Wayne Silverman

Summary

Affiliation: Kennedy Krieger Institute
Country: USA

Publications

  1. ncbi request reprint Down syndrome: cognitive phenotype
    Wayne Silverman
    Department of Behavioral Psychology, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Ment Retard Dev Disabil Res Rev 13:228-36. 2007
  2. ncbi request reprint Obesity enhances verbal memory in postmenopausal women with Down syndrome
    Bindu N Patel
    Laboratory of Epidemiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurobiol Aging 25:159-66. 2004
  3. ncbi request reprint Incidence and temporal patterns of adaptive behavior change in adults with mental retardation
    Warren B Zigman
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314 6399, USA
    Am J Ment Retard 107:161-74. 2002
  4. doi request reprint Successful aging in a 70-year-old man with down syndrome: a case study
    Sharon J Krinsky-McHale
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Intellect Dev Disabil 46:215-28. 2008
  5. pmc Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome
    Nicole Schupf
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, G H Sergievsky Center, New York, NY, USA
    Dement Geriatr Cogn Disord 25:476-82. 2008
  6. doi request reprint Maladaptive behaviors related to dementia status in adults with Down syndrome
    Tiina K Urv
    Eunice Kennedy Shriver Center, University of Massachusetts Medical School, USA
    Am J Ment Retard 113:73-86. 2008
  7. pmc Association between genetic variants in sortilin-related receptor 1 (SORL1) and Alzheimer's disease in adults with Down syndrome
    Joseph H Lee
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA
    Neurosci Lett 425:105-9. 2007
  8. pmc Elevated plasma beta-amyloid peptide Abeta(42) levels, incident dementia, and mortality in Down syndrome
    Nicole Schupf
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, PO Box 16, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 64:1007-13. 2007
  9. pmc Cholesterol level, statin use and Alzheimer's disease in adults with Down syndrome
    Warren B Zigman
    Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, United States
    Neurosci Lett 416:279-84. 2007
  10. ncbi request reprint Bioavailable estradiol and age at onset of Alzheimer's disease in postmenopausal women with Down syndrome
    Nicole Schupf
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Neurosci Lett 406:298-302. 2006

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Down syndrome: cognitive phenotype
    Wayne Silverman
    Department of Behavioral Psychology, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Ment Retard Dev Disabil Res Rev 13:228-36. 2007
    ..This profile of uneven deficits could result from a failure to develop typically automatic processing for speech perception and production, and this possibility is discussed along with its implications for intervention...
  2. ncbi request reprint Obesity enhances verbal memory in postmenopausal women with Down syndrome
    Bindu N Patel
    Laboratory of Epidemiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurobiol Aging 25:159-66. 2004
    ..Our results support the hypothesis that higher endogenous estrogen levels after menopause are associated with better performance on verbal memory...
  3. ncbi request reprint Incidence and temporal patterns of adaptive behavior change in adults with mental retardation
    Warren B Zigman
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314 6399, USA
    Am J Ment Retard 107:161-74. 2002
    ....
  4. doi request reprint Successful aging in a 70-year-old man with down syndrome: a case study
    Sharon J Krinsky-McHale
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Intellect Dev Disabil 46:215-28. 2008
    ..The authors present potential explanations for the phenotypic variability observed in individuals with Down syndrome...
  5. pmc Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome
    Nicole Schupf
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, G H Sergievsky Center, New York, NY, USA
    Dement Geriatr Cogn Disord 25:476-82. 2008
    ..Two tightly linked polymorphisms (PvuII and XbaI) in the first intron of estrogen receptor 1 (ESR1), the gene for ER-alpha, have been reported to influence estrogen receptor expression and may influence the risk of AD...
  6. doi request reprint Maladaptive behaviors related to dementia status in adults with Down syndrome
    Tiina K Urv
    Eunice Kennedy Shriver Center, University of Massachusetts Medical School, USA
    Am J Ment Retard 113:73-86. 2008
    ..Thus, new concerns regarding these types of behaviors could be particularly useful in clarifying the dementia status of adults with Down syndrome and developing individualized plans for support...
  7. pmc Association between genetic variants in sortilin-related receptor 1 (SORL1) and Alzheimer's disease in adults with Down syndrome
    Joseph H Lee
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA
    Neurosci Lett 425:105-9. 2007
    ..Thus, further studies are needed to identify functional variants that influence risk for AD in this uniquely vulnerable population...
  8. pmc Elevated plasma beta-amyloid peptide Abeta(42) levels, incident dementia, and mortality in Down syndrome
    Nicole Schupf
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, PO Box 16, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 64:1007-13. 2007
    ..Individuals with Down syndrome have increased levels of beta-amyloid peptides and an increased risk for AD...
  9. pmc Cholesterol level, statin use and Alzheimer's disease in adults with Down syndrome
    Warren B Zigman
    Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, United States
    Neurosci Lett 416:279-84. 2007
    ..402, p=.095, 95% CI: .138, 1.173). If the protective effects of statins can be further validated, these findings suggest that their use may delay or prevent AD onset in vulnerable populations...
  10. ncbi request reprint Bioavailable estradiol and age at onset of Alzheimer's disease in postmenopausal women with Down syndrome
    Nicole Schupf
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Neurosci Lett 406:298-302. 2006
    ..Our findings support the hypothesis that reductions in estrogen following menopause can contribute to the cascade of pathological processes leading to AD...
  11. pmc Cell type-specific over-expression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21
    Chi Ming Li
    Institute for Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, NY, USA
    BMC Med Genet 7:24. 2006
    ..Down syndrome (DS) is caused by trisomy 21 (+21), but the aberrations in gene expression resulting from this chromosomal aneuploidy are not yet completely understood...
  12. ncbi request reprint Mortality is associated with apolipoprotein E epsilon4 in nondemented adults with Down syndrome
    Warren B Zigman
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    Neurosci Lett 390:93-7. 2005
    ..These results suggest that the apolipoprotein E epsilon4 allele has an independent and strong relation to early mortality...
  13. ncbi request reprint Incidence and prevalence of dementia in elderly adults with mental retardation without down syndrome
    Warren B Zigman
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA
    Am J Ment Retard 109:126-41. 2004
    ....
  14. ncbi request reprint Onset of dementia is associated with age at menopause in women with Down's syndrome
    Nicole Schupf
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
    Ann Neurol 54:433-8. 2003
    ..Our findings support the hypothesis that reductions in estrogens after menopause contribute to the cascade of pathological processes leading to AD...
  15. ncbi request reprint Maladaptive behaviors related to adaptive decline in aging adults with mental retardation
    Tiina K Urv
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Am J Ment Retard 108:327-39. 2003
    ....
  16. ncbi request reprint Implicit memory in aging adults with mental retardation with and without Down syndrome
    Sharon J Krinsky-McHale
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314 6399, USA
    Am J Ment Retard 108:219-33. 2003
    ..Data support existing theories proposing the relative invariance of implicit processes across a range of individual differences in age and intelligence...
  17. doi request reprint Selective attention deficits associated with mild cognitive impairment and early stage Alzheimer's disease in adults with Down syndrome
    Sharon J Krinsky-McHale
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314 6399, USA
    Am J Ment Retard 113:369-86. 2008
    ..Given these qualities this task could be a valuable addition to a neuropsychological battery intended for the assessment of mild cognitive impairment and Alzheimer's disease in adults with Down syndrome...