Helena Chmura Kraemer

Summary

Country: USA

Publications

  1. doi The reliability of clinical diagnoses: state of the art
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University Emerita, Palo Alto, California 94301 and Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 email
    Annu Rev Clin Psychol 10:111-30. 2014
  2. doi Toward sound objective evaluation of clinical measures
    Helena Chmura Kraemer
    Department of Biostatistics in Psychiatry, Stanford University, Stanford, CA, USA
    Am J Geriatr Psychiatry 21:589-95. 2013
  3. doi Discovering, comparing, and combining moderators of treatment on outcome after randomized clinical trials: a parametric approach
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, 1116 Forest Avenue, Palo Alto, CA 94301 3032, USA
    Stat Med 32:1964-73. 2013
  4. doi Determining gene moderation of environmental risk factors for a mental disorder: a "perfect storm" of methodological problems
    Helena Chmura Kraemer
    Stanford University, CA, USA
    Int J Methods Psychiatr Res 21:185-94. 2012
  5. ncbi Toward non-parametric and clinically meaningful moderators and mediators
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, U S A
    Stat Med 27:1679-92. 2008
  6. pmc How and why criteria defining moderators and mediators differ between the Baron & Kenny and MacArthur approaches
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, CA, USA
    Health Psychol 27:S101-8. 2008
  7. doi Events per person-time (incidence rate): a misleading statistic?
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 943305, USA
    Stat Med 28:1028-39. 2009
  8. doi Clinical trials design lessons from the CATIE study
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94301, USA
    Am J Psychiatry 166:1222-8. 2009
  9. pmc Epidemiological methods: about time
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, 1116 Forest Avenue, Palo Alto, CA 94301, USA
    Int J Environ Res Public Health 7:29-45. 2010
  10. doi How to assess the clinical impact of treatments on patients, rather than the statistical impact of treatments on measures
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA
    Int J Methods Psychiatr Res 20:63-72. 2011

Detail Information

Publications28

  1. doi The reliability of clinical diagnoses: state of the art
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University Emerita, Palo Alto, California 94301 and Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 email
    Annu Rev Clin Psychol 10:111-30. 2014
    ....
  2. doi Toward sound objective evaluation of clinical measures
    Helena Chmura Kraemer
    Department of Biostatistics in Psychiatry, Stanford University, Stanford, CA, USA
    Am J Geriatr Psychiatry 21:589-95. 2013
    ....
  3. doi Discovering, comparing, and combining moderators of treatment on outcome after randomized clinical trials: a parametric approach
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, 1116 Forest Avenue, Palo Alto, CA 94301 3032, USA
    Stat Med 32:1964-73. 2013
    ....
  4. doi Determining gene moderation of environmental risk factors for a mental disorder: a "perfect storm" of methodological problems
    Helena Chmura Kraemer
    Stanford University, CA, USA
    Int J Methods Psychiatr Res 21:185-94. 2012
    ....
  5. ncbi Toward non-parametric and clinically meaningful moderators and mediators
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, U S A
    Stat Med 27:1679-92. 2008
    ..Methods based on non-parametric methods specifically designed to facilitate considerations of clinical significance are here introduced for binary moderators and mediators and the discussion opened for what would be needed in general...
  6. pmc How and why criteria defining moderators and mediators differ between the Baron & Kenny and MacArthur approaches
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, CA, USA
    Health Psychol 27:S101-8. 2008
    ....
  7. doi Events per person-time (incidence rate): a misleading statistic?
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 943305, USA
    Stat Med 28:1028-39. 2009
    ..More careful design and survival analyses are recommended in place of use of EPTs...
  8. doi Clinical trials design lessons from the CATIE study
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94301, USA
    Am J Psychiatry 166:1222-8. 2009
    ....
  9. pmc Epidemiological methods: about time
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, 1116 Forest Avenue, Palo Alto, CA 94301, USA
    Int J Environ Res Public Health 7:29-45. 2010
    ....
  10. doi How to assess the clinical impact of treatments on patients, rather than the statistical impact of treatments on measures
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA
    Int J Methods Psychiatr Res 20:63-72. 2011
    ..The strategies discussed here are possible solutions to this dilemma. It is crucial to develop successful strategies to assess the effects of treatments on individual patients...
  11. ncbi Another point of view: superiority, noninferiority, and the role of active comparators
    Helena Chmura Kraemer
    1116 Forest Ave, Palo Alto, CA 94301
    J Clin Psychiatry 72:1350-2. 2011
    ..An alternative view of the situation is presented...
  12. ncbi DSM categories and dimensions in clinical and research contexts
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94301, USA
    Int J Methods Psychiatr Res 16:S8-S15. 2007
    ..Possible objections to the proposal are discussed, concluding with some general criteria for implementing this proposal...
  13. ncbi Size of treatment effects and their importance to clinical research and practice
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305, USA
    Biol Psychiatry 59:990-6. 2006
    ..We recommend three equivalent effect sizes: number needed to treat, area under the receiver operating characteristic curve comparing T and C responses, and success rate difference, chosen specifically to convey clinical significance...
  14. ncbi Caution regarding the use of pilot studies to guide power calculations for study proposals
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif 94305, USA
    Arch Gen Psychiatry 63:484-9. 2006
    ..The argument herein is not meant to discourage clinical researchers from performing pilot studies (or review committees from requiring them) but simply to caution against their use for the objective of guiding power calculations...
  15. ncbi Correlation coefficients in medical research: from product moment correlation to the odds ratio
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, MC5717 Stanford, CA 94305, USA
    Stat Methods Med Res 15:525-45. 2006
    ..The present focus is on effect sizes indicating strength of correlation, that is, effect sizes that describe the strength of monotonic association between two random variables X and Y in a population...
  16. ncbi Lifetime prevalence and pseudocomorbidity in psychiatric research
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif 94305, USA
    Arch Gen Psychiatry 63:604-8. 2006
    ..This bias is what we refer to as pseudocomorbidity...
  17. pmc Assessment of factors influencing preservation of dignity at life's end: creation and the cross-cultural validation of the preservation of dignity card-sort tool
    Vyjeyanthi S Periyakoil
    Department of Medicine, Division of General Internal Medicine and the VA Palo Alto Health Care System, Palo Alto, California, USA
    J Palliat Med 13:495-500. 2010
    ..Preserving patient dignity is a sentinel premise of palliative care. This study was conducted to gain a better understanding of factors influencing preservation of dignity in the last chapter of life...
  18. ncbi Developing the diagnostic and statistical manual V: what will "statistical" mean in DSM-V?
    Helena Chmura Kraemer
    Dept of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, MS 5717, Stanford, CA 94305, USA
    Soc Psychiatry Psychiatr Epidemiol 42:259-67. 2007
    ....
  19. ncbi Comments on 'Evaluating the added predictive ability of a new marker' by M. Pencina, R. D'Agostino, R. D'Agostino Jr, R. Vasan, Statistics in Medicine (DOI: 10.1002/sim.2929)
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University of Medicine, Stanford, CA, USA
    Stat Med 27:196-8. 2008
  20. ncbi Are certain multicenter randomized clinical trial structures misleading clinical and policy decisions?
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, 5717, Stanford, CA 94305, USA
    Contemp Clin Trials 26:518-29. 2005
    ....
  21. ncbi Factors associated with psychiatric hospitalization of individuals diagnosed with dementia and comorbid bipolar disorder
    John O Brooks
    Palo Alto Veterans Affairs Health Care System, Palo Alto, California 94304, USA
    J Geriatr Psychiatry Neurol 19:72-7. 2006
    ..These findings suggest that disorders with increased frequency in BD affect the course of dementia...
  22. ncbi Categorical versus dimensional approaches to diagnosis: methodological challenges
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, C305, 401 Quarry Road, Stanford University School of Medicine, Stanford University, Stanford, CA 94305 5717, USA
    J Psychiatr Res 38:17-25. 2004
    ..We argue that failure to utilize the correct approach under the appropriate circumstances can result in impaired clinical and research decision-making...
  23. ncbi Reconsidering the odds ratio as a measure of 2x2 association in a population
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA
    Stat Med 23:257-70. 2004
    ..In studies assessing reliability or heritability, we recommend the intraclass kappa. In studies in which one binary variable is assessed against a binary criterion, we recommend the weighted kappa...
  24. pmc Creation and the empirical validation of the dignity card-sort tool to assess factors influencing erosion of dignity at life's end
    Vyjeyanthi S Periyakoil
    Department of Medicine, Stanford University, Palo Alto, California 94304, USA
    J Palliat Med 12:1125-30. 2009
    ..The DCT is a promising tool that may help clinicians identify key factors resulting in perceptions of erosion of dignity in adult palliative care patients...
  25. ncbi Measures of clinical significance
    Helena Chmura Kraemer
    Stanford University, Stanford, CA, USA
    J Am Acad Child Adolesc Psychiatry 42:1524-9. 2003
  26. ncbi Care management for low-risk patients with heart failure: a randomized, controlled trial
    Robert Frank DeBusk
    Stanford University School of Medicine, Stanford, California 94304 5735, USA
    Ann Intern Med 141:606-13. 2004
    ..Nurse care management programs for patients with chronic illness have been shown to be safe and effective...
  27. ncbi A simple effect size indicator for two-group comparisons? A comment on r equivalent
    Helena Chmura Kraemer
    Department of Psychiatry, Stanford University, Stanford, CA 94305, USA
    Psychol Methods 10:413-9. 2005
    ....
  28. ncbi Biomarkers in psychiatry: methodological issues
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, CA 94305, USA
    Am J Geriatr Psychiatry 10:653-9. 2002
    ..Authors discuss methods for establishing the validity of a biomarker. Finally, they convey a word of caution about overinterpreting the clinical or scientific value of any biological measure...