S Mitchell Harman

Summary

Affiliation: Kronos Longevity Research Institute
Country: USA

Publications

  1. ncbi request reprint Use of growth hormone for prevention or treatment of effects of aging
    S Mitchell Harman
    Kronos Longevity Research Institute, 2222 E Highland, Suite 220, Phoenix, AZ 85016, USA
    J Gerontol A Biol Sci Med Sci 59:652-8. 2004
  2. pmc Timing and duration of menopausal hormone treatment may affect cardiovascular outcomes
    S Mitchell Harman
    Kronos Longevity Research Institute, Phoenix, AZ 85016, USA
    Am J Med 124:199-205. 2011
  3. ncbi request reprint Is the estrogen controversy over? Deconstructing the Women's Health Initiative study: a critical evaluation of the evidence
    S Mitchell Harman
    Kronos Longevity Research Institute, 2222 E Highland, Ste 220, Phoenix, AZ 85016, USA
    Ann N Y Acad Sci 1052:43-56. 2005
  4. ncbi request reprint Estrogen replacement in menopausal women: recent and current prospective studies, the WHI and the KEEPS
    S Mitchell Harman
    Kronos Longevity Research Institute, 2390 E Camelback, Phoenix, AZ 85016, USA
    Gend Med 3:254-69. 2006
  5. ncbi request reprint What do hormones have to do with aging? What does aging have to do with hormones?
    S Mitchell Harman
    Kronos Longevity Research Institute, Phoenix, AZ 85016, USA
    Ann N Y Acad Sci 1019:299-308. 2004
  6. ncbi request reprint The Kronos longevity research institute
    S Mitchell Harman
    Kronos Longevity Research Institute KLRI, 2222 E Highland, Suite 220, Phoenix, AZ 85016, USA
    Exp Gerontol 38:483-7. 2003
  7. ncbi request reprint Is the WHI relevant to HRT started in the perimenopause?
    S Mitchell Harman
    Kronos Longevity Research Institute, Phoenix, AZ, USA
    Endocrine 24:195-202. 2004
  8. pmc Oxidative stress in older adults: effects of physical fitness
    TINNA TRAUSTADOTTIR
    Kronos Longevity Research Institute, 2222 E Highland Ave, Phoenix, AZ 85016, USA
    Age (Dordr) 34:969-82. 2012
  9. ncbi request reprint Urinary excretion of three nucleic acid oxidation adducts and isoprostane F(2)alpha measured by liquid chromatography-mass spectrometry in smokers, ex-smokers, and nonsmokers
    S Mitchell Harman
    Kronos Longevity Research Institute, Phoenix, AZ, USA
    Free Radic Biol Med 35:1301-9. 2003
  10. ncbi request reprint The effects of growth hormone and sex steroid on lean body mass, fat mass, muscle strength, cardiovascular endurance and adverse events in healthy elderly women and men
    S Mitchell Harman
    National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Horm Res 60:121-4. 2003

Detail Information

Publications33

  1. ncbi request reprint Use of growth hormone for prevention or treatment of effects of aging
    S Mitchell Harman
    Kronos Longevity Research Institute, 2222 E Highland, Suite 220, Phoenix, AZ 85016, USA
    J Gerontol A Biol Sci Med Sci 59:652-8. 2004
    ..Until more research has better defined the risk/benefit relationships, treatment of elderly individuals with rhGH should be confined to controlled research studies...
  2. pmc Timing and duration of menopausal hormone treatment may affect cardiovascular outcomes
    S Mitchell Harman
    Kronos Longevity Research Institute, Phoenix, AZ 85016, USA
    Am J Med 124:199-205. 2011
    ....
  3. ncbi request reprint Is the estrogen controversy over? Deconstructing the Women's Health Initiative study: a critical evaluation of the evidence
    S Mitchell Harman
    Kronos Longevity Research Institute, 2222 E Highland, Ste 220, Phoenix, AZ 85016, USA
    Ann N Y Acad Sci 1052:43-56. 2005
    ..It will examine surrogate end points as well as risk factors for atherosclerosis...
  4. ncbi request reprint Estrogen replacement in menopausal women: recent and current prospective studies, the WHI and the KEEPS
    S Mitchell Harman
    Kronos Longevity Research Institute, 2390 E Camelback, Phoenix, AZ 85016, USA
    Gend Med 3:254-69. 2006
    ..The risks of adverse health effects must be balanced against the benefits associated with HRT Further research into the timing of estrogen replacement treatment may be crucial to the prevention of cardiovascular disease...
  5. ncbi request reprint What do hormones have to do with aging? What does aging have to do with hormones?
    S Mitchell Harman
    Kronos Longevity Research Institute, Phoenix, AZ 85016, USA
    Ann N Y Acad Sci 1019:299-308. 2004
    ....
  6. ncbi request reprint The Kronos longevity research institute
    S Mitchell Harman
    Kronos Longevity Research Institute KLRI, 2222 E Highland, Suite 220, Phoenix, AZ 85016, USA
    Exp Gerontol 38:483-7. 2003
    ..The aging demography of the first half of the century will make KLRI's research increasingly relevant to the population of the U.S. and the world...
  7. ncbi request reprint Is the WHI relevant to HRT started in the perimenopause?
    S Mitchell Harman
    Kronos Longevity Research Institute, Phoenix, AZ, USA
    Endocrine 24:195-202. 2004
    ..Furthermore, animal and clinical evidence supports the use of lower doses of estrogen than were employed in the WHI in older/longer postmenopausal women...
  8. pmc Oxidative stress in older adults: effects of physical fitness
    TINNA TRAUSTADOTTIR
    Kronos Longevity Research Institute, 2222 E Highland Ave, Phoenix, AZ 85016, USA
    Age (Dordr) 34:969-82. 2012
    ..These data suggest that reduced oxidative stress associated with physical fitness results from differences in activity of antioxidant enzymes...
  9. ncbi request reprint Urinary excretion of three nucleic acid oxidation adducts and isoprostane F(2)alpha measured by liquid chromatography-mass spectrometry in smokers, ex-smokers, and nonsmokers
    S Mitchell Harman
    Kronos Longevity Research Institute, Phoenix, AZ, USA
    Free Radic Biol Med 35:1301-9. 2003
    ..Whether characteristic patterns of excretion of these indicators forecast differential disease risk should be explored in future research...
  10. ncbi request reprint The effects of growth hormone and sex steroid on lean body mass, fat mass, muscle strength, cardiovascular endurance and adverse events in healthy elderly women and men
    S Mitchell Harman
    National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Horm Res 60:121-4. 2003
    ....
  11. doi request reprint Vinegar lacks antiglycemic action on enteral carbohydrate absorption in human subjects
    Arline D Salbe
    Kronos Longevity Research Institute, Phoenix, AZ 85016, USA
    Nutr Res 29:846-9. 2009
    ..01) greater after vinegar ingestion compared to placebo, suggesting that vinegar does not act to decrease glycemia by interference with enteral carbohydrate absorption...
  12. pmc High-dose statin use does not impair aerobic capacity or skeletal muscle function in older adults
    TINNA TRAUSTADOTTIR
    Kronos Longevity Research Institute, 2390 E Camelback Rd, Suite 440, Phoenix, AZ 85016, USA
    Age (Dordr) 30:283-91. 2008
    ....
  13. pmc Tart cherry juice decreases oxidative stress in healthy older men and women
    TINNA TRAUSTADOTTIR
    Kronos Longevity Research Institute, Phoenix, AZ, USA
    J Nutr 139:1896-900. 2009
    ..These data suggest that consumption of tart cherry juice improves antioxidant defenses in vivo in older adults as shown by an increased capacity to constrain an oxidative challenge and reduced oxidative damage to nucleic acids...
  14. ncbi request reprint Discrimination of breast cancer by anti-malignin antibody serum test in women undergoing biopsy
    S Mitchell Harman
    Kronos Longevity Research Institute, 2222 North Highland, Suite 220, Phoenix, AZ 85016, USA
    Cancer Epidemiol Biomarkers Prev 14:2310-5. 2005
    ..To objectively assess accuracy of this test for discrimination of breast cancer, we studied a series of women undergoing core breast biopsy...
  15. ncbi request reprint Quantification of 8-iso-prostaglandin-F(2alpha) and 2,3-dinor-8-iso-prostaglandin-F(2alpha) in human urine using liquid chromatography-tandem mass spectrometry
    Yuanling Liang
    Kronos Science Laboratory, Phoenix, AZ, USA
    Free Radic Biol Med 34:409-18. 2003
    ..003 for 2,3-dinor-8-iso-PGF(2alpha), respectively). The excellent accuracy, reproducibility, and high throughput of this method should permit it to be used in large clinical studies and standard clinical laboratories...
  16. ncbi request reprint Postmenopausal hormone therapy: new questions and the case for new clinical trials
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Menopause 13:139-47. 2006
    ....
  17. ncbi request reprint Dehydroepiandrosterone secretion in healthy older men and women: effects of testosterone and growth hormone administration in older men
    Ranganath Muniyappa
    Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 91:4445-52. 2006
    ....
  18. ncbi request reprint Effects of GH and/or sex steroids on circulating IGF-I and IGFBPs in healthy, aged women and men
    Thomas Münzer
    Endocrine Section, Laboratory of Clinical Investigations, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Am J Physiol Endocrinol Metab 290:E1006-13. 2006
    ..Whether GH and/or sex steroid administration alters local tissue production of IGFBPs and whether the latter influence autocrine or paracrine actions of IGF-I remain to be determined...
  19. ncbi request reprint Long-term testosterone supplementation augments overnight growth hormone secretion in healthy older men
    Ranganath Muniyappa
    Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Endocrinol Metab 293:E769-75. 2007
    ..02), with no significant change in IGFBP-3 levels after T vs. placebo. We conclude that low-dose T supplementation for 26 wk increases spontaneous nocturnal GH secretion and morning serum IGF-I concentrations in healthy older men...
  20. ncbi request reprint Growth hormone and sex steroid effects on bone metabolism and bone mineral density in healthy aged women and men
    Colleen Christmas
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 57:M12-8. 2002
    ..Long-term estrogen replacement slows bone loss and prevents fractures in postmenopausal women, whereas the effects of supplementation of GH or testosterone on bone metabolism and BMD in aged individuals remains uncertain...
  21. ncbi request reprint Effects of growth hormone and/or sex steroid administration on whole-body protein turnover in healthy aged women and men
    Xin Huang
    Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 2179, USA
    Metabolism 54:1162-7. 2005
    ..2 g protein.kg-1.d-1; P<.01). These data suggest that low-dose GH administration increases protein synthesis in healthy aged women and men, and that the coadministration of testosterone plus GH enhances this effect in elderly men...
  22. ncbi request reprint Women, hormones, and clinical trials: a beginning, not an end
    Virginia M Miller
    J Appl Physiol 99:381-3. 2005
  23. ncbi request reprint The Women's Health Initiative could not have detected cardioprotective effects of starting hormone therapy during the menopausal transition
    Frederick Naftolin
    Yale University, Department of Obstetrics, Gynecology and Reproductive Sciences, New Haven, Connecticut 06520 8063, USA
    Fertil Steril 81:1498-501. 2004
    ..Randomized controlled trials are urgently needed to test cardioprotection in women starting treatment during the menopausal transition...
  24. ncbi request reprint Masculine vitality: pros and cons of testosterone in treating the andropause
    Sanjay Asthana
    University of Wisconsin Medical School, Madison, USA
    J Gerontol A Biol Sci Med Sci 59:461-5. 2004
  25. ncbi request reprint Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial
    Marc R Blackman
    Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    JAMA 288:2282-92. 2002
    ..Hormone administration to elderly individuals can increase lean body mass (LBM) and decrease fat, but interactive effects of growth hormone (GH) and sex steroids and their influence on strength and endurance are unknown...
  26. ncbi request reprint Interrelationships of serum testosterone and free testosterone index with FFM and strength in aging men
    Tracey Ann Roy
    Laboratory of Clinical Investigation, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Am J Physiol Endocrinol Metab 283:E284-94. 2002
    ..FTI is a better predictor of arm and leg strength than T in aging men...
  27. ncbi request reprint Antiaging technology and pseudoscience
    Aubrey D N J de Grey
    Science 296:656. 2002
  28. ncbi request reprint Is there an antiaging medicine?
    Robert N Butler
    International Longevity Center USA, New York, New York, USA
    J Gerontol A Biol Sci Med Sci 57:B333-8. 2002
    ..This article reports the findings of a consensus workshop that discussed what is known about existing and future interventions to slow, stop, or reverse aging in animals, and how these might be applied to humans through future research...
  29. ncbi request reprint Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men
    Scott D Moffat
    Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Clin Endocrinol Metab 87:5001-7. 2002
    ..These results suggest a possible beneficial relationship between circulating free T concentrations and specific domains of cognitive performance in older men...
  30. pmc Characterization of blood borne microparticles as markers of premature coronary calcification in newly menopausal women
    Muthuvel Jayachandran
    Department of Surgery and Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 1st St SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 295:H931-H938. 2008
    ..Therefore, the characterization of platelet and endothelial microparticles may identify early menopausal women with premature CAC who would not otherwise be identified by the usual risk factor analysis...
  31. ncbi request reprint Aging, androgens, and the metabolic syndrome in a longitudinal study of aging
    Annabelle Rodriguez
    Department of Medicine, Division of Endocrinology, Johns Hopkins Bayview Medical Center, B Building, Suite 114, 4940 Eastern Avenue, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 92:3568-72. 2007
    ..The aim of this study was to evaluate the relationship between the MS and circulating androgen levels in a cohort of men in the Baltimore Longitudinal Study of Aging...
  32. ncbi request reprint Biomarkers of aging: from primitive organisms to humans
    Robert N Butler
    International Longevity Center USA, 60 E 86th St, New York, NY 10028, USA
    J Gerontol A Biol Sci Med Sci 59:B560-7. 2004
    ..Finally, and significantly, it is difficult to obtain funding for this research...
  33. ncbi request reprint Relationship between androgenic hormones and arterial stiffness, based on longitudinal hormone measurements
    Hidetaka Hougaku
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
    Am J Physiol Endocrinol Metab 290:E234-42. 2006
    ..05). Thus the adverse influence of low T on the cardiovascular system in men may be mediated in part via the effects of T on vascular structure and function...