J A Kline

Summary

Country: USA

Publications

  1. pmc Prospective, randomized evaluation of a personal digital assistant-based research tool in the emergency department
    Morris L Rivera
    Dept of Emergency Medicine, Hilo Medical Center, Hilo, HI, USA
    BMC Med Inform Decis Mak 8:3. 2008
  2. ncbi request reprint Electronic medical record review as a surrogate to telephone follow-up to establish outcome for diagnostic research studies in the emergency department
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Acad Emerg Med 12:1127-33. 2005
  3. pmc Pretest probability assessment derived from attribute matching
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    BMC Med Inform Decis Mak 5:26. 2005
  4. ncbi request reprint D-dimer concentrations in normal pregnancy: new diagnostic thresholds are needed
    Jeffrey A Kline
    Emergency Medicine Research, Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Clin Chem 51:825-9. 2005
  5. doi request reprint Impact of anaesthesia-surgery on D-dimer concentration and end-tidal CO2 and O2 in patients undergoing surgery associated with high risk for pulmonary embolism
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Clin Physiol Funct Imaging 28:161-8. 2008
  6. ncbi request reprint Impact of a rapid rule-out protocol for pulmonary embolism on the rate of screening, missed cases, and pulmonary vascular imaging in an urban US emergency department
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Ann Emerg Med 44:490-502. 2004
  7. ncbi request reprint Methodology for a rapid protocol to rule out pulmonary embolism in the emergency department
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Ann Emerg Med 42:266-75. 2003
  8. ncbi request reprint Use of pulse oximetry to predict in-hospital complications in normotensive patients with pulmonary embolism
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina 28323 2861, USA
    Am J Med 115:203-8. 2003
  9. ncbi request reprint Tenecteplase to treat pulmonary embolism in the emergency department
    Jeffrey A Kline
    Emergency Medicine Research, Department of Emergency Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28323 2861, USA
    J Thromb Thrombolysis 23:101-5. 2007
  10. ncbi request reprint Derivation and validation of a Bayesian network to predict pretest probability of venous thromboembolism
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Ann Emerg Med 45:282-90. 2005

Collaborators

Detail Information

Publications100

  1. pmc Prospective, randomized evaluation of a personal digital assistant-based research tool in the emergency department
    Morris L Rivera
    Dept of Emergency Medicine, Hilo Medical Center, Hilo, HI, USA
    BMC Med Inform Decis Mak 8:3. 2008
    ..The aim of this study was to prospectively compare the performance of PDA and paper enrollment instruments with respect to time required and errors generated...
  2. ncbi request reprint Electronic medical record review as a surrogate to telephone follow-up to establish outcome for diagnostic research studies in the emergency department
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Acad Emerg Med 12:1127-33. 2005
    ..Follow-up for diagnostic research studies might be facilitated if medical record review (MRR) could be used instead of telephone calls...
  3. pmc Pretest probability assessment derived from attribute matching
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    BMC Med Inform Decis Mak 5:26. 2005
    ..This report compares a novel attribute-matching method to generate a PTP for acute coronary syndrome (ACS). We compare the new method with a validated logistic regression equation (LRE)...
  4. ncbi request reprint D-dimer concentrations in normal pregnancy: new diagnostic thresholds are needed
    Jeffrey A Kline
    Emergency Medicine Research, Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Clin Chem 51:825-9. 2005
    ..50 mg/L, leading to an increased false-positive D-dimer test when venous thromboembolism (VTE) is clinically suspected in a pregnant patient. Our aim was to determine the effect of normal pregnancy on the D-dimer concentration...
  5. doi request reprint Impact of anaesthesia-surgery on D-dimer concentration and end-tidal CO2 and O2 in patients undergoing surgery associated with high risk for pulmonary embolism
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Clin Physiol Funct Imaging 28:161-8. 2008
    ..The exhaled end-tidal CO2/O2 ratio and the D-dimer concentration are diagnostic markers of pulmonary embolism (PE)...
  6. ncbi request reprint Impact of a rapid rule-out protocol for pulmonary embolism on the rate of screening, missed cases, and pulmonary vascular imaging in an urban US emergency department
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Ann Emerg Med 44:490-502. 2004
    ..0% of patients with a negative protocol would have an adverse outcome...
  7. ncbi request reprint Methodology for a rapid protocol to rule out pulmonary embolism in the emergency department
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Ann Emerg Med 42:266-75. 2003
    ..Finally, we assess the potential effect of the proposed pulmonary embolism rule-out protocol on use of imaging resources and ED throughput...
  8. ncbi request reprint Use of pulse oximetry to predict in-hospital complications in normotensive patients with pulmonary embolism
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina 28323 2861, USA
    Am J Med 115:203-8. 2003
    ..A simple method is needed to risk stratify normotensive patients with pulmonary embolism. We studied whether bedside clinical data can predict in-hospital complications from pulmonary embolism...
  9. ncbi request reprint Tenecteplase to treat pulmonary embolism in the emergency department
    Jeffrey A Kline
    Emergency Medicine Research, Department of Emergency Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28323 2861, USA
    J Thromb Thrombolysis 23:101-5. 2007
    ..Taken together, we submit that the present case report and prior case reports are sufficient to comprise a phase I study of the safety and efficacy of tenecteplase to treat acute pulmonary embolism...
  10. ncbi request reprint Derivation and validation of a Bayesian network to predict pretest probability of venous thromboembolism
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Ann Emerg Med 45:282-90. 2005
    ..We determine the accuracy with which a Bayesian network can identify patients with a low pretest probability of venous thromboembolism, defined as less than or equal to 2%...
  11. pmc Prospective study of clinician-entered research data in the Emergency Department using an Internet-based system after the HIPAA Privacy Rule
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    BMC Med Inform Decis Mak 4:17. 2004
    ..Design and test the reliability of a web-based system for multicenter, real-time collection of data in the emergency department (ED), under waiver of authorization, in compliance with HIPAA...
  12. ncbi request reprint Clinical criteria to prevent unnecessary diagnostic testing in emergency department patients with suspected pulmonary embolism
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, North Carolina 28323 2861, USA
    J Thromb Haemost 2:1247-55. 2004
    ..4% (0.5-3.0%) and 0% (0-6.2%), respectively. The derived eight-factor block rule reduced the pretest probability below the test threshold for d-dimer in two validation populations, but the rule's utility was limited by low specificity...
  13. doi request reprint Comparison of 8 biomarkers for prediction of right ventricular hypokinesis 6 months after submassive pulmonary embolism
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Am Heart J 156:308-14. 2008
    ..We compare the prognostic use of BNP, troponin I, D-dimer, monocyte chemoattractant protein-1, matrix metalloproteinase, myeloperoxidase, C-reactive protein, and caspase 3 as biomarkers of RV damage and adverse outcomes in submassive PE...
  14. ncbi request reprint New diagnostic tests for pulmonary embolism
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Ann Emerg Med 35:168-80. 2000
    ..For comparison, recent data on the diagnostic utility of the alveolar-arterial oxygen gradient and the V/Q scan are included. The potential application of these new tests to a hypothetical ED population is described...
  15. ncbi request reprint Preliminary study of the capnogram waveform area to screen for pulmonary embolism
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA
    Ann Emerg Med 32:289-96. 1998
    ....
  16. pmc D-dimer threshold increase with pretest probability unlikely for pulmonary embolism to decrease unnecessary computerized tomographic pulmonary angiography
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    J Thromb Haemost 10:572-81. 2012
    ....
  17. ncbi request reprint Use of the alveolar dead space fraction (Vd/Vt) and plasma D-dimers to exclude acute pulmonary embolism in ambulatory patients
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Acad Emerg Med 4:856-63. 1997
    ..To evaluate the utility of a modified calculation of the alveolar dead space fraction (Vd/Vt), combined with plasma D-dimers, to aid in the exclusion of acute pulmonary embolism (PE)...
  18. ncbi request reprint Measurement of expired carbon dioxide, oxygen and volume in conjunction with pretest probability estimation as a method to diagnose and exclude pulmonary venous thromboembolism
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Centre, Charlotte, NC 28232, USA
    Clin Physiol Funct Imaging 26:212-9. 2006
    ..Expired pCO(2), pO(2) and breath volume were measured. All patients underwent standardized objective testing for PE including 90-day follow-up. Diagnosis (PE+) required anticoagulation for image-proven PE within 90 days...
  19. ncbi request reprint The clinical features of acute pulmonary embolism in ambulatory patients
    O Susec
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Acad Emerg Med 4:891-7. 1997
    ..To identify clinical findings and predisposing conditions associated with acute pulmonary embolism (PE) in ambulatory patients being evaluated for PE...
  20. ncbi request reprint Diagnostic accuracy of a bedside D-dimer assay and alveolar dead-space measurement for rapid exclusion of pulmonary embolism: a multicenter study
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232 2816, USA
    JAMA 285:761-8. 2001
    ..A previous study suggested that the combination of a normal D-dimer assay and normal alveolar dead-space fraction is a highly sensitive screening test for pulmonary embolism (PE)...
  21. ncbi request reprint Surrogate markers for adverse outcomes in normotensive patients with pulmonary embolism
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Crit Care Med 34:2773-80. 2006
    ..Although echocardiography has proven utility in risk stratifying normotensive patients with pulmonary embolism, echocardiography is not always available...
  22. doi request reprint Comparison of the Simplify D-dimer assay performed at the bedside with a laboratory-based quantitative D-dimer assay for the diagnosis of pulmonary embolism in a low prevalence emergency department population
    M S Runyon
    Department of Emergency Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, North Carolina 28323 2861, USA
    Emerg Med J 25:70-5. 2008
    ..The immunofiltration D-dimer assay could allow point-of-care testing for pulmonary embolism (PE). A study was undertaken to compare a clinician-performed qualitative D-dimer assay with the automated quantitative D-dimer test...
  23. doi request reprint Prospective multicenter assessment of interobserver agreement for radiologist interpretation of multidetector computerized tomographic angiography for pulmonary embolism
    D M Courtney
    Department of Emergency Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    J Thromb Haemost 8:533-9. 2010
    ..Few data exist regarding the interobserver reliability of this endpoint...
  24. ncbi request reprint Alveolar dead space as a predictor of severity of pulmonary embolism
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Acad Emerg Med 7:611-7. 2000
    ..To determine whether the alveolar dead space volume (V(D)alv), expressed as a percentage of the alveolar tidal volume (V(D)alv/V(T)alv), can predict the degree of vascular occlusion caused by pulmonary embolism (PE)...
  25. doi request reprint Prospective multicenter evaluation of the pulmonary embolism rule-out criteria
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    J Thromb Haemost 6:772-80. 2008
    ..We hypothesized that low suspicion and PERC(-) would predict a post-test probability of VTE(+) or death below 2.0%...
  26. ncbi request reprint Prevalence and significance of nonthromboembolic findings on chest computed tomography angiography performed to rule out pulmonary embolism: a multicenter study of 1,025 emergency department patients
    Peter B Richman
    Department of Emergency Medicine, Mayo Clinic Hospital, Scottsdale, AZ, USA
    Acad Emerg Med 11:642-7. 2004
    ..To evaluate the hypothesis that computed tomography (CT) angiography often yields a result interpreted as an alternative diagnosis to pulmonary embolism (PE) in emergency department (ED) patients...
  27. ncbi request reprint Pulseless electrical activity with witnessed arrest as a predictor of sudden death from massive pulmonary embolism in outpatients
    D M Courtney
    Department of Emergency Medicine, Carolinas Medical Center, Medical Education Building, 304 D, 1000 Blythe Boulevard, P O Box 32861, Charlotte, NC 28232, USA
    Resuscitation 49:265-72. 2001
    ..This rule generated sensitivity=67.6% and specificity=94.5% and yielded a posttest probability of MPE of 57%. CONCLUSIONS: outpatients with witnessed cardiac arrest and primary PEA carry a high probability of MPE...
  28. ncbi request reprint Identification of prearrest clinical factors associated with outpatient fatal pulmonary embolism
    D M Courtney
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 8:1136-42. 2001
    ..CONCLUSIONS: Patients in this community with fatal MPE were young with risk factors for pulmonary embolism, and commonly manifested components of a triad including: dyspnea, alteration of mental status/syncope, and shock prior to death...
  29. ncbi request reprint Contrast nephropathy following computed tomography angiography of the chest for pulmonary embolism in the emergency department
    A M Mitchell
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    J Thromb Haemost 5:50-4. 2007
    ..To estimate the frequency of contrast nephropathy after computed tomography angiography (CTA) to rule out pulmonary embolism (PE) in the emergency department (ED) setting...
  30. doi request reprint Rapid clearance of circulating haptoglobin from plasma during acute pulmonary embolism in rats results in HMOX1 up-regulation in peripheral blood leukocytes
    J Zagorski
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    J Thromb Haemost 8:389-96. 2010
    ..We hypothesize that PE with associated PH leads to alterations in plasma protein concentrations indicative of disease severity and prognosis...
  31. ncbi request reprint Prospective multicenter study of quantitative pretest probability assessment to exclude acute coronary syndrome for patients evaluated in emergency department chest pain units
    Alice M Mitchell
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Ann Emerg Med 47:447. 2006
    ....
  32. ncbi request reprint Criteria for the safe use of D-dimer testing in emergency department patients with suspected pulmonary embolism: a multicenter US study
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Ann Emerg Med 39:144-52. 2002
    ....
  33. doi request reprint Tandem measurement of D-dimer and myeloperoxidase or C-reactive protein to effectively screen for pulmonary embolism in the emergency department
    Alice M Mitchell
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 15:800-5. 2008
    ....
  34. ncbi request reprint Multimarker panel to rule out acute coronary syndromes in low-risk patients
    Alice M Mitchell
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Acad Emerg Med 13:803-6. 2006
    ....
  35. ncbi request reprint Activation of poly(ADP-ribose) polymerase in severe hemorrhagic shock and resuscitation
    J A Watts
    Emergency Medicine Research, Carolinas Medical Center, Charlotte, North Carolina 28232 2861, USA
    Am J Physiol Gastrointest Liver Physiol 281:G498-506. 2001
    ..PARP is activated in the ileum by hemorrhage and by resuscitation. Activation of PARP contributes to organ dysfunction in the ileum and liver and appears to be central to the development of metabolic acidosis...
  36. pmc Clinical features from the history and physical examination that predict the presence or absence of pulmonary embolism in symptomatic emergency department patients: results of a prospective, multicenter study
    D Mark Courtney
    Department of Emergency Medicine, Northwestern University, Chicago, IL, USA
    Ann Emerg Med 55:307-315.e1. 2010
    ..The objective of this study is to measure the predictive value of 13 implicit variables...
  37. ncbi request reprint Emergency department hypotension predicts sudden unexpected in-hospital mortality: a prospective cohort study
    Alan E Jones
    Department of Emergency Medicine, 1000 Blythe Blvd, MEB 304D, Carolinas Medical Center, Charlotte, NC 28203, USA
    Chest 130:941-6. 2006
    ..The prevalence and prognostic significance of nontraumatic hypotension measured in the emergency department (ED) have not been studied. We hypothesized that ED hypotension confers risk of in-hospital mortality...
  38. ncbi request reprint Prospective study of the diagnostic accuracy of the simplify D-dimer assay for pulmonary embolism in emergency department patients
    Jeffrey A Kline
    Director, Emergency Medicine Research, Department of Emergency Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28323 2861, USA
    Chest 129:1417-23. 2006
    ....
  39. ncbi request reprint Comparison of the unstructured clinician estimate of pretest probability for pulmonary embolism to the Canadian score and the Charlotte rule: a prospective observational study
    Michael S Runyon
    Department of Emergency Medicine, Carolinas Medical Center, P O Box 32861, Charlotte, NC 28232 2861, USA
    Acad Emerg Med 12:587-93. 2005
    ..However, many clinicians prefer to use clinical gestalt for this purpose. The authors compared the unstructured clinical estimate of pretest probability for PE with two clinical decision rules...
  40. ncbi request reprint Biventricular cardiac dysfunction after acute massive pulmonary embolism in the rat
    D M Sullivan
    Division of Research, Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina 28232-2861, USA
    J Appl Physiol 90:1648-56. 2001
    ..043) and LV (P = 0.005) tissue. These data support the hypothesis that AMPE produces intrinsic biventricular dysfunction and suggest that arterial hypotension is not the principal mechanism of this dysfunction...
  41. ncbi request reprint Frequency of thrombophilia-related genetic variations in patients with idiopathic pulmonary embolism in an urban emergency department
    Lori Kruse
    Department of Emergency Medicine, James G Cannon Research Center, Carolinas Medical Center, Charlotte, NC 28203, USA
    Clin Chem 52:1026-32. 2006
    ....
  42. ncbi request reprint Nontraumatic out-of-hospital hypotension predicts inhospital mortality
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Ann Emerg Med 43:106-13. 2004
    ..Out-of-hospital hypotension may signify need for intensive resuscitation and rapid diagnosis on emergency department (ED) arrival. We hypothesized that nontraumatic out-of-hospital hypotension confers risk of inhospital mortality...
  43. pmc Prospective evaluation of right ventricular function and functional status 6 months after acute submassive pulmonary embolism: frequency of persistent or subsequent elevation in estimated pulmonary artery pressure
    Jeffrey A Kline
    Department of Emergency Medicine, Emergency Medicine Research, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Chest 136:1202-10. 2009
    ..The aim of this work was to document the rate of pulmonary hypertension, as assessed noninvasively by estimated right ventricular systolic pressure (RVSP) of >or= 40 mm Hg 6 months after the diagnosis of submassive PE...
  44. ncbi request reprint Randomized, controlled trial of immediate versus delayed goal-directed ultrasound to identify the cause of nontraumatic hypotension in emergency department patients
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, NC 28203, USA
    Crit Care Med 32:1703-8. 2004
    ..We examined a physician-performed, goal-directed ultrasound protocol for the emergency department management of nontraumatic, symptomatic, undifferentiated hypotension...
  45. pmc The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Crit Care Med 37:1649-54. 2009
    ..We examined the utility of the SOFA score for assessing outcome of patients with severe sepsis with evidence of hypoperfusion at the time of emergency department (ED) presentation...
  46. ncbi request reprint Prospective study of the clinical features and outcomes of emergency department patients with delayed diagnosis of pulmonary embolism
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 14:592-8. 2007
    ....
  47. doi request reprint 12-lead ECG findings of pulmonary hypertension occur more frequently in emergency department patients with pulmonary embolism than in patients without pulmonary embolism
    Michael R Marchick
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Ann Emerg Med 55:331-5. 2010
    ..We hypothesize that ECG findings consistent with pulmonary hypertension would be observed more frequently in patients with pulmonary embolism...
  48. ncbi request reprint Role of fatty acids in the recovery of cardiac function during resuscitation from hemorrhagic shock
    C B Custalow
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina 28232, USA
    Shock 15:231-8. 2001
    ..These data indicate that hemorrhagic shock renders the heart unable to mobilize endogenous fuels, and suggest that withdrawal of fatty acid oxidation will impair myocardial energy metabolism during resuscitation...
  49. ncbi request reprint Effects of angiotensin (1-7) upon right ventricular function in experimental rat pulmonary embolism
    J A Watts
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Histol Histopathol 26:1287-94. 2011
    ..Supplemental delivery of ANG (1-7) reduced the development of RV dysfunction, suggesting a novel approach to protecting RV function in the setting of acute experimental PE...
  50. ncbi request reprint Research fundamentals: V. The use of laboratory animal models in research
    B J O'Neil
    Department of Emergency Medicine, Grace Receiving Hospital Detroit, MI, USA
    Acad Emerg Med 6:75-82. 1999
    ..Important considerations in choosing, applying, and developing animal research models are outlined. Practical discussions of potential problems with animal models are also provided...
  51. pmc Factors associated with positive D-dimer results in patients evaluated for pulmonary embolism
    Christopher Kabrhel
    Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Acad Emerg Med 17:589-97. 2010
    ..To help clinicians better target testing, this study sought to quantify the effect of risk factors for a positive quantitative D-dimer in patients evaluated for PE...
  52. pmc D-dimer and exhaled CO2/O2 to detect segmental pulmonary embolism in moderate-risk patients
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, NC 28203, USA
    Am J Respir Crit Care Med 182:669-75. 2010
    ..Pulmonary embolism (PE) decreases the exhaled end-tidal ratio of carbon dioxide to oxygen (etCO(2)/O(2))...
  53. doi request reprint Accuracy of very low pretest probability estimates for pulmonary embolism using the method of attribute matching compared with the Wells score
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 17:133-41. 2010
    ..The authors tested the accuracy of this method for forecasting a very low probability of venous thromboembolism (VTE) in symptomatic emergency department (ED) patients...
  54. doi request reprint Right ventricular heart failure from pulmonary embolism: key distinctions from chronic pulmonary hypertension
    John A Watts
    Emergency Medicine Research, Carolinas Medical Center, 1542 Garden Terrace, Charlotte, NC 28203, USA
    J Card Fail 16:250-9. 2010
    ....
  55. doi request reprint Incidence and predictors of repeated computed tomographic pulmonary angiography in emergency department patients
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Ann Emerg Med 54:41-8. 2009
    ..We sought to measure the frequency of repeat CT pulmonary angiography in emergency department (ED) patients...
  56. pmc One year mortality of patients treated with an emergency department based early goal directed therapy protocol for severe sepsis and septic shock: a before and after study
    Michael A Puskarich
    Department of Emergency Medicine, Carolinas Medical Center, 1000 Blythe Blvd, Charlotte, North Carolina 28203, USA
    Crit Care 13:R167. 2009
    ..We sought to determine one year outcomes associated with implementation of early goal directed therapy (EGDT) in the emergency department (ED) care of sepsis...
  57. pmc Performance of the Mortality in Emergency Department Sepsis score for predicting hospital mortality among patients with severe sepsis and septic shock
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Am J Emerg Med 26:689-92. 2008
    ..The aim of the study was to test if the Mortality in Emergency Department Sepsis (MEDS) score accurately predicts death among emergency department (ED) patients with severe sepsis and septic shock...
  58. doi request reprint Proinflammatory events in right ventricular damage during pulmonary embolism: effects of treatment with ketorolac in rats
    John A Watts
    Emergency Medicine Research, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    J Cardiovasc Pharmacol 54:246-52. 2009
    ..Ketorolac reduced CINC-1 stimulated chemotaxis of isolated neutrophils. PE converted cardiac tissue into a proinflammatory phenotype. Ketorolac reduced RV inflammatory genes, reduced neutrophil influx, and improved RV function in rat PE...
  59. ncbi request reprint Interobserver agreement for the diagnosis of venous thromboembolism on computed tomography chest angiography and indirect venography of the lower extremities in emergency department patients
    Peter B Richman
    Department of Emergency Medicine, Mayo Clinic Hospital, Charlotte, NC, USA
    Acad Emerg Med 13:295-301. 2006
    ..CT venography of the lower extremities combined with standard CT angiography of the chest may result in an increased overall diagnosis rate of venous thromboembolism (pulmonary embolism or deep venous thrombosis)...
  60. ncbi request reprint Prospective use of a clinical decision rule to identify pulmonary embolism as likely cause of outpatient cardiac arrest
    D Mark Courtney
    Department of Emergency Medicine, Feinberg School of Medicine, Northwestern University, Emergency Medicine, 259 E Erie Suite 100, Chicago, IL 60611, USA
    Resuscitation 65:57-64. 2005
    ..CONCLUSIONS: We implemented successfully a CDR in a large, urban prehospital system to detect PE rapidly as most likely cause of cardiac arrest...
  61. ncbi request reprint Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1072-81. 2003
    ..Experimental PE increased lung and systemic production of TxB(2). Inhibition at the COX-1/2 enzyme was equally as effective as inhibition of thromboxane synthase at reducing alveolar dead space and improving heart function after PE...
  62. ncbi request reprint Operational performance of validated physiologic scoring systems for predicting in-hospital mortality among critically ill emergency department patients
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Crit Care Med 33:974-8. 2005
    ..We tested the prognostic accuracy of these instruments for predicting mortality among a cohort of critically ill emergency department patients...
  63. doi request reprint Risk of thromboembolism varies, depending on category of immobility in outpatients
    Daren M Beam
    Brody School of Medicine at East Carolina University, Greenville, NC, USA
    Ann Emerg Med 54:147-52. 2009
    ..Immobility predisposes to venous thromboembolism, but this risk may vary, depending on the underlying cause of immobility...
  64. doi request reprint Randomized trial of computerized quantitative pretest probability in low-risk chest pain patients: effect on safety and resource use
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Ann Emerg Med 53:727-35.e1. 2009
    ..We hypothesize that the presentation of a quantitative pretest probability of acute coronary syndrome would safely reduce unnecessary resource use in low-risk emergency department (ED) chest pain patients...
  65. doi request reprint Systematic review of emergency physician-performed ultrasonography for lower-extremity deep vein thrombosis
    Patrick R Burnside
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 15:493-8. 2008
    ..The authors performed a systematic review to evaluate published literature on diagnostic performance of emergency physician-performed ultrasonography (EPPU) for the diagnosis and exclusion of deep venous thrombosis (DVT)...
  66. ncbi request reprint Inhibition of CINC-1 decreases right ventricular damage caused by experimental pulmonary embolism in rats
    John Zagorski
    Department of Emergency Medicine, James G Cannon Research Center, Carolinas Medical Center, Charlotte, NC 28203, USA
    J Immunol 179:7820-6. 2007
    ..These results suggest that selective anti-inflammatory therapies targeted at neutrophil chemoattractants will reduce cardiac inflammation and reduce RV damage in the setting of PE...
  67. ncbi request reprint Chemokines accumulate in the lungs of rats with severe pulmonary embolism induced by polystyrene microspheres
    John Zagorski
    Department of Emergency Medicine, James G Cannon Research Center, Carolinas Medical Center, Charlotte, NC 28203, USA
    J Immunol 171:5529-36. 2003
    ....
  68. ncbi request reprint Cardiac inflammation contributes to right ventricular dysfunction following experimental pulmonary embolism in rats
    John A Watts
    Emergency Medicine Research, Carolinas Medical Center, Cannon Research Center, Charlotte, NC 28232 2861, USA
    J Mol Cell Cardiol 41:296-307. 2006
    ..Experimental agranulocytosis reduced RV, suggesting that neutrophil influx contributed to RV damage...
  69. pmc Prospective external validation of the clinical effectiveness of an emergency department-based early goal-directed therapy protocol for severe sepsis and septic shock
    Alan E Jones
    Assistant Director of Research, Department of Emergency Medicine, 1000 Blythe Blvd, MEB 304e, Carolinas Medical Center, Charlotte, NC 28203, USA
    Chest 132:425-32. 2007
    ..To determine the clinical effectiveness of implementing early goal-directed therapy (EGDT) as a routine protocol in the emergency department (ED)...
  70. ncbi request reprint Cardiac UCP2 expression and myocardial oxidative metabolism during acute septic shock in the rat
    Michael J Roshon
    Division of Research, Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina 28323 2861, USA
    Shock 19:570-6. 2003
    ..These data argue against the hypothesis that UCP-2 causes decreased cardiac mechanical efficiency in septic shock...
  71. doi request reprint Indirect computed tomography venography: a report of vascular opacification
    Patrick R Burnside
    Carolinas Medical Center, Charlotte, NC, USA
    Emerg Radiol 17:195-201. 2010
    ..5% for DVT thrombus. CTV imaging produces a very small HU gradient between clot and blood in leg veins. These findings highlight the importance of ancillary radiological findings in assessing presence of DVT on CTV...
  72. ncbi request reprint Research fundamentals: choosing an appropriate journal, manuscript preparation, and interactions with editors
    D J DeBehnke
    Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Acad Emerg Med 8:844-50. 2001
    ..Methods for completing each step of this process are described. Following these methods will increase the chance of publishing one's work in the highest-quality and most appropriate journal...
  73. pmc The significance of non-sustained hypotension in emergency department patients with sepsis
    Michael R Marchick
    Emergency Medicine Research, Department of Emergency Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232 2861, USA
    Intensive Care Med 35:1261-4. 2009
    ..We hypothesized that ED non-sustained hypotension increases risk of in-hospital mortality in patients with sepsis...
  74. ncbi request reprint Severity of emergency department hypotension predicts adverse hospital outcome
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Shock 22:410-4. 2004
    ..1; 95% CI 1.5-7.1). Mortality among patients who present to the ED with undifferentiated shock is high. The depth and duration of systolic blood pressure appears to have a dose-response relationship to adverse hospital outcome...
  75. doi request reprint Emergency clinician-performed compression ultrasonography for deep venous thrombosis of the lower extremity
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Ann Emerg Med 52:437-45. 2008
    ..However, the diagnostic accuracy of emergency clinician-performed ultrasonography performed by a heterogenous group of clinicians remains undefined...
  76. pmc The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Crit Care Med 36:2734-9. 2008
    ..Quantitative resuscitation consists of structured cardiovascular intervention targeting predefined hemodynamic end points. We sought to measure the treatment effect of quantitative resuscitation on mortality from sepsis...
  77. ncbi request reprint Emergency echocardiography to detect pericardial effusion in patients in PEA and near-PEA states
    Vivek S Tayal
    Department of Emergency Medicine, P O Box 32861, Charlotte, NC 28232, USA
    Resuscitation 59:315-8. 2003
    ..We observed the value of EM echo by emergency physicians in detecting pericardial effusion in patients in PEA and near PEA states...
  78. ncbi request reprint Frequency of thromboprophylaxis and incidence of in-hospital venous thromboembolism in a cohort of emergency department patients
    Alan E Jones
    Department of Emergency Medicine, Emergency Medicine Research, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232 2861, USA
    J Thromb Thrombolysis 25:160-4. 2008
    ..Our objective was to quantify the rate of thromboprophylaxis and incidence of in-hospital VTE, based upon risk of VTE, in a cohort of patients admitted through the emergency department (ED)...
  79. ncbi request reprint Emergency medicine practitioner knowledge and use of decision rules for the evaluation of patients with suspected pulmonary embolism: variations by practice setting and training level
    Michael S Runyon
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 14:53-7. 2007
    ..Several clinical decision rules (CDRs) have been validated for pretest probability assessment of pulmonary embolism (PE), but the authors are unaware of any data quantifying and characterizing their use in emergency departments...
  80. doi request reprint Transcriptional profile of right ventricular tissue during acute pulmonary embolism in rats
    John Zagorski
    Department of Emergency Medicine, James G Cannon Research Center, Carolinas Medical Center, Charlotte, NC 28203, USA
    Physiol Genomics 34:101-11. 2008
    ..This pattern suggests an extensive shift in cardiac physiology favoring the expression of the "fetal gene program."..
  81. doi request reprint Systematic bias introduced by the informed consent process in a diagnostic research study
    Alice M Mitchell
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 15:225-30. 2008
    ..The authors hypothesized that the prevalence of venous thromboembolism (VTE) would be lower among study participants and that medical acuity and refusal to provide a blood sample would be the most common reasons for nonparticipation...
  82. pmc Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial
    Alan E Jones
    Department of Emergency Medicine, 1000 Blythe Blvd, Carolinas Medical Center, Charlotte, NC 28203, USA
    JAMA 303:739-46. 2010
    ..Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department...
  83. ncbi request reprint Emergency department resuscitative procedures: animal laboratory training improves procedural competency and speed
    Catherine B Custalow
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 9:575-86. 2002
    ..Certain resuscitative procedures can be lifesaving, but are performed infrequently by emergency medicine (EM) residents on human subjects. Alternative training methods for gaining procedural proficiency must be explored and tested...
  84. ncbi request reprint Diagnostic accuracy of left ventricular function for identifying sepsis among emergency department patients with nontraumatic symptomatic undifferentiated hypotension
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
    Shock 24:513-7. 2005
    ..5 (95% CI 1.1-45). Among ED patients with non-traumatic undifferentiated symptomatic hypotension, the presence of hyperdynamic LVF on focused echo is highly specific for sepsis as the etiology of shock...
  85. ncbi request reprint Elevated brain natriuretic peptide in septic patients without heart failure
    Alan E Jones
    Ann Emerg Med 42:714-5. 2003
  86. ncbi request reprint Risk stratification of community-acquired pneumonia: what does all of this mean?
    Alan E Jones
    Ann Emerg Med 52:61-2. 2008
  87. ncbi request reprint Evaluation of capnography using a genetic algorithm to predict PaCO2
    Milo Engoren
    Department of Anesthesiology, St Vincent Mercy Medical Center, 2213 Cherry St, Toledo, OH 43608, USA
    Chest 127:579-84. 2005
    ..A genetic algorithm is a computer technique for discovering relationships between variables. The purpose of this study was to use a genetic algorithm to improve the precision of Paco(2) prediction in comparison to Petco(2)...
  88. ncbi request reprint Determination of left ventricular function by emergency physician echocardiography of hypotensive patients
    Christopher L Moore
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA
    Acad Emerg Med 9:186-93. 2002
    ..To determine whether emergency physicians (EPs) with goal-directed training can use echocardiography to accurately assess left ventricular function (LVF) in hypotensive emergency department (ED) patients...
  89. ncbi request reprint End tidal CO(2) is reduced during hypotension and cardiac arrest in a rat model of massive pulmonary embolism
    D Mark Courtney
    Division of Emergency Medicine, Northwestern Memorial Hospital, Chicago, IL, USA
    Resuscitation 53:83-91. 2002
    ....
  90. ncbi request reprint Determination of the effect of in vitro time, temperature, and tourniquet use on whole blood venous point-of-care lactate concentrations
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 14:587-91. 2007
    ..The authors sought to determine the effect of in vitro time, temperature, and removable tourniquet use on changes in venous point-of-care lactate concentrations...
  91. ncbi request reprint Fatal pulmonary embolism immediately after transatlantic air travel to the United States: less than one in a million
    Jeffrey A Kline
    Thromb Haemost 87:342. 2002
  92. ncbi request reprint The effects of dichloroacetate in a rabbit model of acute hind-limb ischemia and reperfusion
    Jeffrey S Wilson
    Division of Vascular and Endovascular Surgery, University of South Florida College of Medicine, Tampa, FL, USA
    J Am Coll Surg 197:591-5. 2003
    ..We hypothesize that the administration of DCA during acute limb ischemia may have a beneficial effect by reducing the severity of anaerobic metabolism and lessening the irreversible injury...
  93. ncbi request reprint The beneficial effects of dichloroacetate in acute limb ischemia
    Timothy A Platz
    Department of Vascular and Endovascular Surgery, Naval Medical Center Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23708, USA
    Mil Med 172:628-33. 2007
    ..The purpose of this study was to determine the effects of dichloroacetate (DCA) in acute limb ischemia...
  94. ncbi request reprint Pleural effusions in the critically ill: the evolving role of bedside ultrasound
    Alan E Jones
    Crit Care Med 33:1874-5. 2005
  95. ncbi request reprint Echocardiographic and functional cardiopulmonary problems 6 months after first-time pulmonary embolism in previously healthy patients
    Brad G Stevinson
    MS4, School of Medicine, Georgetown University, Washington DC, USA
    Eur Heart J 28:2517-24. 2007
    ....
  96. ncbi request reprint Procalcitonin test in the diagnosis of bacteremia: a meta-analysis
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Ann Emerg Med 50:34-41. 2007
    ..We seek to evaluate the diagnostic performance of the procalcitonin test for the diagnosis of bacteremia in the emergency department (ED) population...
  97. ncbi request reprint Crash course in decision making
    Jeffrey A Kline
    Acad Emerg Med 11:179-80. 2004
  98. ncbi request reprint Estimating the pretest probability threshold to justify empiric administration of heparin prior to pulmonary vascular imaging for pulmonary embolism
    Kerstin E Hogg
    Department of Emergency Medicine, Hope Hospital, Manchester, UK
    Thromb Res 118:547-53. 2006
    ..For these three time points, we estimate the pretest probability of pulmonary embolism to justify the empiric administration of heparin...
  99. ncbi request reprint Use of goal-directed therapy for severe sepsis and septic shock in academic emergency departments
    Alan E Jones
    Crit Care Med 33:1888-9; author reply 1889-90. 2005
  100. ncbi request reprint Focused training of emergency medicine residents in goal-directed echocardiography: a prospective study
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Acad Emerg Med 10:1054-8. 2003
    ..To determine if a focused transthoracic echocardiography (TTE) training course would improve the accuracy of completion and interpretation of a goal-directed TTE by emergency medicine residents...