T R Kosten

Summary

Country: USA

Publications

  1. ncbi request reprint Regional cerebral blood flow during acute and chronic abstinence from combined cocaine-alcohol abuse
    T R Kosten
    Division of Substance Abuse, Yale University School of Medicine, New Haven, CT, USA
    Drug Alcohol Depend 50:187-95. 1998
  2. ncbi request reprint Elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123I] beta-CIT SPECT
    R T Malison
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Am J Psychiatry 155:832-4. 1998
  3. ncbi request reprint [123I]beta-CIT SPECT imaging of dopamine transporter availability after mazindol administration in human cocaine addicts
    R T Malison
    Department of Psychiatry, Yale University School of Medicine, Connecticut, USA
    Psychopharmacology (Berl) 137:321-5. 1998
  4. ncbi request reprint Elevated central serotonin transporter binding availability in acutely abstinent cocaine-dependent patients
    L K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Psychiatry 157:1134-40. 2000
  5. ncbi request reprint Hydromorphone-naloxone combinations in opioid-dependent humans under a naloxone novel-response discrimination procedure
    A H Oliveto
    Department of Psychiatry, Yale University School of Medicine, USA
    Exp Clin Psychopharmacol 6:169-78. 1998
  6. ncbi request reprint Significant interaction between clozapine and cocaine in cocaine addicts
    C K Farren
    Department of Psychiatry, Division of Substance Abuse, Yale University School of Medicine, New Haven, CT, USA
    Drug Alcohol Depend 59:153-63. 2000
  7. ncbi request reprint When is less treatment better? The role of social anxiety in matching methadone patients to psychosocial treatments
    S K Avants
    Substance Abuse Center, Yale University School of Medicine, New Haven, Connecticut 06529, USA
    J Consult Clin Psychol 66:924-31. 1998
  8. ncbi request reprint Day treatment versus enhanced standard methadone services for opioid-dependent patients: a comparison of clinical efficacy and cost
    S K Avants
    Yale University School of Medicine, Conn, USA
    Am J Psychiatry 156:27-33. 1999
  9. ncbi request reprint Effects of cocaine prior to and during bupropion maintenance in cocaine-abusing volunteers
    A Oliveto
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06519, USA
    Drug Alcohol Depend 63:155-67. 2001
  10. ncbi request reprint Desipramine in opioid-dependent cocaine abusers maintained on buprenorphine vs methadone
    A H Oliveto
    Department of Psychiatry, Yale University School of Medicine, West Haven, Conn, USA
    Arch Gen Psychiatry 56:812-20. 1999

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Regional cerebral blood flow during acute and chronic abstinence from combined cocaine-alcohol abuse
    T R Kosten
    Division of Substance Abuse, Yale University School of Medicine, New Haven, CT, USA
    Drug Alcohol Depend 50:187-95. 1998
    ..These perfusion defects appeared to be primarily due to combined alcohol and cocaine abuse and frontal but not parietal defects appeared to resolve partially during 21 days of abstinence...
  2. ncbi request reprint Elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123I] beta-CIT SPECT
    R T Malison
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Am J Psychiatry 155:832-4. 1998
    ..The authors examined whether striatal dopamine transporters were altered in acutely (96 hours or less) abstinent cocaine-abusing subjects, as suggested by postmortem studies...
  3. ncbi request reprint [123I]beta-CIT SPECT imaging of dopamine transporter availability after mazindol administration in human cocaine addicts
    R T Malison
    Department of Psychiatry, Yale University School of Medicine, Connecticut, USA
    Psychopharmacology (Berl) 137:321-5. 1998
    ..e., 2-4 mg) occupy a small percentage (i.e., < 25%) of DAT in human cocaine abusers and that much higher, potentially intolerable doses (i.e., > or = 30 mg/day) may be required to antagonize significantly cocaine binding in vivo...
  4. ncbi request reprint Elevated central serotonin transporter binding availability in acutely abstinent cocaine-dependent patients
    L K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Psychiatry 157:1134-40. 2000
    ..The authors tested for evidence of serotonergic dysfunction during acute abstinence from cocaine, a period of high risk for relapse in cocaine dependence...
  5. ncbi request reprint Hydromorphone-naloxone combinations in opioid-dependent humans under a naloxone novel-response discrimination procedure
    A H Oliveto
    Department of Psychiatry, Yale University School of Medicine, USA
    Exp Clin Psychopharmacol 6:169-78. 1998
    ..These findings are consistent with nonhuman data and suggest that this procedure may be useful as a human laboratory model of opioid withdrawal...
  6. ncbi request reprint Significant interaction between clozapine and cocaine in cocaine addicts
    C K Farren
    Department of Psychiatry, Division of Substance Abuse, Yale University School of Medicine, New Haven, CT, USA
    Drug Alcohol Depend 59:153-63. 2000
    ..These data suggested a possible therapeutic role for clozapine in the treatment of cocaine addiction in humans, but also suggests caution due to the near-syncopal event and the increase in serum cocaine levels...
  7. ncbi request reprint When is less treatment better? The role of social anxiety in matching methadone patients to psychosocial treatments
    S K Avants
    Substance Abuse Center, Yale University School of Medicine, New Haven, Connecticut 06529, USA
    J Consult Clin Psychol 66:924-31. 1998
    ....
  8. ncbi request reprint Day treatment versus enhanced standard methadone services for opioid-dependent patients: a comparison of clinical efficacy and cost
    S K Avants
    Yale University School of Medicine, Conn, USA
    Am J Psychiatry 156:27-33. 1999
    ....
  9. ncbi request reprint Effects of cocaine prior to and during bupropion maintenance in cocaine-abusing volunteers
    A Oliveto
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06519, USA
    Drug Alcohol Depend 63:155-67. 2001
    ..These results suggest that bupropion does not alter the acute subjective or cardiovascular effects of cocaine in a robust manner...
  10. ncbi request reprint Desipramine in opioid-dependent cocaine abusers maintained on buprenorphine vs methadone
    A H Oliveto
    Department of Psychiatry, Yale University School of Medicine, West Haven, Conn, USA
    Arch Gen Psychiatry 56:812-20. 1999
    ..Cocaine abuse occurs in 40% to 60% of patients entering opioid maintenance treatment, and effective pharmacotherapies are needed for this combined dependence...
  11. ncbi request reprint Prediction of dopamine transporter binding availability by genotype: a preliminary report
    L K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Psychiatry 157:1700-3. 2000
    ..Evidence of a relationship between genotype and binding availability was assessed for the dopamine and serotonin transporter genes...
  12. ncbi request reprint Effect of LAAM dose on opiate use in opioid-dependent patients. A pilot study
    A H Oliveto
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT, USA
    Am J Addict 7:272-82. 1998
    ..22 +/- 0.08 and 0.53 +/- 0.12, under the high- and low-dose conditions, respectively (F = 11.8; P = 0.01). These results show that LAAM dose regimen affects the degree of abstinence from opioids...
  13. ncbi request reprint Interactions of cocaine with nimodipine: a brief report
    T R Kosten
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT, USA
    Am J Addict 8:77-81. 1999
    ..In three subjects, a 90 mg dose of nimodipine showed a greater attenuation than that of 60 mg. Subjective effects of cocaine were not altered by either dose of nimodipine...
  14. ncbi request reprint Quantitative morphology of the caudate and putamen in patients with cocaine dependence
    L K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Am J Psychiatry 158:486-9. 2001
    ....
  15. ncbi request reprint Effects of d-amphetamine and caffeine in humans under a cocaine discrimination procedure
    A H Oliveto
    Yale School of Medicine, Department of Psychiatry, New Haven, Connecticut, USA
    Behav Pharmacol 9:207-17. 1998
    ....
  16. ncbi request reprint Nicotine transdermal patch and atypical antipsychotic medications for smoking cessation in schizophrenia
    T P George
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Center, New Haven, CT 06519, USA
    Am J Psychiatry 157:1835-42. 2000
    ....
  17. ncbi request reprint Substance use disorders in patients with posttraumatic stress disorder: a review of the literature
    L K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Am J Psychiatry 158:1184-90. 2001
    ..This article reviews studies pertaining to the epidemiology, clinical phenomenology, and pathophysiology of comorbid PTSD and substance use disorders...