Research Topics
| S Mitchell HarmanSummaryAffiliation: Kronos Longevity Research Institute Country: USA Publications
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Detail Information
Publications
Use of growth hormone for prevention or treatment of effects of agingS Mitchell Harman
Kronos Longevity Research Institute, 2222 E Highland, Suite 220, Phoenix, AZ 85016, USA
J Gerontol A Biol Sci Med Sci 59:652-8. 2004..Until more research has better defined the risk/benefit relationships, treatment of elderly individuals with rhGH should be confined to controlled research studies...
Timing and duration of menopausal hormone treatment may affect cardiovascular outcomesS Mitchell Harman
Kronos Longevity Research Institute, Phoenix, AZ 85016, USA
Am J Med 124:199-205. 2011....- Is the estrogen controversy over? Deconstructing the Women's Health Initiative study: a critical evaluation of the evidenceS Mitchell Harman
Kronos Longevity Research Institute, 2222 E Highland, Ste 220, Phoenix, AZ 85016, USA
Ann N Y Acad Sci 1052:43-56. 2005..It will examine surrogate end points as well as risk factors for atherosclerosis... - Estrogen replacement in menopausal women: recent and current prospective studies, the WHI and the KEEPSS Mitchell Harman
Kronos Longevity Research Institute, 2390 E Camelback, Phoenix, AZ 85016, USA
Gend Med 3:254-69. 2006..The risks of adverse health effects must be balanced against the benefits associated with HRT Further research into the timing of estrogen replacement treatment may be crucial to the prevention of cardiovascular disease... - What do hormones have to do with aging? What does aging have to do with hormones?S Mitchell Harman
Kronos Longevity Research Institute, Phoenix, AZ 85016, USA
Ann N Y Acad Sci 1019:299-308. 2004.... - The Kronos longevity research instituteS Mitchell Harman
Kronos Longevity Research Institute KLRI, 2222 E Highland, Suite 220, Phoenix, AZ 85016, USA
Exp Gerontol 38:483-7. 2003..The aging demography of the first half of the century will make KLRI's research increasingly relevant to the population of the U.S. and the world... - Is the WHI relevant to HRT started in the perimenopause?S Mitchell Harman
Kronos Longevity Research Institute, Phoenix, AZ, USA
Endocrine 24:195-202. 2004..Furthermore, animal and clinical evidence supports the use of lower doses of estrogen than were employed in the WHI in older/longer postmenopausal women... 
Oxidative stress in older adults: effects of physical fitnessTINNA TRAUSTADOTTIR
Kronos Longevity Research Institute, 2222 E Highland Ave, Phoenix, AZ 85016, USA
Age (Dordr) 34:969-82. 2012..These data suggest that reduced oxidative stress associated with physical fitness results from differences in activity of antioxidant enzymes...- Urinary excretion of three nucleic acid oxidation adducts and isoprostane F(2)alpha measured by liquid chromatography-mass spectrometry in smokers, ex-smokers, and nonsmokersS Mitchell Harman
Kronos Longevity Research Institute, Phoenix, AZ, USA
Free Radic Biol Med 35:1301-9. 2003..Whether characteristic patterns of excretion of these indicators forecast differential disease risk should be explored in future research... - The effects of growth hormone and sex steroid on lean body mass, fat mass, muscle strength, cardiovascular endurance and adverse events in healthy elderly women and menS Mitchell Harman
National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
Horm Res 60:121-4. 2003.... - Vinegar lacks antiglycemic action on enteral carbohydrate absorption in human subjectsArline D Salbe
Kronos Longevity Research Institute, Phoenix, AZ 85016, USA
Nutr Res 29:846-9. 2009..01) greater after vinegar ingestion compared to placebo, suggesting that vinegar does not act to decrease glycemia by interference with enteral carbohydrate absorption... - High-dose statin use does not impair aerobic capacity or skeletal muscle function in older adultsTINNA TRAUSTADOTTIR
Kronos Longevity Research Institute, 2390 E Camelback Rd, Suite 440, Phoenix, AZ 85016, USA
Age (Dordr) 30:283-91. 2008.... - Tart cherry juice decreases oxidative stress in healthy older men and womenTINNA TRAUSTADOTTIR
Kronos Longevity Research Institute, Phoenix, AZ, USA
J Nutr 139:1896-900. 2009..These data suggest that consumption of tart cherry juice improves antioxidant defenses in vivo in older adults as shown by an increased capacity to constrain an oxidative challenge and reduced oxidative damage to nucleic acids... - Discrimination of breast cancer by anti-malignin antibody serum test in women undergoing biopsyS Mitchell Harman
Kronos Longevity Research Institute, 2222 North Highland, Suite 220, Phoenix, AZ 85016, USA
Cancer Epidemiol Biomarkers Prev 14:2310-5. 2005..To objectively assess accuracy of this test for discrimination of breast cancer, we studied a series of women undergoing core breast biopsy... - Quantification of 8-iso-prostaglandin-F(2alpha) and 2,3-dinor-8-iso-prostaglandin-F(2alpha) in human urine using liquid chromatography-tandem mass spectrometryYuanling Liang
Kronos Science Laboratory, Phoenix, AZ, USA
Free Radic Biol Med 34:409-18. 2003..003 for 2,3-dinor-8-iso-PGF(2alpha), respectively). The excellent accuracy, reproducibility, and high throughput of this method should permit it to be used in large clinical studies and standard clinical laboratories... - Postmenopausal hormone therapy: new questions and the case for new clinical trialsJoAnn E Manson
Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Menopause 13:139-47. 2006.... - Dehydroepiandrosterone secretion in healthy older men and women: effects of testosterone and growth hormone administration in older menRanganath Muniyappa
Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892, USA
J Clin Endocrinol Metab 91:4445-52. 2006..The clinical significance of sex steroid modulation of DHEA secretion in older persons remains to be elucidated... - Effects of GH and/or sex steroids on circulating IGF-I and IGFBPs in healthy, aged women and menThomas Münzer
Endocrine Section, Laboratory of Clinical Investigations, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Am J Physiol Endocrinol Metab 290:E1006-13. 2006..Whether GH and/or sex steroid administration alters local tissue production of IGFBPs and whether the latter influence autocrine or paracrine actions of IGF-I remain to be determined... - Long-term testosterone supplementation augments overnight growth hormone secretion in healthy older menRanganath Muniyappa
Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland, USA
Am J Physiol Endocrinol Metab 293:E769-75. 2007..02), with no significant change in IGFBP-3 levels after T vs. placebo. We conclude that low-dose T supplementation for 26 wk increases spontaneous nocturnal GH secretion and morning serum IGF-I concentrations in healthy older men... - Growth hormone and sex steroid effects on bone metabolism and bone mineral density in healthy aged women and menColleen Christmas
Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Gerontol A Biol Sci Med Sci 57:M12-8. 2002..Given the known biphasic actions of GH on bone and the apparent favorable biochemical effects of GH + T in men, the longer-term effects of GH + T on BMD in aged men remain to be clarified... - Effects of growth hormone and/or sex steroid administration on whole-body protein turnover in healthy aged women and menXin Huang
Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205-2179, USA
Metabolism 54:1162-7. 2005..2 g protein.kg-1.d-1; P<.01). These data suggest that low-dose GH administration increases protein synthesis in healthy aged women and men, and that the coadministration of testosterone plus GH enhances this effect in elderly men... - Women, hormones, and clinical trials: a beginning, not an endVirginia M Miller
J Appl Physiol 99:381-3. 2005 - The Women's Health Initiative could not have detected cardioprotective effects of starting hormone therapy during the menopausal transitionFrederick Naftolin
Yale University, Department of Obstetrics, Gynecology and Reproductive Sciences, New Haven, Connecticut 06520 8063, USA
Fertil Steril 81:1498-501. 2004..Randomized controlled trials are urgently needed to test cardioprotection in women starting treatment during the menopausal transition... - Masculine vitality: pros and cons of testosterone in treating the andropauseSanjay Asthana
University of Wisconsin Medical School, Madison, USA
J Gerontol A Biol Sci Med Sci 59:461-5. 2004 - Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trialMarc R Blackman
Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
JAMA 288:2282-92. 2002..Hormone administration to elderly individuals can increase lean body mass (LBM) and decrease fat, but interactive effects of growth hormone (GH) and sex steroids and their influence on strength and endurance are unknown... - Interrelationships of serum testosterone and free testosterone index with FFM and strength in aging menTracey Ann Roy
Laboratory of Clinical Investigation, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
Am J Physiol Endocrinol Metab 283:E284-94. 2002..FTI is a better predictor of arm and leg strength than T in aging men... - Antiaging technology and pseudoscienceAubrey D N J de Grey
Science 296:656. 2002 - Is there an antiaging medicine?Robert N Butler
International Longevity Center USA, New York, New York, USA
J Gerontol A Biol Sci Med Sci 57:B333-8. 2002..This article reports the findings of a consensus workshop that discussed what is known about existing and future interventions to slow, stop, or reverse aging in animals, and how these might be applied to humans through future research... - Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly menScott D Moffat
Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging/National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
J Clin Endocrinol Metab 87:5001-7. 2002..These results suggest a possible beneficial relationship between circulating free T concentrations and specific domains of cognitive performance in older men... - Characterization of blood borne microparticles as markers of premature coronary calcification in newly menopausal womenMuthuvel Jayachandran
Department of Surgery and Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 1st St SW, Rochester, MN 55905, USA
Am J Physiol Heart Circ Physiol 295:H931-H938. 2008..Therefore, the characterization of platelet and endothelial microparticles may identify early menopausal women with premature CAC who would not otherwise be identified by the usual risk factor analysis... - Aging, androgens, and the metabolic syndrome in a longitudinal study of agingAnnabelle Rodriguez
Department of Medicine, Division of Endocrinology, Johns Hopkins Bayview Medical Center, B Building, Suite 114, 4940 Eastern Avenue, Baltimore, Maryland 21224, USA
J Clin Endocrinol Metab 92:3568-72. 2007..The aim of this study was to evaluate the relationship between the MS and circulating androgen levels in a cohort of men in the Baltimore Longitudinal Study of Aging... - Biomarkers of aging: from primitive organisms to humansRobert N Butler
International Longevity Center USA, 60 E 86th St, New York, NY 10028, USA
J Gerontol A Biol Sci Med Sci 59:B560-7. 2004..Finally, and significantly, it is difficult to obtain funding for this research... - Relationship between androgenic hormones and arterial stiffness, based on longitudinal hormone measurementsHidetaka Hougaku
Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
Am J Physiol Endocrinol Metab 290:E234-42. 2006..05). Thus the adverse influence of low T on the cardiovascular system in men may be mediated in part via the effects of T on vascular structure and function...