RICHARD CENEDELLA

Summary

Affiliation: Kirksville College of Osteopathic Medicine
Country: USA

Publications

  1. doi request reprint Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes
    Richard J Cenedella
    Department of Biochemistry, A T Still University of Health Sciences, 800 West Jefferson Street, Kirksville, MO 63501, USA
    Lipids 44:477-87. 2009
  2. ncbi request reprint Status of caveolin-1 in various membrane domains of the bovine lens
    Richard J Cenedella
    Department of Biochemistry, A T Still University of Health Sciences, Kirksville, MO 63501, USA
    Exp Eye Res 85:473-81. 2007
  3. ncbi request reprint Comparison of effects of U18666A and enantiomeric U18666A on sterol synthesis and induction of apoptosis
    Richard J Cenedella
    Department of Biochemistry, Kirksville College of Osteopathic Medicine, Kirksville, Missouri 63501, USA
    Lipids 40:635-40. 2005
  4. ncbi request reprint Concentration and distribution of ubiquinone (coenzyme Q), the endogenous lipid antioxidant, in the rat lens: effect of treatment with simvastatin
    Richard J Cenedella
    Department of Biochemistry, Kirksville College of Osteopathic Medicine, Kirksville, MO 63501, USA
    Mol Vis 11:594-602. 2005
  5. ncbi request reprint Multiple forms of 22 kDa caveolin-1 alpha present in bovine lens cells could reflect variable palmitoylation
    Richard J Cenedella
    Department of Biochemistry, Kirksville College of Osteopathic Medicine, A T Still University of Health Sciences, Kirksville, MO 63501, USA
    Exp Eye Res 82:229-35. 2006
  6. ncbi request reprint Diethylstilbestrol increases intracellular calcium in lens epithelial cells
    Abbas Samadi
    Department of Biochemistry, College of Osteopathic Medicine, Kirksville, MO 63501, USA
    Pflugers Arch 450:145-54. 2005
  7. ncbi request reprint Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor
    Richard J Cenedella
    Department of Biochemistry, Kirksville College of Osteopathic Medicine, Kirksville, MO 63501, USA
    J Lipid Res 45:1232-41. 2004
  8. ncbi request reprint Distribution of caveolin-1 in bovine lens and redistribution in cultured bovine lens epithelial cells upon confluence
    Patricia S Sexton
    Department of Biochemistry, Kirksville College of Osteopathic Medicine, 800 West Jefferson, Kirksville, MO 63501, USA
    Exp Eye Res 78:75-82. 2004
  9. ncbi request reprint Discordant expression of the sterol pathway in lens underlies simvastatin-induced cataracts in Chbb: Thom rats
    Richard J Cenedella
    Department of Biochemistry, Kirksville College of Osteopathic Medicine, Kirksville, MO, USA
    J Lipid Res 44:198-211. 2003
  10. ncbi request reprint Rapid, non-genomic actions of progesterone and estradiol on steady-state calcium and resting calcium influx in lens epithelial cells
    Abbas Samadi
    Dept of Biochemistry, Kirksville College of Osteopathic Medicine, Kirksville, MO 63501, USA
    Pflugers Arch 444:700-9. 2002

Research Grants

  1. LENS CHOLESTEROL METABOLISM AND THE U18666A CATARACT
    RICHARD CENEDELLA; Fiscal Year: 2000
  2. LENS MEMBRANE STEROID BINDING PROTEIN (MSRP)
    RICHARD CENEDELLA; Fiscal Year: 2002
  3. A NEW ANIMAL MODEL FOR CATARACTS: STUDY OF MECHANISM
    RICHARD CENEDELLA; Fiscal Year: 1980
  4. LENS CHOLESTEROL METABOLISM AND THE U18666A CATARACT
    RICHARD CENEDELLA; Fiscal Year: 1993
  5. LENS CHOLESTEROL METABOLISM AND THE U18666A CATARACT
    RICHARD CENEDELLA; Fiscal Year: 1990
  6. Lens Cholesterol Metobolism and the U1866A Cataract.
    RICHARD CENEDELLA; Fiscal Year: 2005

Detail Information

Publications12

  1. doi request reprint Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes
    Richard J Cenedella
    Department of Biochemistry, A T Still University of Health Sciences, 800 West Jefferson Street, Kirksville, MO 63501, USA
    Lipids 44:477-87. 2009
    ..The similarity of the effects of natural and enantiomeric U18666A on cells and the capacity of intercalated U18666A to increase membrane order are arguments in favor of this possibility...
  2. ncbi request reprint Status of caveolin-1 in various membrane domains of the bovine lens
    Richard J Cenedella
    Department of Biochemistry, A T Still University of Health Sciences, Kirksville, MO 63501, USA
    Exp Eye Res 85:473-81. 2007
    ..We estimate that these domains occupied 25-30% of the fiber cell membrane surface. Thus, the status of caveolin-1 in lens epithelial cells appears markedly different from that in fiber cells...
  3. ncbi request reprint Comparison of effects of U18666A and enantiomeric U18666A on sterol synthesis and induction of apoptosis
    Richard J Cenedella
    Department of Biochemistry, Kirksville College of Osteopathic Medicine, Kirksville, Missouri 63501, USA
    Lipids 40:635-40. 2005
    ....
  4. ncbi request reprint Concentration and distribution of ubiquinone (coenzyme Q), the endogenous lipid antioxidant, in the rat lens: effect of treatment with simvastatin
    Richard J Cenedella
    Department of Biochemistry, Kirksville College of Osteopathic Medicine, Kirksville, MO 63501, USA
    Mol Vis 11:594-602. 2005
    ..Our goal was to identify the Ubs and determine the concentration and distribution of Ubs in the rat lens and the effect of treatment with simvastatin, a cholesterol synthesis inhibitor, on lens levels...
  5. ncbi request reprint Multiple forms of 22 kDa caveolin-1 alpha present in bovine lens cells could reflect variable palmitoylation
    Richard J Cenedella
    Department of Biochemistry, Kirksville College of Osteopathic Medicine, A T Still University of Health Sciences, Kirksville, MO 63501, USA
    Exp Eye Res 82:229-35. 2006
    ..We suggest that the observed spectrum of caveolin multiforms could reflect variable palmitoylation of its three cysteine residues and result in populations of caveolin-1 alpha molecules with separate physical and functional properties...
  6. ncbi request reprint Diethylstilbestrol increases intracellular calcium in lens epithelial cells
    Abbas Samadi
    Department of Biochemistry, College of Osteopathic Medicine, Kirksville, MO 63501, USA
    Pflugers Arch 450:145-54. 2005
    ..These results indicate that DES releases CPA-sensitive stores of intracellular Ca(2+), perhaps by inhibiting SERCA-dependent Ca(2+) sequestration...
  7. ncbi request reprint Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor
    Richard J Cenedella
    Department of Biochemistry, Kirksville College of Osteopathic Medicine, Kirksville, MO 63501, USA
    J Lipid Res 45:1232-41. 2004
    ..Induction of apoptosis may begin by intercalation of U18666A into cell membranes. By increasing membrane structural order, U18666A may also increase light scatter, thus directly contributing to lens opacification...
  8. ncbi request reprint Distribution of caveolin-1 in bovine lens and redistribution in cultured bovine lens epithelial cells upon confluence
    Patricia S Sexton
    Department of Biochemistry, Kirksville College of Osteopathic Medicine, 800 West Jefferson, Kirksville, MO 63501, USA
    Exp Eye Res 78:75-82. 2004
    ..EGF stimulated phosphorylation of caveolin-1 in human A431 cells but not lens cells...
  9. ncbi request reprint Discordant expression of the sterol pathway in lens underlies simvastatin-induced cataracts in Chbb: Thom rats
    Richard J Cenedella
    Department of Biochemistry, Kirksville College of Osteopathic Medicine, Kirksville, MO, USA
    J Lipid Res 44:198-211. 2003
    ....
  10. ncbi request reprint Rapid, non-genomic actions of progesterone and estradiol on steady-state calcium and resting calcium influx in lens epithelial cells
    Abbas Samadi
    Dept of Biochemistry, Kirksville College of Osteopathic Medicine, Kirksville, MO 63501, USA
    Pflugers Arch 444:700-9. 2002
    ....
  11. ncbi request reprint Beware of combining erythromycin with a statin
    Richard J Cenedella
    J Am Osteopath Assoc 103:117. 2003
  12. ncbi request reprint Immunomagnetic capture of lens membrane fractions containing steroid binding protein
    Patricia S Sexton
    Department of Biochemistry, Kirksville College of Osteopathic Medicine, 800 West Jefferson, Kirksville, MO 63501, USA
    Biochem Biophys Res Commun 295:1027-31. 2002
    ..Microsomes contained the 28 kDa MSBP. Lens fiber cell membrane contained a 55 kDa immunoreactive protein. The role of this serendipitously recognized protein in binding of steroids is unknown...

Research Grants31

  1. LENS CHOLESTEROL METABOLISM AND THE U18666A CATARACT
    RICHARD CENEDELLA; Fiscal Year: 2000
    ..Alpha crystallin binds to membrane at both low and high affinity sites. By using bifunctional crosslinking agents we hope to identify the membrane components responsible for crystallin binding at these sites. ..
  2. LENS MEMBRANE STEROID BINDING PROTEIN (MSRP)
    RICHARD CENEDELLA; Fiscal Year: 2002
    ..Preliminary findings and published data support the possibility that steroids can rapidly elevate intracellular calcium and inhibit Na+/K+-ATPase activity in lens epithelial cells. ..
  3. A NEW ANIMAL MODEL FOR CATARACTS: STUDY OF MECHANISM
    RICHARD CENEDELLA; Fiscal Year: 1980
    ..The proposed project promises to develop a new model for the study of cataracts and will provide new information on the biochemistry of cataracts which could contribute to a greater understanding of human lens disorders...
  4. LENS CHOLESTEROL METABOLISM AND THE U18666A CATARACT
    RICHARD CENEDELLA; Fiscal Year: 1993
    ....
  5. LENS CHOLESTEROL METABOLISM AND THE U18666A CATARACT
    RICHARD CENEDELLA; Fiscal Year: 1990
    ....
  6. Lens Cholesterol Metobolism and the U1866A Cataract.
    RICHARD CENEDELLA; Fiscal Year: 2005
    ..These are obvious benefits to public health considering the intended life-long use of the drugs. ..