Elaine Tierney

Summary

Affiliation: Kennedy Krieger Institute
Country: USA

Publications

  1. ncbi request reprint Behavior phenotype in the RSH/Smith-Lemli-Opitz syndrome
    E Tierney
    Department of Psychiatry, Kennedy Krieger Institute, Baltimore, Maryland 21231, USA
    Am J Med Genet 98:191-200. 2001
  2. ncbi request reprint Parent satisfaction in a multi-site acute trial of risperidone in children with autism: a social validity study
    Elaine Tierney
    Department of Psychiatry, Kennedy Krieger Institute, Baltimore, MD, USA
    Psychopharmacology (Berl) 191:149-57. 2007
  3. pmc Abnormalities of cholesterol metabolism in autism spectrum disorders
    Elaine Tierney
    Kennedy Krieger Institute, Baltimore, Maryland 21211, USA
    Am J Med Genet B Neuropsychiatr Genet 141:666-8. 2006
  4. ncbi request reprint Autism spectrum disorder in Fragile X syndrome: differential contribution of adaptive socialization and social withdrawal
    Dejan B Budimirovic
    Center for Genetic Disorders of Cognition and Behavior, Kennedy Krieger Institute, Baltimore, Maryland 21211, USA
    Am J Med Genet A 140:1814-26. 2006
  5. ncbi request reprint Positive effects of methylphenidate on inattention and hyperactivity in pervasive developmental disorders: an analysis of secondary measures
    David J Posey
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Biol Psychiatry 61:538-44. 2007
  6. ncbi request reprint Autism spectrum disorder in fragile X syndrome: communication, social interaction, and specific behaviors
    Walter E Kaufmann
    Kennedy Krieger Institute, Baltimore, Maryland 21211, USA
    Am J Med Genet A 129:225-34. 2004
  7. ncbi request reprint Smith-Lemli-Opitz syndrome and autism spectrum disorder
    Irena Bukelis
    Center for Genetic Disorders of Cognition and Behavior, Department of Psychiatry, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, 3901 Greenspring Ave, Baltimore, MD 21211, USA
    Am J Psychiatry 164:1655-61. 2007
  8. ncbi request reprint Risperidone for the core symptom domains of autism: results from the study by the autism network of the research units on pediatric psychopharmacology
    Christopher J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4800, USA
    Am J Psychiatry 162:1142-8. 2005
  9. doi request reprint Autism: the role of cholesterol in treatment
    Alka Aneja
    Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, and Department of Psychiatry, Kennedy Krieger Institute, Baltimore, MD 21211, USA
    Int Rev Psychiatry 20:165-70. 2008
  10. pmc Analysis of short-term behavioral effects of dietary cholesterol supplementation in Smith-Lemli-Opitz syndrome
    Elaine Tierney
    Department of Psychiatry, Kennedy Krieger Institute, Baltimore, MD, USA
    Am J Med Genet A 152:91-5. 2010

Detail Information

Publications27

  1. ncbi request reprint Behavior phenotype in the RSH/Smith-Lemli-Opitz syndrome
    E Tierney
    Department of Psychiatry, Kennedy Krieger Institute, Baltimore, Maryland 21231, USA
    Am J Med Genet 98:191-200. 2001
    ..1993, 1994]. Thus, SLOS is a metabolic disorder that can be associated with autism and other behavioral characteristics that define a distinctive and diagnostically important behavioral disorder...
  2. ncbi request reprint Parent satisfaction in a multi-site acute trial of risperidone in children with autism: a social validity study
    Elaine Tierney
    Department of Psychiatry, Kennedy Krieger Institute, Baltimore, MD, USA
    Psychopharmacology (Berl) 191:149-57. 2007
    ..Designing studies that consider the consumer's perspective will help to forge a better alliance between participants and researchers...
  3. pmc Abnormalities of cholesterol metabolism in autism spectrum disorders
    Elaine Tierney
    Kennedy Krieger Institute, Baltimore, Maryland 21211, USA
    Am J Med Genet B Neuropsychiatr Genet 141:666-8. 2006
    ..These findings suggest that, in addition to SLOS, there may be other disorders of sterol metabolism or homeostasis associated with ASD...
  4. ncbi request reprint Autism spectrum disorder in Fragile X syndrome: differential contribution of adaptive socialization and social withdrawal
    Dejan B Budimirovic
    Center for Genetic Disorders of Cognition and Behavior, Kennedy Krieger Institute, Baltimore, Maryland 21211, USA
    Am J Med Genet A 140:1814-26. 2006
    ....
  5. ncbi request reprint Positive effects of methylphenidate on inattention and hyperactivity in pervasive developmental disorders: an analysis of secondary measures
    David J Posey
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Biol Psychiatry 61:538-44. 2007
    ....
  6. ncbi request reprint Autism spectrum disorder in fragile X syndrome: communication, social interaction, and specific behaviors
    Walter E Kaufmann
    Kennedy Krieger Institute, Baltimore, Maryland 21211, USA
    Am J Med Genet A 129:225-34. 2004
    ..Altogether, our findings demonstrate that the diagnosis of ASD in FraX reflects, to a large extent, an impairment in social interaction that is expressed with variable severity in young males with FraX...
  7. ncbi request reprint Smith-Lemli-Opitz syndrome and autism spectrum disorder
    Irena Bukelis
    Center for Genetic Disorders of Cognition and Behavior, Department of Psychiatry, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, 3901 Greenspring Ave, Baltimore, MD 21211, USA
    Am J Psychiatry 164:1655-61. 2007
  8. ncbi request reprint Risperidone for the core symptom domains of autism: results from the study by the autism network of the research units on pediatric psychopharmacology
    Christopher J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4800, USA
    Am J Psychiatry 162:1142-8. 2005
    ..The authors report on whether risperidone improves the core symptoms of autism, social and communication impairment and repetitive and stereotyped behavior...
  9. doi request reprint Autism: the role of cholesterol in treatment
    Alka Aneja
    Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, and Department of Psychiatry, Kennedy Krieger Institute, Baltimore, MD 21211, USA
    Int Rev Psychiatry 20:165-70. 2008
    ..There is an increasing recognition that this single-gene disorder of abnormal cholesterol synthesis may be a model for understanding genetic causes of autism and the role of cholesterol in ASD...
  10. pmc Analysis of short-term behavioral effects of dietary cholesterol supplementation in Smith-Lemli-Opitz syndrome
    Elaine Tierney
    Department of Psychiatry, Kennedy Krieger Institute, Baltimore, MD, USA
    Am J Med Genet A 152:91-5. 2010
    ..The results of this study call into question anecdotal reports supporting rapid behavioral benefits previously reported for dietary cholesterol supplementation in SLOS and underscore the need for a larger placebo-controlled trial...
  11. doi request reprint Cognitive and behavioral aspects of Smith-Lemli-Opitz syndrome
    Andrea Diaz-Stransky
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Med Genet C Semin Med Genet 160:295-300. 2012
    ..This would accelerate the development of treatments for SLOS, and perhaps also further understanding of non-syndromic psychiatric disorders such as autism and attention deficit hyperactivity disorder...
  12. doi request reprint Behavioral and psychiatric features of Sturge-Weber syndrome
    Elizabeth Turin
    Kennedy Krieger Institute, Department of Psychiatry, Baltimore, MD 21205, USA
    J Nerv Ment Dis 198:905-13. 2010
    ..Problems with mood, attention, sleep, learning, and substance use were common. Disruptive behavior disorders and their association with medical conditions should be further investigated...
  13. pmc Increased symptoms of attention deficit hyperactivity disorder and major depressive disorder symptoms in Nail-patella syndrome: potential association with LMX1B loss-of-function
    Carmen López-Arvizu
    Department of Psychiatry, Center for Genetic Disorders of Cognition and Behavior, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 156:59-66. 2011
    ..The co-occurrence of these symptoms may be related to mesencephalic dopaminergic neurologic pathway abnormalities that are a consequence of LMX1B loss of function...
  14. ncbi request reprint Social behavior profile in young males with fragile X syndrome: characteristics and specificity
    Alice S M Kau
    Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Am J Med Genet A 126:9-17. 2004
    ..In agreement with recent studies, our data suggest that FraX+Aut, and more generally SBP, is a distinctive subphenotype among boys with FraX, which may share some pathophysiological mechanisms with IA...
  15. ncbi request reprint Parent-defined target symptoms respond to risperidone in RUPP autism study: customer approach to clinical trials
    L Eugene Arnold
    Ohio State University, 479 S Galena Road, Sunbury, OH 43074, USA
    J Am Acad Child Adolesc Psychiatry 42:1443-50. 2003
    ..A consumer-oriented efficacy assessment in clinical trials should measure changes in chief complaint and consumer request (symptoms of most concern to patient/caregiver), which may be diluted in change scores of multisymptom scales...
  16. ncbi request reprint Weight and leptin changes among risperidone-treated youths with autism: 6-month prospective data
    Andres Martin
    Yale Child Study Center, Yale University, New Haven, CT 06520, USA
    Am J Psychiatry 161:1125-7. 2004
    ..The authors examined the developmental impact and temporal characteristics of risperidone-associated weight change...
  17. ncbi request reprint Research knowledge among parents of children participating in a randomized clinical trial
    Benedetto Vitiello
    Child and Adolescent Treatment and Preventive Intervention Research Branch, National Institute of Mental Health, Bethesda, MD 20892 9633, USA
    J Am Acad Child Adolesc Psychiatry 44:145-9. 2005
    ..Parental permission is required for child research, but parents' understanding of research aims and procedures has not been well documented. Parental research knowledge was assessed during a clinical trial in autism...
  18. ncbi request reprint Assessment of the integrity of study blindness in a pediatric clinical trial of risperidone
    Benedetto Vitiello
    Division of Services and Intervention Research, National Institute of Mental Health, Bethesda, MD 20892 9633, USA
    J Clin Psychopharmacol 25:565-9. 2005
    ..The blindness of clinical evaluators and parents was examined in a clinical trial of risperidone in autism...
  19. ncbi request reprint Acute and long-term safety and tolerability of risperidone in children with autism
    Michael G Aman
    The Nisonger Center, Ohio State University, Columbus, Ohio 43210 1296, USA
    J Child Adolesc Psychopharmacol 15:869-84. 2005
    ..Most AEs were mild to moderate and failed to interfere with therapeutic changes; there were no unanticipated AEs. The side effects of most concern were somnolence and weight gain...
  20. ncbi request reprint Parent-rated anxiety symptoms in children with pervasive developmental disorders: frequency and association with core autism symptoms and cognitive functioning
    Denis G Sukhodolsky
    The Child Study Center, Yale University, 230 South Frontage Road, New Haven, CT 06520, USA
    J Abnorm Child Psychol 36:117-28. 2008
    ..Limited data are available on the prevalence of anxiety in these children. We examined frequency and correlates of parent-rated anxiety symptoms in a large sample of children with PDD...
  21. ncbi request reprint Risperidone and adaptive behavior in children with autism
    Susan K Williams
    Yale University, New Haven, CT 06520 7900, USA
    J Am Acad Child Adolesc Psychiatry 45:431-9. 2006
    ..To evaluate the impact of risperidone on adaptive behavior in children with autistic disorder who have serious behavior problems and to examine different methods of scoring the Vineland Adaptive Behavior Scales to measure change...
  22. ncbi request reprint Dietary status and impact of risperidone on nutritional balance in children with autism: a pilot study
    Ronald L Lindsay
    Children s Health Center of St Joseph s Hospital and Medical Center, Arizona 85013, USA
    J Intellect Dev Disabil 31:204-9. 2006
    ..Risperidone may be effective in improving tantrums, aggression, or self-injurious behaviour in children with autism, but often leads to weight gain...
  23. ncbi request reprint Risperidone in children with autism and serious behavioral problems
    James T McCracken
    University of California, Los Angeles, USA
    N Engl J Med 347:314-21. 2002
    ..However, data on the safety and efficacy of atypical antipsychotic agents in children are limited...
  24. ncbi request reprint Effects of short- and long-term risperidone treatment on prolactin levels in children with autism
    George M Anderson
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 61:545-50. 2007
    ..The effects of short- and long-term risperidone treatment on serum prolactin were assessed in children and adolescents with autism...
  25. ncbi request reprint Children's Yale-Brown Obsessive Compulsive Scale modified for pervasive developmental disorders
    Lawrence Scahill
    Yale Child Study Center, Yale University, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 45:1114-23. 2006
    ..To examine the psychometric properties of the Children's Yale-Brown Obsessive Compulsive Scales (CYBOCS) modified for pervasive developmental disorders (PDDs)...
  26. ncbi request reprint Validity of the autism diagnostic interview-revised
    Luc Lecavalier
    Nisonger Center, The Ohio State University, Columbus, USA
    Am J Ment Retard 111:199-215. 2006
    ..They indicated some similarities between constructs, but also that the ADI-R measures autism in a unique fashion...
  27. ncbi request reprint A prospective open trial of guanfacine in children with pervasive developmental disorders
    Lawrence Scahill
    Yale Child Study Center, P O Box 207900, New Haven, CT 06520, USA
    J Child Adolesc Psychopharmacol 16:589-98. 2006
    ..A common complaint for children with pervasive developmental disorder (PDD) is hyperactivity. The purpose of this pilot study was to gather preliminary information on the efficacy of guanfacine in children with PDD and hyperactivity...