autoimmune encephalomyelitis
    Ann J Canonigo-Balancio
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 183:7259-67. 2009
    ..Therefore, our study establishes T cell-expressed SLAT/Def6 as a pivotal positive regulator of Th17 inflammatory responses and, thus, essential in controlling autoimmune and inflammatory diseases...
  23. ncbi Protein kinase Ctheta controls Th1 cells in experimental autoimmune encephalomyelitis
    Shahram Salek-Ardakani
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 175:7635-41. 2005
    ..These data provide evidence of a pivotal role for PKCtheta in the generation and effector function of autoimmune Th1 cells...
  24. pmc Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells
    Matthias Hundt
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 183:1685-94. 2009
    ..Furthermore, LAT palmitoylation functions primarily as a sorting signal required for its PM transport...
  25. ncbi Perspectives on PKCtheta in T cell activation
    Caitlin E Sedwick
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Mol Immunol 41:675-86. 2004
    ....
  26. pmc Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment
    Takanori So
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 103:3740-5. 2006
    ....
  27. ncbi Clustering of T cell ligands on artificial APC membranes influences T cell activation and protein kinase C theta translocation to the T cell plasma membrane
    Francesca Giannoni
    Department of Medicine, University of California, San Diego, CA 92093, USA
    J Immunol 174:3204-11. 2005
    ..Engineered aAPC may have immediate application for basic and clinical immunology studies pertaining to modulation of T cells ex vivo...
  28. pmc SLAT regulates CD8+ T cell clonal expansion in a Cdc42- and NFAT1-dependent manner
    Sonia Feau
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 190:174-83. 2013
    ..Taken together, these data describe a new and pivotal role of SLAT-mediated NFAT activation in CD8(+) T cells, providing new insight into the signaling pathways involved in CD8(+) T cell proliferation...
  29. ncbi Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression
    Celine Charvet
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 177:5024-31. 2006
    ..Thus, Vav1 is a critical regulator of a PI3K/Akt/FOXO1 pathway, which controls T cell cycle progression and proliferation...
  30. pmc Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cells
    Takanori So
    Divisions of Molecular Immunology and Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:2903-8. 2011
    ..Thus, by recruiting TCR-related intracellular molecules into the TRAF2 complex, OX40 provides the T cell with a high level of NF-κB activity needed for longevity...
  31. pmc Protein kinase C theta (PKCtheta): a key player in T cell life and death
    Keitaro Hayashi
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Pharmacol Res 55:537-44. 2007
    ..Therefore, PKCtheta is a critical enzyme that regulates T cell function at multiple stages, and it represents an attractive drug target for allergic and autoimmune diseases...
  32. ncbi SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells
    Yoshihiko Tanaka
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Immunity 18:403-14. 2003
    ..Consistent with these results, pharmacological inhibition of ZAP-70 also induced Th2 skewing. Thus, SLAT is a protein which plays a role in Th2 development and/or activation, perhaps by interfering with ZAP-70 signaling...
  33. ncbi Differential regulation of Th2 and Th1 lung inflammatory responses by protein kinase C theta
    Shahram Salek-Ardakani
    Division Molecular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, La Jolla, CA 92121, USA
    J Immunol 173:6440-7. 2004
    ..These data suggest that PKCtheta can play roles in aspects of both Th2 and Th1 responses, but lung inflammation induced by Th2 cells is more dependent on this protein kinase than lung inflammation induced by Th1 cells...
  34. ncbi Protein kinase C-theta (PKCtheta), a potential drug target for therapeutic intervention with human T cell leukemias
    Martin Villalba
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Curr Cancer Drug Targets 2:125-37. 2002
    ..Therefore, given the essential role of PKCtheta in IL-2 production, IL-2 gene regulation by PKCtheta could also be of therapeutic interest...
  35. ncbi Regulation of immune responses by E3 ubiquitin-protein ligases
    Nan Fang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, Calif, USA
    Curr Dir Autoimmun 5:161-75. 2002
  36. pmc In and out of the bull's eye: protein kinase Cs in the immunological synapse
    Kok Fai Kong
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Trends Immunol 34:234-42. 2013
    ..Further work is needed to identify mechanisms underlying PKC recruitment or exclusion at the IS, potential redundancy among IS-localized PKCs, and the relevance of PKC localization for IS dynamics and lymphocyte activation...
  37. pmc The yin and yang of protein kinase C-theta (PKCθ): a novel drug target for selective immunosuppression
    Elizabeth Yan Zhang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
    Adv Pharmacol 66:267-312. 2013
    ..Early progress in developing such drugs is being made, but additional studies on the role of PKCθ in the human immune system are urgently needed...
  38. doi Dynamic palmitoylation and the role of DHHC proteins in T cell activation and anergy
    Nadejda Ladygina
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, California, USA
    Adv Immunol 109:1-44. 2011
    ..Reversible protein palmitoylation will likely prove to be an important posttranslational mechanism that regulates cellular responses, similar to protein phosphorylation and ubiquitination...
  39. ncbi Navigating the leukocyte signaling maze guided by Ariadne's thread
    Amnon Altman
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 10:1134-6. 2009
    ..The term 'Ariadne's thread' is used to describe the understanding of complex issues. Immunologists attending the 5th Leukocyte Signal Transduction Workshop discussed the Ariadne's thread woven about intracellular signaling pathways...
  40. ncbi Ordered just so: lipid rafts and lymphocyte function
    Caitlin E Sedwick
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Sci STKE 2002:re2. 2002
    ....
  41. ncbi Protein kinase C(theta) in T cell activation
    Noah Isakov
    Department of Microbiology and Immunology, Faculty of Health Sciences, and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Annu Rev Immunol 20:761-94. 2002
    ..The selective expression of PKC theta in T cells and its essential role in mature T cell activation establish it as an attractive drug target for immunosuppression in transplantation and autoimmune diseases...
  42. ncbi Vav-induced activation of the human IFN-gamma gene promoter is mediated by upregulation of AP-1 activity
    Osamu Kaminuma
    Department of Immunology, The Tokyo Metropolitan Institute of Medical Science, 2 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    FEBS Lett 514:153-8. 2002
    ..Vav activates the IFN-gamma promoter via upregulation of AP-1-binding through a Rac1/JNK pathway...
  43. ncbi Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Ctheta
    Heather R Melowic
    Department of Chemistry, University of Illinois, Chicago, Illinois 60607, USA
    J Biol Chem 282:21467-76. 2007
    ..Collectively, these results show that PKC has a unique membrane binding and activation mechanism that may account for its subcellular targeting properties...
  44. ncbi The adaptor protein 3BP2 associates with VAV guanine nucleotide exchange factors to regulate NFAT activation by the B-cell antigen receptor
    Isabelle Foucault
    Institut National de la Sante Et de la Recherche Medicale Unite 576, Nice, France
    Blood 105:1106-13. 2005
    ..Finally, evidence was provided that 3BP2 functionally cooperates with Vav proteins and Rho GTPases to activate NFATs. Our results show that 3BP2 may regulate BCR-mediated gene activation through Vav proteins...
  45. pmc Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line
    Youjia Cao
    Department of Pharmacology and Cancer Biology and Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    EMBO J 21:4809-19. 2002
    ..Vav1 cells. Finally, evidence is presented to suggest that the alternative Vav family members, Vav-2 and Vav-3, are activated during TCR ligation, and partially compensate for the loss of Vav-1 in Jurkat T cells...
  46. pmc A single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimulator (ICOS)
    Yohsuke Harada
    Research Institute for Biological Sciences, Faculty of Science and Technology, Tokyo University of Science, 2669 Yamazaki, Noda, Chiba 278 0022, Japan
    J Exp Med 197:257-62. 2003
    ..Together, these observations lead us to believe that the difference of a single amino acid, which affects Grb2 binding ability, may define a functional difference between the CD28- and ICOS-mediated costimulatory signals...
  47. ncbi Engagement of protein kinase C-theta in interferon signaling in T-cells
    Kishore K Srivastava
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Lakeside Veterans Administration Medical Center, Chicago, Illinois 60611, USA
    J Biol Chem 279:29911-20. 2004
    ..Altogether, these findings demonstrate that PKC-theta is an interferon-inducible kinase and strongly suggest that it plays an important role in the generation of interferon-responses in T-cells...
  48. pmc PKCdelta acts upstream of SPAK in the activation of NKCC1 by hyperosmotic stress in human airway epithelial cells
    Laura Smith
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 283:22147-56. 2008
    ..Inhibition of PKCdelta activity with rottlerin blocked the increase in SPAK kinase activity. The results indicate that PKCdelta acts upstream of SPAK to increase activity of NKCC1 during hyperosmotic stress...
  49. pmc PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling
    Alexander Zarbock
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    J Exp Med 205:2339-47. 2008
    ....

Research Grants39

  1. FUNCTION AND REGULATION OF VAV IN LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 2002
    ....
  2. SIGNAL TRANSDUCTION IN T LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 2006
    ....
  3. PKC theta in the Immune Synapse and T Cell Anergy
    Amnon Altman; Fiscal Year: 2003
    ..They offer the potential for developing novel therapeutic strategies, which may be useful for modulating CD28 costimulation in disease. ..
  4. SIGNAL TRANSDUCTION IN T LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 2002
    ....
  5. FUNCTION AND REGULATION OF VAV IN LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 2000
    ....
  6. SIGNAL TRANSDUCTION IN T LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 1993
    ..Understanding the roles of PKC and TPKs in T cell activation may lead to rational design of pharmacological approaches aimed at correcting abnormal T cell responses resulting from defective signaling...
  7. SIGNAL TRANSDUCTION IN T LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 1992
    ..Understanding the roles of PKC and TPKs in T cell activation may lead to rational design of pharmacological approaches aimed at correcting abnormal T cell responses resulting from defective signaling...
  8. PKC Theta--A Novel Drug Target in T Cell Leukemias
    Amnon Altman; Fiscal Year: 2003
    ..abstract_text> ..
  9. SIGNAL TRANSDUCTION IN T LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 2004
    ....
  10. FUNCTION AND REGULATION OF VAV IN LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 2004
    ....
  11. SIGNAL TRANSDUCTION IN T LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 2005
    ....
  12. Immune regulation by SLAT, a Novel Th2-Expressed Protein
    Amnon Altman; Fiscal Year: 2007
    ..These studies will characterize a novel, multifunctional TCR-proximal protein. [unreadable] [unreadable]..
  13. The Fourth International Leukocyte Signal Transduction Workshop: Clinical Implica
    Amnon Altman; Fiscal Year: 2007
    ..abstract_text> ..
  14. SIGNAL TRANSDUCTION IN T LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 2009
    ..Understanding of these pathways is likely to establish a more rational basis for the use of PKC? as a drug target in autoimmune and allergic diseases, and in T cell leukemias/lymphomas ..
  15. FUNCTION AND REGULATION OF VAV IN LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 2001
    ....
  16. FUNCTION AND REGULATION OF VAV IN LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 2005
    ....
  17. SIGNAL TRANSDUCTION IN T LYMPHOCYTE ACTIVIATION
    Amnon Altman; Fiscal Year: 2001
    ..The proposed studies are intended to fill some important gaps in our understanding of signal transduction through the TCR. ..
  18. SIGNAL TRANSDUCTION IN T LYMPHOCYTE ACTIVIATION
    Amnon Altman; Fiscal Year: 1999
    ..The proposed studies are intended to fill some important gaps in our understanding of signal transduction through the TCR. ..
  19. SIGNAL TRANSDUCTION IN T LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 2011
    ..Understanding of these pathways is likely to establish a more rational basis for the use of PKC? as a drug target in autoimmune and allergic diseases, and in T cell leukemias/lymphomas ..
  20. SIGNAL TRANSDUCTION IN T LYMPHOCYTE ACTIVIATION
    Amnon Altman; Fiscal Year: 2000
    ..The proposed studies are intended to fill some important gaps in our understanding of signal transduction through the TCR. ..
  21. Immune regulation by SLAT, a Novel Th2-Expressed Protein
    Amnon Altman; Fiscal Year: 2008
    ..These studies will characterize a novel, multifunctional TCR-proximal protein. ..
  22. Immune regulation by SLAT, a Novel Th2-Expressed Protein
    Amnon Altman; Fiscal Year: 2006
    ..These studies will characterize a novel, multifunctional TCR-proximal protein. [unreadable] [unreadable]..
  23. Immune regulation by SLAT, a Novel Th2-Expressed Protein
    Amnon Altman; Fiscal Year: 2009
    ..These studies will characterize a novel, multifunctional TCR-proximal protein. ..
  24. SIGNAL TRANSDUCTION IN T LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 2010
    ..Understanding of these pathways is likely to establish a more rational basis for the use of PKC? as a drug target in autoimmune and allergic diseases, and in T cell leukemias/lymphomas ..
  25. FUNCTION AND REGULATION OF VAV IN LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 1999
    ....
  26. SIGNAL TRANSDUCTION IN T LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 2003
    ....
  27. Immune regulation by SLAT, a Novel Th2-Expressed Protein
    Amnon Altman; Fiscal Year: 2010
    ..These studies will characterize a novel, multifunctional TCR-proximal protein. ..
  28. FUNCTION AND REGULATION OF VAV IN LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 2003
    ....