ARNULF HANS WERNER KOEPPEN

Summary

Country: USA

Publications

  1. pmc Friedreich's ataxia: pathology, pathogenesis, and molecular genetics
    Arnulf H Koeppen
    VA Medical Center, 113 Holland Ave, and Albany Medical College, 47 New Scotland Ave, Albany, NY 12208, USA
    J Neurol Sci 303:1-12. 2011
  2. pmc Nikolaus Friedreich and degenerative atrophy of the dorsal columns of the spinal cord
    Arnulf H Koeppen
    Neurology and Research Services, VA Medical Center, Departments of Neurology and Pathology, Albany Medical College, Albany, New York 12208, USA
    J Neurochem 126:4-10. 2013
  3. pmc The reciprocal cerebellar circuitry in human hereditary ataxia
    Arnulf H Koeppen
    Research Service, Veterans Affairs Medical Center, 113 Holland Ave, Albany, NY 12208, USA
    Cerebellum 12:493-503. 2013
  4. pmc Friedreich ataxia: neuropathology revised
    Arnulf H Koeppen
    Research Service, Veterans Affairs Medical Center, Albany, New York 12208, USA
    J Neuropathol Exp Neurol 72:78-90. 2013
  5. pmc Friedreich's ataxia causes redistribution of iron, copper, and zinc in the dentate nucleus
    Arnulf H Koeppen
    Research Service 151, Veterans Affairs Medical Center, 113 Holland Ave, Albany, NY, 12208, USA
    Cerebellum 11:845-60. 2012
  6. doi request reprint The dorsal root ganglion in Friedreich's ataxia
    Arnulf H Koeppen
    Research Service 151, Veterans Affairs Medical Center, 113 Holland Ave, Albany, NY 12208, USA
    Acta Neuropathol 118:763-76. 2009
  7. doi request reprint The pathology of superficial siderosis of the central nervous system
    Arnulf H Koeppen
    Research Service, VA Medical Center, Albany, NY 12208, USA
    Acta Neuropathol 116:371-82. 2008
  8. ncbi request reprint The pathogenesis of spinocerebellar ataxia
    Arnulf H Koeppen
    Neurology and Pathology Services, VA Medical Center, Albany, New York 12208, USA
    Cerebellum 4:62-73. 2005
  9. ncbi request reprint A brief history of Pelizaeus-Merzbacher disease and proteolipid protein
    Arnulf H Koeppen
    Neurology Service 127, VA Medical Center, 113 Holland Avenue, Albany, NY 12208, USA
    J Neurol Sci 228:198-200. 2005
  10. ncbi request reprint Heme oxygenase in experimental intracerebral hemorrhage: the benefit of tin-mesoporphyrin
    Arnulf H Koeppen
    Neurology Service, VA Medical Center, Albany, New York 12208, USA
    J Neuropathol Exp Neurol 63:587-97. 2004

Research Grants

  1. Iron in the pathogenesis of Friedreich's ataxia
    ARNULF HANS WERNER KOEPPEN; Fiscal Year: 2010

Collaborators

Detail Information

Publications21

  1. pmc Friedreich's ataxia: pathology, pathogenesis, and molecular genetics
    Arnulf H Koeppen
    VA Medical Center, 113 Holland Ave, and Albany Medical College, 47 New Scotland Ave, Albany, NY 12208, USA
    J Neurol Sci 303:1-12. 2011
    ....
  2. pmc Nikolaus Friedreich and degenerative atrophy of the dorsal columns of the spinal cord
    Arnulf H Koeppen
    Neurology and Research Services, VA Medical Center, Departments of Neurology and Pathology, Albany Medical College, Albany, New York 12208, USA
    J Neurochem 126:4-10. 2013
    ..It is remarkable that Friedreich also described the abnormal hearts in the disease that now bears his name since hypertrophic cardiomyopathy is now recognized as the main cause of death in Friedreich's ataxia...
  3. pmc The reciprocal cerebellar circuitry in human hereditary ataxia
    Arnulf H Koeppen
    Research Service, Veterans Affairs Medical Center, 113 Holland Ave, Albany, NY 12208, USA
    Cerebellum 12:493-503. 2013
    ..These observations offer a semiquantitative assessment of the critical role of the DN in the ataxic phenotype of SCA and FRDA while other parts of the circuitry appear less important...
  4. pmc Friedreich ataxia: neuropathology revised
    Arnulf H Koeppen
    Research Service, Veterans Affairs Medical Center, Albany, New York 12208, USA
    J Neuropathol Exp Neurol 72:78-90. 2013
    ..In light of the selective vulnerability of organs and tissues to systemic frataxin deficiency, many questions about the pathogenesis of Friedreich ataxia remain...
  5. pmc Friedreich's ataxia causes redistribution of iron, copper, and zinc in the dentate nucleus
    Arnulf H Koeppen
    Research Service 151, Veterans Affairs Medical Center, 113 Holland Ave, Albany, NY, 12208, USA
    Cerebellum 11:845-60. 2012
    ..The results suggest that MT can provide effective protection against endogenous Cu and Zn toxicity in FRDA, similar to the neuroprotective sequestration of Fe in holoferritin...
  6. doi request reprint The dorsal root ganglion in Friedreich's ataxia
    Arnulf H Koeppen
    Research Service 151, Veterans Affairs Medical Center, 113 Holland Ave, Albany, NY 12208, USA
    Acta Neuropathol 118:763-76. 2009
    ..The observations support the conclusions that satellite cells and DRG neurons are affected by iron dysmetabolism; and that regeneration and inappropriate myelination of small axons in DR are characteristic of the disease...
  7. doi request reprint The pathology of superficial siderosis of the central nervous system
    Arnulf H Koeppen
    Research Service, VA Medical Center, Albany, NY 12208, USA
    Acta Neuropathol 116:371-82. 2008
    ..The conversion of heme iron to hemosiderin probably involves both translational and transcriptional activation of ferritin biosynthesis...
  8. ncbi request reprint The pathogenesis of spinocerebellar ataxia
    Arnulf H Koeppen
    Neurology and Pathology Services, VA Medical Center, Albany, New York 12208, USA
    Cerebellum 4:62-73. 2005
    ..The role of polyglutamine-containing intranuclear and cytoplasmic inclusion bodies in SCA remains unknown but protein aggregation may be the common step in the pathogenesis of these otherwise rather heterogeneous disorders...
  9. ncbi request reprint A brief history of Pelizaeus-Merzbacher disease and proteolipid protein
    Arnulf H Koeppen
    Neurology Service 127, VA Medical Center, 113 Holland Avenue, Albany, NY 12208, USA
    J Neurol Sci 228:198-200. 2005
  10. ncbi request reprint Heme oxygenase in experimental intracerebral hemorrhage: the benefit of tin-mesoporphyrin
    Arnulf H Koeppen
    Neurology Service, VA Medical Center, Albany, New York 12208, USA
    J Neuropathol Exp Neurol 63:587-97. 2004
    ..The ICH disrupted the blood-brain barrier sufficiently to allow SnMP to enter the brain in pharmacological amounts, and the metalloporphyrin provided significant protection against neuronal loss...
  11. ncbi request reprint Wallerian degeneration: history and clinical significance
    Arnulf H Koeppen
    Departments of Neurology and Pathology, Albany Medical College, Neurology Service 127, VA Medical Center, Albany, NY 12208, USA
    J Neurol Sci 220:115-7. 2004
  12. ncbi request reprint A brief history of brain iron research
    Arnulf H Koeppen
    Department of Neurology, Stratton VA Medical Center, 113 Holland Avenue, Albany, NY 12208, USA
    J Neurol Sci 207:95-7. 2003
  13. doi request reprint The neuropathology of late-onset Friedreich's ataxia
    Arnulf H Koeppen
    Cerebellum 10:96-103. 2011
    ..Frataxin levels in the dentate nucleus of two patients with late onset were similar to those of seven patients with juvenile onset...
  14. ncbi request reprint The dentate nucleus in Friedreich's ataxia: the role of iron-responsive proteins
    Arnulf H Koeppen
    Research, Veterans Affairs Medical Center, Albany, NY 12208, USA
    Acta Neuropathol 114:163-73. 2007
    ..Neuronal loss in the dentate nucleus is the likely result of trans-synaptic degeneration...
  15. ncbi request reprint Tin-protoporphyrin prevents experimental superficial siderosis in rabbits
    Arnulf H Koeppen
    Neurology Service, VA Medical Center, Albany, New York 12208, USA
    J Neuropathol Exp Neurol 61:689-701. 2002
    ..It did not alter the microglial response. The observations allowed the conclusion that SnPP suppressed heme oxidation but did not affect other steps in the pathogenesis of superficial siderosis...
  16. doi request reprint Pathology and pathogenesis of sensory neuropathy in Friedreich's ataxia
    Jennifer A Morral
    VA Medical Center, Albany, NY 12208, USA
    Acta Neuropathol 120:97-108. 2010
    ..Sural nerves in FRDA showed no convincing change in ferritin and ferroportin, militating against local iron dysmetabolism. The result stands out in contrast to the previously reported changes in dorsal spinal roots of patients with FRDA...
  17. ncbi request reprint Pelizaeus-Merzbacher disease
    Arnulf H Koeppen
    Neurology Research Service, Stratton VA Medical Center and Albany Medical College, NY 12208, USA
    J Neuropathol Exp Neurol 61:747-59. 2002
    ..Several naturally occurring and transgenic animal models with PLP gene mutations or deletions have contributed to our understanding of dysmyelination in PMD and the general knowledge of myelination and myelin repair...
  18. ncbi request reprint Iron and iron-responsive proteins in the cardiomyopathy of Friedreich's ataxia
    Susan Michael
    Research Service, Veterans Affairs Medical Center, Albany, New York, USA
    Cerebellum 5:257-67. 2006
    ..Progressive cardiomyopathy in FRDA is the likely result of iron-catalyzed mitochondrial damage followed by muscle fiber necrosis and a chronic reactive myocarditis...
  19. ncbi request reprint Clinical features and neuropathology of autosomal dominant spinocerebellar ataxia (SCA17)
    Arndt Rolfs
    Department of Neurology, University of Rostock, Rostock, Germany
    Ann Neurol 54:367-75. 2003
    ..Based on clinical and genetic data, we conclude that SCA17 is rare among white SCA patients. SCA17 should be considered in sporadic and familial cases of ataxia with accompanying psychiatric symptoms and dementia...
  20. ncbi request reprint Ocular apraxia in recessive ataxia
    Arnulf H Koeppen
    Arch Neurol 59:874; author reply 874. 2002

Research Grants1

  1. Iron in the pathogenesis of Friedreich's ataxia
    ARNULF HANS WERNER KOEPPEN; Fiscal Year: 2010
    ..Chelation therapy in an effort to remove iron from affected tissues remains controversial. The proposed investigation will help clarify the potential benefit of chelation therapy in FRDA. ..