Affiliation: Kennedy Krieger Institute
- Hepatocyte growth factor enhances death receptor-induced apoptosis by up-regulating DR5Yang Li
Hugo W, Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA
BMC Cancer 8:325. 2008..Dependent on cell context and the involvement of specific downstream effectors, both pro- and anti-apoptotic effects of HGF have been reported...
- Regulation of glioblastoma stem cells by retinoic acid: role for Notch pathway inhibitionM Ying
Department of Neuro Oncology, Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA
Oncogene 30:3454-67. 2011..Our findings identify mechanisms by which RA targets GBM-derived stem-like tumor-initiating cells and novel targets applicable to differentiation therapies for glioblastoma...
- EphB2 receptor controls proliferation/migration dichotomy of glioblastoma by interacting with focal adhesion kinaseS D Wang
Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA
Oncogene 31:5132-43. 2012..These novel findings suggest that tumor cell invasion can be therapeutically targeted by inhibiting EphB2 signaling, and that optimal antitumor responses to EphB2 targeting may require concurrent use of anti-proliferative agents...