Datta B. Roles of P67/MetAP2 as a tumor suppressor. Biochim Biophys Acta. 2009;1796:281-92 pubmed publisher
..In this article, roles of p67/MetAP2 in the suppression of cancer development are also discussed. ..
Datta B, Ghosh A, Majumdar A, Datta R. Autoproteolysis of rat p67 generates several peptide fragments: the N-terminal fragment, p26, is required for the protection of eIF2alpha from phosphorylation. Biochemistry. 2007;46:3465-75 pubmed
..Altogether, our data provide evidence that rat p67 has autoproteolytic activity that generates p26, which is required to block eIF2alpha from phosphorylation. ..
Datta B, Datta R, Majumdar A, Ghosh A. The stability of eukaryotic initiation factor 2-associated glycoprotein, p67, increases during skeletal muscle differentiation and that inhibits the phosphorylation of extracellular signal-regulated kinases 1 and 2. Exp Cell Res. 2005;303:174-82 pubmed
..p67 binds to ERK2 and inhibits its activity in vitro. Taken together, these results suggest that the stability of p67 increases during myotube formation while inhibiting the phosphorylation of ERKs 1 and 2. ..
Datta B, Majumdar A, Datta R, Balusu R. Treatment of cells with the angiogenic inhibitor fumagillin results in increased stability of eukaryotic initiation factor 2-associated glycoprotein, p67, and reduced phosphorylation of extracellular signal-regulated kinases. Biochemistry. 2004;43:14821-31 pubmed
..These results suggest that fumagillin increases the stability of p67 and its affinity to ERKs 1 and 2 and causes the inhibition of the phosphorylation of ERKs 1 and 2. ..